Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody https://www.biorxiv.org/content/10.64898/2026.01.06.697868v1

Deep behavioral phenotyping of pathogen infected mosquitoes reveals species-specific behavior changes enhancing transmission https://www.biorxiv.org/content/10.64898/2026.01.06.697763v1

Distinctive spore architecture and developmental biology of Turicibacter sanguinis reveal unexpected diversity among gut spore formers https://www.biorxiv.org/content/10.64898/2026.01.06.697881v1

A plant virus-based virus like-particle platform for therapeutic vaccination targeting IL-23A https://www.biorxiv.org/content/10.64898/2026.01.06.697872v1

Arousal modulates functional connectivity through structured and hemispherically asymmetric community architecture during wakefulness https://www.biorxiv.org/content/10.64898/2026.01.06.697875v1

DNA methylation reveals evolved buffering responses to climate-driven sex ratio skew in sea turtles https://www.biorxiv.org/content/10.64898/2026.01.06.697884v1

Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma https://www.biorxiv.org/content/10.64898/2026.01.06.697857v1

A personalized eye-tracking system reveals complex state-dependent visual acquisition in lizards https://www.biorxiv.org/content/10.64898/2026.01.06.697876v1

Functional characterization of a multi-cancer risk locus on chromosome band 2q33.1 near CASP8 https://www.biorxiv.org/content/10.64898/2026.01.06.697866v1

Home is where the host is: Evolutionary history of geographic spread, host switching, and adaptive genomic signatures in two generalist Group B Streptococcus clonal groups https://www.biorxiv.org/content/10.64898/2026.01.06.697867v1

Dynamic sedimentary ancient DNA models of Fennoscandic Holocene plant communities reveal the role of temperature and competition https://www.biorxiv.org/content/10.64898/2026.01.06.697859v1

Expanding and Decoding the Chemistry of Phospholipid Headgroup in Eukaryotes https://www.biorxiv.org/content/10.64898/2026.01.06.697852v1

SLBP-independent control of maternal histone mRNA https://www.biorxiv.org/content/10.64898/2026.01.06.697898v1

Long-lasting astrocyte remodeling in Dravet Syndrome Scn1a+/- mouse model. https://www.biorxiv.org/content/10.64898/2026.01.06.697745v1

Sparkling Water Co-Consumption Enhances Oxytocin-Linked HR Synchrony and Social Connection in Live Sports Spectatorship https://www.biorxiv.org/content/10.64898/2026.01.05.697802v1

SCREWx: A Screwless, Chronic, Recoverable, and Lightweight Neuropixels fixture for freely-moving rodents https://www.biorxiv.org/content/10.64898/2026.01.06.697790v1

Chromosome axis protein SYCP2 recruits HORMAD2 to enable meiotic synapsis quality control in mice https://www.biorxiv.org/content/10.64898/2026.01.06.697704v1

Biological signatures of history: Examination of composite biomes and Y chromosome analysis from da Vinci-associated cultural artifacts https://www.biorxiv.org/content/10.64898/2026.01.06.697880v1

The non-coding facet of Pink1 mRNA regulates mitochondria homeostasis https://www.biorxiv.org/content/10.64898/2026.01.05.697839v1

Periplasmic gatekeeping of phage DNA entry by rSAM enzyme-mediated maturation of an effector with His-X-Ser repeats https://www.biorxiv.org/content/10.64898/2026.01.06.697848v1

Phage Endolysin Enables Targeted Manipulation of the Small Intestinal Microbiota and Uncovers Niche Overlap Between Oral and Butyrate-Producing Taxa https://www.biorxiv.org/content/10.64898/2026.01.06.697609v1

MyoL-Dependent Coupling of Preconoidal Rings to Conoid Is Required for Motility in Toxoplasma gondii https://www.biorxiv.org/content/10.64898/2026.01.06.697858v1

Mettl3-catalyzed m6A methylation determines CD8+ T cell differentiation fate in tumor https://www.biorxiv.org/content/10.64898/2026.01.06.697843v1

Neuro-metabolic pathways of high-protein meal reducing food craving https://www.biorxiv.org/content/10.64898/2026.01.06.697861v1

Enhanced tRNA array method version 2 for simultaneous in vitro synthesis of 21 tRNAs https://www.biorxiv.org/content/10.64898/2026.01.06.697847v1

Cellular consequences, citrullination substrates, and antigenicity resulting from wild-type and targeted PAD4 on cell surfaces https://www.biorxiv.org/content/10.64898/2026.01.05.696859v1

Protein Language Models and Structure-Based Machine Learning for Prediction of Allosteric Binding Sites in Protein Kinases: An Explainable AI Framework Grounded in Energy Landscape-Encoded Frustration https://www.biorxiv.org/content/10.64898/2026.01.05.697819v1

Bedaquiline inhibits the ATP synthase leak channel and prevents glutamate-induced neuronal death https://www.biorxiv.org/content/10.64898/2026.01.05.697836v1

Epidural Thin Film Implants of Polymerized Curcumin Downregulate Inflammatory Markers and Improve Functional Recovery After Spinal Cord Injury in Mice https://www.biorxiv.org/content/10.64898/2026.01.05.697760v1

Structural investigation of an engineered feruloyl esterase with improved MHET degrading properties https://www.biorxiv.org/content/10.64898/2026.01.05.697840v1

Delta PSA: A New Metric for Conformational Dynamics Underlying Macrocyclic Peptide Permeability https://www.biorxiv.org/content/10.64898/2026.01.06.697862v1

Context-dependent reorganization of behavioral strategy during transfer from home-cage to head-fixed performance https://www.biorxiv.org/content/10.64898/2026.01.05.697827v1

Gene-centered identification of cis-regulatory islands reveals regulatory landscapes complementary to motif-centric approaches https://www.biorxiv.org/content/10.64898/2026.01.05.697455v1

Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures https://www.biorxiv.org/content/10.64898/2026.01.05.697808v1

Spontaneous mutation rate in Saccharomyces cerevisiae is lower in nutritional and genotypic conditions reducing specific growth rate https://www.biorxiv.org/content/10.64898/2026.01.06.697716v1

Seasonal differences in predation risk among seagrass epifauna species stabilize community-level predation over time https://www.biorxiv.org/content/10.64898/2026.01.05.697804v1

Kinesin-1 trans-synaptically regulates synaptic localization of SARM1 for asymmetric neuron diversification https://www.biorxiv.org/content/10.64898/2026.01.05.697830v1

All-in-one Single-Cell Proteomic Analysis of Protein Alterations in Human Oocytes Undergoing in Vitro Aging https://www.biorxiv.org/content/10.64898/2026.01.05.697813v1

Molecular signatures of maladaptive plasticity in the amygdala in a rat model of chronic neuropathic pain https://www.biorxiv.org/content/10.64898/2026.01.05.697820v1

Ultra-fast genetic recovery of dead fish through cross-family germline stem cell transplantation https://www.biorxiv.org/content/10.64898/2026.01.05.697817v1

Climate stress priming of juvenile Southern California giant kelp (Macrocystis pyrifera) to thermal extremes https://www.biorxiv.org/content/10.64898/2026.01.05.697421v1

Loss of Acid Ceramidase in Myeloid Cells Protects from Chronic Colitis in IL10-Deficent Mice https://www.biorxiv.org/content/10.64898/2026.01.05.697503v1

Graft-Induced Reprogramming Under Arterial Hemodynamic Stress is Associated with a Shared Proteomic Phenotype in Arterial and Venous Conduits Following Coronary Artery Bypass Grafting https://www.biorxiv.org/content/10.64898/2026.01.04.697589v1

Impacts of mutation accumulation and order on tumor initiation revealed by engineered murine colorectal cancer organoids https://www.biorxiv.org/content/10.64898/2026.01.05.697837v1

Can AI Conduct Autonomous Scientific Research? Case Studies on Two Real-World Tasks https://www.biorxiv.org/content/10.64898/2026.01.05.697809v1

Circulating miR-4532 is associated with loss of ambulation in dysferlinopathy https://www.biorxiv.org/content/10.64898/2026.01.05.697793v1

Codon Deoptimization of Multispecific Biologics Reduces Mispairing During Transient Mammalian Protein Expression https://www.biorxiv.org/content/10.64898/2026.01.05.694717v1

MR-μScope: a multi-scale and simultaneous MRI-miniaturized microscopy system for elucidating neurovascular coupling https://www.biorxiv.org/content/10.64898/2026.01.05.697821v1

The use of cross-validation has overestimated the value of genomic selection in plant breeding https://www.biorxiv.org/content/10.64898/2026.01.05.697784v1

Maternal lipids prime quiescent neural stem cells to reactivate in response to dietary nutrients https://www.biorxiv.org/content/10.64898/2026.01.05.697812v1