Hannah Isles
@hannah-isles.bsky.social
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Associate editor at Science Immunology Swiftie ✌🏻 Sheffield, UK 🌳
On the April cover of
#ScienceImmunology
: The brain’s perception of hunger (rather than nutrient availability) regulates circulating immune cell dynamics. Read more here:
www.science.org/doi/10.1126/...
7 months ago
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Science Swifties this is a must-read 🤩
add a skeleton here at some point
8 months ago
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In
#Science
#Immunology
this week: human naïve B cells can bind and neutralize
#H5N1
, potentially offering protection against
#birdflu
.
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Human naïve B cells recognize prepandemic influenza virus hemagglutinins
Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.
https://www.science.org/doi/10.1126/sciimmunol.ado9572
10 months ago
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reposted by
Hannah Isles
Claire Olingy
10 months ago
I’ll be here (joint with T cell Differentiation in Tissue Microenvironments) next week! Send me a message or email if you’d like to set up a time to chat. Looking forward to an exciting meeting!
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reposted by
Hannah Isles
Christiana Fogg
11 months ago
New review out in
#science
#immunology
on tuberculosis immunopathology by
@tomscriba.bsky.social
et al.🫁🦠
www.science.org/doi/10.1126/...
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Immunopathology in human tuberculosis
The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.
https://www.science.org/doi/10.1126/sciimmunol.ado5951
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This week in
#ScienceImmunology
: Germinal Center B cells require asparagine (Asn)
#metabolism
for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase.
@ajclarke.bsky.social
@yfy1.bsky.social
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Asparagine availability controls germinal center B cell homeostasis
Asparagine metabolism is a critical regulator of germinal center B cell function.
https://www.science.org/doi/10.1126/sciimmunol.adl4613
11 months ago
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reposted by
Hannah Isles
Yavuz Yazicioglu
11 months ago
Thrilled to share our latest work on how the non-essential amino acid
#asparagine
metabolically regulates germinal centers. Huge thanks to my PhD supervisor
@ajclarke.bsky.social
, colleagues, and collaborators at the
@ndorms.bsky.social
@ox.ac.uk
and
@crick.ac.uk
www.science.org/doi/10.1126/...
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Asparagine availability controls germinal center B cell homeostasis
Asparagine metabolism is a critical regulator of germinal center B cell function.
https://www.science.org/doi/10.1126/sciimmunol.adl4613
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reposted by
Hannah Isles
Kat Mayer-Barber,PhD
11 months ago
Best
#Nikolaus
🎅! Our paper on how the 🫁 microenvironment can shape
#innate
immunity against
#viruses
is out
@sciimmunology.bsky.social
This was a herculean effort brilliantly led by
@pauljbaker.bsky.social
who singlehandedly established the model in the lab during the pandemic. 🧪
#Immunosky
1/9
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reposted by
Hannah Isles
Kat Mayer-Barber,PhD
11 months ago
🙏 to
@niaidnews.bsky.social
, first author
@pauljbaker.bsky.social
and my amazing lab team, our collaborators
@kerryhilligan.bsky.social
@danbarberphd.bsky.social
🙏to editor extraordinaire
@hannah-isles.bsky.social
and the reviewers who guided us along the way 9/9
www.science.org/doi/10.1126/...
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The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication
Recent or ongoing respiratory inflammation in the lung regulates antiviral immune responses to SARS-CoV-2.
https://www.science.org/doi/10.1126/sciimmunol.adp7951
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reposted by
Hannah Isles
Science Magazine
11 months ago
Two new studies in Science describe synthetic biology-based strategies that expand the possibilities of harnessing immune cells to treat disease. Learn more in this week's issue:
scim.ag/49nfztS
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reposted by
Hannah Isles
Seth Thomas Scanlon
12 months ago
Now in
#Science
#Immunology
: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that
#NRF2
suppression mediated by the
#redox
sensor
#KEAP1
is required for optimal expansion of
#CD8
#TCells
during chronic antigen exposure!
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The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation
KEAP1 promotes persistent T cell immunity and a stem-like T cell response during chronic antigen stimulation by repressing NRF2.
https://www.science.org/doi/10.1126/sciimmunol.adk2954
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New in
#ScienceImmunology
: Research from
@boztugk.bsky.social
and team identifies an inborn error of
#immunity
caused by human LTβR deficiency, resulting in defective stromal cell signaling and impaired humoral immune responses. Read more:
www.science.org/doi/10.1126/...
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LTβR deficiency causes lymph node aplasia and impaired B cell differentiation
Loss-of-function mutations in LTBR result in a stromal defect, leading to dysfunctional secondary lymphoid organs and combined immunodeficiency in humans.
https://www.science.org/doi/10.1126/sciimmunol.adq8796
12 months ago
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Last week in
#ScienceImmunology
: An alternative approach to target TIM-3 for cancer
#immunotherapy
? Zhang et al. found that palmitoylation of human TIM-3 promoted its stability. Blocking palmitoylation accelerated TIM-3 degradation, prevented immune
#exhaustion
and promoted anti-tumor
#immunity
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Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity
Targeting TIM-3 palmitoylation mediated by DHHC9 enhances CAR-T cell– and NK cell–based tumor immunotherapy by suppressing immune exhaustion.
https://www.science.org/doi/10.1126/sciimmunol.adp7302
12 months ago
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Fantastic visit to
@cambridgeuni.bsky.social
pathology department today. Lots of exciting science and beautiful place to visit 🧪 thanks to
@labliston.bsky.social
for hosting!
12 months ago
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reposted by
Hannah Isles
Seth Thomas Scanlon
12 months ago
At
#ScienceImmunology
, I lead a fantastic team of
#research
#editors
comprising Chris Fogg (
@cnfogg.bsky.social
), Claire Olingy (
@claireolingy.bsky.social
), and Hannah Isles (
@hannah-isles.bsky.social
)! Be sure to give them a follow!
www.science.org/journal/scii...
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New here 🙋🏻♀️
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12 months ago
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reposted by
Hannah Isles
Carolyn King
about 1 year ago
let's do this!! I am excited to reconnect with scientists here. thx
@oneyrolles.bsky.social
for the push 😀
#Immunology
announcement: SAVE THE DATE: 26-29 August in Basel 🇨🇭 Mauro Gaya (CIML) and I are organizing an
#EMBO
workshop on Adaptive
#immunity
in barrier tissues; details coming soon!
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