Cells can contain the same DNA “instructions” but become different cell types and behave differently. Scientists are studying the role that epigenetic regulation plays in this process.

Today we mark the eighth anniversary of St. Jude Global and its work to address disparities in outcomes for children worldwide. Through collaboration with WHO and global partners, St. Jude Global expands access to care while sharing knowledge, technology and expertise.

Transposons, or “jumping genes” that self-replicate and move through the genome can cause problems, especially for germ cells. Scientists uncovered how cells identify unwanted transposons by sensing the RNA they produce and activating silencing pathways. ow.ly/IGsx50Z3lYZ

At the World Health Assembly in Geneva, St. Jude convened researchers, policymakers and people with lived experience to advance shared priorities for children’s health. Decisions at this level influence policies, health systems and access to care worldwide. #WHA79

On Clinical Trials Day, we recognize the essential role clinical trials play in advancing the St. Jude mission. Our investigators study new treatment strategies, refine existing approaches and work to deliver more precise care for patients.

Honored to see @drtedros.who.int recognize the St. Jude-WHO partnership expanding access to childhood cancer medicines globally. Together, we’ve delivered 1.5M medicines for 2,400 children in five countries. #WHA79 #ChildhoodCancer #GlobalHealth

Findings show a small RNA in the cholera bacterium influencing Vibrio cholerae colonization of the gut. Human-associated variants regulate 85% of genes tied to virulence and intestinal colonization, supporting the need for improved outbreak surveillance. ow.ly/cF2A50YZG6Q

The Global Platform for Access to Childhood Cancer Medicines is expanding more than treatment access. In Ghana and Nepal, improved data systems and cancer registries are helping leaders better understand disease burden, plan care and identify gaps. ow.ly/j97t50YYVbP

Recent findings from St. Jude combine clinical, imaging and molecular data to guide treatment for H3 G34–mutant diffuse hemispheric glioma (DHG), helping move beyond strategies designed for adults to treat this rare brain tumor in children. ow.ly/LE9N50YXCkm #BTAM #StJudeResearch

Xin-yan Chen, PhD, a postdoc in the lab of Chunliang Li, PhD, Tumor Cell Biology, shared research on KMT2A-rearranged leukemia earning top honors at the 12th St. Jude Comprehensive Cancer Center Postdoctoral Symposium. Learn more about Chen: https://ow.ly/W2H050YW9mV

Hongbo Chi, PhD, Department of Immunology chair, has been elected to the National Academy of Sciences in recognition of his field-defining research connecting immunology, metabolism and adaptive immunity. ow.ly/Hkvm50YUJyl

Julie R. Park, MD, Oncology chair, shared a powerful look at next-generation therapies for childhood solid tumors as the #ASPHO2026 Oncology Luminary Speaker.

In aplastic anemia, the immune system destroys blood stem cells. New single-cell DNA sequencing of 619 patients shows some stem cells can acquire mutations that let them evade immune attack—restoring blood production without increasing risk of MDS or leukemia. ow.ly/70lU50YTc2g

Kim Nichols, MD has received the 2026 George R. Buchanan Lectureship Award from ASPHO, recognizing leadership in pediatric hematology/oncology and advances in hereditary cancer risk care. #ASPHO2026

St. Jude is proud to sponsor the ASPHO Early Career Roundtable Luncheon today at #ASPHO2026, supporting training and mentorship for the next generation of pediatric hematology/oncology clinicians and physician-scientists. #ASPHO #PedsHemeOnc

Researchers developed a strategy using AI and genetic data to identify drug targets with strong anti-cancer potential and low toxicity, revealing IRS4 as a potential dependency across pediatric and adult solid tumors. ow.ly/u5sn50YRZgV

At the conclusion of #AACR26, we are highlighting our St. Jude graduate students, fellows and postdocs who presented their research. #StJudeResearch

St. Jude scientists report an antisense oligonucleotide (ASO) strategy that reversed multiple symptoms of HNRNPH2-related neurodevelopmental disorder in preclinical models. ow.ly/Lh4y50YO9ab

St. Jude researchers found a tumor-specific DNA “switch” that helps keep the cancer gene MYC turned on in MYC-amplified Group 3 medulloblastoma. Disabling this switch lowered MYC activity, suggesting a more targeted treatment path. ow.ly/2gPb50YO5wC

At #AACR26, Charalampos Kalodimos, PhD, chaired and presented “Conformational landscapes of protein kinases and their therapeutic exploitation” in the Structural Insights to Cancer Biology and Therapy major symposium. #StJudeResearch

St. Jude and the Damon Runyon Cancer Research Foundation awarded the 2026 fellowships to a class of early-career researchers. Five investigators will receive four years of funding to pursue innovative projects in pediatric cancer research. https://ow.ly/8AMk50YNwqJ

Meet Our Experts concludes today with Renato Umeton, PhD, vice president of data science and chief of artificial intelligence. Join us from 11-11:30 a.m. at booth 2346 for the opportunity to meet with Umeton and discuss how St. Jude is using AI to help shape discoveries. #AACR26

As St. Jude Comprehensive Cancer Center Director, Charles W.M. Roberts, MD, PhD, highlights the importance of participating in the @theaacr.bsky.social annual meeting and the role of St. Jude as the first and only NCI-designated Comprehensive Cancer Center devoted solely to children. #AACR26

Dr. Charles W. M. Roberts of @stjuderesearch.bsky.social explains that the AACR Annual Meeting accelerates advances in cancer science and medicine by bringing together researchers and others from around the world to share ideas and collaborate. #AACR26

Meet Our Experts continues with Adam Durbin, MD, PhD, Molecular Oncology. Visit booth 2346 from 12-12:30 p.m. to meet Durbin and learn about high-risk pediatric cancers. He's also presenting in the Pediatric Cancer from Mechanism to Translation minisymposium at 2:35 p.m. #AACR26 #StJudeResearch

At #AACR26, Hongbo Chi, PhD, presented “Metabolic reprogramming and engineering of cancer immunity” as part of the Mechanisms of Immune Evasion and Immune Dysregulation major symposium.

St. Jude researchers identified therapy-specific DNA mutation “fingerprints” that link pediatric chemotherapy and radiation to secondary cancers. The findings could support earlier detection and safer treatment strategies for survivors. ow.ly/pvz150YMl8B

The @theaacr.bsky.social Exhibit Hall is open! Stop by the St. Jude booth (2346) to learn about the impact of our research enterprise and how our collaborative, patient-focused approach is transforming the future of cancer research. Visit stjude.org/aacr for more information. #AACR26

The newly-inducted 2026 class of Fellows of the AACR Academy are introduced to the #AACR26 delegates at the AACR Annual Meeting Opening Ceremony.

Join @lmguentherlab.bsky.social, MD, Molecular Oncology, from 3-3:30 p.m. at booth 2346. She will share her expertise in pediatric sarcoma ahead of her presentation at the Interface of Radiation Science and Pediatric Oncology Town Hall tonight at 6:30 p.m. #AACR26 #StJudeResearch

Congratulations to Charles W.M. Roberts, MD, PhD, on being named a 2026 Fellow of the @theaacr.bsky.social Academy and receiving the Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research at #AACR2026.

St. Jude will be in San Diego, April 17-22, for the @theaacr.bsky.social Annual Meeting where researchers will share their expertise through talks and poster presentations during the meeting. Learn more about where to find us: stjude.org/aacr #AACR2026 #StJudeResearch

Led by St. Jude, an international collaboration mapped the spread of the dominant H5N1 avian influenza strain, D1.1, across North American wild birds. The continent-wide map helps interpret bird-to-human infections and supports ongoing surveillance. ow.ly/YaRv50YK5iS

Scientists at St. Jude developed patient-derived 3D tumor organoids and matched xenografts that preserve the molecular, genetic and cellular complexity of embryonal pediatric brain tumors. These models can speed functional assays and preclinical drug testing. https://ow.ly/vjSw50YK26w

James Hoffman, PharmD, shows how a growth mindset can strengthen leadership in health care. By emphasizing learning and shared responsibility, his approach supports better decision making, collaboration and continuous improvement in quality and safety at St. Jude.

Moving into a new clinical environment takes years of planning. St. Jude is preparing to transition into two new 15-story towers, the Clinical Center and the Clinical Office Building.

In Zambia, inconsistent access to quality-assured childhood cancer medicines has disrupted care and weakened local trust. Through the Global Platform for Access to Childhood Cancer Medicines, a more reliable supply can help families stay engaged in treatment. ow.ly/20zX50YFhFq

As many as one in four cancers are driven by mutations in the SWI/SNF chromatin-remodeling complex. St. Jude researchers identified PHIP as a critical vulnerability in cancers with broad SWI/SNF inactivation, including rhabdoid tumors in children. /ow.ly/umU850YEVsa

During Graduate Student Appreciation Week, we recognize trainees from the St. Jude Graduate School of Biomedical Sciences and partner institutions for their contributions to discovery, data analysis and translational research. #GSAW2026

St. Jude collaborated with the @ash.hematology.org and the Munich Leukemia Laboratory to establish the ASH HematOmics Program (ASHOP), an open platform that unites multi-omics and clinical outcomes data from nearly 6,000 patients with blood cancers. ow.ly/eYa450YEvf1

Qualitative research captures lived experiences and context that numbers alone can miss. At St. Jude, Dylan Graetz, MD, and Erica Kaye, MD, led a symposium to help apply these methods in care and research, bringing patient and family voices into the process.

New estimates from St. Jude and the @ihmeuw.bsky.social show childhood cancer remains a leading cause of childhood death worldwide, with 85% of new cases and 94% of deaths occurring in low- and middle-income countries. ow.ly/RNmp50YCFmu

Scientists found tumors reprogram dendritic cells by reducing mitochondrial activity, weakening antitumor immunity. Restoring mitochondrial function improved tumor control and enhanced immune checkpoint blockade in preclinical models. https://ow.ly/4cie50YCutC

ImmunoMemphis 2026, hosted by St. Jude and the @tum.de, will be held May 26-29, in Memphis, TN. The in-person symposium will bring together the immunological community to discuss unresolved questions in T cell biology.

Chief Legal Officer Robyn Diaz, JD, helps St. Jude leadership stay informed on emerging developments, assess potential impacts and plan responsibly to ensure work to advance the institution’s mission continues.

Researchers found that large language models can analyze survivorship interviews, but results depend on prompt design. The study provides some of the first evidence for how AI could be integrated into care to improve support for survivors of childhood cancer. ow.ly/sZS950YzGQg

Robert Webster, PhD, emeritus faculty member at St. Jude, has been elected a fellow of the American Association for the Advancement of Science (AAAS) for his more than five decades of influenza research. ow.ly/sEJE50YzfQE

St. Jude and Baylor College of Medicine scientists showed how a ZFTA-RELA fusion protein can lock ependymoma cells in developmental limbo by keeping brain development programs switched on. https://ow.ly/tp3X50YyMz7

Children and infants living with or exposed to HIV face unique challenges when treatment requires daily medication and pediatric options are limited. Through clinical trials, St. Jude is working to expand HIV treatment and prevention options designed for the youngest age groups. ow.ly/LEKT50YxPR0

St. Jude scientists led a multi-institute collaboration to create PanNDA, a first-of-its-kind atlas mapping proteomes across six neurodegenerative diseases and more than 10,000 brain proteins. PanNDA can be used as a resource to advance diagnosis and treatment. https://ow.ly/ryy450YxEVb