Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/... #CryoET

A new year brings new opportunities: we are looking to fill a permanent professorship position with a Microbiologist preferably with expertise on archaeal biology, RNA biology or imaging techniques to unravel cell biology in prokaryotes! Please share and/or apply :)! www.nature.com/naturecareer...

Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...

Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET

JOB ALERT: Operations Director (DCI–Lausanne). The DCI, a joint initiative of EPFL, UNIL, UNIGE and UNIBE, is recruiting an Operations Director to lead the cryo-EM facility in Lausanne. 📩 Questions: CEO of the DCI: @chgenoud.bsky.social 🔗 Apply here: careers.epfl.ch/job/Lausanne...

This is an amazing position, DCI Lausanne is looking for a new director! It is one of the best cryoEM centers out there, with an fantastic infrastructure and some of the most exceptional experts in microscopy that I ever had the chance to work with! careers.epfl.ch/job/Lausanne...

Thrilled to share the preprint from my PhD! 🥳 Where I characterised epithelial cell extrusion in a sea anemone 🔗 www.biorxiv.org/content/10.6... Big thanks to my supervisor @prhsteinmetz.bsky.social and coauthors @noahbruderer.bsky.social @lionlchristiaen.bsky.social at🇳🇴 @msarscentre.bsky.social ⬇️🧵

Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious? Either way, we have good news. We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July. Sign up: meetings.embo.org/event/26-arc... We look forward to seeing you in Cambridge, UK. Please repost!

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...

Microbial eukaryotes keep challenging assumptions about eukaryotic cell and genome biology. Our upcoming workshop explores the frontier of protist genomics and how it shapes cell biology, ecology and evolution. Please save the date! Talks, posters and ECR events Websites and details coming soon

“Cultivation of Methanonezhaarchaeia, the third class of methanogens within the phylum Thermoproteota” by @kohtzarchaeota.bsky.social, Sylvia Nupp, and myself is out in Science Advances. 90% enriched culture of a methyl-dismutating thermoproteotal methanogen. #Microsky 🧪 tinyurl.com/bdcc3uzs

Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉 In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria. www.nature.com/articles/s41...

Love the caption of Fig. 3 in this impressive preprint: "A Goodsell-esque 3D orthogonal rendering of an IsoNet2-processed FIB-milled tomogram of C. reinhardtii" doi.org/10.64898/202... Since I am no expert, what does the cryoET community think of IsoNet? @cellarchlab.com doi.org/10.1038/s414...

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6... Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

Very excited to share that our project SPRING has been selected for funding in the ERC CoG 2025 grant competition. Many thanks to my fantastic team, colleagues @embl.org and all collaborators for their support.

We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)! GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging. Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations. 👉 www.unige.ch/genexm/

🥳 Our new paper on C2CD3 is out in @plosbiology.org With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET. Big congrats to @ebertiaux.bsky.social and all involved.

Happy to share our fun team-up with @centriolelab.bsky.social & @stearnslab.bsky.social to reveal the architecture of the mammalian centriole’s Distal Ring 🛟. Very cool multiscale integration of #UExM 📏🔬with #CryoET ❄️🔬. Congrats to @ebertiaux.bsky.social & @computingcaitie.bsky.social #TeamTomo 🧪

The curious case of the comb jelly, where we described a comb jelly with the ability to reverse its development to an earlier stage of life, is now also available at #spotify 🤩 #ctenophores 🪼⏪ open.spotify.com/episode/6c2O... with @joanjsoto.bsky.social @msarscentre.bsky.social

Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...

Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)

Interested in applying U-ExM to cells, tissues, organoids, or cryo-sections? Our EMBO workshop is open for applications! 🧫🔬 Deadline: 12 Jan 2026 — don’t miss it!

wow... crawling motility in Asgard #archaea!! www.biorxiv.org/content/10.1... look at these crazy moves!! Let's face it, what these cells want for Christmas is #cilia... the best type of motility appendage...

How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1

want to see a chemotaxis array (G) and a post-discharge T6SS (I) ? inside 𝘝𝘪𝘣𝘳𝘪𝘰 𝘧𝘪𝘴𝘤𝘩𝘦𝘳𝘪 inside a 𝘌𝘱𝘳𝘺𝘮𝘢 𝘴𝘤𝘰𝘭𝘰𝘱𝘦𝘴 crypt ? go no further... #CryoET #CryoEM #teamtomo #MicroSky

CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!

Out now in Nature Communications: Convergent evolution of viral-like Borg archaeal extrachromosomal elements and giant eukaryotic viruses www.nature.com/articles/s41... @luisvalentin.bsky.social @lingdong-shi.bsky.social @martianmicrobe.bsky.social @mschoelmerich.bsky.social

This has now been published in print! Check it out: www.science.org/doi/10.1126/...

📣 Applications for the #EIPOD-Linc Postdoctoral Fellowships Programme are open! Join us to work on self-designed interdisciplinary research on projects related to exploring life in context. ✍ Apply now: www.embl.org/about/info/p...

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

Tired of knowing what you are looking for in your tomograms? Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos) Code is on GitHub if you want to try it out

Clone-FISH paper out: Manuscript/resource alert #microsky 🦠 We present a collection of 30 E. coli (CloneFISH) cultures, each carrying a plasmid for the heterologous expression of a (near) full-length 16S rRNA gene from one of 30 lineages of archaea, including 17 yet uncultured ones.

The Center for Microscopy and Image Analysis at the University of Zurich is seeking a new Head: jobs.uzh.ch/job-vacancie... It is super fun to work with them, tons of expertise and cutting edge instrumentation in ❄️🔬 Application deadline: December 15, 2025.

Wound healing is a hallmark feature of all life, including single cells. In a new preprint, Ambika Nadkarni @biochembika.bsky.social investigates a new dimension in cellular wound healing: how cells recover AFTER the wound has been closed www.biorxiv.org/content/10.1...

Stavros and I picked the name of his Asgard archaeon! Skadiarchaeum cthulhuensis. We thought that if we cannot change the fact that people name microbes after fantasy characters, we should go all in.

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...

Great collaboration with @brunlabcaulo.bsky.social for resolving the Tad pilus machine structure by cryo-ET. Beautiful work by graduate students James Iarocci and Ryu Williston in our lab. Preprint:https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1

Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

This paper has been a must! Great collaboration with @mkrupovic.bsky.social and @yifanzhou.bsky.social, a N&V by a legend of halophilic archaea tinyurl.com/yc3dcv72, and one picture of one of our expeditions to Dallol making the cover of the November issue of @natmicrobiol.nature.com rdcu.be/eLtCH

Thank you so much Martin and everyone @pilhoferlab.bsky.social for 5 years of super fun science and your support - imaging Lokis wouldn’t have been possible anywhere else! 🦠🔬

Exciting day for the lab: our 1rst paper is officially out in @currentbiology.bsky.social 🥳 Wonderful collaboration wt @gautamdey.bsky.social showing how Cryo-ExM achieves consistent immunostaining in diverse diatoms, from the lab and the natural environment 1/n #ProtistsOnSky tinyurl.com/2zxaund7

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

After exploring Europe’s coastlines, EMBL’s TREC expedition is moving inland! 💧 The new Traversing Ecosystems phase focuses on freshwater habitats – studying how human activity and environmental change affect life at the molecular level. www.embl.org/news/science...

Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧

Baker Lab 2025 The container is our field gear for the research expedition for Uruguay. sites.utexas.edu/baker-lab/sp...