Great to see this from @vmetzis.bsky.social & co published Dissection of CDX2 regulatory elements identifies a repressive element that converts to an enhancer with a nuclear receptor motif switch www.cell.com/developmenta...

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Check out our new paper linking morphoregulatory adducins with neural progenitor proliferation and neurogenesis:

Exciting new study by Polina Oberst and @studerl.bsky.social in @cp-devcell.bsky.social identifies cholesterol imbalance as a convergent mechanism across multiple genetic and environmental factors of major depressive disorder. www.cell.com/developmenta...

EpiSci - Hi there! Our review “Mechanotransduction in stem cells” is finally published. With @carstenschulte4.bsky.social we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/

Preprint alert! We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength. doi.org/10.1101/2025...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

I am absolutely thrilled to be hosting @nicolasrivron.bsky.social as a speaker for the External Seminar Series on October 13th. Come and learn all about early human pregnancy using stem cell-based models. For external people who would like to join, please see: forms.office.com/e/Zra4b4H4xx

Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers. www.nature.com/articles/s41...

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social labs www.nature.com/articles/s41...

EBV induces CNS homing of B cells attracting inflammatory T cells. www.nature.com/articles/s41...

“A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro” Nice work by @danielmedinacano.bsky.social @tvierbuchen.bsky.social @em6wong.bsky.social @stadtfeldlab.bsky.social 🧪🧫🧠 www.cell.com/developmenta...

Immune responses need to be fast ⏱️ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more: febs.onlinelibrary.wiley.com/doi/10.1002/... #Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh 🧵 www.sciencedirect.com/science/arti...

Is anyone in continental Europe looking for a lab manager? I have a fabulous candidate - let me know and please RT!

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com! Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab. www.nature.com/articles/s41...

Excited to share our recent viewpoint with @storerlab.bsky.social led by Kirsten Sadler, on epigenetic mechanisms of regenerative resilience. Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

Beautiful work by Yu et al from the Xianhua Piao lab in @nature.com demonstrating that microglia-derived IGF1 regulates GABAergic neurogenesis. Very elegant combination of primary human data and hPSC-derived neuroimmune hMGE organoids. Congrats to all the authors. www.nature.com/articles/s41...

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

Beautiful work by Yu et al from the Xianhua Piao lab in @nature.com demonstrating that microglia-derived IGF1 regulates GABAergic neurogenesis. Very elegant combination of primary human data and hPSC-derived neuroimmune hMGE organoids. Congrats to all the authors. www.nature.com/articles/s41...

Exciting new work in @cp-cellstemcell.bsky.social from the Shuibing Chen lab, developing ChemPerturb-seq, which is integrated with in vivo barcoded screening to identify a cocktail of small molecules that enhance human beta cell and islet survival after transplantation. www.cell.com/cell-stem-ce...

Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary

Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab @marcotrizzino.bsky.social modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills @the-node.bsky.social #developmental @ccrb27.bsky.social thenode.biologists.com/jobs/postdoc...

Beautiful and inspiring work from Gero Miesenböck and colleagues www.nature.com/articles/s41...

Nanobody rescue of behavioral deficits of NMDA receptor hypofunction establish a proof of concept that nanobodies can target brain receptors @nature.com www.nature.com/articles/s41...

Ryan’s paper out in Neuron (bit.ly/3IICGFX). He derived bona fide parvalbumin (PV+) cortical interneurons from hPSCs, one the slowest developing neurons, and could capturing interneuron-related disease phenotypes linked to schizophrenia - including impaired gamma-oscillations - in his assembloids.

Great technique from my @crick.ac.uk colleagues in @petrznam.bsky.social lab Reconstructing neural circuits with barcoded Rabies virus & in situ sequencing www.biorxiv.org/content/10.1...

Our latest work is out today in @science.org: a self-organizing system that models organizer-driven patterning and commissural axon guidance in human neural development. Work led by Massimo Onesto with Neal Amin in the lab

Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born authors.elsevier.com/sd/article/S...

Very excited to share our new work on gastruloids by the incredible Cat Triandafillou! We mapped gene expression across 26 individual gastruloids at single-cell resolution and discovered some pretty amazing patterns about how these "mini-embryos" organize themselves. www.biorxiv.org/content/10.1...

Bassem Hassan @bassemh.bsky.social, Corey Harwell & yours truly are co-chairs for 2026 Neural Development #GRC August 2-7, 2026 in Newport, RI 🇺🇸 - if you are interested in updates on the conference & to hear about our 🤩 line-up of speakers...follow @neuraldevgrc.bsky.social! 🧠🪰🐭🐙🐸🦎🧒🏻🧫🧪🧠

Save the Date! Development has teamed up with the Wellcome-funded consortium the Human Developmental Biology Initiative to co-organise a meeting on #HumanDevelopment. 📅7 - 9 Sep 2026 📍University of Warwick, UK Register your interest for #HumanDev26: www.biologists.com/meetings/dev...

Sharing today the latest from our lab, just published in Nature Biomedical Engineering. As stem cell models gain traction for disease modeling and drug testing, one of the bottlenecks has been scaling up production. In work led by Yuki and Genta, we present a simple and cost-effective solution.

Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

Superb paper by Megan Cooper and colleagues ! Mosaic STAT5B gain-of-function associated with demyelinating disease and autoimmunity url: rupress.org/jhi/article/...

Exciting Research Professorship Position in Stem Cell and Developmental Biology at the University of Leuven. Amazing research ecosystem, great colleagues, high quality of life, tenure track. For those interested in joining us, please see below: www.kuleuven.be/personeel/jo...

hanging out with strangers in a campus pub should be considered part of the serious process of thinking

Morphodynamics of human early brain organoid development @nature.com @akanksha-jain.bsky.social @graycamplab.bsky.social nature.com/articles/s41...

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story: www.cell.com/cell-host-mi...

Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_... #Neuroscience #Postdoc #ResearchOpportunity

Whether or not you’re in Hong Kong for #ISSCR2025 this week, if you work with stem cells, have a read through at our brief collection of recent articles.

New work on dynamics of morphogen signaling: Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input Morphogen signalling dynamics + GRN for tissue patterning www.biorxiv.org/content/10.1...

Nice work from Du & Warmflash using micropatterned hESCs to dissect midbrain-hindbrain boundary formation Timing of WNT signalling, not strength or duration, specifies midbrain-hindbrain boundary Good example of recapitulating developmental signalling in vitro www.biorxiv.org/content/10.1...

Beautiful paper in @cp-neuron.bsky.social from the Lodato lab demonstrating how inborn errors of immunity can directly lead to neuropathology. Mutations causing Cxcr4 hyperactivation perturb cerebellar progenitor dynamics and lead to sensorimotor defects. www.sciencedirect.com/science/arti...

Over the past couple of weeks, several asked if I could share the individual slides summarizing our recently published framework in @nature.com on designing experiments with #organoids, #assembloids, and transplantation. Here they are—6 slides capturing the key takeaways👇

Still openings, check it out!

Thrilled that Sir Mel Greaves will be our next speaker for the @humantechnopole.bsky.social External Seminar Series on June 5th. Thanks to Andrea Sottoriva for hosting! For external people wanting to join, please see: forms.office.com/e/dtD3NcRKMN.

Thrilled that Sir Mel Greaves will be our next speaker for the @humantechnopole.bsky.social External Seminar Series on June 5th. Thanks to Andrea Sottoriva for hosting! For external people wanting to join, please see: forms.office.com/e/dtD3NcRKMN.