Carolyn King
@immunologyking.bsky.social
📤 2913
📥 1231
📝 105
🇺🇸🇨🇭immunologist
@UniBasel.bsky.social
www.baselimmunology.com
reposted by
Carolyn King
Pete Buttigieg
4 days ago
It's an old and obvious pattern. An unpopular president - failing on the economy and losing his grip on power at home - decides to launch a war for regime change abroad. The American people don’t want to “run” a foreign country while our leaders fail to improve life in this one.
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Carolyn King
Zampieri Lab
19 days ago
We have multiple open positions in our lab (
www.zampierilab.org
). Interested candidates should apply through the University of Basel’s official recruitment portal:
www.unibas.ch/en/Working-a...
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Home - Zampieri Lab
By studying fundamental mechanisms regulating short- and long-term metabolic adaptation to genetic and chemical perturbations, our lab aims at finding new and unconventional therapeutic strategies, fr...
https://www.zampierilab.org
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Carolyn King
Torsten Schwede
19 days ago
Good morning Basel!
@unibas.ch
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Bryan Bryson
20 days ago
Two pieces of fun news: 1. We've launched a new website for our lab:
www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
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The Bryson Lab | Vaccine Development & Research at MIT
Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.
https://www.brysonlab.org/
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www.nasa.gov/missions/osi...
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Sugars, ‘Gum,’ Stardust Found in NASA's Asteroid Bennu Samples - NASA
The asteroid Bennu continues to provide new clues to scientists’ biggest questions about the formation of the early solar system and the origins of life. As
https://www.nasa.gov/missions/osiris-rex/sugars-gum-stardust-found-in-nasas-asteroid-bennu-samples/
23 days ago
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there is so much fabulous research taking place across Europe!!!! really exciting new projects funded by the ERC. congratulations to all 💪🏽
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28 days ago
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Carolyn King
Bryan Bryson
about 1 month ago
The
@ragoninstitute.bsky.social
is launching a new faculty search for a computational immunologist! Applications are open now and reviewed on a rolling basis. Please share broadly with your networks!
#immunosky
www.nature.com/naturecareer...
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Computational Immunologist - Boston, Massachusetts (US) job with Ragon Institute of MGH, MIT, & Harvard | 12849577
The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard in Cambridge MA, together with the Departmen
https://www.nature.com/naturecareers/job/12849577/computational-immunologist/
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www.srf.ch/news/interna...
and this, the same week my son's
@baselstadt.bsky.social
middle school SCIENCE teacher proclaimed that vaccines kill people, Trump is the only president against war and the former president was a pedophile. Look out?! if conspiracy theories are hitting
#Swiss
schools 🙃
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US-Kritik an EU: Europa drohe Verlust von Demokratie und Freiheit
Die USA sehen Demokratie und Meinungsfreiheit in Europa gefährdet – Brüssel reagiert empört. Das Wichtigste in Kürze.
https://www.srf.ch/news/international/spannungen-usa-europa-trump-kritisiert-europa-us-strategie-sorgt-fuer-spannungen
about 1 month ago
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Carolyn King
Waggoner Lab
about 1 month ago
@biorxivpreprint.bsky.social
Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses
www.biorxiv.org/content/10.6...
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Carolyn King
Max Gutierrez
about 2 months ago
👇👇Last days to submit your abstract to be considered for a short talk! Deadline 24 November!https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026
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Tuberculosis: Understanding the Disease Across Scales | Keystone Symposia
Join us at the Keystone Symposia on Tuberculosis: Understanding the Disease Across Scales, March 2026, in Cape Town, with field leaders!
https://www.keystonesymposia.org/conferences/conference-listing/meeting/travel/c42026
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Carolyn King
Olivier Neyrolles
4 months ago
Excited to share Wendy Le Mouëllic’s PhD work, now published in
@pnas.org
! It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance. Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
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Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...
https://www.pnas.org/doi/10.1073/pnas.2503966122
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Carolyn King
IPBS Toulouse
about 1 month ago
IPBS researchers created LiveLung-TB, a BSL-3 imaging platform that visualizes real-time immune responses in Mtb-infected lungs. They found most CD4 T cells fail to reach infected cells, revealing physical barriers that limit TB immunity—a new window into host-pathogen dynamics! 🔬🫁
#Tuberculosis
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When participants used ChatGPT to draft essays, brain scans revealed a 47 percent drop in neural connectivity across regions associated with memory, language, and critical reasoning. Their brains worked less, but they felt just as engaged—a kind of metacognitive mirage.
add a skeleton here at some point
about 1 month ago
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Carolyn King
Harry Wallop
about 1 month ago
Great culture can save lives. Literally. Amazing letter in today’s
@thetimes.com
about Tom Stoppard
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Carolyn King
Waggoner Lab
about 1 month ago
Happy to share an update to a 2018 preprint from
@labwaggoner.bsky.social
and our collaborators! Added Mb1-Cre models and mechanistic insights into Ddx3x regulation of B cell development
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Find Ddx3x is required in B cells in females
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Carolyn King
Calum Bain
about 1 month ago
Thanks for sharing
@mucosalimmunol.bsky.social
. This work was led by
@lizihegarty.bsky.social
during her PhD
@edinuni-irr.bsky.social
funded by
@wellcometrust.bsky.social
. Now being continued after our relocation to
@uofgsii.bsky.social
. Might be of interest to
@emds2025.bsky.social
attendees!
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Carolyn King
Dorentina Humolli
about 2 months ago
🚀New preprint from our lab! I am very excited to finally share what has been the main focus of my PhD for the past almost 3 years! It is about viral dark matter and a powerful tool we built to shed light on it. 🧬💡 Continue reading (🧵)
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Carolyn King
Alexander Harms
about 2 months ago
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
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Carolyn King
Gregor Weiss
about 2 months ago
The Center for Microscopy and Image Analysis at the University of Zurich is seeking a new Head:
jobs.uzh.ch/job-vacancie...
It is super fun to work with them, tons of expertise and cutting edge instrumentation in ❄️🔬 Application deadline: December 15, 2025.
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UZH: Head of the Center for Microscopy and Image Analysis (Core Facility)
The Center for Microscopy and Image Analysis (ZMB) is a nationally and internationally recognized Core Facility at the University of Zurich (UZH), providing access to state-of-the-art light and electr...
https://jobs.uzh.ch/job-vacancies/head-of-the-center-for-microscopy-and-image-analysis-core-facility/2f3d622f-1097-4a13-9078-6ca55f726aa6
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Carolyn King
Bella Rauch
2 months ago
Can we improve peer review? We think we can! Check out an experiment I helped with as part of
@solvingforsci.bsky.social
's mission to make science better. And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
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Carolyn King
Vienna Airway Lab
2 months ago
New murine study reveals characteristics of mature IgE PCs and localizes long-lived IgE PCs in the spleen in addition to bone marrow. 🔗
cell.com/immunity/fulltext/S1074-7613(25)00465-0
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Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario et al. find that IgE-producing plasma cells mature, acquire survival adaptations, and persist for extended periods of...
https://cell.com/immunity/fulltext/S1074-7613(25)00465-0
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Carolyn King
Jeffrey AKA The Hairless Hippie
2 months ago
open.substack.com/pub/kellysca...
The fact of the matter is that helping people costs money and that is just not popular with corporations that, for all practical purposes, own a vast number of congresspersons. Get money out of politics and we can move onward and upward
#EndCitizensUnited
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How the US sets its poverty rate is shocking
It's so horrible, it should actually piss you off
https://open.substack.com/pub/kellyscaletta/p/how-the-us-sets-its-poverty-rate?utm_campaign=post&utm_medium=email
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2 months ago
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Carolyn King
Kara McKinley
3 months ago
Lab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social
made menstruating mice + used them to discover early events in menstruation. He is on the job market!
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Carolyn King
Marion Pepper
3 months ago
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
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Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...
https://www.biorxiv.org/content/10.1101/2025.10.03.680350v1.abstract?%3Fcollection=
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Carolyn King
Shabaana Khader
3 months ago
Dear
#microbiology
and
#immunology
community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
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Carolyn King
Ruth Ann Crystal
3 months ago
The HPV vaccine is doing what had been promised. 17 years after it became available, HPV infections decreased significantly in vaccinated people and unvaccinated people because of herd immunity.
buff.ly/WvjQ1BS
h/t
@boghuma.bsky.social
#medsky
#pedsky
🛟🧪
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Carolyn King
Immunity
4 months ago
Online now: Sensory neurons shape local macrophage identity via TGF-β signaling
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Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.
http://dlvr.it/TMvFQP
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Carolyn King
Charlie Pyle
4 months ago
You can now explore the mRNA expression of your favorite TB gene of interest in our recently published human pulmonary M.tb granuloma single-cell dataset at the Broad Single Cell PORTAL!
@broadinstitute.org
@wallacewly.bsky.social
singlecell.broadinstitute.org/single_cell/...
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Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation - Single Cell Portal
Granulomas are classic manifestations of tuberculosis pathogenesis. They result from an ensemble of immune responses to Mycobacterium tuberculosis infection, but the identities, arrangement, cellular interactions, and regulation of the cells that comprise them have thus far been incompletely understood. To better understand the composition of granulomas, we conducted spatial and single-cell RNA sequencing of granulomas in biopsy specimens from patients with tuberculosis. We found that granulomas consist of concentric transcriptional laminae surrounding areas of central necrosis. We identified distinct populations of granuloma-associated stromal cells, fibroblasts, lymphocytes, mast cells, dendritic cells, neutrophils, and macrophages. Furthermore, gene expression among these cell populations differed by location within granulomas. We used inferential analysis to predict dominant granuloma cell-cell interactions, the activity of major signaling pathways, and transcription factor activities. Using spatial deconvolution, we mapped a conserved pattern of cellular organization dominated by macrophages rich in SPP1/osteopontin expression. Trajectory analysis of macrophage subtypes mapped their differentiation and supported the importance of SPP1 to granuloma macrophage polarization. Using the Mycobacterium marinum-zebrafish model, we found that mycobacterial infection induces spp1 expression in macrophages and that spp1 ablation results in granuloma formation defects and reduced survival in adult animals. Cumulatively, we have identified a dominant macrophage granuloma population as well as its central regulatory gene in human samples and confirmed the importance of spp1 to granuloma biology in vivo.
https://singlecell.broadinstitute.org/single_cell/study/SCP3268/paired-single-cell-and-spatial-transcriptional-profiling-reveals-a-central-osteopontin-macrophage-response-mediating-tuberculous-granuloma-formation
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Carolyn King
Michelle Linterman
3 months ago
Great to have this out, and such a pleasure to work together.
@smguillaume.bsky.social
@cristianbeccaria.bsky.social
@iannaconelab.bsky.social
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who's in the background 😊
@profshanecrotty.bsky.social
?
4 months ago
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another beautiful study by
@jie-immunology.bsky.social
on IL-21-producing Blimp-1+ Th1 effectors and IgA after mucosal vaccination
www.biorxiv.org/content/10.1...
clear links to
www.biorxiv.org/content/10.1...
and our own work
www.biorxiv.org/content/10.1...
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Mechanisms of superior respiratory IgA responses against SARS-CoV-2 after mucosal vaccination
Mucosal immunization and respiratory IgA offer significant promise in protecting against airborne pathogens, including SARS-CoV-2. However, the conditions and mechanisms that lead to the robust induct...
https://www.biorxiv.org/content/10.1101/2025.09.22.677712v1
4 months ago
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Carolyn King
Karen Attiah
4 months ago
Some personal news: I've been fired from the Washington Post in the aftermath of the Charlie Kirk shooting. Thread incoming.
substack.com/@karenattiah...
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The Washington Post Fired Me — But My Voice Will Not Be Silenced.
I spoke out against hatred and violence in America — and it cost me my job.
https://substack.com/@karenattiah/note/p-173531760?utm_source=notes-share-action&r=2bz6j
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Carolyn King
Marion Pepper
4 months ago
Enormous thanks to
@immunologyking.bsky.social
and
@maurogaya.bsky.social
for organizing a vibrant, invigorating
#EMBObarriertissues
workshop. A poignant reminder of how critical immunological studies are for ameliorating human disease. And a lot of fun people. 🐟
#wickelfisch
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Carolyn King
Michelle Linterman
4 months ago
Thank you
@immunologyking.bsky.social
&
@maurogaya.bsky.social
for organising the
#EMBObarrierTissues
meeting in Basel this week. Great science, great people, great atmosphere ❤️
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Carolyn King
Eduardo Villablanca
4 months ago
🎉 Huge congratulations to
@immunologyking.bsky.social
&
@maurogaya.bsky.social
for an outstanding
@embo.org
workshop: adaptive immunity in barrier tissues Brilliant science, inspiring discussions, and friendships that make it one of the best!
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Carolyn King
Gustavo Monasterio Ocares
4 months ago
Back from one of the best conferences I’ve attended!The
@embo.org
Workshop on Barrier Immunity,brilliantly organized by
@maurogaya.bsky.social
&
@immunologyking.bsky.social
! Outstanding science from many, including
@mucosalimmunology.bsky.social
,
@danmucida.bsky.social
&
@martinaparigi.bsky.social
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I only heard tonight that Mike is no longer with us. All credit to him in setting me on this path as an immunologist. The description of his teaching brings back such warm memories. I recognize so many of the scientists on his collage. What a gift to the world he was.
www.cell.com/immunity/ful...
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Michael Cancro (1949–2025)
Just a few weeks ago, researchers and educators connected to immunology lost a wonderful friend and colleague: Michael Cancro, professor of pathology and lab medicine at the University of Pennsylvania...
https://www.cell.com/immunity/fulltext/S1074-7613(25)00130-X
4 months ago
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Carolyn King
Timmons Roberts
5 months ago
My lab's been attacked by an anti-wind group and their lawyers. They threatened the science funding of my whole university, to shut me and my undergraduate research assistants up. NYT just covered it. 1/n
www.nytimes.com/2025/08/25/c...
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Law Firm Pressures Brown University to Erase Research on Anti-Wind Groups
https://www.nytimes.com/2025/08/25/climate/brown-university-offshore-wind-marzulla.html?unlocked_article_code=1.g08.cAcd.MyLJWrRWdIhk&smid=url-share
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Carolyn King
Quintana Lab
5 months ago
Fascinating talk by rising star
@camilahcoelho.bsky.social
- Latin America representing
@iuis-online.bsky.social
#IUIS2025
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always a pleasure discussing all things
#tuberculosis
with this group
@seegerlab.bsky.social
@berndwollscheid.bsky.social
& Michael Berney
5 months ago
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Carolyn King
Fabian Rivera-Chávez
5 months ago
1/ Excited to share the first preprint from my lab! 🎉 My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut. Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
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Cholera toxin-induced disease generates epithelial cell-derived L-lactate that promotes Vibrio cholerae growth in the small intestine
Cholera toxin (CT) promotes Vibrio cholerae colonization by altering gut metabolism to favor pathogen growth. We have previously found that CT-induced disease leads to increased concentrations of L-la...
https://www.biorxiv.org/content/10.1101/2025.08.12.669941v2
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Carolyn King
Grabmacherjoggi Basel
5 months ago
Veranstaltungs-Hinweis: Heute ist in Basel Tag der Stadttore. Noch bis 17.00 Uhr können das St.Johanns-Tor, das Spalentor und St.Alban-Tor und der Pulverturm beim Waisenhaus besichtigt werden. (Foto: Spalentor um 1912)
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Carolyn King
Waggoner Lab
5 months ago
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
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Carolyn King
Journal of Experimental Medicine
5 months ago
@bengern.bsky.social
et al. show that the early interplay between
#neutrophils
& CD4 T cells is pivotal in determining
#TB
pathology, and that depleting neutrophils can improve outcomes even at late timepoints, which has therapeutic relevance
rupress.org/jem/article/...
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#EMBObarrierTissues
- ready to swim!! looking forward to hosting you all in Basel with
@maurogaya.bsky.social
in August
6 months ago
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Carolyn King
Adrian Liston
6 months ago
Rather like I learned computers with MS-DOS while my son learned on an iPad. I had to learn the hard and slow way, because of tech limitations; he can leap over but at a surface level. I think it can be done and improve outcomes, but it will need new and radically different teaching. 3/3
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Hopp
#Frauenfussball
!!!
#EM2025
(🇩🇪v🇫🇷)
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6 months ago
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#Boulder
knows what's up
6 months ago
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