SpaceBar: a cellular barcoding approach for simultaneous analysis of cell clonal and spatial identities. www.nature.com/articles/s41...

The SpatialEx(+) framework uses histology to generate and integrate complementary spatial multi-omics data across samples. www.nature.com/articles/s41...

Two distinct RNA-regulated destabilization domains support 3-color, live-cell imaging of single mRNAs. www.nature.com/articles/s41...

Metient: a statistical framework for inferring patterns of metastatic spread and reconstructing cancer migration history. www.nature.com/articles/s41...

Multicell: a deep learning method to capture complex cell dynamics in multicellular development. www.nature.com/articles/s41...

A Resource paper provides a detailed atlas of morphogen-induced responses in human neural organoids. www.nature.com/articles/s41...

Self-supervised reconstruction structured illumination microscopy allows long-term imaging of cellular processes. www.nature.com/articles/s41...

An Analysis compares the performance of 27 single-cell perturbation response prediction methods under comprehensive test conditions. www.nature.com/articles/s41...

In this month's Creature Column, we feature the ascidian tunicate Ciona, a model for marine systems life sciences. www.nature.com/articles/s41...

Scikit-bio: a Python library for biological omic data analysis. www.nature.com/articles/s41...

A Perspective reviews computational methods for cross-species knowledge transfer. www.nature.com/articles/s41...

A Perspective reviews recent and emerging developments in building multimodal foundation transformer models in genomics. www.nature.com/articles/s41...

An Analysis from benchmarks computational tools for RNA modification detection using nanopore direct RNA sequencing. www.nature.com/articles/s41...

Novae: a graph-based foundation model for spatial transcriptomics modeling and analysis tasks. www.nature.com/articles/s41...

Carta leverages lineage tracing data to infer the optimal trajectory of cell differentiation. www.nature.com/articles/s41...

FACED 2.0: a method for high-speed, large FOV, volumetric 2-photon voltage and calcium imaging in the mouse and zebrafish brain. www.nature.com/articles/s41...

CellSAM uses an object detector, CellFinder, to detect cells and prompt the Segment Anything Model to generate segmentations with human-level performance across a range of bioimage data. www.nature.com/articles/s41...

A Method to Watch: Artificial intelligence agents for biology www.nature.com/articles/s41...

A Method to Watch: Protein editing www.nature.com/articles/s41...

A Method to Watch: Cell typing by electrophysiology www.nature.com/articles/s41...

A Method to Watch: Predicting RNA structures www.nature.com/articles/s41...

A Method to Watch: Understanding enhancer logic through synthetic design www.nature.com/articles/s41...

A Method to Watch: Cracking the cancer microbiome www.nature.com/articles/s41...

A Method to Watch: Intrinsic protein disorder at scale www.nature.com/articles/s41...

A Method to Watch: The virtual cell www.nature.com/articles/s41...

NimbusImage: a cloud computing platform for image analysis. www.nature.com/articles/s41...

MIHCLE: minimum information about a high containment laboratory experiment. Reporting standards for experiments with pathogens in BLS-3 and -4 laboratories. www.nature.com/articles/s41...

Deep Imputation for Skeleton data (DISK) imputes missing animal tracking keypoints in videos and motion capture recordings. www.nature.com/articles/s41...

LatentSNA is a method for network analysis in human neuroimaging, that links neural activity with behavior. www.nature.com/articles/s41...

C-COMPASS: a tool to predict spatial cellular distribution of proteins and lipids. www.nature.com/articles/s41...

RFdiffusion2 builds de novo enzyme active sites using atom-level functional group constraints. www.nature.com/articles/s41...

CaBLAM: a bioluminescent, genetically encoded calcium indicator for high-contrast imaging in cells and in vivo. www.nature.com/articles/s41...

Parallelized single-molecule fluorescence and FRET experiments enable quantitative analysis of molecule function from multiple samples in a single experiment. www.nature.com/articles/s41...

ROSE-3D is a single-molecule localization microscopy method with high isotropic resolution, for whole-cell and multicolor imaging. www.nature.com/articles/s41...

An Analysis benchmarks 50 state-of-the-art TCR-epitope binding prediction methods. www.nature.com/articles/s41...

DeepCor: a deep-learning-based denoising approach for fMRI data. www.nature.com/articles/s41...

ExoSloNano: nanogold probe-based labeling of proteins in live cells for cryo-ET and CLEM. @lindseynyoung.bsky.social @thevillalab.bsky.social www.nature.com/articles/s41...

We are looking for a new editor with expertise in genetics, genomics and/or molecular biology to join our editorial team in the US (NYC/Jersey City) or China (Shanghai/Beijing)! Only 2 days left to get your applications in! springernature.wd3.myworkdayjobs.com/SpringerNatu... pic.x.com/o3rJgvFnOq

Method of the Year 2025: In her feature, @vivienm.bsky.social asks scientists about their strategies and decision-making as they scale EM-based approaches for larger brains. www.nature.com/articles/s41...

Method of the Year 2025: In his Comment, Moritz Helmstaedter looks into the future of connectomics and the feasibility of scaling up to larger brains. www.nature.com/articles/s41...

Method of the Year 2025: In their Comment, Wei-Chung Allen Lee @darbly.bsky.social and Ramin Khajeh discuss alternatives to the well-established approaches used in connectomics. www.nature.com/articles/s41...

Method of the Year 2025: In his Comment, @janfunkey.bsky.social discusses current challenges in connectomics, which is time-consuming and labor-intensive. He focuses on proofreading and discusses how automated models might be further developed to embrace uncertainty. www.nature.com/articles/s41...

Method of the Year 2025: A Comment from @martamcosta2 discusses challenges and prospects of comparative connectomics, which provides insights into variability between individuals, developmental changes, differences between sexes and evolutionary changes between species www.nature.com/articles/s41...

Method of the Year 2025: In his Comment, @clayreid.bsky.social discusses functional connectomics, which links structure and function by combining electron microscopic reconstruction of brain tissue with calcium imaging of neuronal activity. www.nature.com/articles/s41...

Method of the Year 2025: This Comment from the Murthy lab showcases how complete connectomes can lead to hypotheses about circuit function and generate predictions that can then be tested with genetic tools, as illustrated with examples from the Drosophila community. www.nature.com/articles/s41...

Our Method of the Year 2025 is...drumroll please...EM-based connectomics!! Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬 www.nature.com/articles/s41...

Time to get excited! We will be announcing our 2025 Method of the Year next week!! 🥳🌟🧪🖥️🔍 Will you guess it correctly?

FX-Cell: methods for single-cell RNA sequencing from plant tissues. www.nature.com/articles/s41...

An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @crick.ac.uk @psich.bsky.social psich.bsky.social @adrianawanner.bsky.social @andreas-t-schaefer.bsky.social @ucl.ac.uk @uclnpp.bsky.social www.nature.com/articles/s41...

Cryo-IEF: a comprehensive foundation model for image processing in single-particle cryo-EM. www.nature.com/articles/s41...