I'm super excited to announce that I will join the Human Technopole @humantechnopole.bsky.social in Milan in April 2026 as a Research Group Leader.

Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg

#microsky #synbiosky www.science.org/doi/10.1126/...

30 years ago today, December 31st 1995, the last ever Calvin & Hobbes comic strip was published. Even now, I still find it so poignant & moving.

Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly @cellcellpress.bsky.social @abrahamlabhms.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Viral infection and brain inflammation with seizures in PARK7 deficiency url: rupress.org/jhi/article/...

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis: Neuron www.cell.com/neuron/fullt...

1/ We’re seeking Sponsors for the 3rd International Symposium on Inborn Errors of Immunity (IEI), and their phenocopies, to be held in Lofoten, Norway, in June 2027. www.hgid.org/collaborativ...

Happy Holidays from our lab to yours 🎄☃️🦌 It's an absolute privilege to work with this amazing group of scientists. All the best for 2026!

Incredible resource of ~1M single-cell transcriptomes, NeuRoDev, that captures temporal and cellular variation across human brain development. Congrats to Asia Zonca and Erik Bot from the Davila-Velderrain group at @humantechnopole.bsky.social for leading this work! www.biorxiv.org/content/10.6...

New work from the Treutlein lab & @graycamplab.bsky.social, examining neural organoid response to morphogens 🧪🧠🧫🧬 www.nature.com/articles/s41...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons www.nature.com/articles/s41... @natneuro.nature.com

Congratulations to all the @humantechnopole.bsky.social PhD students who celebrated their graduation day. It was truly amazing to see all that they achieved over the past years. Special congrats to Eleonora Conti and @nicolapalazzi.bsky.social! #ProudPI

Good to see the peer reviewed version of this published A chemo-optogenetic system for spatiotemporal control of gene expression We use it to: - Reconstruct SHH mediated neural tube patterning in vitro - Measure extracellular half-life of Shh www.cell.com/developmenta...

Exciting opportunity to learn about #humanbrainmodels and #singlecelltechnology! July 13-17 2026 we for the first time will offer the Utrecht Summer School titled "Advanced human brain models in the single-cell era" for master and PhD students. Apply now: utrechtsummerschool.nl/courses/life...

🧠Very excited to share our new preprint on microglia in chimeric brain slice cultures 🔬 the chimeric slices offer an opportunity to investigate human microglia in a flexible and physiologically-relevant 3D environment 👉🏼read the full preprint here www.researchsquare.com/article/rs-8...

Nature research paper: Viral RNA blocks circularization to evade host codon usage control go.nature.com/4iB6yCh

We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists. The piece is available open access in Nature Communications: www.nature.com/articles/s41...

Excited to share the final piece of my postdoctoral work from the Joyner Lab, exploring the regenerative potential of the adult cerebellar astroglia in collaboration with @ricardkoche. 🧠 www.biorxiv.org/content/10.6...

So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this! And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social! www.cell.com/developmenta...

Please consider applying, @dev-journal.bsky.social provides: - Profile raising - Mentor sessions - Leadership training and a growing network of supportive peers.

Looking for some Thanksgiving reading? 🦃🦃🦃 🚨Check out our new preprint on CRISPore-seq!🚨 Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.

PhD position in my lab in #AI #RNA, in co-supervision with superstar @florianjug.bsky.social www.polimi.it/dottorato/fu...

This week we introduced an #assembloid-based platform to begin studying how #enteroviruses affect human neuromuscular systems. This is a collaboration with Jan Carette here at Stanford. Work led by Christine Peters, Jimena Andersen and Min-Yin Li.

Incredibly proud of Greta Galeotti for passing her first year Thesis Committee Meeting today after presenting her work on HSV-1 latency in human trigeminal neurons. A huge thanks to Greg Smith and @ilegnini.bsky.social for their input and the productive discussion. #ProudPI

Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids | EMBO reports www.embopress.org/doi/full/10....

Huge congratulations to @nicolapalazzi.bsky.social for successfully passing his PhD viva. It has been an amazing journey and a privilege to work with you over the past years! Can't wait to share the exciting discoveries you made. Thanks also to the examiners Mirko Cortese and Ilija Brizic. #ProudPI

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com www.nature.com/articles/s41...

Development that lasts a life time. Check out the 2025 special issue of @dev-journal.bsky.social on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues journals.biologists.com/dev/issue/15...

New work by @gleesonlab.bsky.social & colleagues in @cp-cellstemcell.bsky.social “A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders” 🧪🧠🧫🧬 www.cell.com/cell-stem-ce...

Already 53 phenomenal papers published in the @jhumimmunity.org ! Look it up and submit your best papers to the only journal focused on human inborn errors of immunity, their phenocopies, and related topics in human immunology: rupress.org/jhi

Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.

How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...

An amazing day as Eleonora Conti successfully defended her PhD, a first for the lab. It is difficult to put into words how proud I am of Eleonora and the stellar work she has done. Truly a star in the making! Big thanks to the examiners @antoinezalc.bsky.social and @ilegnini.bsky.social. #ProudPI

Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...

'This multicellular system with induced pluripotent stem cell-derived neurons, microglia, oligodendroglia, astrocytes, pericytes, and brain microvascular endothelial cells has potential for opening possibilities for disease modeling, drug discovery and development' #Immunology #Neuroimmunology

Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate

Could not be prouder of @analaura-duarte.bsky.social who passed her first year Thesis Committee Meeting today discussing her project on the neuropathology induced by inborn errors of immunity. Very exciting times ahead! Big thanks to Aleksandra Badura and Alice Giustacchini for their input. #ProudPI

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution. www.biorxiv.org/cgi/content/...

Many thanks to @nicolasrivron.bsky.social for today’s External Seminar Series at @humantechnopole.bsky.social. It was amazing to learn all about early human pregnancy using stem cell-based models, species-specific differences and the role of evolution on early development.

A wonderful autumn hike.

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains 1/ doi.org/10.1101/2025...

Very sad news, John Gurdon has died. A developmental biologist's developmental biologist, Nobel prize winner His work is the foundation of much of today's dev & stem cell bio. An inspiration to many, including me. Always asking questions & wanting the answers www.magd.cam.ac.uk/news/profess...

The ethical framework for embryo models needs clarity and simplicity. The spirit of the integrated/non-integrated distinction was to more prominently regulate models that could potentially develop into a fetus. Hafez Ismaili M’hamdi discusses this. www.progress.org.uk/complexity-w...

🏆 Congratulations to the winners of our Best Presentation Award, Eleonora Conti (@harschnitz.bsky.social Group) and Best Poster Award: Alexandra Livanova (Sottoriva Group); Emily Georgiades (Bienko Group); @veronicalarocca.bsky.social (Harschnitz Group)

My group @humantechnopole.bsky.social is searching for a #postdoc to work at the interface between #neurodevelopment and #cancerbiology focusing on neurofibromatosis type 1: careers.humantechnopole.it/job/Postdoc-...

Could not be more proud of Eleonora Conti who won the Best Talk Award and of Veronica La Rocca who won Best Poster Award at today's @humantechnopole.bsky.social PhD & Postdoc Symposium! A real tribute to all their hard work and a sign of exciting things to come. Incredibly well-deserved. #ProudPI

Big day at @humantechnopole.bsky.social with today's PhD & Postdoc Symposium providing a stellar line up of speakers and poster presenters. This year's theme is 'Research in Motion: Dynamics in Time, Space, and Technology'. So much exciting science to enjoy!

Very excited that Francesca Peri will be our next speaker for the @humantechnopole.bsky.social External Seminar Series this Thursday, October 2nd. Big thanks to @nereokalebic.bsky.social for hosting! For external people wanting to join, please see: forms.office.com/e/qk5AhGnaVZ.

1/ 🧵 I am excited to share a new preprint from our group: Single-cell Dam&T-seq during mouse corticogenesis reveals how genome–lamina interactions regulate long neuronal genes. doi.org/10.1101/2025... #Neurodevelopment #Epigenetics @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social