Tanmay Bharat
@tbharat-lab.bsky.social
📤 1258
📥 498
📝 39
MRC-LMB
#cryoET
#biofilms
#S
-layers
#antibiotics
https://www2.mrc-lmb.cam.ac.uk/groups/bharat/
pinned post!
Assembly, architecture and functional roles of microbial surface layers Review article published in
@natrevmicro.nature.com
with
@bupbuse.bsky.social
, Andriko von Kügelgen and
@vikramalva.bsky.social
. S-layers are everywhere!
www.nature.com/articles/s41...
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Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
https://www.nature.com/articles/s41579-025-01258-8
about 1 month ago
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Tanmay Bharat
EMBO
8 days ago
Sign up now for the EMBO Workshop "#MolecularBiology of #Archaea: Life Through the Prism of Archaea" in Cambridge, UK, 6–10 July 2026. Deadline: 15 April
https://meetings.embo.org/event/26-archaea
#MolecularBiology
#Archaea
#EMBOArchaeaBiology
#EMBOevents
#CellBiology
#StructuralBiology
#ecology
#evolution
#biophysics
🧪
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reposted by
Tanmay Bharat
Kelly Nguyen
3 days ago
We have an opening for a research support officer. Come and join us! Please share.
add a skeleton here at some point
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reposted by
Tanmay Bharat
Buzz Baum
9 days ago
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious? Either way, we have good news. We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July. Sign up:
meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK. Please repost!
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Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
https://meetings.embo.org/event/26-archaea
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Tanmay Bharat
Sjors Scheres
14 days ago
Postdoc opportunity with Michel Goedert and myself to work on
#cryoEM/#cryoET
structures of
#amyloids
. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
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Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/spa-1/candidate/so/pm/4/pl/1/opp/2752-Postdoctoral-Scientist-Neurobiology-Dr-Michel-Goedert-LMB-2752/en-GB
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reposted by
Tanmay Bharat
James Briscoe
20 days ago
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
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Top UK scientist says research visa restrictions endanger economy
Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.
https://www.bbc.com/news/articles/ckgl4vrlk7do
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Tanmay Bharat
EMBL
28 days ago
Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from
@mpi-cbg.de
in Dresden. He is also Professor of Molecular Biology
@tudresden.bsky.social
, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
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Tanmay Bharat
Géraldine Laloux
about 1 month ago
Apply now to attend the next EMBO Bacterial Networks meeting
#EMBOBacNet
🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info:
meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair
@s-lab.bsky.social
and ECR
@coralietesseur.bsky.social
#MicroSky
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Tanmay Bharat
Dr Katherine Duncan
about 1 month ago
‘The latest surveillance data found that the number of antibiotic-resistant infections in 2024 equated to an average of nearly 400 newly reported cases a week.’
www.theguardian.com/society/2025...
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Deaths linked to antibiotic-resistant superbugs rose 17% in England in 2024
Data also shows an average of nearly 400 newly reported cases of antibiotic-resistant infections a week last year
https://www.theguardian.com/society/2025/nov/13/deaths-linked-to-antibiotic-resistant-superbugs-rose-17-in-england-in-2024?CMP=Share_iOSApp_Other
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reposted by
Tanmay Bharat
Vikram Alva
about 1 month ago
Pleased to share our review on S-layers with
@bupbuse.bsky.social
, Andriko von Kügelgen, and
@tbharat-lab.bsky.social
, where we explore recent advances and argue that deeper insight into S-layers is key to deciphering microbial interactions and community organization.
@mpi-bio-fml.bsky.social
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Assembly, architecture and functional roles of microbial surface layers Review article published in
@natrevmicro.nature.com
with
@bupbuse.bsky.social
, Andriko von Kügelgen and
@vikramalva.bsky.social
. S-layers are everywhere!
www.nature.com/articles/s41...
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Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
https://www.nature.com/articles/s41579-025-01258-8
about 1 month ago
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An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
about 2 months ago
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Be our neighbour, please apply!
add a skeleton here at some point
about 2 months ago
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reposted by
Tanmay Bharat
Michael Eisen
2 months ago
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!!
formatmypaper.com
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reposted by
Tanmay Bharat
Lori Passmore
3 months ago
We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA
#cryoEM
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reposted by
Tanmay Bharat
James Manton
3 months ago
The final version of our multispectral microscopy manuscript is now online at Nature Photonics:
www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
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reposted by
Tanmay Bharat
George O'Toole (he/him/his)
4 months ago
Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...
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Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with
@kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social
@wellcometrust.bsky.social
4 months ago
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Tanmay Bharat
Rob Klose
5 months ago
My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor!
www.justgiving.com/page/colin-k...
(Please repost!)
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Colin Kleanthous' fundraiser for Motor Neurone Disease Association
Help Colin Kleanthous raise money to support Motor Neurone Disease Association
https://www.justgiving.com/page/colin-kleanthous-iveagh
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reposted by
Tanmay Bharat
Sjors Scheres
4 months ago
Sofia Lövestam's vault structure is now online in Structure
@cellpress.bsky.social
. 🥳 How beautifully explorative is
#cryoEM
! We never planned to do this. The vaults just came down with
#amyloids
from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
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Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...
https://www.cell.com/structure/fulltext/S0969-2126(25)00262-X
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reposted by
Tanmay Bharat
MRC Laboratory of Molecular Biology
5 months ago
#ICYMI
,
@newscientist.com
spoke to Wes Robertson, Group Leader in the LMB’s PNAC Division, about the ‘gargantuan effort’ behind synthesising E. coli with just 57 codons:
www.newscientist.com/article/2490...
#LMBintheNews
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E. coli genome has been remade with 101,000 changes to its DNA
The recoded bacterium uses only 57 of the 64 possible genetic codes, freeing up seven to be used for different purposes
https://www.newscientist.com/article/2490640-e-coli-genome-has-been-remade-with-101000-changes-to-its-dna/
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Tanmay Bharat
Nature
5 months ago
The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments
go.nature.com/45GeSM0
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Monoclonal antibodies revolutionized biomedical science and health care
The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.
https://go.nature.com/45GeSM0
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reposted by
Tanmay Bharat
Carter Lab
5 months ago
Excited to share our latest work with
@simonbullock11.bsky.social
! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1..
.
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Tanmay Bharat
MRC Laboratory of Molecular Biology
5 months ago
The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by
#cryoEM
. Read about the event and find more photos here:
www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews
🧪🔬
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Highly recommend, speaking from experience!
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5 months ago
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Tanmay Bharat
George O'Toole (he/him/his)
5 months ago
We are excited to be a part of a collaboration lead by Tarafder and Bharat titled "Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms" - this work has exciting implications for biofilm-targeted therapeutics.
www.biorxiv.org/content/10.1...
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Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms led by
@abultarafder.bsky.social
Great collaboration with
@pearce-maths.bsky.social
and
@geiselbiofilm.bsky.social
www.biorxiv.org/cgi/content/...
5 months ago
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reposted by
Tanmay Bharat
Brittany Trang
5 months ago
NEW from me at STAT: We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's
#AlphaFold
to prominence (and a Nobel Prize), as its NIH funding runs out. More
@statnews.com
:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬
#bioML
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AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
https://www.statnews.com/2025/07/21/casp-new-funding-from-alphafold-developer-google-deepmind-after-nih-grant-runs-out/
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reposted by
Tanmay Bharat
Sjors Scheres
5 months ago
Another chance to join the amazing
@mrclmb.bsky.social
with its generous core funding that allows it scientists to perform world-leading science, and with the best research culture you'll have ever experienced! 🤩
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reposted by
Tanmay Bharat
Phil Holliger
5 months ago
We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry (
www.jobs.ac.uk/job/DNW809/r...
) at the MRC Laboratory of Molecular Biology (LMB).
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Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
https://www.jobs.ac.uk/job/DNW809/research-group-leader-in-chemical-synthetic-biology
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reposted by
Tanmay Bharat
Da-Neng Wang
5 months ago
It was an honor to be part of this celebration at the LMB. Richard and Nigel’s work on bacteriorhodopsin has inspired generations of structural biologists, and they have set an example of being especially friendly and helpful.
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reposted by
Tanmay Bharat
Kelly Nguyen
6 months ago
Highly collaborative efforts that involved 6 lab members and the labs of
@yiliangding.bsky.social
and
@rdaslab.bsky.social
. We uncovered a telomerase dimer and its potential role in telomere maintenance.
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reposted by
Tanmay Bharat
News from UK Research and Innovation
6 months ago
Gut bacteria can remove PFAS ‘forever chemicals’ from our body
#MRC
#AcademicSky
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Gut bacteria can remove PFAS ‘forever chemicals’ from our body
Study finds that toxic PFAS could be absorbed by a gut microbe, potentially protecting us from a range of health issues associated with ‘forever chemicals’.
https://www.ukri.org/news/gut-bacteria-can-remove-pfas-forever-chemicals-from-our-body/?utm_source=dlvr.it&utm_medium=%5Bbluesky%5D
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Exciting study from
@kiranrpatil.bsky.social
and colleagues. Hannah Ochner from the group performed cryo FIB imaging. Congrats!
add a skeleton here at some point
6 months ago
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Congrats to
@adamfountain.bsky.social
. Brilliant study tackling one of the deadliest pathogens around.
add a skeleton here at some point
6 months ago
0
5
0
reposted by
Tanmay Bharat
Sjors Scheres
6 months ago
We have a 3-year funded postdoc position to work on structures of
#amyloid
filaments. If you are an expert in protein biochemistry, structural biology or
#cryoEM
/
#cryoET
, this could be for you! Feel free to email me with any questions. Come join us! 🤩
www.nature.com/naturecareer...
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Postdoctoral Scientist - Structural Studies - Dr Sjors Scheres - LMB 2640 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12840844
Postdoctoral Scientist Starting Salary: £41,344 Fixed term: 3 years MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a postdoc...
https://www.nature.com/naturecareers/job/12840844/postdoctoral-scientist-structural-studies-dr-sjors-scheres-lmb-2640/?LinkSource=PremiumListing
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Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance Exciting paper by Adam Fountain and Lalita Ramakrishnan. Cryo-ET by
@janboehning.bsky.social
Congrats!
www.biorxiv.org/content/10.1...
6 months ago
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Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi Out in
@pnas.org
Congrats
@janboehning.bsky.social
@abultarafder.bsky.social
Miles Graham
@mathieucoureuil.bsky.social
@mrclmb.bsky.social
@hopitalnecker.bsky.social
www.pnas.org/doi/10.1073/...
6 months ago
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The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon out in
@pnas.org
Tight collaboration with Sherman Foo, Alice Cezanne and
@buzzbaum.bsky.social
, Sulfolobus cryo-ET from
@idocaspy.bsky.social
www.pnas.org/doi/10.1073/...
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A self-assembling surface layer flattens the cytokinetic furrow to aid cell division in an archaeon | PNAS
The surface layer or “S-layer” is a two-dimensional lattice of proteins that coats a wide range of archaea and bacteria in place of a cell wall or ...
https://www.pnas.org/doi/10.1073/pnas.2501044122
6 months ago
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reposted by
Tanmay Bharat
Joe Greener
6 months ago
Interested in a postdoc position combining computational protein design and molecular simulation? There is an open position in my group at the MRC-LMB in Cambridge, UK.
www.nature.com/naturecareer...
Feel free to message me with any questions.
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Postdoctoral Scientist - Structural Studies - Dr Joe Greener - LMB 2633 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12840475
Postdoctoral Scientist Salary £41,344 per annum Fixed Term – 3 years MRC Laboratory of Molecular Biology, Cambridge, UK We are looking for a postd...
https://www.nature.com/naturecareers/job/12840475/postdoctoral-scientist-structural-studies-dr-joe-greener-lmb-2633
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reposted by
Tanmay Bharat
7 months ago
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
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'
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_details_form.jobspec?p_id=179710
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Incredibly grateful to my mentors, lab members, and generous collaborators who continue to inspire our work. Thankful also to microbial cell surfaces and tomography, which continue to deliver the excitement everyday!
add a skeleton here at some point
7 months ago
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Tanmay Bharat
Sjors Scheres
7 months ago
The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in
#cryoEM
images of brain-derived
#amyloid
filaments.
www.biorxiv.org/content/10.1...
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Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
The vault protein is expressed in most eukaryotic cells, where it is assembled on polyribosomes into large hollow barrel-shaped complexes. Despite its widespread and abundant presence in cells, the bi...
https://www.biorxiv.org/content/10.1101/2025.05.27.656403v1
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reposted by
Tanmay Bharat
Max Planck Institute of Biochemistry
7 months ago
John Briggs has been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences. Congratulations to him and the other outstanding researchers from across the world! ❕https://royalsociety.org/news/2025/05/new-fellows/
@briggsgroup.bsky.social
@royalsociety.org
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Tanmay Bharat
MRC Laboratory of Molecular Biology
7 months ago
Congratulations to LMB Group Leaders Leo James, Greg Jefferis & Marta Zlatic who have been elected Fellows of the
@royalsociety.org
! Congratulations also to the
#LMBAlumni
joining them: John Briggs, Graham Hatfull & Baljit Khakh. Read more:
www2.mrc-lmb.cam.ac.uk/leo-james-gr...
#LMBNews
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reposted by
Tanmay Bharat
MRC Laboratory of Molecular Biology
8 months ago
A colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted
#cryoEM
to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more:
tinyurl.com/mwwcunkc
#LMBResearch
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Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface.
@bupbuse.bsky.social
@vikramalva.bsky.social
Please also see concurrent beautiful work from
@adriasogues.bsky.social
and Han Remaut.
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8 months ago
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reposted by
Tanmay Bharat
Josh Dickerson
8 months ago
After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it. 🔗
www.pnas.org/doi/10.1073/...
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Reducing the effects of radiation damage in cryo-EM using liquid helium temperatures | PNAS
The physical limit in determining the atomic structure of biological molecules is radiation damage. In electron cryomicroscopy, there have been num...
https://www.pnas.org/doi/10.1073/pnas.2421538122
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Tanmay Bharat
Buzz Baum
8 months ago
Excited to announce the Molecular Biology of Archaea (MBoA) 2026! Join us in Cambridge, UK, from 6–10 July 2026 for the only international meeting dedicated to Archaea.
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Tanmay Bharat
MPI for Biology Tübingen & Friedrich Miescher Laboratory
9 months ago
When the pressure is on, Archaea go multicellular! A new
@science.org
study reveals surprising organizational capacity in archaea. 🍞“It’s like rising sourdough loaf”:
tinyurl.com/yc2nxmr6
#Archaea
#Multicellularity
@archaeon-alex.bsky.social
@tbharat-lab.bsky.social
@vikramalva.bsky.social
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reposted by
Tanmay Bharat
Joe Greener
9 months ago
This has been a long journey, but it's now out in final form.
@kjamali.bsky.social
academic.oup.com/bioinformati...
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