Tanmay Bharat
@tbharat-lab.bsky.social
📤 1329
📥 550
📝 43
MRC-LMB
#cryoET
#biofilms
#S
-layers
#antibiotics
https://www2.mrc-lmb.cam.ac.uk/groups/bharat/
pinned post!
Assembly, architecture and functional roles of microbial surface layers Review article published in
@natrevmicro.nature.com
with
@bupbuse.bsky.social
, Andriko von Kügelgen and
@vikramalva.bsky.social
. S-layers are everywhere!
www.nature.com/articles/s41...
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Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
https://www.nature.com/articles/s41579-025-01258-8
6 months ago
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Interaction of Pf4 tactoids with bacteria and synthetic colloidal rods Important biophysical measurements on the Pseudomonas aeruginosa biofilm-related phage Pf4 by Dirk Aarts laboratory with
@abultarafder.bsky.social
link.springer.com/article/10.1...
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Interaction of Pf4 tactoids with bacteria and synthetic colloidal rods - European Biophysics Journal
We investigated the interaction of liquid crystal droplets, formed by a phase separating system of elongated virus particles and polymer with rod-like impurities. The virus particles were Pf4, which w...
https://link.springer.com/article/10.1007/s00249-026-01844-5
1 day ago
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Tanmay Bharat
cryoEM papers
3 days ago
Measurement of atomic scattering factors by cryoelectron microscopy
pubmed.ncbi.nlm.nih.gov/42101996/
#cryoem
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Oxygen gradients reshape cross-feeding through emergent spatial organization of gut commensal bacteria
www.biorxiv.org/content/10.6...
Use of isotope labels and cryo-CLEM-FIB-SIMS to study microbial communities by Hannah Ochner. Collaboration with
@kiranrpatil.bsky.social
@jmghigolab.bsky.social
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Oxygen gradients reshape cross-feeding through emergent spatial organization of gut commensal bacteria
Microbial interactions unfold within environments structured by physical transport and chemical gradients. Yet most mechanistic studies rely on well-mixed systems that mask the reciprocal influences of environmental heterogeneity on metabolism and ecology. Here, we investigate how the physical environment modulates the interaction between the gut commensal Bacteroides thetaiotaomicron and Escherichia coli . In anoxic liquid culture, cell-resolved isotope imaging and genetic perturbations reveal exploitative cross-feeding, where E. coli consumes diffusible sugars released by B . thetaiotaomicron during starch degradation. When exposed to intestinal-like oxygen gradients in microfluidics, the interaction is restructured by spatial organization. The species self-organize into complementary niches: E. coli locally depletes sugars and oxygen, thereby expanding the anoxic niche required by B. thetaiotaomicron . A reactive transport model confirms that this organization arises from coupled feedback between physical transport and metabolic reaction rates. Together, our results reveal how physical structure and chemical gradients convert an exploitative cross-feeding interaction into a dynamic niche-construction process that generates emergent spatial organization and stabilizes coexistence. ### Competing Interest Statement The authors have declared no competing interest.
https://www.biorxiv.org/content/10.64898/2026.05.02.721930v1
6 days ago
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Tanmay Bharat
Sjors Scheres
12 days ago
Come and work with us on
#cryoEM
of alpha-synuclein amyloid filaments from
#Parkinsons
disease! 🥳
fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
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Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2253
£42,694 per annum | Fixed-term for 3 years | Full-time | Closing date: 17 May 2026
https://fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/CandidateExperience/en/sites/UKRI-Careers/job/2253?keyword=lmb&mode=job-location
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reposted by
Tanmay Bharat
MRC Laboratory of Molecular Biology
14 days ago
Congratulations to
@lapassmore.bsky.social
, Joint Head of the LMB’s Structural Studies Division, who has been elected an international member of
@nationalacademies.org
Congratulations to
#LMBalumni
Andrea Brand who has also been elected. Read more:
mrclmb.ac.uk/news-events/...
#LMBNews
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Tanmay Bharat
MRC Laboratory of Molecular Biology
21 days ago
Congratulations to Manu Hegde, Group Leader & Joint Head of
@cellbiol-mrclmb.bsky.social
, who has been elected a member of the American Academy of Arts & Sciences. Congratulations also to the
#LMBalumni
joining him, Julie Ahringer & Edward Egelman. Read more:
mrclmb.ac.uk/news-events/...
#LMBNews
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Tanmay Bharat
Biochemical Society
29 days ago
A leader in the cell biology of signalling, the 2027 Centenary Award is presented to
Matthew Freeman
in recognition of his pioneering discoveries into the biological significance and mechanisms of rhomboid intramembrane proteases and pseudoprotease and unwavering commitment to mentorship!
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reposted by
Tanmay Bharat
Sjors Scheres
about 1 month ago
Our latest
@biorxivpreprint.bsky.social
: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa.
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.03.30.715211v1
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Tanmay Bharat
Stephan Kamrad
about 1 month ago
Check out our new paper applying fast DIA proteomics to bacterial co-cultures at scale.
www.nature.com/articles/s41...
@kiranrpatil.bsky.social
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Interspecies interactions drive bacterial proteome reorganization and emergent metabolism - Nature Ecology & Evolution
An analysis of the responses of 15 diverse human gut bacteria in more than 100 pairwise co-cultures reveals extensive remodelling of the bacterial proteome and metabolome in response to the presence o...
https://www.nature.com/articles/s41559-026-03030-4
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Tanmay Bharat
MRC Laboratory of Molecular Biology
about 2 months ago
Tuberculosis remains the world’s deadliest infectious disease. Lalita Ramakrishnan’s group,
@cellbiol-mrclmb.bsky.social
&
@medcambridge.bsky.social
, studies how TB thrives, including what drives its drug tolerance. Read more:
new.express.adobe.com/webpage/GdOa...
#LMBintheNews
#WorldTBDay
#EndTB
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CITIID Research Highlight: Lalita Ramakrishnan
See the story
https://new.express.adobe.com/webpage/GdOanITcUxt0i/
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Tanmay Bharat
Joe Greener
about 2 months ago
Check out our pre-print, where we train a protein and small molecule force field from scratch with a graph neural network. We show comparable performance to existing, manually-tuned force fields on a range of tasks including binding free energy prediction. (1/4)
arxiv.org/abs/2603.16770
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Training a force field for proteins and small molecules from scratch
Force fields for molecular dynamics are usually developed manually, limiting their transferability and making systematic exploration of functional forms challenging. We developed a graph neural networ...
https://arxiv.org/abs/2603.16770
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Tanmay Bharat
Sjors Scheres
about 2 months ago
We're excited to announce the beta-release of
#RELION-5.1
! 🥳 This release has important updates on our
#amyloid
processing pipeline, as described in this preprint:
doi.org/10.64898/202...
There are also some tweaks for
#teamtomo
.
#OpenSoftwareAcceleratesScience
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Tanmay Bharat
Matthew Freeman
about 2 months ago
Interested in one of the top jobs in European biology?
@embo.org
has opened a call for its next Director, to succeed Fiona Watt Really spectacular opportunity! Spread the word...
www.embo.org/features/emb...
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EMBO starts search for its next Director – Features – EMBO
The process to appoint the next EMBO Director is underway. The incoming Director will take office in February 2028, succeeding Fiona Watt, who has led the organization since January 2022
https://www.embo.org/features/embo-starts-search-for-its-next-director/
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Tanmay Bharat
EMBL Events
2 months ago
Join #EMBOCryoEM to get a comprehensive foundation in advanced single-particle and cellular tomography techniques – we'll cover the entire workflow from sample preparation to data collection and image processing. https://s.embl.org/cry26-01-bl Apply by: 11 May 2026
@embo.org
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Tanmay Bharat
Buzz Baum
2 months ago
Archaea hit prime time:
www.bbc.co.uk/programmes/m...
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BBC Radio 4 - In Our Time, Archaea
How a discovery in the 1970s changed the theory of the origin of complex life on earth.
https://www.bbc.co.uk/programmes/m002sg10
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Tanmay Bharat
Lori Passmore
3 months ago
We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social
Please get in touch if you have any questions.
www.nature.com/naturecareer...
add a skeleton here at some point
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reposted by
Tanmay Bharat
MRC Laboratory of Molecular Biology
3 months ago
Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR
www.nature.com/naturecareer...
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Tanmay Bharat
Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺
3 months ago
Our latest preprint: Together with the team of Jan Löwe,
@danieltamarit.bsky.social
and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...
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Tanmay Bharat
Sjors Scheres
3 months ago
Please spread the word: the Structural Studies Division
@mrclmb.bsky.social
is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
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Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
https://mrc.tal.net/vx/mobile-0/appcentre-int/brand-3/spa-1/candidate/so/pm/1/pl/3/opp/2775-Research-Group-Leader-Tenure-Track-Structural-Studies-LMB-2775/en-GB
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reposted by
Tanmay Bharat
MRC Laboratory of Molecular Biology
3 months ago
How did life arise from simple chemical building blocks? New
#LMBResearch
led by
@edogia.bsky.social
in
@philholliger.bsky.social
group has identified a small self-replicating ribozyme that could be the answer. Read more:
mrclmb.ac.uk/news-events/...
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Tanmay Bharat
John Lees
3 months ago
We are hiring for group leaders again — EBI is a great place to start your research group!
embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
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Research Group Leader
Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...
https://embl.wd103.myworkdayjobs.com/EMBL/job/Hinxton-Cambridgeshire/Research-Group-Leader_JR2407
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Tanmay Bharat
Buzz Baum
4 months ago
A reminder to sign up for the 2026 EMBO archaeal meeting im Cambridge:
meetings.embo.org/event/26-arc...
. Registration is open. We are looking forward to hosting you!
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Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
https://meetings.embo.org/event/26-archaea
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Tanmay Bharat
EMBO
5 months ago
Sign up now for the EMBO Workshop "#MolecularBiology of #Archaea: Life Through the Prism of Archaea" in Cambridge, UK, 6–10 July 2026. Deadline: 15 April
https://meetings.embo.org/event/26-archaea
#MolecularBiology
#Archaea
#EMBOArchaeaBiology
#EMBOevents
#CellBiology
#StructuralBiology
#ecology
#evolution
#biophysics
🧪
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reposted by
Tanmay Bharat
Kelly Nguyen
5 months ago
We have an opening for a research support officer. Come and join us! Please share.
add a skeleton here at some point
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reposted by
Tanmay Bharat
Buzz Baum
5 months ago
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious? Either way, we have good news. We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July. Sign up:
meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK. Please repost!
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Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
https://meetings.embo.org/event/26-archaea
2
78
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reposted by
Tanmay Bharat
Sjors Scheres
5 months ago
Postdoc opportunity with Michel Goedert and myself to work on
#cryoEM/#cryoET
structures of
#amyloids
. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
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Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
https://mrc.tal.net/vx/mobile-0/appcentre-ext/brand-3/spa-1/candidate/so/pm/4/pl/1/opp/2752-Postdoctoral-Scientist-Neurobiology-Dr-Michel-Goedert-LMB-2752/en-GB
1
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reposted by
Tanmay Bharat
James Briscoe
5 months ago
BBC News - Top UK scientist says research visa restrictions endanger economy
www.bbc.com/news/article...
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Top UK scientist says research visa restrictions endanger economy
Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.
https://www.bbc.com/news/articles/ckgl4vrlk7do
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Tanmay Bharat
EMBL
6 months ago
Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from
@mpi-cbg.de
in Dresden. He is also Professor of Molecular Biology
@tudresden.bsky.social
, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
11
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Tanmay Bharat
Géraldine Laloux
6 months ago
Apply now to attend the next EMBO Bacterial Networks meeting
#EMBOBacNet
🗓️13-18 September 2026 📍Sant Feliu de Guixols, Spain 📝Program and registration info:
meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair
@s-lab.bsky.social
and ECR
@coralietesseur.bsky.social
#MicroSky
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reposted by
Tanmay Bharat
Dr Katherine Duncan
6 months ago
‘The latest surveillance data found that the number of antibiotic-resistant infections in 2024 equated to an average of nearly 400 newly reported cases a week.’
www.theguardian.com/society/2025...
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Deaths linked to antibiotic-resistant superbugs rose 17% in England in 2024
Data also shows an average of nearly 400 newly reported cases of antibiotic-resistant infections a week last year
https://www.theguardian.com/society/2025/nov/13/deaths-linked-to-antibiotic-resistant-superbugs-rose-17-in-england-in-2024?CMP=Share_iOSApp_Other
0
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reposted by
Tanmay Bharat
Vikram Alva
6 months ago
Pleased to share our review on S-layers with
@bupbuse.bsky.social
, Andriko von Kügelgen, and
@tbharat-lab.bsky.social
, where we explore recent advances and argue that deeper insight into S-layers is key to deciphering microbial interactions and community organization.
@mpi-bio-fml.bsky.social
add a skeleton here at some point
0
15
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Assembly, architecture and functional roles of microbial surface layers Review article published in
@natrevmicro.nature.com
with
@bupbuse.bsky.social
, Andriko von Kügelgen and
@vikramalva.bsky.social
. S-layers are everywhere!
www.nature.com/articles/s41...
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Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
https://www.nature.com/articles/s41579-025-01258-8
6 months ago
3
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38
An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
6 months ago
10
387
191
Be our neighbour, please apply!
add a skeleton here at some point
7 months ago
0
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reposted by
Tanmay Bharat
Michael Eisen
7 months ago
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!!
formatmypaper.com
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reposted by
Tanmay Bharat
Lori Passmore
8 months ago
We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA
#cryoEM
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Tanmay Bharat
James Manton
8 months ago
The final version of our multispectral microscopy manuscript is now online at Nature Photonics:
www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
add a skeleton here at some point
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Tanmay Bharat
George O'Toole (he/him/his)
8 months ago
Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...
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Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with
@kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social
@wellcometrust.bsky.social
8 months ago
3
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Tanmay Bharat
Rob Klose
10 months ago
My wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor!
www.justgiving.com/page/colin-k...
(Please repost!)
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Colin Kleanthous' fundraiser for Motor Neurone Disease Association
Help Colin Kleanthous raise money to support Motor Neurone Disease Association
https://www.justgiving.com/page/colin-kleanthous-iveagh
0
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reposted by
Tanmay Bharat
Sjors Scheres
9 months ago
Sofia Lövestam's vault structure is now online in Structure
@cellpress.bsky.social
. 🥳 How beautifully explorative is
#cryoEM
! We never planned to do this. The vaults just came down with
#amyloids
from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
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Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps
Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...
https://www.cell.com/structure/fulltext/S0969-2126(25)00262-X
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Tanmay Bharat
MRC Laboratory of Molecular Biology
9 months ago
#ICYMI
,
@newscientist.com
spoke to Wes Robertson, Group Leader in the LMB’s PNAC Division, about the ‘gargantuan effort’ behind synthesising E. coli with just 57 codons:
www.newscientist.com/article/2490...
#LMBintheNews
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E. coli genome has been remade with 101,000 changes to its DNA
The recoded bacterium uses only 57 of the 64 possible genetic codes, freeing up seven to be used for different purposes
https://www.newscientist.com/article/2490640-e-coli-genome-has-been-remade-with-101000-changes-to-its-dna/
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Tanmay Bharat
Nature
9 months ago
The story of the discovery of monoclonal antibodies 50 years ago shows how the free exchange of ideas can lead to life-changing treatments
go.nature.com/45GeSM0
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Monoclonal antibodies revolutionized biomedical science and health care
The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.
https://go.nature.com/45GeSM0
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Tanmay Bharat
Carter Lab
9 months ago
Excited to share our latest work with
@simonbullock11.bsky.social
! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before.
www.biorxiv.org/content/10.1..
.
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Tanmay Bharat
MRC Laboratory of Molecular Biology
9 months ago
The LMB recently hosted a symposium to mark 50 years since Richard Henderson and Nigel Unwin published the structure of bacteriorhodopsin, the first 3D structure of a protein determined by
#cryoEM
. Read about the event and find more photos here:
www2.mrc-lmb.cam.ac.uk/the-structur...
#LMBNews
🧪🔬
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Highly recommend, speaking from experience!
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10 months ago
0
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Tanmay Bharat
George O'Toole (he/him/his)
10 months ago
We are excited to be a part of a collaboration lead by Tarafder and Bharat titled "Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms" - this work has exciting implications for biofilm-targeted therapeutics.
www.biorxiv.org/content/10.1...
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Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms led by
@abultarafder.bsky.social
Great collaboration with
@pearce-maths.bsky.social
and
@geiselbiofilm.bsky.social
www.biorxiv.org/cgi/content/...
10 months ago
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Tanmay Bharat
Brittany Trang
10 months ago
NEW from me at STAT: We've learned that DeepMind is going to fund CASP, the protein structure competition that brought Google DeepMind's
#AlphaFold
to prominence (and a Nobel Prize), as its NIH funding runs out. More
@statnews.com
:
www.statnews.com/2025/07/21/c...
🖥️🩺🧪🧬
#bioML
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AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
https://www.statnews.com/2025/07/21/casp-new-funding-from-alphafold-developer-google-deepmind-after-nih-grant-runs-out/
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Tanmay Bharat
Sjors Scheres
10 months ago
Another chance to join the amazing
@mrclmb.bsky.social
with its generous core funding that allows it scientists to perform world-leading science, and with the best research culture you'll have ever experienced! 🤩
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