Cigarette Smoke and E-Cigarette Aerosol Extracts Induce Myelopoiesis and Suppress Inflammatory Cytokine Production https://www.biorxiv.org/content/10.64898/2025.12.21.693601v1

Ensembles of Graph Neural Networks Supervised by Genotype-to-Phenotype Structures Improved Genomic Prediction Performance https://www.biorxiv.org/content/10.64898/2025.12.21.695855v1

Reconstructing substitution histories on phylogenies, with accuracy, precision, and coverage https://www.biorxiv.org/content/10.64898/2025.12.21.695861v1

Restoration of Higher-Order Cortical Processing in Rat V2 by Retinal Sheet Transplants in Degenerated Rats https://www.biorxiv.org/content/10.64898/2025.12.21.690582v1

Revealing the Drivers Underlying Distinct Evolutionary Trajectories in Lung Adenocarcinoma https://www.biorxiv.org/content/10.64898/2025.12.19.695410v1

Invasion of new adaptive zones retains telltale signs of directional selection at macroevolutionary scales in mammals https://www.biorxiv.org/content/10.64898/2025.12.21.695821v1

An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity https://www.biorxiv.org/content/10.64898/2025.12.21.695840v1

A new class of proteinaceous biomaterial with unprecedented properties in unicellular eukaryotes https://www.biorxiv.org/content/10.64898/2025.12.22.695910v1

A panel of CYP6Z genes drives broad-spectrum cross-resistance to public health insecticides in the major malaria vector An. gambiae s.s. https://www.biorxiv.org/content/10.64898/2025.12.22.695880v1

ILC2s govern imprinting of alveolar macrophage-mediated immunity upon secondary helminth infection in the lung https://www.biorxiv.org/content/10.64898/2025.12.22.695921v1

Immunological liver-skin axis: a systemic Vγ4+ γδT17 cell responselinks psoriasis-like inflammation and MASLD https://www.biorxiv.org/content/10.64898/2025.12.22.695890v1

Direction and orientation preferences in mouse superior colliculus and its retinal inputs exhibit a topography of cardinal biases atop locally mixed tuning https://www.biorxiv.org/content/10.64898/2025.12.21.695778v1

Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model https://www.biorxiv.org/content/10.64898/2025.12.18.695152v1

Fully Human Stem Cell-Derived BBB Model for Clinical Disease Modeling and Neurotropic AAV selection https://www.biorxiv.org/content/10.64898/2025.12.21.695793v1

The atypical antidepressant and cognitive enhancer tianeptine disinhibits hippocampal CA1 pyramidal neurons by reducing GABAergic neurotransmission https://www.biorxiv.org/content/10.64898/2025.12.21.695760v1

Defining bottlenecks and physiological impact of an orthogonal translation initiation system https://www.biorxiv.org/content/10.64898/2025.12.21.695813v1

Concentration-dependent suppression of macrolide resistance in Mycobacterium avium by combination therapy: an improved in vitro time-kill assay and PK/PD modelling study https://www.biorxiv.org/content/10.64898/2025.12.21.695645v1

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL https://www.biorxiv.org/content/10.64898/2025.12.21.694897v1

Redefining the topology of the human bone marrow using augmented spatial transcriptomic analysis https://www.biorxiv.org/content/10.64898/2025.12.22.694222v1

Optimal Maturation Protocols for High-Affinity Antibody Targets: A Path-Integral Approach https://www.biorxiv.org/content/10.64898/2025.12.21.695799v1

An accurate phasing tool via high-quality heterozygous variations https://www.biorxiv.org/content/10.64898/2025.12.21.695866v1

Computational array reconstruction for spatial transcriptomics https://www.biorxiv.org/content/10.64898/2025.12.19.695576v1

Lipid nanoparticle protein coronas form via lipoprotein fusion rather than shell-like adsorption https://www.biorxiv.org/content/10.64898/2025.12.21.695162v1

FoxO transcription factors couple the urea cycle and gluconeogenesis by controlling Ass1 https://www.biorxiv.org/content/10.64898/2025.12.22.695746v1

Dynamic adjustment of feeding behavior depending on dominant-subordinate relationship in large-billed crows. https://www.biorxiv.org/content/10.64898/2025.12.21.694083v1

Charting the cognitive development of children using adult 'polygenic g scores' https://www.biorxiv.org/content/10.64898/2025.12.19.695378v1

Membrane contacts between caveolae and the endoplasmic reticulum regulate uptake and metabolic trapping of long-chain fatty acids https://www.biorxiv.org/content/10.64898/2025.12.22.695939v1

Antifungal susceptibility profile of clinically relevant species of the genus Sporothrix: establishment of Epidemiological Cutoff Values (ECVs) according to CLSI broth microdilution methodology https://www.biorxiv.org/content/10.64898/2025.12.19.695392v1

Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection https://www.biorxiv.org/content/10.64898/2025.12.21.695867v1

Nutrient-limited conditions reveal the activity of a minor groove binder, MGB-BP-3, against Escherichia coli https://www.biorxiv.org/content/10.64898/2025.12.22.695926v1

Gene expression profiling of dendritic cell tolerance dysfunction in women with Systemic lupus erythematosus https://www.biorxiv.org/content/10.64898/2025.12.21.695630v1

Mortality Risk-Stratified Septic Serum Depresses Contractility and Mitochondrial Function in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes https://www.biorxiv.org/content/10.64898/2025.12.21.695853v1

Vitreous Inflammation as an Early Indicator of Retinal Ganglion Cell Loss Following Acute Optic Nerve Injury in Mice https://www.biorxiv.org/content/10.64898/2025.12.20.694725v1

Low-Rank Tensor Decomposition for Cross-Bispectral Analysis of EEG Data https://www.biorxiv.org/content/10.64898/2025.12.21.695795v1

Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Bifactor Models https://www.biorxiv.org/content/10.64898/2025.12.21.695029v1

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson' s Disease-like Pathogenesis in Vivo https://www.biorxiv.org/content/10.64898/2025.12.21.695762v1

NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2025.12.21.695860v1

Vector coordinate transformation in the Drosophila navigation system https://www.biorxiv.org/content/10.64898/2025.12.20.695733v1

Eukaryotic initiation factor 3d Regulates Context-Dependent Pain Hypersensitivity Through the Integrated Stress Response https://www.biorxiv.org/content/10.64898/2025.12.21.695844v1

DIME: Data-driven Importance MEtric Guides Localization of the Seizure Onset Zone from Intracranial EEG Data https://www.biorxiv.org/content/10.64898/2025.12.19.695626v1

Multiplexed Pan Soluble Ligandome Assaying via OASIS https://www.biorxiv.org/content/10.64898/2025.12.21.695830v1

Monocrotaline treatment of the rat predisposes to altered lipopolysaccharide-induced lung responses. https://www.biorxiv.org/content/10.64898/2025.12.21.695829v1

Dynamic domain interactions encode possible CheA autophosphorylation mechanisms revealed by coarse-grained simulations https://www.biorxiv.org/content/10.64898/2025.12.21.695815v1

Quantum Computing Reveals Energetics of Tau Peptide Fragments https://www.biorxiv.org/content/10.64898/2025.12.21.695828v1

Quantum implementation of multi-pattern string matching for k-mer detection https://www.biorxiv.org/content/10.64898/2025.12.21.695808v1

OTRec: Deep learning recommender for prospective druggable disease-target associations https://www.biorxiv.org/content/10.64898/2025.12.21.695803v1

nAPOGEE: A machine-learning platform for clinically actionable pathogenicity assessment of all mitochondrial noncoding variants https://www.biorxiv.org/content/10.64898/2025.12.20.695671v1

Efficient Generation of Humanized Cloned Cattle via Embryonic Stem Cell-Mediated Dual-Round Site-Specific Editing https://www.biorxiv.org/content/10.64898/2025.12.20.695363v1

Emergence of a new material through ligation of DNA nanostar hydrogels https://www.biorxiv.org/content/10.64898/2025.12.21.695831v1

Regulation of the Rheb GTPase via GATOR1 Complex https://www.biorxiv.org/content/10.64898/2025.12.20.695697v1