The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41... The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.

Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team. www.nature.com/articles/s41...

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social

My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k... (Please repost!)

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳 How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look. www.cell.com/structure/fu...

#ICYMI, @newscientist.com spoke to Wes Robertson, Group Leader in the LMB’s PNAC Division, about the ‘gargantuan effort’ behind synthesising E. coli with just 57 codons: www.newscientist.com/article/2490... #LMBintheNews

The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments go.nature.com/45GeSM0

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by #cryoEM. Read about the event and find more photos here: www2.mrc-lmb.cam.ac.uk/the-structur... #LMBNews 🧪🔬

Highly recommend, speaking from experience!

We are excited to be a part of a collaboration lead by Tarafder and Bharat titled "Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms" - this work has exciting implications for biofilm-targeted therapeutics. www.biorxiv.org/content/10.1...

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms led by @abultarafder.bsky.social Great collaboration with @pearce-maths.bsky.social and @geiselbiofilm.bsky.social www.biorxiv.org/cgi/content/...

NEW from me at STAT: We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's #AlphaFold to prominence (and a Nobel Prize), as its NIH funding runs out. More @statnews.com: www.statnews.com/2025/07/21/c... 🖥️🩺🧪🧬 #bioML

Another chance to join the amazing @mrclmb.bsky.social with its generous core funding that allows it scientists to perform world-leading science, and with the best research culture you'll have ever experienced! 🤩

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

It was an honor to be part of this celebration at the LMB. Richard and Nigel’s work on bacteriorhodopsin has inspired generations of structural biologists, and they have set an example of being especially friendly and helpful.

Highly collaborative efforts that involved 6 lab members and the labs of @yiliangding.bsky.social and @rdaslab.bsky.social. We uncovered a telomerase dimer and its potential role in telomere maintenance.

Gut bacteria can remove PFAS ‘forever chemicals’ from our body #MRC #AcademicSky

Exciting study from @kiranrpatil.bsky.social and colleagues. Hannah Ochner from the group performed cryo FIB imaging. Congrats!

Congrats to @adamfountain.bsky.social . Brilliant study tackling one of the deadliest pathogens around.

We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩 www.nature.com/naturecareer...

Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance Exciting paper by Adam Fountain and Lalita Ramakrishnan. Cryo-ET by @janboehning.bsky.social Congrats! www.biorxiv.org/content/10.1...

Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi Out in @pnas.org Congrats @janboehning.bsky.social @abultarafder.bsky.social Miles Graham @mathieucoureuil.bsky.social @mrclmb.bsky.social @hopitalnecker.bsky.social www.pnas.org/doi/10.1073/...

The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon out in @pnas.org Tight collaboration with Sherman Foo, Alice Cezanne and @buzzbaum.bsky.social, Sulfolobus cryo-ET from @idocaspy.bsky.social www.pnas.org/doi/10.1073/...

Interested in a postdoc position combining computational protein design and molecular simulation? There is an open position in my group at the MRC-LMB in Cambridge, UK. www.nature.com/naturecareer... Feel free to message me with any questions.

A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecru...

Incredibly grateful to my mentors, lab members, and generous collaborators who continue to inspire our work. Thankful also to microbial cell surfaces and tomography, which continue to deliver the excitement everyday!

The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments. www.biorxiv.org/content/10.1...

John Briggs has been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences. Congratulations to him and the other outstanding researchers from across the world! ❕https://royalsociety.org/news/2025/05/new-fellows/ @briggsgroup.bsky.social ‪@royalsociety.org

Congratulations to LMB Group Leaders Leo James, Greg Jefferis & Marta Zlatic who have been elected Fellows of the @royalsociety.org! Congratulations also to the #LMBAlumni joining them: John Briggs, Graham Hatfull & Baljit Khakh. Read more: www2.mrc-lmb.cam.ac.uk/leo-james-gr... #LMBNews

A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch

Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.

After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it. 🔗 www.pnas.org/doi/10.1073/...

Excited to announce the Molecular Biology of Archaea (MBoA) 2026! Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.

When the pressure is on, Archaea go multicellular! A new @science.org study reveals surprising organizational capacity in archaea. 🍞“It’s like rising sourdough loaf”: tinyurl.com/yc2nxmr6 #Archaea #Multicellularity @archaeon-alex.bsky.social @tbharat-lab.bsky.social @vikramalva.bsky.social

This has been a long journey, but it's now out in final form. @kjamali.bsky.social academic.oup.com/bioinformati...

Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...

How do SMC complexes capture DNA? 🧪 Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway. Read more: tinyurl.com/4s8nrrkk #LMBResearch

The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha

Sad news about Karen Davies' passing. Karen was an inspiration in bioenergetics and cryoET. Her pioneering postdoctoral work on ATP synthase and respiratory supercomplexes marked turning points in the field. I created Scholar profile to acknowledge her contribution scholar.google.com/citations?hl...

Don’t miss this fascinating #LMBSeminar from Simonetta Gribaldo: One or two membranes? Investigating the transition between monoderm and diderm cell envelopes across the Tree of Bacteria. Visit our website to find out how to join us at 11am on Mon 10th March: www2.mrc-lmb.cam.ac.uk/news-and-eve...

“It was like discovering a new continent.” BBC’s History Hour revisits the moment Max Perutz discovered the structure of haemoglobin, featuring archival interviews with Max and contributions from LMB emeritus scientist Alan Fersht. Listen here: www.bbc.co.uk/programmes/w... #LMBintheNews

Closing date is 18 March! Happy to answer any queries by email or DM.

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social

We are looking for a Senior Administrator to join our Structural Studies Division, to provide proactive assistance to the Heads of Division & efficiently manage all aspects of administration to support our researchers. More info: www.jobs.ac.uk/job/DLY086/s... Closes 19 MAR #AdminJobs #CambridgeJobs

Don’t miss Ian Gilmore’s #LMBSeminar at 11am on Monday 3rd March. Ian Gilmore, from the National Physical Laboratory, will discuss ‘Cryo-OrbiSMS – high resolution mass spectrometry imaging in the native biological state’ Visit our website for more details: www2.mrc-lmb.cam.ac.uk/news-and-eve...

We are looking for a senior administrator to take care of the Structural Studies Division at @mrclmb.bsky.social. Come and work for the benefit of human health in a fantastic environment. Happy to chat! www.jobs.ac.uk/job/DLY086/s...

Reminder - still one month to apply to be a tenure track group leader at MRC LMB. Please do reach out for any information.

Not long until the deadline for this faculty position @dunnschool.bsky.social... Are you the one to lead a group doing great research in a special environment, while teaching outstanding students? www.path.ox.ac.uk/vacancy/asso...

If working for Google no longer fits with your core values, and you are an AI/ML expert with an interest in proteins, you could apply for our open group leader position in the Structural Studies Division of the @mrclmb.bsky.social. Happy to chat! www.theguardian.com/us-news/2025...