Ivano Legnini
@ilegnini.bsky.social
π€ 279
π₯ 510
π 15
Group Leader
@humantechnopole.bsky.social
Molecular and Systems Biology. RNA enthusiast
1/6 We are hiring!!! π£π£π£ Fully funded postdoc position in my group!
humantechnopole.it/en/research-...
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Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA Β The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
https://humantechnopole.it/en/research-groups/legnini-group/
7 days ago
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Looking for a master student to help with a superexciting EU-funded project on mRNA metabolism. It'll involve cutting-edge sequencing and imaging techniques as well as computational workflows and modelling - great training opportunity! Get in touch if interested
humantechnopole.it/en/research-...
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Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA Β The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
https://humantechnopole.it/en/research-groups/legnini-group/
2 months ago
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Ivano Legnini
FEBS Letters
3 months ago
Immune responses need to be fast β±οΈ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more:
febs.onlinelibrary.wiley.com/doi/10.1002/...
#Immunology
#RNA
#mRNAmetabolism
@ilegnini.bsky.social
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MDC-BIMSB
3 months ago
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology π Lisbon β³ Apply by Oct 8 π
nimsb.unl.pt/wp-content/u...
#Job
#SciencePositions
#JobOffer
#GroupLeaders
#Innovation
#systemsbiology
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Human Technopole
4 months ago
π A stellar wrap-up for the Milan
#RNA
Salon! On 18 July, 120+ scientists gathered at HT for the final event of the season. π¬ Matthias Hentze
@embl.org
opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and
@mchiaragrieco.bsky.social
@ceredalab.bsky.social
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Manuel Irimia
4 months ago
This job involve spending 1-2 years in Berlin and 1-2 years in Barcelona, a truly unique opportunity! π As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.
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Manuel Irimia
4 months ago
π¨π¨π¨ Please RT! We're looking for a postdoc to join an exciting joint project between our lab
@upf.edu
&
@crg.eu
(Barcelona) and the Sander lab
@mdc-berlin.bsky.social
(Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25π
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https://www.upf.edu/documents/2869130/0/Informal_ad-LaCaixa-Irimia.pdf
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Kamil Lisek
4 months ago
Weβre happy to share our new preprint form @N_Rajewsky, with
@tmpentimalli.bsky.social
i.bsky.social
@Ilan Theurillat lab! π 𧬠Spatiotemporal atlas of tumorβstroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation. π
biorxiv.org/content/10.1...
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Spatiotemporal dynamics of tumor microenvironment remodeling
During tumorigenesis, interactions between tumor and stromal cells progressively remodel the tumor microenvironment (TME) towards pro-tumoral functions. Understanding early TME remodeling dynamics is ...
https://biorxiv.org/content/10.1101/2025.07.15.662972v1
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Ivano Legnini
Gregor Diensthuber
4 months ago
π¨ New preprint alert π¨ We systematically benchmarked
@nanoporetech.com
's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations π§¬π.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
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Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing
Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...
https://bit.ly/4lXqNul
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EMBL Events
4 months ago
βΌοΈ Don't forget to submit your abstract for #EMBLSpatialBiology! The new deadline is 15 July π
https://s.embl.org/spb25-01-bl
π 14β17 Oct πEMBL Heidelberg and Virtual β¨ ESSB will provide a fee subsidy for the top accepted abstracts. More info β‘οΈ
https://s.embl.org/SPB25-01-practical-information
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Ivano Legnini
Science News
4 months ago
Scientists 3-D printed objects inside of living cells for the first time. Naturally, they chose to print an elephant.
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Scientists 3-D printed a tiny elephant inside a cell
The first structures ever 3-D printed inside living cells point to applications for biology research.
https://buff.ly/Lw0NrzU
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Ivano Legnini
Stegle Lab
4 months ago
π’ Announcing the MOPITAS Autumn School on Spatial Transcriptomics Data Analysis β taking place November 12β14, in Munich. Don't miss this excellent opportunity to deepen your expertise in data science and multi-OMICS analysis - especially as a PhD student in the data science community.
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5 months ago
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Mireya Plass
5 months ago
π¨We are looking for post-doctoral candidates to apply for a MSCA fellowship. Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics. Computational & wet-lab candidates are welcomed!
#postdoc
#MSCA
#Barcelona
#singlecell
.
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Postdoctoral Fellowships
The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.
https://marie-sklodowska-curie-actions.ec.europa.eu/actions/postdoctoral-fellowships
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Ivano Legnini
Danny IncaRNAto
5 months ago
#RNA
Framework 2.9.3 is out! Lots of improvements! Check it out:
github.com/dincarnato/R...
& see the CHANGELOG (
raw.githubusercontent.com/dincarnato/R...
) for the details!
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Ivano Legnini
Science Magazine
5 months ago
In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells. Learn more:
scim.ag/4jVfcuk
#SciencePerspective
:
scim.ag/3STvdWC
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Human Technopole
5 months ago
𧬠Ageing, immunity & chronic diseases: HT wins β¬2.5M
@erc.europa.eu
Advanced Grant for a 5-year project led by
@nicolesoranzo.bsky.social
. Using AI & big data, the group will decode how our immune system weakens over time. A huge step for precision medicine!
humantechnopole.it/en/news/agei...
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Ageing and Chronic Diseases: Europe Rewards Human Technopoleβs Research - Human Technopole
The ERC has awarded HT a β¬2.5 million grant for a study investigating how lifestyle, biology and environmental exposures weaken the immune system over the course of life and increase vulnerability to ...
https://humantechnopole.it/en/news/ageing-and-chronic-diseases-europe-rewards-human-technopoles-research/
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Sebastian Kadener
5 months ago
But this is happening to people around us: foreign professors, teachers, students, postdocs, neighbors. And sometimes much worse. Please donβt assume this canβt happen where you live. And if you witness it, say something. Silence is complicity.
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Ivano Legnini
Coscia Lab
5 months ago
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution. Kudos to
@melissaklingeberg.bsky.social
π₯³ and big thanks to all our collaborators!
bit.ly/3SCARw4
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An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...
https://bit.ly/3SCARw4
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Ivano Legnini
Manolis Maragkakis
5 months ago
π¨ Weβre looking for a curious mind to join our lab at the NIH! Passionate about
#RNA
biology,
#MachineLearning
, and the
#genomics
of
#aging
? Interested in a postdoc or a PhD research visit at NIH? Letβs connect. π© DM or email for details!
#Bioinformatics
#AI
#ComputationalBiology
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Ivano Legnini
Max DelbrΓΌck Center
5 months ago
Organoids are becoming a valid alternative, but they canβt fully replace animal research β yet. At the #mdcBerlin, weβre working on better models and transparent communication. That's what @eara.eu's #BOARD25 is all about! More on our organoid research: π
www.mdc-berlin.de/themen/organ...
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Ivano Legnini
Stefano Cacciatore
5 months ago
KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics
#visium
#visiumhd
#seurat
#giotto
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Ivano Legnini
Mark A. Hanson
5 months ago
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. π€¬π€― Any lab using
@flybase.bsky.social
please donate using the link in post below. This incredible community, on whose backs our
#Drosophila
labs depend, can't be left out to dry.
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Arnau SebΓ©-PedrΓ³s
6 months ago
Check out our latest work on the evolution of animal genome regulation out today in
@nature.com
. Nicely summarized below by
@ianakim.bsky.social
.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap
@erc.europa.eu
at
@crg.eu
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Oliver Harschnitz
6 months ago
Monday is the big day! Very much looking forward to welcoming all participants and speakers of the Neurogenomics Conference to
@humantechnopole.bsky.social
in Milan. It promises to be an exciting few days filled with amazing science.
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Ivano Legnini
the Node
6 months ago
We need your help! What kind of posts would you like to see on the Node? What do you think about the design of the website, our social media presence and the emails we send out? Tell us what you think in this survey - it'll only take 5min:
www.surveymonkey.com/r/7QHYQCW
#DevBio
#StemCells
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Ivano Legnini
Mike Fainzilber
6 months ago
Online now at
@cp-cell.bsky.social
, the culmination of a 12-year effort. π§΅ to follow later this evening
www.cell.com/cell/fulltex...
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Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
https://www.cell.com/cell/fulltext/S0092-8674(25)00498-2
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Ivano Legnini
Sternberg Lab
6 months ago
1/10 Today in
@science.org
in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells.
drive.google.com/file/d/1I-Ub...
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EMBL Events
7 months ago
π’ Make sure to apply for #EMBOFISHingRNAs by 25 May! Learn how to apply three RNA visualisation techniques: π¬ Conventional in situ hybridisation (ISH) π¬ Hybridisation chain reaction ISH (HCR-ISH) π¬ Single molecule fluorescent ISH (smFISH) ππ»
https://s.embl.org/fis25-01-bl
#EMBOFISHingRNAs
π 31 Aug β 5 Sep
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Human Technopole
7 months ago
π¨ Fully funded
#PhD
opportunities at Human Technopole in Milan! π¬ Apply by 9 June to join top research groups in Comp Bio, Struct Bio, Genomics, Neurogenomics, Mol Cell Bio π Open to grads worldwide via SEMM π
humantechnopole.it/en/news/10-f...
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Ivano Legnini
Tancredi M Pentimalli
7 months ago
Our 3D study of the tumor microenvironment is finally out! Play around with the data yourself at
lung-3d-browser.mdc-berlin.de
(Kudos to
@danilexn.bsky.social
π ) Many thanks to Nikolaus Rajewsky lab at
@mdc-bimsb.bsky.social
and everyone involved, it takes a village to raise a multimodal paper!
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Oliver Harschnitz
7 months ago
Incredibly exciting times for regenerative medicine. Very happy to see the truly groundbreaking work led by the Tabar and Studer labs published. Huge congrats to all those involved!
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Tim Onion
7 months ago
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Ivano Legnini
Science Magazine
7 months ago
Scientific conferences attract thousands of foreign researchers to the United States every year. But some are reassessing their travel plans because of objections to U.S. policy and fears of being interrogated or detained by customs officials.
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International scientists rethink U.S. conference attendance
Opposition to Trump administration and fears of customs run-ins are shifting travel plans
https://scim.ag/4iUsSWR
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Ivano Legnini
Alexandra Witze
8 months ago
Heard about that French scientist who got turned away at the border?
@heidiledford.bsky.social
& I report on researchers' increasing anxiety about traveling in or out of the US: π§ͺ
www.nature.com/articles/d41...
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βAnxiety is palpableβ: detention of researchers at US border spurs travel worries
Several high-profile incidents in the past month have scientists on edge.
https://www.nature.com/articles/d41586-025-00859-w
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8 months ago
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Carmelo Ferrai
8 months ago
I am Absolutely delighted to share the preprint of our last collaborative efforts where we investigated the impact of sonostimulation of Mesenchymal Stem Cells. Thread -1-
www.biorxiv.org/content/10.1...
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Sonoepigenetics: Spatiotemporal Calcium Dynamics and cAMP Signaling Driven by High Frequency Nanomechanostimulation Regulates Transient Epigenetic Modifications and Early Osteogenic Commitment in Mese...
Cells effectively balance and integrate numerous pathways to adapt to external signals in an attempt to regain homeostasis, although the complex nuclear mechanotransduction mechanism through which thi...
https://www.biorxiv.org/content/10.1101/2025.03.17.643773v1
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Molecular Biosystems Conference
8 months ago
π― Calling all students & postdocs! Applications for
#mbiosys25
fellowships are now open! 𧬠We have multiple fellowships to support ECRs attend the meeting and join us in Chile for cutting-edge discussions in gene regulation & functional genomics. π Apply by April 30! π
molbiosystems.com
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Molecular Biosystems Conference
Molecular Biosystems Conference
https://molbiosystems.com
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Ivano Legnini
EMBO Press
8 months ago
Register today for the 29 April
@embl.org
symposium 'Sustainable research: fit for the future'. Hear how
@embo.org
promotes sustainable research initiatives throughout its programs. Attend in-person or join the discussion virtually with key sustainability stakeholders!
www.embl.org/about/info/s...
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Sustainable research: fit for the future
https://www.embl.org/about/info/sustainability/events/sustainable-research-fit-for-the-future/
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Ivano Legnini
Stefan Marciniak
9 months ago
For those affected by the
#Pubmed
problems right now, Europe PMC is fine (slow, but fine)
europepmc.org
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Europe PMCHome - Europe PMC
Europe PMC is an archive of life sciences journal literature.
https://europepmc.org
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Ivano Legnini
Luca Sofri
9 months ago
Le calze e le scarpe di quello che ha chiesto a Zelensky perchΓ© non si era messo un abito.
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Matthew Taliaferro
9 months ago
Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!
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Tancredi M Pentimalli
9 months ago
#Spatialtranscriptomics
is revolutionizing gene expression profiling at subcellular resolution! π¬These 'molecular microscopes' can unlock disease mechanisms & guide therapies...but how to bring ST to the clinic? Our thoughts w @N_Rajewsky &
@nukappa.bsky.social
out
@annualreviews.bsky.social
π§΅π
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Ivano Legnini
Human Technopole
9 months ago
π The first 2025 Call for Access for our National Facilities is now open! Researchers can apply for cutting-edge services in the fields of omics, imaging and data analysis. Submit your proposal by 31 May! Apply here π
humantechnopole.it/en/national-...
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National Facilities - Human Technopole
https://humantechnopole.it/en/national-facilities/
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Ivano Legnini
Jamie Hackett
9 months ago
Want to start an independent research group? ...with core funding, outstanding facilities & a curiosity-driven culture? Join us at
@embl.org
We are recruiting across research themes, inc (epi)genomics, human dev bio, predictive modelling & neurobiologyπ
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
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Group Leader - Molecular Mechanisms of Environmental Adaptation
We are seeking to recruit a highly motivated scientist to establish and lead an independent research laboratory at the EMBL Epigenetics and Neurobiology Unit in Rome. EMBL provides a unique environmen...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/details/Group-Leader---Molecular-Mechanisms-of-Environmental-Adaptation_JR333?locations=e80afa7e65f5100729fabc0fe6750000&workerSubType=e80afa7e65f510072917c4bbf01e0000
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Florian Jug
9 months ago
π¬π€ As pre-announced a few days ago... please let us proudly present to you: π΄πππππππππ - your ticket to imaging more, imaging more gentle, and/or imaging more efficient. π¬
doi.org/10.1101/2025...
Like β€οΈ, repost π, and most importantly... please send feedback βοΈ our way! π
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Florian Jug
9 months ago
The preprint is now available! Check it out... and... if you want to repost, why not πthe post down hereπ, so others get the bioRxiv link right away? Oh, and... ππ‘ππ§π€π¬! π
doi.org/10.1101/2025...
bsky.app/profile/flor...
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Oliver Harschnitz
9 months ago
Excellent postdoctoral opportunity in the Giustacchini group
@humantechnopole.bsky.social
. Exciting science studying haematologic malignancies combined with amazing mentorship. Highly recommended! Please share π
careers.humantechnopole.it/o/postdoc-in...
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Human Technopole - Postdoc in Mechanisms of Leukemogenesis β Giustacchini Group
APPLICATION CLOSING DATE: February 20th, 2025Human Technopole (HT)Β is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing
https://careers.humantechnopole.it/o/postdoc-in-mechanisms-of-leukemogenesis-giustacchini-group
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Ivano Legnini
MDC-BIMSB
9 months ago
π’ Job Alert! The NOVA Institute for Medical Systems Biology (NIMSB) is hiring 3 Technology Platform Leaders in: 𧬠Genomics (single-cell & spatial) π§ͺ Metabolomics/Proteomics π Data Science Join a cutting-edge research environment! Apply by 16 March 2025 π
nimsb.unl.pt/join-us/
(1/3)
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Join us - NIMSB
https://nimsb.unl.pt/join-us/
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Incredibly cool project with an excellent mentor and an outstanding group. Highly recommended!
add a skeleton here at some point
10 months ago
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