A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL https://www.biorxiv.org/content/10.64898/2025.12.21.694897v1

Redefining the topology of the human bone marrow using augmented spatial transcriptomic analysis https://www.biorxiv.org/content/10.64898/2025.12.22.694222v1

Optimal Maturation Protocols for High-Affinity Antibody Targets: A Path-Integral Approach https://www.biorxiv.org/content/10.64898/2025.12.21.695799v1

An accurate phasing tool via high-quality heterozygous variations https://www.biorxiv.org/content/10.64898/2025.12.21.695866v1

Computational array reconstruction for spatial transcriptomics https://www.biorxiv.org/content/10.64898/2025.12.19.695576v1

Lipid nanoparticle protein coronas form via lipoprotein fusion rather than shell-like adsorption https://www.biorxiv.org/content/10.64898/2025.12.21.695162v1

FoxO transcription factors couple the urea cycle and gluconeogenesis by controlling Ass1 https://www.biorxiv.org/content/10.64898/2025.12.22.695746v1

Dynamic adjustment of feeding behavior depending on dominant-subordinate relationship in large-billed crows. https://www.biorxiv.org/content/10.64898/2025.12.21.694083v1

Charting the cognitive development of children using adult 'polygenic g scores' https://www.biorxiv.org/content/10.64898/2025.12.19.695378v1

Membrane contacts between caveolae and the endoplasmic reticulum regulate uptake and metabolic trapping of long-chain fatty acids https://www.biorxiv.org/content/10.64898/2025.12.22.695939v1

Antifungal susceptibility profile of clinically relevant species of the genus Sporothrix: establishment of Epidemiological Cutoff Values (ECVs) according to CLSI broth microdilution methodology https://www.biorxiv.org/content/10.64898/2025.12.19.695392v1

Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection https://www.biorxiv.org/content/10.64898/2025.12.21.695867v1

Nutrient-limited conditions reveal the activity of a minor groove binder, MGB-BP-3, against Escherichia coli https://www.biorxiv.org/content/10.64898/2025.12.22.695926v1

Gene expression profiling of dendritic cell tolerance dysfunction in women with Systemic lupus erythematosus https://www.biorxiv.org/content/10.64898/2025.12.21.695630v1

Mortality Risk-Stratified Septic Serum Depresses Contractility and Mitochondrial Function in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes https://www.biorxiv.org/content/10.64898/2025.12.21.695853v1

Vitreous Inflammation as an Early Indicator of Retinal Ganglion Cell Loss Following Acute Optic Nerve Injury in Mice https://www.biorxiv.org/content/10.64898/2025.12.20.694725v1

Low-Rank Tensor Decomposition for Cross-Bispectral Analysis of EEG Data https://www.biorxiv.org/content/10.64898/2025.12.21.695795v1

Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Bifactor Models https://www.biorxiv.org/content/10.64898/2025.12.21.695029v1

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson' s Disease-like Pathogenesis in Vivo https://www.biorxiv.org/content/10.64898/2025.12.21.695762v1

NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2025.12.21.695860v1

Vector coordinate transformation in the Drosophila navigation system https://www.biorxiv.org/content/10.64898/2025.12.20.695733v1

Eukaryotic initiation factor 3d Regulates Context-Dependent Pain Hypersensitivity Through the Integrated Stress Response https://www.biorxiv.org/content/10.64898/2025.12.21.695844v1

DIME: Data-driven Importance MEtric Guides Localization of the Seizure Onset Zone from Intracranial EEG Data https://www.biorxiv.org/content/10.64898/2025.12.19.695626v1

Multiplexed Pan Soluble Ligandome Assaying via OASIS https://www.biorxiv.org/content/10.64898/2025.12.21.695830v1

Monocrotaline treatment of the rat predisposes to altered lipopolysaccharide-induced lung responses. https://www.biorxiv.org/content/10.64898/2025.12.21.695829v1

Dynamic domain interactions encode possible CheA autophosphorylation mechanisms revealed by coarse-grained simulations https://www.biorxiv.org/content/10.64898/2025.12.21.695815v1

Quantum Computing Reveals Energetics of Tau Peptide Fragments https://www.biorxiv.org/content/10.64898/2025.12.21.695828v1

Quantum implementation of multi-pattern string matching for k-mer detection https://www.biorxiv.org/content/10.64898/2025.12.21.695808v1

OTRec: Deep learning recommender for prospective druggable disease-target associations https://www.biorxiv.org/content/10.64898/2025.12.21.695803v1

nAPOGEE: A machine-learning platform for clinically actionable pathogenicity assessment of all mitochondrial noncoding variants https://www.biorxiv.org/content/10.64898/2025.12.20.695671v1

Efficient Generation of Humanized Cloned Cattle via Embryonic Stem Cell-Mediated Dual-Round Site-Specific Editing https://www.biorxiv.org/content/10.64898/2025.12.20.695363v1

Emergence of a new material through ligation of DNA nanostar hydrogels https://www.biorxiv.org/content/10.64898/2025.12.21.695831v1

Regulation of the Rheb GTPase via GATOR1 Complex https://www.biorxiv.org/content/10.64898/2025.12.20.695697v1

Exploration of diuretic potential of different parts (flower, bark, leaf) of Butea Monosperma https://www.biorxiv.org/content/10.64898/2025.12.22.696018v1

Sex-dependent carry-over between winter associations and breeding proximity in a communally roosting parrot https://www.biorxiv.org/content/10.64898/2025.12.21.695283v1

Genomic stop codon scanning reveals quantitative principles of nonsense-mediated mRNA decay https://www.biorxiv.org/content/10.64898/2025.12.20.695734v1

Histological and Metagenomic Analysis of Microbial Communities in Archaeological Human Bones https://www.biorxiv.org/content/10.64898/2025.12.21.695837v1

Longitudinal modelling reveals widespread non-additive genetic effects underlying developmental plasticity https://www.biorxiv.org/content/10.64898/2025.12.19.695443v1

Emergence of D1.1 reassortant H5N1 avian influenza viruses in North America https://www.biorxiv.org/content/10.64898/2025.12.19.695329v1

Vulnerability and adaptations to climate change in EU protected areas: a Natura 2000 managers' perspective https://www.biorxiv.org/content/10.64898/2025.12.19.695111v1

Detecting the Indo-Pacific finless porpoises (Neophocaena phocaenoides) in Hong Kong waters using environmental DNA https://www.biorxiv.org/content/10.64898/2025.12.21.695310v1

Longitudinal Neurocognitive Trajectories in a Large Cohort of Youth Who Use Cannabis: Combining Self-Report and Toxicology https://www.biorxiv.org/content/10.64898/2025.12.20.695698v1

Bayesian Nonparametric Identification of Frequency-Selective Neural Oscillatory States https://www.biorxiv.org/content/10.64898/2025.12.20.695571v1

Cyfip2 mediates sensorimotor integration of visual input through Rac1-dependent actin remodeling https://www.biorxiv.org/content/10.64898/2025.12.21.695802v1

Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson's Disease Model https://www.biorxiv.org/content/10.64898/2025.12.20.695709v1

Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation https://www.biorxiv.org/content/10.64898/2025.12.21.695842v1

Feel the Beat: The Impact of Rhythms on Dynamic Visual Search https://www.biorxiv.org/content/10.64898/2025.12.20.695695v1

Diverse Visual Experience Promotes Integrated Representations and Mitigates Bias in Deep Neural Networks for Face Perception https://www.biorxiv.org/content/10.64898/2025.12.19.695398v1

Intrinsic Molecular Timers and a Biphasic Amplitude Limit Regulate the Integrated Stress Response https://www.biorxiv.org/content/10.64898/2025.12.20.694968v1

Genetic Diversity and Phylogenetic Relationships of Cultivated and Wild Urochloa Species Conserved in the ILRI Forage Genebank https://www.biorxiv.org/content/10.64898/2025.12.20.695694v1