📢 Applications are open for the 4th installment of our ChemTools conference. We'll explore: 🧪 Platforms & tools for analyzing cell/tissue networks ⚡ Methods to perturb biological networks 🔍 Applications that yield new insights 🛏️ Lodging + meals covered ➡️ Apply by Dec 5: https://janelia.news/CHM26

We are looking for an #AIEngineer to help build protein language models that capture evolutionary constraints with @matsen.bsky.social and @jbloomlab.bsky.social at #AI@HHMI @hhmijanelia.bsky.social hhmi.wd1.myworkdayjobs.com/en-US/Extern...

🌟 Launch your own lab at Janelia 🌟 Advance our understanding of biology through theory, computational modeling & machine learning. 🔹 No teaching requirements 🔹 100% internally funded 🔹 Collaborate with expert support teams 📅 Apply by Nov. 4 👉 https://janelia.link/groupleader

🧪For more than a decade, the GENIE Project Team has collaborated with tool developers & users to take innovative biological sensors from novel prototypes to widely used laboratory staples. Now, @janeliagenie.bsky.social is unveiling their latest collaborations. www.janelia.org/news/unleash...

📢 Applications are open! Join us in May to explore computational simulation of biomechanical body models, bridging #neuroethology, #ML, physics simulation & computer vision. 🧠🤖 👁 🛏️ Lodging, meals & registration covered ➡️ Apply by Nov. 21 @ https://janelia.news/SIB26

Become a Theory Fellow at Janelia. 🔍 Use computation & theory to tackle biological problems. 🖥️ Leverage state-of-the-art computational infrastructure 🤝 Collaborate across scientific disciplines Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram

Preprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...

📢 Conduct your PhD thesis research at Janelia. 🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology. 🌐 Collaborate across disciplines 🛠️ Work with tool builders 🤝 Train in a supportive environment ➡️ janelia.org/graduate

Research detailing how nicotinic acetylcholine receptors—the main type of neurotransmitter receptor in the fly brain—change during development lays the groundwork for understanding the molecular composition, regulation & adaptability of these synapses➡️ https://hhmi.news/4mFMhMY

🎉Congratulations to David Baker, winner of the @royalsociety.org's Croonian Medal and Lecture for pioneering the design of completely new proteins and playing key roles in the development of protein structure prediction and protein engineering tools. 🔗 royalsociety.org/medals-and-p...

🧪 New proteomics research is enabling scientists to decipher how neurotransmitter receptors behave & change as an organism develops, information that could help scientists better understand the formation & function of synapses.➡️ https://hhmi.news/4mFMhMY

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader

❄️Time-deterministic cryo-optical microscopy, developed by researchers at the University of Osaka, Janelia & collaborating institutions, rapidly freezes live cells under an optical microscope, capturing a snapshot of cellular activity in high resolution➡️ https://hhmi.news/421MTUL

Please join us in congratulating HHMI Investigators Jennifer Doudna (@jenniferdoudna.bsky.social) and David R. Liu, recipients of national awards from the American Chemical Society (@acs.org) for 2026.‬‬ 🔗 cen.acs.org/people/award...

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

🖥️ PEELing, a user-friendly platform developed by the Li Lab & Janelia’s Scientific Computing Software support team, allows researchers to analyze spatial proteomics data with the click of a mouse ➡️ https://hhmi.news/47FETwh

📷Happy #WorldPhotographyDay! 🎉To celebrate, we’re sharing a few macrophotography images taken by Janelia Research Specialist Igor Siwanowicz. 🔬Siwanowicz's images have placed 20+ times in the Nikon Small World & Olympus BioScapes competitions & were featured on US Postal Service stamps in 2023.

✨ We’re #hiring Theory Fellows!✨ Janelia is recruiting early-career scientists to join our collaborative research environment and use #computation & #theory to tackle bold questions in #biology. 🔗 Apply by Nov. 3 👉 janelia.link/theoryfellow... @hhmi.org

🧠 Scientists have struggled to build computational models simple enough to understand what individual neurons in the primary visual cortex are doing. 🖥️ Now, Janelia researchers are helping to solve that problem with a new class of simplified “minimodels.”

🧠🪰 New from GENIE @HHMIJanelia: far-red #RubyACRs from the Spudich Lab enable robust optogenetic inhibition in freely behaving #Drosophila — validated with ephys, imaging & behavior. 📄 Paper bit.ly/3H7S7af 🪰 Get flies bit.ly/41iVNwK med.uth.edu/bmb/spudich/ #OptoInhibition #FlyNeuro #FlyOptogenetics

🪰 A new ‘Eyemap’ developed by a team led by Arthur Zhao & @michaelreiser.bsky.social reveals how visual information detected by the fly’s eye shows up in neurons deep in the brain. Remarkably, the eye’s shape determines how flies see motion.👁️ 🔗 hhmi.news/4kSZjou

🧠 New research reveals that distinct areas in the brain’s visual cortex are responsible for different types of learning: unstructured, exploration-based unsupervised learning and instructed, goal-oriented supervised learning. #worldbrainday 🔗 www.janelia.org/news/zoning-...

🐸 Imagine you’re sitting by a pond listening to the din of croaking frogs. What if you could use the changes in volume of the combined croaking to figure out how many frogs are in the pond? 🔬 That’s the idea behind a new method to count the individual molecules in fluorescence microscopy images.

A new model developed by Janelia researchers to predict the visual responses of individual neurons in the primary visual cortex is an important first step in understanding visual processing & how other brain areas carry out more complicated computations ➡️ www.janelia.org/news/new-com...

📢 Students & postdocs in #TheoreticalNeuroscience 👉 Join us this November for a "by the students, for the students" workshop featuring whiteboard-style tutorials, in-depth discussions, and research talks. ✈️ Travel, lodging & registration covered Apply by Aug. 5 @ janelia.news/THE25

🏊 Serotonin controls how hard a zebrafish swims as changes in its body or environment effect its effort. Now, researchers are uncovering how neurons figure out when & how much serotonin to secrete – providing new insights into neuromodulation ➡️ www.janelia.org/news/new-res...

💻A new class of simplified ‘minimodels’ developed by Fengtong Du, Miguel Angel Núñez-Ochoa, @marius10p.bsky.social & @computingnature.bsky.social can predict the visual responses of individual neurons in the primary visual cortex, helping shed light on how we see.👀 ➡️ www.janelia.org/news/new-com...

ATTN: students & postdocs in #theoreticalneuroscience! Applications are now open for @hhmijanelia.bsky.social's "by the students, for the students" #neurotheory workshop, which will take place Nov. 9 - 14, 2025.

🥼 Janelia researchers are developing new tools to help accelerate biological discovery, like blinx – a new method that enables scientists to surpass the resolution limit of fluorescence microscopy. 🔬 🔗 www.janelia.org/news/new-met...

🧠Zoning out could be beneficial—and may actually help us learn faster. 🥼New research led by @zhong-lin.bsky.social @marius10p.bsky.social @computingnature.bsky.social 🔗 www.janelia.org/news/zoning-...

🚶Aimlessly wandering around a city or exploring the new mall may seem unproductive, but new research led by @zh0ng0.bsky.social @marius10p.bsky.social @computingnature.bsky.social suggests it could play an important role in how our brains learn.‬‬ 🧠 🔗 www.janelia.org/news/zoning-...

In this video you can see a visual map of some of the neurons within a fruit fly’s ventral nerve cord (VNC), like that of a human’s spinal cord. Neurons progressively stack on top of each other and at the end of the video, you can see a rough neuronal map of the VNC.

🧠 Janelia researchers are helping to uncover how neuromodulators reach neurons & revealing a significant role for astrolia in neuromodulation – highlighting the importance of including info about non-neuronal cells in research into how the brain works. www.janelia.org/news/on-the-...

🐟 New research probing the inner workings of neuromodulation in zebrafish could help scientists better understand how the brain enables flexible behavior and provide insight into mood disorders like depression. 🔗 www.janelia.org/news/new-res...

This fiery mixture of red and green neurons in the brain of a mouse shows how interconnected different types of neurons can be. Shown in green are the excitatory pyramidal neurons, and in red are inhibitory interneurons. Credit: Nelson Spruston and Erik Bloss, @hhmijanelia.bsky.social

🖥️A new method developed by Alex Hillsley, @janfunkey.bsky.social & collaborators counts the individual molecules contained in a single spot of light detected by a fluorescence microscope—a quantity important for understanding the underlying biology of a living system. www.janelia.org/news/new-met...

🖥️ STIM, a new tool developed at Janelia & @mdc-berlin.bsky.social‬, aligns sections of irregularly spaced 2D spatial transcriptomics data & renders them as images to reconstruct 3D volumes of gene expression, allowing researchers to see how all genes are expressed & organized in 3D tissue. 🧬

🥼Researchers, led by @mishaahrens.bsky.social, Ziqiang Wei & Takashi Kawashima, are decoding how neurons carry out computations carefully calibrated to an animal’s movement & environment to precisely regulate the release of neuromodulators. www.janelia.org/news/new-res...

🦠 New research led by @aaandmoore.bsky.social‬ @buvansr.bsky.social‬ @vgelfand.bsky.social‬ shows vimentin filaments that provide support & shape to cells are more independent & dynamic than previously thought, providing new insight into their role in cellular processes. 🔗 hhmi.news/4kEYZe2

🧠 New research led by Janelia Group Leader @jvoigts.bsky.social‬ & MIT's Mark Harnett finds that as we navigate, neural activity patterns can encode competing hypotheses about which landmark will lead to the correct destination. news.mit.edu/2025/how-bra...

🪰 Realistic animal models – like a virtual fly developed by researchers at Janelia and Google DeepMind – could help scientists more fully understand how the nervous system, body & environment work together to control behavior.

👀 For more than 15 years, Janelia researchers have been on a mission to catalogue the neurons of the fly optic lobes & develop genetic tools to study them. This effort has culminated in a complete inventory of all the visual neurons in the fruit fly ➡️ www.nature.com/articles/d41...

🥼 Hundreds of Janelia scientists worked for more than a decade to create tools to study the fly brain, releasing a “greatest hits” collection in 2024. hhmi.news/41EXaGU ⏩ A new peer reviewed #preprint outlines this #OpenScience resource, made possible by our FlyLight Project Team hhmi.news/3QJYuls

👀 For biologists, seeing is believing. But sometimes, biologists have a hard time seeing. Now, a new technique corrects one particularly vexing challenge: simultaneously imaging all the molecules in an intact tissue sample, down to the level of single cells ➡️ www.janelia.org/news/new-tec...

Are you a student or postdoc working on theory for biological problems? Just over two weeks left to apply for our fall workshop here at @hhmijanelia.bsky.social. It’s free and we cover travel expenses! www.janelia.org/you-janelia/...

🎉 Congratulations to Kym Delventhal @kymdelventhal.bsky.social‬, Janelia’s Director of Molecular and Cellular Genomics, on being named President of the Association of Biomolecular Resource Facilities @abrf.bsky.social‬, a membership association for shared resource professionals.‬ abrf.org

🧠 Janelia researchers have developed a new way to map how individual connections between neurons change across the entire brain during learning, giving scientists a new view into how changes in behavior show up in the brain. www.janelia.org/news/new-ima...

🐟 New research led by the Ahrens Lab reveals how astrocytes trigger a biochemical circuit that regulates neuronal activity in zebrafish, causing the fish to stop swimming when they aren’t getting anywhere – a behavior critical for survival ➡️ www.janelia.org/news/on-the-...

Happy to officially introduce FilaBuster - a strategy for rapid, light-mediated intermediate filament disassembly. Compatible with multiple IF types, modular in design, and precise enough to induce localized filament disassembly in live cells. www.biorxiv.org/content/10.1...

🥼 A novel system designed by the Dudman Lab & Janelia Experimental Technology allowed the team to test hypotheses about the role of different brain regions in flexible, goal-directed action & shed new light on the role of the striatum in motor control.