Ivano Legnini
@ilegnini.bsky.social
📤 320
📥 542
📝 28
Group Leader
@humantechnopole.bsky.social
Molecular and Systems Biology. RNA enthusiast
Happy 🥲 We're now looking for a postdoc and a technician to work on this super exciting 5 years project on mRNA mtabolism and poly(A) tail length control. Links to apply here: Postdoc:
careers.humantechnopole.it/job/Postdoc-...
Technician:
careers.humantechnopole.it/job/Technici...
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6 days ago
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Erin Schuman
19 days ago
Had a great day at Human Technopole - lots of stimulating discussions with students and faculty and also, this should be a new standard, Aperol spritz after the seminar!
@humantechnopole.bsky.social
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Still a few days to apply :)
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22 days ago
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Nature
24 days ago
Nature research paper: Single-cell and isoform-specific translational profiling of the mouse brain
go.nature.com/4aYPQu7
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Single-cell and isoform-specific translational profiling of the mouse brain - Nature
Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hippocampal neuronal and non-neuronal cell types, highlighting functional differences between CA1 and CA3.
https://go.nature.com/4aYPQu7
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Camilla Ciolli Mattioli
about 1 month ago
Thrilled to announce that I’ve just opened my research lab at
@helmholtz-hiri.bsky.social
! A huge thank you to my mentor Roi Avraham (and lab members!) for the incredible training and support that made this possible.
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1/6 We're hiring! Fully funded postdoc position in my group
humantechnopole.it/en/research-...
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Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
https://humantechnopole.it/en/research-groups/legnini-group/
about 1 month ago
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Stacey Ogden 🦔
3 months ago
SHH exosomes surfing along the OUTSIDE of mesenchymal cell cytonemes - check it out!
www.biorxiv.org/content/10.6...
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Exosome secretion is required for sonic hedgehog dispersal and signal gradient formation in the embryonic limb mesenchyme
Carrier-assisted diffusion and cytoneme transport have been postulated to disperse Hedgehog across diverse embryonic tissues, yet their relative contributions to patterning mesenchymal tissues remains...
https://www.biorxiv.org/content/10.64898/2025.12.05.692671v1
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Naomi Moris
3 months ago
Lovely little pre-Christmas present to see this out
@natcellbio.nature.com
! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍
www.nature.com/articles/s41...
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Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology
Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
https://www.nature.com/articles/s41556-025-01813-8
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James Briscoe
3 months ago
Good to see the peer reviewed version of this published A chemo-optogenetic system for spatiotemporal control of gene expression We use it to: - Reconstruct SHH mediated neural tube patterning in vitro - Measure extracellular half-life of Shh
www.cell.com/developmenta...
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Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control of morphogen production in vitro. Using light-controlled Sonic hedgehog expression, they recapitulate neural tube...
https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00495-2
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Still a couple of weeks to apply for a fully funded PhD position in
#AI
and
#RNA
biology!!!
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3 months ago
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Ivano Legnini
Human Technopole
4 months ago
🔬 Join Human Technopole! 🧠 Our
@ilegnini.bsky.social
Group seeks a
#Postdoc
in Molecular Systems Biology to study genetic–environmental interactions in early neurodevelopment. Apply by 30 Nov 2025 👉
careers.humantechnopole.it/job/Postdoc-...
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Postdoc in Molecular Systems Biology
Postdoc in Molecular Systems Biology
https://careers.humantechnopole.it/job/Postdoc-in-Molecular-Systems-Biology/640-en_GB
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And in addition to the postdoc position (1 week left to apply!), just opened a PhD position in AI and RNA biology 🤩
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4 months ago
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PhD position in my lab in
#AI
#RNA
, in co-supervision with superstar
@florianjug.bsky.social
www.polimi.it/dottorato/fu...
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4 months ago
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One more week to apply 🐣
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4 months ago
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1/6 We are hiring!!! 🐣🐣🐣 Fully funded postdoc position in my group!
humantechnopole.it/en/research-...
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Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
https://humantechnopole.it/en/research-groups/legnini-group/
4 months ago
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Looking for a master student to help with a superexciting EU-funded project on mRNA metabolism. It'll involve cutting-edge sequencing and imaging techniques as well as computational workflows and modelling - great training opportunity! Get in touch if interested
humantechnopole.it/en/research-...
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Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
https://humantechnopole.it/en/research-groups/legnini-group/
6 months ago
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Ivano Legnini
FEBS Letters
7 months ago
Immune responses need to be fast ⏱️ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more:
febs.onlinelibrary.wiley.com/doi/10.1002/...
#Immunology
#RNA
#mRNAmetabolism
@ilegnini.bsky.social
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MDC-BIMSB
7 months ago
Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology 📍 Lisbon ⏳ Apply by Oct 8 🔗
nimsb.unl.pt/wp-content/u...
#Job
#SciencePositions
#JobOffer
#GroupLeaders
#Innovation
#systemsbiology
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Human Technopole
8 months ago
🎉 A stellar wrap-up for the Milan
#RNA
Salon! On 18 July, 120+ scientists gathered at HT for the final event of the season. 🔬 Matthias Hentze
@embl.org
opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and
@mchiaragrieco.bsky.social
@ceredalab.bsky.social
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Manuel Irimia
8 months ago
This job involve spending 1-2 years in Berlin and 1-2 years in Barcelona, a truly unique opportunity! 🌍 As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.
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Manuel Irimia
8 months ago
🚨🚨🚨 Please RT! We're looking for a postdoc to join an exciting joint project between our lab
@upf.edu
&
@crg.eu
(Barcelona) and the Sander lab
@mdc-berlin.bsky.social
(Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets. Deadline: 30/09/25👇
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https://www.upf.edu/documents/2869130/0/Informal_ad-LaCaixa-Irimia.pdf
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Kamil Lisek
8 months ago
We’re happy to share our new preprint form @N_Rajewsky, with
@tmpentimalli.bsky.social
i.bsky.social
@Ilan Theurillat lab! 🎉 🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation. 🔗
biorxiv.org/content/10.1...
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Spatiotemporal dynamics of tumor microenvironment remodeling
During tumorigenesis, interactions between tumor and stromal cells progressively remodel the tumor microenvironment (TME) towards pro-tumoral functions. Understanding early TME remodeling dynamics is ...
https://biorxiv.org/content/10.1101/2025.07.15.662972v1
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Gregor Diensthuber
8 months ago
🚨 New preprint alert 🚨 We systematically benchmarked
@nanoporetech.com
's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)
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Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing
Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...
https://bit.ly/4lXqNul
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EMBL Events
8 months ago
‼️ Don't forget to submit your abstract for #EMBLSpatialBiology! The new deadline is 15 July 👉
https://s.embl.org/spb25-01-bl
📅 14–17 Oct 📍EMBL Heidelberg and Virtual ✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️
https://s.embl.org/SPB25-01-practical-information
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Ivano Legnini
Science News
8 months ago
Scientists 3-D printed objects inside of living cells for the first time. Naturally, they chose to print an elephant.
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Scientists 3-D printed a tiny elephant inside a cell
The first structures ever 3-D printed inside living cells point to applications for biology research.
https://buff.ly/Lw0NrzU
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Ivano Legnini
Stegle Lab
9 months ago
📢 Announcing the MOPITAS Autumn School on Spatial Transcriptomics Data Analysis – taking place November 12–14, in Munich. Don't miss this excellent opportunity to deepen your expertise in data science and multi-OMICS analysis - especially as a PhD student in the data science community.
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9 months ago
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Mireya Plass
9 months ago
🚨We are looking for post-doctoral candidates to apply for a MSCA fellowship. Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics. Computational & wet-lab candidates are welcomed!
#postdoc
#MSCA
#Barcelona
#singlecell
.
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Postdoctoral Fellowships
The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.
https://marie-sklodowska-curie-actions.ec.europa.eu/actions/postdoctoral-fellowships
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Danny IncaRNAto
9 months ago
#RNA
Framework 2.9.3 is out! Lots of improvements! Check it out:
github.com/dincarnato/R...
& see the CHANGELOG (
raw.githubusercontent.com/dincarnato/R...
) for the details!
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Ivano Legnini
Science Magazine
9 months ago
In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells. Learn more:
scim.ag/4jVfcuk
#SciencePerspective
:
scim.ag/3STvdWC
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Human Technopole
9 months ago
🧬 Ageing, immunity & chronic diseases: HT wins €2.5M
@erc.europa.eu
Advanced Grant for a 5-year project led by
@nicolesoranzo.bsky.social
. Using AI & big data, the group will decode how our immune system weakens over time. A huge step for precision medicine!
humantechnopole.it/en/news/agei...
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Ageing and Chronic Diseases: Europe Rewards Human Technopole’s Research - Human Technopole
The ERC has awarded HT a €2.5 million grant for a study investigating how lifestyle, biology and environmental exposures weaken the immune system over the course of life and increase vulnerability to ...
https://humantechnopole.it/en/news/ageing-and-chronic-diseases-europe-rewards-human-technopoles-research/
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Sebastian Kadener
9 months ago
But this is happening to people around us: foreign professors, teachers, students, postdocs, neighbors. And sometimes much worse. Please don’t assume this can’t happen where you live. And if you witness it, say something. Silence is complicity.
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Ivano Legnini
Coscia Lab
10 months ago
Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution. Kudos to
@melissaklingeberg.bsky.social
🥳 and big thanks to all our collaborators!
bit.ly/3SCARw4
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An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day
Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...
https://bit.ly/3SCARw4
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Manolis Maragkakis
10 months ago
🚨 We’re looking for a curious mind to join our lab at the NIH! Passionate about
#RNA
biology,
#MachineLearning
, and the
#genomics
of
#aging
? Interested in a postdoc or a PhD research visit at NIH? Let’s connect. 📩 DM or email for details!
#Bioinformatics
#AI
#ComputationalBiology
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Ivano Legnini
Max Delbrück Center
10 months ago
Organoids are becoming a valid alternative, but they can’t fully replace animal research – yet. At the #mdcBerlin, we’re working on better models and transparent communication. That's what @eara.eu's #BOARD25 is all about! More on our organoid research: 🔗
www.mdc-berlin.de/themen/organ...
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Ivano Legnini
Stefano Cacciatore
10 months ago
KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics
#visium
#visiumhd
#seurat
#giotto
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Ivano Legnini
Mark A. Hanson
10 months ago
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯 Any lab using
@flybase.bsky.social
please donate using the link in post below. This incredible community, on whose backs our
#Drosophila
labs depend, can't be left out to dry.
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Arnau Sebé-Pedrós
10 months ago
Check out our latest work on the evolution of animal genome regulation out today in
@nature.com
. Nicely summarized below by
@ianakim.bsky.social
.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap
@erc.europa.eu
at
@crg.eu
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Oliver Harschnitz
10 months ago
Monday is the big day! Very much looking forward to welcoming all participants and speakers of the Neurogenomics Conference to
@humantechnopole.bsky.social
in Milan. It promises to be an exciting few days filled with amazing science.
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the Node
10 months ago
We need your help! What kind of posts would you like to see on the Node? What do you think about the design of the website, our social media presence and the emails we send out? Tell us what you think in this survey - it'll only take 5min:
www.surveymonkey.com/r/7QHYQCW
#DevBio
#StemCells
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Mike Fainzilber
10 months ago
Online now at
@cp-cell.bsky.social
, the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
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Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
https://www.cell.com/cell/fulltext/S0092-8674(25)00498-2
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Ivano Legnini
Sternberg Lab
10 months ago
1/10 Today in
@science.org
in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells.
drive.google.com/file/d/1I-Ub...
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EMBL Events
11 months ago
📢 Make sure to apply for #EMBOFISHingRNAs by 25 May! Learn how to apply three RNA visualisation techniques: 🔬 Conventional in situ hybridisation (ISH) 🔬 Hybridisation chain reaction ISH (HCR-ISH) 🔬 Single molecule fluorescent ISH (smFISH) 👉🏻
https://s.embl.org/fis25-01-bl
#EMBOFISHingRNAs
📅 31 Aug – 5 Sep
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Human Technopole
11 months ago
🚨 Fully funded
#PhD
opportunities at Human Technopole in Milan! 🔬 Apply by 9 June to join top research groups in Comp Bio, Struct Bio, Genomics, Neurogenomics, Mol Cell Bio 🌍 Open to grads worldwide via SEMM 👉
humantechnopole.it/en/news/10-f...
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Ivano Legnini
Tancredi M Pentimalli
11 months ago
Our 3D study of the tumor microenvironment is finally out! Play around with the data yourself at
lung-3d-browser.mdc-berlin.de
(Kudos to
@danilexn.bsky.social
👏 ) Many thanks to Nikolaus Rajewsky lab at
@mdc-bimsb.bsky.social
and everyone involved, it takes a village to raise a multimodal paper!
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Oliver Harschnitz
11 months ago
Incredibly exciting times for regenerative medicine. Very happy to see the truly groundbreaking work led by the Tabar and Studer labs published. Huge congrats to all those involved!
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Tim Onion
11 months ago
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Ivano Legnini
Science Magazine
12 months ago
Scientific conferences attract thousands of foreign researchers to the United States every year. But some are reassessing their travel plans because of objections to U.S. policy and fears of being interrogated or detained by customs officials.
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International scientists rethink U.S. conference attendance
Opposition to Trump administration and fears of customs run-ins are shifting travel plans
https://scim.ag/4iUsSWR
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Alexandra Witze
12 months ago
Heard about that French scientist who got turned away at the border?
@heidiledford.bsky.social
& I report on researchers' increasing anxiety about traveling in or out of the US: 🧪
www.nature.com/articles/d41...
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‘Anxiety is palpable’: detention of researchers at US border spurs travel worries
Several high-profile incidents in the past month have scientists on edge.
https://www.nature.com/articles/d41586-025-00859-w
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12 months ago
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