SHH exosomes surfing along the OUTSIDE of mesenchymal cell cytonemes - check it out! www.biorxiv.org/content/10.6...

Lovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...

Good to see the peer reviewed version of this published A chemo-optogenetic system for spatiotemporal control of gene expression We use it to: - Reconstruct SHH mediated neural tube patterning in vitro - Measure extracellular half-life of Shh www.cell.com/developmenta...

Still a couple of weeks to apply for a fully funded PhD position in #AI and #RNA biology!!!

🔬 Join Human Technopole! 🧠 Our @ilegnini.bsky.social Group seeks a #Postdoc in Molecular Systems Biology to study genetic–environmental interactions in early neurodevelopment. Apply by 30 Nov 2025 👉 careers.humantechnopole.it/job/Postdoc-...

And in addition to the postdoc position (1 week left to apply!), just opened a PhD position in AI and RNA biology 🤩

PhD position in my lab in #AI #RNA, in co-supervision with superstar @florianjug.bsky.social www.polimi.it/dottorato/fu...

One more week to apply 🐣

1/6 We are hiring!!! 🐣🐣🐣 Fully funded postdoc position in my group! humantechnopole.it/en/research-...

Looking for a master student to help with a superexciting EU-funded project on mRNA metabolism. It'll involve cutting-edge sequencing and imaging techniques as well as computational workflows and modelling - great training opportunity! Get in touch if interested humantechnopole.it/en/research-...

Immune responses need to be fast ⏱️ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more: febs.onlinelibrary.wiley.com/doi/10.1002/... #Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social

Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology 📍 Lisbon ⏳ Apply by Oct 8 🔗 nimsb.unl.pt/wp-content/u... #Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology

🎉 A stellar wrap-up for the Milan #RNA Salon! On 18 July, 120+ scientists gathered at HT for the final event of the season. 🔬 Matthias Hentze @embl.org opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and @mchiaragrieco.bsky.social @ceredalab.bsky.social

This job involve spending 1-2 years in Berlin and 1-2 years in Barcelona, a truly unique opportunity! 🌍 As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.

🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇

We’re happy to share our new preprint form @N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat lab! 🎉 🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation. 🔗 biorxiv.org/content/10.1...

🚨 New preprint alert 🚨 We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍. bit.ly/4lXqNul Follow along for a little recap (1/12)

‼️ Don't forget to submit your abstract for #EMBLSpatialBiology! The new deadline is 15 July 👉 https://s.embl.org/spb25-01-bl 📅 14–17 Oct 📍EMBL Heidelberg and Virtual ✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️ https://s.embl.org/SPB25-01-practical-information

Scientists 3-D printed objects inside of living cells for the first time. Naturally, they chose to print an elephant.

📢 Announcing the MOPITAS Autumn School on Spatial Transcriptomics Data Analysis – taking place November 12–14, in Munich. Don't miss this excellent opportunity to deepen your expertise in data science and multi-OMICS analysis - especially as a PhD student in the data science community.

🧡

🚨We are looking for post-doctoral candidates to apply for a MSCA fellowship. Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics. Computational & wet-lab candidates are welcomed! #postdoc #MSCA #Barcelona #singlecell.

#RNA Framework 2.9.3 is out! Lots of improvements! Check it out: github.com/dincarnato/R... & see the CHANGELOG (raw.githubusercontent.com/dincarnato/R...) for the details!

In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells. Learn more: scim.ag/4jVfcuk #SciencePerspective: scim.ag/3STvdWC

🧬 Ageing, immunity & chronic diseases: HT wins €2.5M @erc.europa.eu Advanced Grant for a 5-year project led by @nicolesoranzo.bsky.social. Using AI & big data, the group will decode how our immune system weakens over time. A huge step for precision medicine! humantechnopole.it/en/news/agei...

But this is happening to people around us: foreign professors, teachers, students, postdocs, neighbors. And sometimes much worse. Please don’t assume this can’t happen where you live. And if you witness it, say something. Silence is complicity.

Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution. Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4

🚨 We’re looking for a curious mind to join our lab at the NIH! Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging? Interested in a postdoc or a PhD research visit at NIH? Let’s connect. 📩 DM or email for details! #Bioinformatics #AI #ComputationalBiology

Organoids are becoming a valid alternative, but they can’t fully replace animal research – yet. At the #mdcBerlin, we’re working on better models and transparent communication. That's what @eara.eu's #BOARD25 is all about! More on our organoid research: 🔗 www.mdc-berlin.de/themen/organ...

KODAMA goes spatial. doi.org/10.1101/2025... #spatialtranscriptomics #visium #visiumhd #seurat #giotto

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using @flybase.bsky.social please donate using the link in post below. This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social. www.nature.com/articles/s41... This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu

Monday is the big day! Very much looking forward to welcoming all participants and speakers of the Neurogenomics Conference to @humantechnopole.bsky.social in Milan. It promises to be an exciting few days filled with amazing science.

We need your help! What kind of posts would you like to see on the Node? What do you think about the design of the website, our social media presence and the emails we send out? Tell us what you think in this survey - it'll only take 5min: www.surveymonkey.com/r/7QHYQCW #DevBio #StemCells

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening www.cell.com/cell/fulltex...

1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

📢 Make sure to apply for #EMBOFISHingRNAs by 25 May! Learn how to apply three RNA visualisation techniques: 🔬 Conventional in situ hybridisation (ISH) 🔬 Hybridisation chain reaction ISH (HCR-ISH) 🔬 Single molecule fluorescent ISH (smFISH) 👉🏻 https://s.embl.org/fis25-01-bl#EMBOFISHingRNAs📅 31 Aug – 5 Sep

🚨 Fully funded #PhD opportunities at Human Technopole in Milan! 🔬 Apply by 9 June to join top research groups in Comp Bio, Struct Bio, Genomics, Neurogenomics, Mol Cell Bio 🌍 Open to grads worldwide via SEMM 👉 humantechnopole.it/en/news/10-f...

Our 3D study of the tumor microenvironment is finally out! Play around with the data yourself at lung-3d-browser.mdc-berlin.de (Kudos to @danilexn.bsky.social👏 ) Many thanks to Nikolaus Rajewsky lab at @mdc-bimsb.bsky.social and everyone involved, it takes a village to raise a multimodal paper!

Incredibly exciting times for regenerative medicine. Very happy to see the truly groundbreaking work led by the Tabar and Studer labs published. Huge congrats to all those involved!

Scientific conferences attract thousands of foreign researchers to the United States every year. But some are reassessing their travel plans because of objections to U.S. policy and fears of being interrogated or detained by customs officials.

Heard about that French scientist who got turned away at the border? @heidiledford.bsky.social & I report on researchers' increasing anxiety about traveling in or out of the US: 🧪 www.nature.com/articles/d41...

🤟🤟🤟

I am Absolutely delighted to share the preprint of our last collaborative efforts where we investigated the impact of sonostimulation of Mesenchymal Stem Cells. Thread -1- www.biorxiv.org/content/10.1...

🎯 Calling all students & postdocs! Applications for #mbiosys25 fellowships are now open! 🧬 We have multiple fellowships to support ECRs attend the meeting and join us in Chile for cutting-edge discussions in gene regulation & functional genomics. 📆 Apply by April 30! 🔗 molbiosystems.com

Register today for the 29 April @embl.org symposium 'Sustainable research: fit for the future'. Hear how @embo.org promotes sustainable research initiatives throughout its programs. Attend in-person or join the discussion virtually with key sustainability stakeholders! www.embl.org/about/info/s...

For those affected by the #Pubmed problems right now, Europe PMC is fine (slow, but fine) europepmc.org

Le calze e le scarpe di quello che ha chiesto a Zelensky perché non si era messo un abito.

Save the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!