That time I was subject of scientific study, and not an editor.....🏃‍♀️🧪

A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health. (THREAD 🧵) scim.ag/3JgfUWd

🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/... @sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)! You can submit your abstracts here: iuis2025.org/abstracts/ I hope to see many of you this August in beautiful Vienna!!! #Immunology #Science2025 #CallForAbstracts #IUIS

Happy World #DayofImmunology!

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸 www.science.org/doi/10.1126/...

In #ScienceImmunology, researchers describe how #hunger perception in the brain can mimic the effects of #fasting and alter circulating immune cell levels. Read about this study and more: scim.ag/4j3gx2A

It's #WorldTBDay! Sharing a recent review article in Science Immunology by @tomscriba.bsky.social about our current understanding of the immunopathology of #TB www.science.org/doi/10.1126/...

New research in #ScienceImmunology provides insight into the mechanisms underlying photosensitivity, or ultraviolet light-induced skin inflammation, in certain autoimmune disorders. scim.ag/4iv9kaO

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!

The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production. www.science.org/doi/10.1126/...

Check out the paper below with its related Perspective in @science.org Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae | Science www.science.org/doi/10.1126/...

This week in #Science #Immunology: researchers @ @uwmadison.bsky.social use #AAV vectors to deliver 2 Abs—one neutralizing #SIV infectivity & killing infected cells via #ADCC & another mediating ADCC but non-neutralizing—to prevent resurgence of SIV replication in #macaques after discontinuing #ART!

This week in #Science #Immunology: Peng Shao, Noah Butler, & colleagues at University of Iowa show that TRAF3 is critical for early #TFollicularHelper ( #Tfh ) cell differentiation!

🧬🧪Protein codes promote selective subcellular compartmentalization | Science www.science.org/doi/10.1126/... Henry Kilgore @itamarchinn.bsky.social @pgmikhael.bsky.social Ilan Mitnikov, et al. @aihealthmit.bsky.social @whiteheadinstitute.bsky.social @mitofficial.bsky.social

Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...

Recently in #Science #Immunology: Vidit Bhandakar, Teresa Dinter, & Stefani Spranger from the Koch Institute at @mitofficial.bsky.social have written a terrific #Review on how #DendriticCell signals specify #CD8 #TCell fates in #cancer! #DCs

This is ... a public ... service ... announcement!

Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...

In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.

@karenvincent.bsky.social welcome!

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

The January issue of #Science #Immunology is now live! This week: new insights into #NLRP3 #inflammasome activation; key distinctions btw rodent & human #PD1 orthologs uncovered; & targeting thrombospondin-1 (Thbs1) to suppress #HSC #inflammaging! www.science.org/toc/sciimmun...

Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout) www.science.org/doi/10.1126/...

First issue of #Science #Immunology out for 2025! Check out this paper by Masabuchi et al. defining why rodent and human PD-1 function differently!🐀🚶‍♀️@enfuhui.bsky.social www.science.org/doi/10.1126/...

My holiday gift to all of you: The editors of @science.org's favorite papers of 2024, all wrapped up nicely in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

#Immunology by First release now @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection https://buff.ly/3DjNQ1e By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

Good news on a H5N1 vaccine efficacy in a preclinical model in case it is needed science.org/doi/10.1126/...

New review out in #science #immunology on tuberculosis immunopathology by @tomscriba.bsky.social et al.🫁🦠 www.science.org/doi/10.1126/...

Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months. Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn

The cover of the Dec 2024 issue of #Science #Immunology highlights life stages of the #intestinal #helminth Heligmosomoides polygyrus bakeri (Hpb). Bohnacker et al. show that Hpb can suppress type 2 immune responses through the activity of glutamate dehydrogenase. www.science.org/toc/sciimmun...

Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!

I can't think of a better first post than to highlight STM's recent special issue on #longcovid. www.science.org/toc/stm/16/773

This week in #ScienceImmunology: Olivier Demaria, Eric Vivier, & al. use tetraspecific #NKCell engager (comprising an anti- #NKp46 Ab fragment + #IgG1 #Fc fragment + #IL2 variant + anti- #CD20 Ab) to target #BCell -specific #NonHodgkin #lymphoma (B-NHL) in mouse & NHP models! bit.ly/SI_adp3720

Continuing my posts on recent #myeloidcell papers in #ScienceImmunology, Sreya Bagchi, Edgar G. Engleman, & al. reported that tumor-associated macrophages accumulate and drive tumor growth in obesity-associated cancers due to enhanced signaling through the acid-sensing receptor GPR65.

In July, #ScienceImmunology published work that unraveled the #celldeath pathways in human airway #epithelium that drive #COVID19 severity www.science.org/doi/10.1126/...

How engineered T cells are changing the face of some autoimmune diseases via B cell depletion science.org/content/arti...

Also this week #ScienceMagazine cover study: Sequence modeling and design from molecular to genome scale with Evo www.science.org/doi/10.1126/... accompanied by a Perspective: Learning the language of DNA www.science.org/doi/10.1126/...

Delighted that my first post here is to share a story by Jennifer Couzin-Frankel I was lucky enough to work on at Science the last few weeks. Can CAR-T therapy be as big a breakthrough for autoimmune diseases as it has been for cancer? Meet the researchers trying to find out: tinyurl.com/356amkt8

In August, two papers highlight advances in #vaccine strategies to induce broadly neutralizing #antibodies against #HIV from Tom Caniels & colleagues, and Ashley Nelson & colleagues, with a Focus article by Rama Amara. www.science.org/doi/10.1126/...

Happy to be in this new blue place 💙 and share some recent #ScienceImmunology papers on infectious diseases like #HIV, #COVID19 and #Schistosomiasis 🦠🪱

At #ScienceImmunology, I lead a fantastic team of #research #editors comprising Chris Fogg (@cnfogg.bsky.social), Claire Olingy (@claireolingy.bsky.social), and Hannah Isles (@hannah-isles.bsky.social)! Be sure to give them a follow! www.science.org/journal/scii...

Autoimmune diseases have long been considered incurable. In today’s episode, we discuss how CAR-T cell therapy, an effective treatment for blood cancer, could move the needle in the right direction. Listen here 🎧: pod.link/73329284

Janelle Goetcheus, physician and healer to D.C.'s homeless, dies at 84 - https://is.gd/ehOBaf (Washington Post)