Huge congratulations to @nicolapalazzi.bsky.social for successfully passing his PhD viva. It has been an amazing journey and a privilege to work with you over the past years! Can't wait to share the exciting discoveries you made. Thanks also to the examiners Mirko Cortese and Ilija Brizic. #ProudPI

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues journals.biologists.com/dev/issue/15...

New work by @gleesonlab.bsky.social & colleagues in @cp-cellstemcell.bsky.social “A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬 www.cell.com/cell-stem-ce...

Already 53 phenomenal papers published in the @jhumimmunity.org ! Look it up and submit your best papers to the only journal focused on human inborn errors of immunity, their phenocopies, and related topics in human immunology: rupress.org/jhi

Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.

How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...

An amazing day as Eleonora Conti successfully defended her PhD, a first for the lab. It is difficult to put into words how proud I am of Eleonora and the stellar work she has done. Truly a star in the making! Big thanks to the examiners @antoinezalc.bsky.social and @ilegnini.bsky.social. #ProudPI

Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...

'This multicellular system with induced pluripotent stem cell-derived neurons, microglia, oligodendroglia, astrocytes, pericytes, and brain microvascular endothelial cells has potential for opening possibilities for disease modeling, drug discovery and development' #Immunology #Neuroimmunology

Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate

Could not be prouder of @analaura-duarte.bsky.social who passed her first year Thesis Committee Meeting today discussing her project on the neuropathology induced by inborn errors of immunity. Very exciting times ahead! Big thanks to Aleksandra Badura and Alice Giustacchini for their input. #ProudPI

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Many thanks to @nicolasrivron.bsky.social for today’s External Seminar Series at @humantechnopole.bsky.social. It was amazing to learn all about early human pregnancy using stem cell-based models, species-specific differences and the role of evolution on early development.

A wonderful autumn hike.

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains 1/ doi.org/10.1101/2025...

Very sad news, John Gurdon has died. A developmental biologist's developmental biologist, Nobel prize winner His work is the foundation of much of today's dev & stem cell bio. An inspiration to many, including me. Always asking questions & wanting the answers www.magd.cam.ac.uk/news/profess...

The ethical framework for embryo models needs clarity and simplicity. The spirit of the integrated/non-integrated distinction was to more prominently regulate models that could potentially develop into a fetus. Hafez Ismaili M’hamdi discusses this. www.progress.org.uk/complexity-w...

🏆 Congratulations to the winners of our Best Presentation Award, Eleonora Conti (@harschnitz.bsky.social Group) and Best Poster Award: Alexandra Livanova (Sottoriva Group); Emily Georgiades (Bienko Group); @veronicalarocca.bsky.social (Harschnitz Group)

My group @humantechnopole.bsky.social is searching for a #postdoc to work at the interface between #neurodevelopment and #cancerbiology focusing on neurofibromatosis type 1: careers.humantechnopole.it/job/Postdoc-...

Could not be more proud of Eleonora Conti who won the Best Talk Award and of Veronica La Rocca who won Best Poster Award at today's @humantechnopole.bsky.social PhD & Postdoc Symposium! A real tribute to all their hard work and a sign of exciting things to come. Incredibly well-deserved. #ProudPI

Big day at @humantechnopole.bsky.social with today's PhD & Postdoc Symposium providing a stellar line up of speakers and poster presenters. This year's theme is 'Research in Motion: Dynamics in Time, Space, and Technology'. So much exciting science to enjoy!

Very excited that Francesca Peri will be our next speaker for the @humantechnopole.bsky.social External Seminar Series this Thursday, October 2nd. Big thanks to @nereokalebic.bsky.social for hosting! For external people wanting to join, please see: forms.office.com/e/qk5AhGnaVZ.

1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

Excited to share our preprint, now available online on BioRxiv! biorxiv.org/content/10.1.... We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.

Two fantastic days of science, ideas, and connection at the @humantechnopole.bsky.social faculty retreat. Grateful to everyone for sharing their exciting work and sparking such inspiring discussions. Truly a pleasure to spend time with this amazing community.

Great to see this from @vmetzis.bsky.social & co published Dissection of CDX2 regulatory elements identifies a repressive element that converts to an enhancer with a nuclear receptor motif switch www.cell.com/developmenta...

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Check out our new paper linking morphoregulatory adducins with neural progenitor proliferation and neurogenesis:

Exciting new study by Polina Oberst and @studerl.bsky.social in @cp-devcell.bsky.social identifies cholesterol imbalance as a convergent mechanism across multiple genetic and environmental factors of major depressive disorder. www.cell.com/developmenta...

EpiSci - Hi there! Our review “Mechanotransduction in stem cells” is finally published. With @carstenschulte4.bsky.social we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/

Preprint alert! We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength. doi.org/10.1101/2025...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

I am absolutely thrilled to be hosting @nicolasrivron.bsky.social as a speaker for the External Seminar Series on October 13th. Come and learn all about early human pregnancy using stem cell-based models. For external people who would like to join, please see: forms.office.com/e/Zra4b4H4xx

Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers. www.nature.com/articles/s41...

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social labs www.nature.com/articles/s41...

EBV induces CNS homing of B cells attracting inflammatory T cells. www.nature.com/articles/s41...

“A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro” Nice work by @danielmedinacano.bsky.social @tvierbuchen.bsky.social @em6wong.bsky.social @stadtfeldlab.bsky.social 🧪🧫🧠 www.cell.com/developmenta...

Immune responses need to be fast ⏱️ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more: febs.onlinelibrary.wiley.com/doi/10.1002/... #Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...

Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com! Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab. www.nature.com/articles/s41...

Excited to share our recent viewpoint with @storerlab.bsky.social led by Kirsten Sadler, on epigenetic mechanisms of regenerative resilience. Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

Beautiful work by Yu et al from the Xianhua Piao lab in @nature.com demonstrating that microglia-derived IGF1 regulates GABAergic neurogenesis. Very elegant combination of primary human data and hPSC-derived neuroimmune hMGE organoids. Congrats to all the authors. www.nature.com/articles/s41...

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

Beautiful work by Yu et al from the Xianhua Piao lab in @nature.com demonstrating that microglia-derived IGF1 regulates GABAergic neurogenesis. Very elegant combination of primary human data and hPSC-derived neuroimmune hMGE organoids. Congrats to all the authors. www.nature.com/articles/s41...

Exciting new work in @cp-cellstemcell.bsky.social from the Shuibing Chen lab, developing ChemPerturb-seq, which is integrated with in vivo barcoded screening to identify a cocktail of small molecules that enhance human beta cell and islet survival after transplantation. www.cell.com/cell-stem-ce...

Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary