ICYMI: A team of researchers unveiled the complete connectome of an entire male fruit fly central nervous system, encompassing the central brain, optic lobes, and ventral nerve cord. https://hhmi.news/4o3EJnk

A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...

Join the team at Janelia to use #theory, computation, and modeling to tackle bold questions in #biology. Collaborate across scientific disciplines to drive discovery. Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram #computationalbiology #sciencecareers

Excited to announce our new pre-print (www.biorxiv.org/cgi/content/...)! This collaborative work (co-led by Adriane Otopalik and Gerry Rubin) examines how neuronal circuits regulate social behaviors, like courtship🫶 and aggression🥊, across sexes. #neuroscience #Drosophila #WomenInSTEM 🧪1/

🦠 New research provides a mechanism for understanding how environmental changes to somatic cells are passed through the germline, helping scientists better understand transgenerational effects, like the malnutrition of a parent affecting its offspring. https://hhmi.news/4mCD3QO

🪰 Srinivas Turaga @hhmijanelia.bsky.social opened #CRSy25 Day 3’s afternoon session with “Simulating the brain and body of the fruit fly” From detailed connectomes to full-body physics, they model how neural circuits generate flight & walking - bridging the gap between brain structure and behaviour.

🌟 Apply to lead a lab at Janelia 🌟 We’re #hiring Group Leaders in our Computation & Theory research area. 🔹 5-year renewable appointment 🔹 Internal funding + generous resources 🔹 Collaboration across disciplines 📅 Apply by Nov. 4 👉 https://janelia.link/groupleader

🎉 Congrats to Research Scientist Igor Siwanowicz: 5th & 8th place in the 2025 Nikon Small World Photomicrography Competition for his images of spores of a small tropical fern & mallow pollen germinating on stigma while being parasitized by a filamentous fungus. https://hhmi.news/491e0Uf

Opening talk: 🧠🐟 How does the whole brain coordinate learning, memory & movement? @mishaahrens.bsky.social @hhmijanelia.bsky.social unveils whole-brain imaging in zebrafish exploring how neural & body dynamics shape behaviour and adaptation.

🧞Like its namesake, Janelia’s GENIE Project Team makes wishes come true. Luckily for biologists, this genie doesn’t grant just 3 requests. 🧪Learn about how GENIE has accelerated the development of best-in-class sensors for measuring neuronal activity. https://hhmi.news/4gFqwKX

🧠 A new wiring diagram of the 166,000+ neurons in the brain & nerve cord of a male fruit fly is a key tool in uncovering how the brain enables complex behavior—information that could ultimately help scientists better understand what causes different diseases ➡️ https://hhmi.news/4o3EJnk

Today marks 4 years of enjoying the beautiful @hhmijanelia.bsky.social campus 🌳

📢Apply by Dec. 3 for our joint graduate programs with the Johns Hopkins University School of Medicine in neuroscience & cross-disciplinary biology. 🧠Develop interdisciplinary research projects 🌍Join a collaborative environment 🔬Leverage shared resources & support teams ➡️ janelia.org/graduate

🔊 Listen to Senior Group Leader Hari Shroff discuss microscopy, biology and his path through science in the latest episode of Ashoka University's The Science of It podcast: https://www.youtube.com/watch?v=dyoP5HwAFAc&list=PLaTCrA79FLSx-NV34W0Ee2Ei8FgmBDEKn&index=16

Pleased to have this review out in @cp-trendsneuro.bsky.social. In it we discuss various aspects of the intersection between foraging behaviors and neuroscience, and offer some future directions: www.sciencedirect.com/science/arti...

🪰 A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system—a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the millions of connections between them. 🔗 https://hhmi.news/4o3EJnk

Become a Theory Fellow @hhmijanelia.bsky.social 🧪 Work alongside experimentalists to test and refine theories 🎯 Receive mentorship from leading computational scientists 🔁 Contribute to Janelia’s cross-disciplinary research environment Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram

🥼 New research from the Wang Lab reveals a novel connection between lysosomes & the epigenome and provides new insights into how lysosomes regulate longevity over generations & drive the histone-based transfer of epigenetic information between cells. 🔗 https://hhmi.news/4mCD3QO

Plenary speaker spotlight ✨ Meng Wang (@bcmhouston.bsky.social / @hhmi.org) at #ASBMB26: “Racing the clock: Molecular mechanisms of aging.” ➡️Dive into the biochemical basis of aging, from metabolism to the genome: ow.ly/68i150X37Pm. #MakeItPossibble #AgingResearch #FutureOfScience

✨ ICYMI: Researchers detail how neurotransmitter receptors in the fly brain change during development ➡️ https://hhmi.news/4mFMhMY

🪱New research from the Wang Lab shows how changes in a worm’s lysosomes promoting longevity are transferred to its offspring through the epigenome, revealing how epigenetic modifications that help organisms cope with environmental stress can be inherited. 🔗 www.janelia.org/news/leaving...

🥼 Working with tool developers & support teams, Janelia’s GENIE Project Team recently created next generation sensors for detecting the neurotransmitters glutamate & GABA and adapted a new tool aimed at controlling & studying specific neural circuits in flies. 🔗 https://hhmi.news/4gFqwKX

📢 Applications are open for the 4th installment of our ChemTools conference. We'll explore: 🧪 Platforms & tools for analyzing cell/tissue networks ⚡ Methods to perturb biological networks 🔍 Applications that yield new insights 🛏️ Lodging + meals covered ➡️ Apply by Dec 5: https://janelia.news/CHM26

We are looking for an #AIEngineer to help build protein language models that capture evolutionary constraints with @matsen.bsky.social and @jbloomlab.bsky.social at #AI@HHMI @hhmijanelia.bsky.social hhmi.wd1.myworkdayjobs.com/en-US/Extern...

🌟 Launch your own lab at Janelia 🌟 Advance our understanding of biology through theory, computational modeling & machine learning. 🔹 No teaching requirements 🔹 100% internally funded 🔹 Collaborate with expert support teams 📅 Apply by Nov. 4 👉 https://janelia.link/groupleader

🧪For more than a decade, the GENIE Project Team has collaborated with tool developers & users to take innovative biological sensors from novel prototypes to widely used laboratory staples. Now, @janeliagenie.bsky.social is unveiling their latest collaborations. www.janelia.org/news/unleash...

📢 Applications are open! Join us in May to explore computational simulation of biomechanical body models, bridging #neuroethology, #ML, physics simulation & computer vision. 🧠🤖 👁 🛏️ Lodging, meals & registration covered ➡️ Apply by Nov. 21 @ https://janelia.news/SIB26

Become a Theory Fellow at Janelia. 🔍 Use computation & theory to tackle biological problems. 🖥️ Leverage state-of-the-art computational infrastructure 🤝 Collaborate across scientific disciplines Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram

Preprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...

📢 Conduct your PhD thesis research at Janelia. 🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology. 🌐 Collaborate across disciplines 🛠️ Work with tool builders 🤝 Train in a supportive environment ➡️ janelia.org/graduate

Research detailing how nicotinic acetylcholine receptors—the main type of neurotransmitter receptor in the fly brain—change during development lays the groundwork for understanding the molecular composition, regulation & adaptability of these synapses➡️ https://hhmi.news/4mFMhMY

🎉Congratulations to David Baker, winner of the @royalsociety.org's Croonian Medal and Lecture for pioneering the design of completely new proteins and playing key roles in the development of protein structure prediction and protein engineering tools. 🔗 royalsociety.org/medals-and-p...

🧪 New proteomics research is enabling scientists to decipher how neurotransmitter receptors behave & change as an organism develops, information that could help scientists better understand the formation & function of synapses.➡️ https://hhmi.news/4mFMhMY

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader

❄️Time-deterministic cryo-optical microscopy, developed by researchers at the University of Osaka, Janelia & collaborating institutions, rapidly freezes live cells under an optical microscope, capturing a snapshot of cellular activity in high resolution➡️ https://hhmi.news/421MTUL

Please join us in congratulating HHMI Investigators Jennifer Doudna (@jenniferdoudna.bsky.social) and David R. Liu, recipients of national awards from the American Chemical Society (@acs.org) for 2026.‬‬ 🔗 cen.acs.org/people/award...

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

🖥️ PEELing, a user-friendly platform developed by the Li Lab & Janelia’s Scientific Computing Software support team, allows researchers to analyze spatial proteomics data with the click of a mouse ➡️ https://hhmi.news/47FETwh

📷Happy #WorldPhotographyDay! 🎉To celebrate, we’re sharing a few macrophotography images taken by Janelia Research Specialist Igor Siwanowicz. 🔬Siwanowicz's images have placed 20+ times in the Nikon Small World & Olympus BioScapes competitions & were featured on US Postal Service stamps in 2023.

✨ We’re #hiring Theory Fellows!✨ Janelia is recruiting early-career scientists to join our collaborative research environment and use #computation & #theory to tackle bold questions in #biology. 🔗 Apply by Nov. 3 👉 janelia.link/theoryfellow... @hhmi.org

🧠 Scientists have struggled to build computational models simple enough to understand what individual neurons in the primary visual cortex are doing. 🖥️ Now, Janelia researchers are helping to solve that problem with a new class of simplified “minimodels.”

🧠🪰 New from GENIE @HHMIJanelia: far-red #RubyACRs from the Spudich Lab enable robust optogenetic inhibition in freely behaving #Drosophila — validated with ephys, imaging & behavior. 📄 Paper bit.ly/3H7S7af 🪰 Get flies bit.ly/41iVNwK med.uth.edu/bmb/spudich/ #OptoInhibition #FlyNeuro #FlyOptogenetics

🪰 A new ‘Eyemap’ developed by a team led by Arthur Zhao & @michaelreiser.bsky.social reveals how visual information detected by the fly’s eye shows up in neurons deep in the brain. Remarkably, the eye’s shape determines how flies see motion.👁️ 🔗 hhmi.news/4kSZjou

🧠 New research reveals that distinct areas in the brain’s visual cortex are responsible for different types of learning: unstructured, exploration-based unsupervised learning and instructed, goal-oriented supervised learning. #worldbrainday 🔗 www.janelia.org/news/zoning-...

🐸 Imagine you’re sitting by a pond listening to the din of croaking frogs. What if you could use the changes in volume of the combined croaking to figure out how many frogs are in the pond? 🔬 That’s the idea behind a new method to count the individual molecules in fluorescence microscopy images.

A new model developed by Janelia researchers to predict the visual responses of individual neurons in the primary visual cortex is an important first step in understanding visual processing & how other brain areas carry out more complicated computations ➡️ www.janelia.org/news/new-com...

📢 Students & postdocs in #TheoreticalNeuroscience 👉 Join us this November for a "by the students, for the students" workshop featuring whiteboard-style tutorials, in-depth discussions, and research talks. ✈️ Travel, lodging & registration covered Apply by Aug. 5 @ janelia.news/THE25

🏊 Serotonin controls how hard a zebrafish swims as changes in its body or environment effect its effort. Now, researchers are uncovering how neurons figure out when & how much serotonin to secrete – providing new insights into neuromodulation ➡️ www.janelia.org/news/new-res...

💻A new class of simplified ‘minimodels’ developed by Fengtong Du, Miguel Angel Núñez-Ochoa, @marius10p.bsky.social & @computingnature.bsky.social can predict the visual responses of individual neurons in the primary visual cortex, helping shed light on how we see.👀 ➡️ www.janelia.org/news/new-com...

ATTN: students & postdocs in #theoreticalneuroscience! Applications are now open for @hhmijanelia.bsky.social's "by the students, for the students" #neurotheory workshop, which will take place Nov. 9 - 14, 2025.