Gregor Weiss
@weiss-lab.bsky.social
📤 960
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Assistant Prof at University of Zürich -- host-pathogen interactions across scales --
reposted by
Gregor Weiss
Quanta Magazine
16 days ago
Asgard archaea were first found in mud at the bottom of the North Sea. Today, cellular biologists Martin Pilhofer and Christa Schleper are exploring one of their more elusive structural elements: a totally tubular system that looks a lot like our own.
www.quantamagazine.org/tiny-tubes-r...
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reposted by
Gregor Weiss
Pilhofer Lab 🦠❄️🔬
about 1 month ago
DNA and Cas9 on a CIS? Wow 🤯 Injecting excitement into the field! Very cool!
@zhangf.bsky.social
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Gregor Weiss
Pilhofer Lab 🦠❄️🔬
about 1 month ago
Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to
@vasilgaisin.bsky.social
and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky
#teamtomo
#Chloroflexota
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It's been ~13 years ago in the lab of Grant Jensen, when Martin
@pilhoferlab.bsky.social
showed me how to prepare media, do first protein preps and negative stain EM. I had no idea how much more I’d learn from him over the next years - THANK YOU MARTIN for this incredible ride 🙏🙏🙏
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about 2 months ago
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reposted by
Gregor Weiss
Nature
about 2 months ago
This surprisingly relaxing footage is from SIX MILES under the ocean – and it’s the deepest ecosystem yet discovered
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Gregor Weiss
Géraldine Laloux
2 months ago
#MicroSky
Summer read! Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator & prey 🧛 How do they do it? Our review 📖
@coralietesseur.bsky.social
@ysantin.bsky.social
www.sciencedirect.com/science/arti...
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Strategies and mechanisms of contact-dependent predation in bacteria
Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…
https://www.sciencedirect.com/science/article/pii/S136952742500061X
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Come and join Martin‘s Lab at the University of Zurich and become our colleague 🧫🔬
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2 months ago
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reposted by
Gregor Weiss
Xabier Vázquez-Campos
2 months ago
Our new preprint with a new
#Asgard
from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool
#cryoem
images, protein modelling, etc Big group effort with a lot of people involved
#archaeasky
#archaea
www.biorxiv.org/content/10.1...
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An Asgard archaeon from a modern analog of ancient microbial mats
It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...
https://www.biorxiv.org/content/10.1101/2025.07.22.663070
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reposted by
Gregor Weiss
Will Wan
3 months ago
Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries!
www.sciencedirect.com/science/arti...
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A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries
Cryo-electron tomography (cryo-ET) enables 3D visualization of complex biological environments without the need for purification, thereby preserving t…
https://www.sciencedirect.com/science/article/pii/S0959440X25001344
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Gregor Weiss
Susan Schlimpert
3 months ago
Happy to see our collaborative work on the contractile injection system (CIS) in Streptomyces published. We show that the membrane protein CisA gives Streptomyces CIS a licence to kill.
@pilhoferlab.bsky.social
& Bastien Casu,
@joesallmen.bsky.social
#MicroSky
elifesciences.org/articles/104...
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Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA
CryoEM, genetic, and cell biological analyses reveal that the conserved membrane protein CisA mediates membrane recruitment of contractile injection systems Streptomyces coelicolor, enabling their act...
https://elifesciences.org/articles/104064
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reposted by
Gregor Weiss
Pilhofer Lab 🦠❄️🔬
3 months ago
Excited and honored to be joining the EMBO Member community 🥳 Congratulations also to all the other newly elected members! -Martin
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#cryoET
folks, this is your chance to combine a beautiful location 🏔️ with cutting-edge imaging of weirdo microbes 🦠 Florian is an amazing colleague & scientist and I am sure he will also show you how to 🎿🚵🏼🏃♂️🍺
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3 months ago
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reposted by
Gregor Weiss
Jan-Willem Veening
4 months ago
New tenure track assistant professor position in molecular microbiology in our department
@dmf-unil.bsky.social
@unil.bsky.social
! We are casting a wide net for an experimental molecular microbiologist. Apply here:
wwwfbm.unil.ch/releve/appli...
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DMF: Tenure Track Assistant Professor towards Associate Professor in Molecular Microbiology - Site des postulations FBM
https://wwwfbm.unil.ch/releve/application/announce/show/133
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A great day for
#teamtomo
First,
@cellarchlab.com
shows the beauty of the mitochondrial respiratory chain (
www.science.org/doi/10.1126/...
. ... and now my colleagues
@florianwollweber.bsky.social
&
@xujwet.bsky.social
visualized tubulins in Asgard archaea 😍🤯
www.cell.com/cell/fulltex...
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6 months ago
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reposted by
Gregor Weiss
Ben Engel
6 months ago
We're on the cover of
@science.org
this week. Awesome work by
@florentwaltz.bsky.social
.
#CryoET
is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by
@verenaresch.bsky.social
. Always a pleasure making
#SciArt
with you!🧪🧶🧬🌾
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reposted by
Gregor Weiss
Ben Engel
6 months ago
Press release from
@unibas.ch
and
@biozentrum.unibas.ch
about our new
#cryoET
study on mitochondrial respirasomes. Led by the unstoppable
@florentwaltz.bsky.social
🙌 🧪🧶🧬
#TeamTomo
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reposted by
Gregor Weiss
Pilhofer Lab 🦠❄️🔬
7 months ago
Check out 👀 this awesome preprint on new cultures of Asgard (Hod) archaea with beautiful 🔬 images by Imachi et al.
www.biorxiv.org/content/10.1...
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Eukaryotes' closest relatives are internally simple syntrophic archaea
Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...
https://www.biorxiv.org/content/10.1101/2025.02.26.640444v1
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Small Things Considered wrote a blog post about our recent findings on bacterial predation. Thanks a lot
@stcmicrobeblog.bsky.social
for highlighting captain Aureispira 😊🏴☠️
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7 months ago
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reposted by
Gregor Weiss
Ben Engel
9 months ago
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality
#cryoET
tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜:
www.biorxiv.org/content/10.1...
A short thread🧵👇
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Gregor Weiss
Knut Drescher
9 months ago
We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation. Details here 👇
www.nature.com/articles/s41...
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Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation - Nature Microbiology
Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.
https://www.nature.com/articles/s41564-024-01886-5
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Thanks to an
@snf-ch.bsky.social
Starting Grant, my group will move to the Institute of Medical Microbiology at University of Zürich in summer 2025. Let's move cryoET literally next to the clinics and investigate bacterial pathogens from molecules to the patient
#FreezeInTheClinics
🏥❄️🔬
9 months ago
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reposted by
Gregor Weiss
Pilhofer Lab 🦠❄️🔬
10 months ago
It’s wildin’ out there in the microbial world 💀🦠 - with Aureispira grappling and stabbing 🔪🩸 and Yersinia sacrificing themselves 🫥🤕 Now, it’s time we expose the violent tendencies 🥷 of a salty 🧂
#archaea
in our new paper in Science Advances!
www.science.org/doi/10.1126/...
🧵1/5
#cryoET
#teamtomo
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