Curious about or committed to collective behavior? Please register and submit your abstract ASAP! We are hoping to have a big crowd in Heidelberg in February.

😳 mastodon.social/@glyph/11546...

The songbird basal ganglia connectome https://www.biorxiv.org/content/10.1101/2025.10.25.684569v1

A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...

The new @mpi-cbg.de research group leader Daniela Egas Santander is looking for a Postdoctoral Researcher (m/f/d) in Applied Topology for Biology. Apply until November 16th here: careers.mpi-cbg.de/jobs/6002777...

Join the team at Janelia to use #theory, computation, and modeling to tackle bold questions in #biology. Collaborate across scientific disciplines to drive discovery. Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram #computationalbiology #sciencecareers

Hello dear diary, today I've added some minor features, like highlighting boxes and canvas selecting objects + manual transform mode. Small update, mucho trabajo, but it should be helpful for user experience #bigvolumebrowser

The Shanahan Fellowship is a unique PostDoc opportunity at the intersection of Neuroscience and Data Science. If you are considering a PostDoc in this area, I encourage you to apply! Applications are open! And due by Dec 1st alleninstitute.org/shanahan-fou...

Very excited to be co-organizing this meeting. Hope to see you there!

Excited to share our new #biorxivpreprint: “Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1... We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10

The connectome of the entire male Drosophila central nervous system is out!! Acquired using FIB-SEM @ 8x8x8nm, we aligned 7.5 mio 2D images aligned into one seamless 3D volume, which was used to segment & proofread neurons and synapses. @hhmijanelia.bsky.social www.biorxiv.org/content/10.1...

Cell Physics community is missing Jochen Guck deeply.. He was a very kind and generous person, one of the most creative minds, and always ready to help everyone in the field.. He inspired many of us.. He will always be missed..

Great Job - Great Colleagues - Great Science👍 Help us pick the next generation of @hhmi.org Investigators, Freeman Hrabowski Scholars, Hanna Gray Fellows, Gilliam Fellows Relocation to DC is required, perfect for academic PIs looking for their next chapter hhmi.wd1.myworkdayjobs.com/External/job...

I love this piece! It shows the many ways a connectome can be put to use, AND the many complementary modalities that are needed, beyond the connectome, to answer real questions. And it makes me feel good about having helped to generate the thing. :)

🔊 Listen to Senior Group Leader Hari Shroff discuss microscopy, biology and his path through science in the latest episode of Ashoka University's The Science of It podcast: https://www.youtube.com/watch?v=dyoP5HwAFAc&list=PLaTCrA79FLSx-NV34W0Ee2Ei8FgmBDEKn&index=16

#QuPath + Imglib2 and #BDV ❤️ Promising start! (Mainly Léo and Pete's work github.com/qupath/qupat... + a small addition)

I managed to make #ABBA work with a white background and dark mode! #FijiSc #BDV. Useless for the moment, but I like it.

Apply now!!! 🔥

We're very proud to be releasing the complete male fly CNS connectome! It's the product of a huge team effort here at Janelia in partnership with the Cambridge Fly Connectomics group (@jefferis.bsky.social and colleagues), plus invaluable collaborators. More soon... www.janelia.org/project-team...

“framing science as a debate to be won makes it easy to paint established scientists as opponents who must be overcome” An interesting thesis and suggestion of a solution www.nytimes.com/2025/10/03/o... 🎁

New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling: gcamp6f.com/2025/08/11/i... Featuring work by @lorenabenedetti.bsky.social, O'Hare et al. and Lin et al.!

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism

NEWS🎉 We’re excited to announce @hhmijanelia.bsky.social Investigator David Stern will join the Institute from Janelia Research Campus. His lab studies how aphids transform plants at the genetic level, uncovering secrets of #evolution & new strategies for pest control. @hhmi.org bit.ly/4np96Fb

We're announcing a new update to MTEB: RTEB It's a new multilingual text embedding retrieval benchmark with private (!) datasets, to ensure that we measure true generalization and avoid (accidental) overfitting. Details in our blogpost below 🧵

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

Back to work on #bigvolumebrowser, I've added the import of point clouds that change over time. The test data generation was a pleasant detour into the world of attractors (Thomas' cyclically symmetric is shown).

This may be the most important paper ever published about NIH funded research. www.science.org/doi/10.1126/...

The final version of our transformer-based model of natural selection has come out in MBE. I hope some molecular evolution researchers find this interesting & useful as a way to express richer models of natural selection. doi.org/10.1093/mol... (short 🧵)

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠 I'm looking for people who are excited about revealing the many molecular layers of the "hidden connectome" with expansion microscopy, in a highly intersectional environment exploring ideas in meta-science. mrc.tal.net/vx/mobile-0/...

You may have heard me talk about learned shape representations for a long time, but it took @afoix.bsky.social's hard work to bring it to life 🍾 Catch her at @neuripsconf.bsky.social to find out more!!

Do you study proteins? The new PDBe entry pages make it easier to explore protein structures. 🟢 Visualise ligands & macromolecules with improved 3D viewers 🟢 Get background info from AI-based annotations 🟢 Add your own annotations to viewers without leaving the browser @pdbeurope.bsky.social 🧬🖥️

I gave a talk at Blender Conference yesterday, showing how biological volumes work, and how to visualize them in Blender 😋 youtu.be/WPajSWX730o?... #bcon25

Passive morphogenesis of the gut: work by @zhaoshh.bsky.social @lepuslapis.bsky.social @mpipks.bsky.social @mpi-cbg.de @csbdresden.bsky.social and collaborators at Princeton University, @flatironinstitute.org now #published @pnas.org: doi.org/10.1073/pnas.2505160122

The final version of our "Thrifty" paper is up now: elifesciences.org/articles/10... . We were motivated to fit wide-context mutation models based on previous analyses showing "mesoscale" effects and a position-specific effect. But, how to avoid exploding the number of parameters? 🧵

🌟 Launch your own lab at Janelia 🌟 Advance our understanding of biology through theory, computational modeling & machine learning. 🔹 No teaching requirements 🔹 100% internally funded 🔹 Collaborate with expert support teams 📅 Apply by Nov. 4 👉 https://janelia.link/groupleader

We are looking for an #AIEngineer to help build protein language models that capture evolutionary constraints with @matsen.bsky.social and @jbloomlab.bsky.social at #AI@HHMI @hhmijanelia.bsky.social hhmi.wd1.myworkdayjobs.com/en-US/Extern...

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience. #neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...

🪰 How do dozens of tiny fly muscles cooperate to move a leg? We’re excited to share the first 3D, data-driven musculoskeletal model of Drosophila legs based on Hill-type muscles, running in OpenSim and MuJoCo simulation environments. Preprint: arxiv.org/abs/2509.06426

ModernBERT goes MULTILINGUAL! One of the most requested models I've seen, @jhuclsp.bsky.social has trained state-of-the-art massively multilingual encoders using the ModernBERT architecture: mmBERT. Stronger than an existing models at their sizes, while also much faster! Details in 🧵

Become a Theory Fellow at Janelia. 🔍 Use computation & theory to tackle biological problems. 🖥️ Leverage state-of-the-art computational infrastructure 🤝 Collaborate across scientific disciplines Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram

Preprint - Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo. www.biorxiv.org/content/10.1...

Our new preprint is about the airway epithelium microtubule network, cilia, basal body protein composition, averaging of volumetric fluorescence data, and expansion microscopy. Four years of very hard work from our very talented Emma van Grinsven. www.biorxiv.org/content/10.1... (1/N)

🥳Congrats! Exciting to see the similarities and differences between hunger-modulation from our findings in the brain and the VNC. Internal state configures olfactory behavior and early sensory processing in Drosophila larvae | Science Advances www.science.org/doi/10.1126/...

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

UMA: A Family of Universal Models for Atoms www.compchemhighlights.org/2025/08/uma-... #compchem

github.com/allierc/MPM_pytorch @HHMIJanelia pytorch version of github.com/yuanming-hu/...

On the Theoretical Limitations of Embedding-Based Retrieval Google DeepMind demonstrates that vector embeddings have fundamental limitations in representing all possible document combinations. 📝 arxiv.org/abs/2508.21038 👨🏽‍💻 github.com/google-deepm...

Research team @nadlerlab.bsky.social, A. Honigmann @biotec-tud.bsky.social, B.Drobot @hzdr.bsky.social, M. Hof @heyrovskeho-ustav.bsky.social develops approach to visualize lipids in cells & uncovers the main transport mechanism for lipids within the cell. @nature.com www.mpi-cbg.de/news-outreac...

📢We're #hiring Group Leaders! Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning. 🔹5-year renewable appointment 🔹Pioneer new tools & approaches 🔹Collaborate across disciplines Apply by Nov. 4👉 https://janelia.link/groupleader