www.biorxiv.org/content/10.1... #phagesky #phage

www.biorxiv.org/content/10.1... #phagesky #phage

If you are interested in the topics of Adele's thesis, see one of the two experimental works here as preprint: doi.org/10.1101/2025... In addition to reviews within the thesis (co-first & co-author): doi.org/10.1128/msys... doi.org/10.1016/j.ti... + other papers during her PhD👇 #3yearsPhD in 🇩🇰

www.nature.com/articles/s41... #microsky

Multiomic analysis of the only megaphage in culture. In press today. Unlocking the genomic repertoire of a cultivated megaphage | npj Viruses share.google/HgU1cjRnaHWv... #phage #bacteriophage

journals.plos.org/plospathogen... #microsky congrats @imrsankhan.bsky.social and @gavinhthomas.bsky.social lab & collabs.

www.nature.com/articles/s41... #phagesky #phage defence

Interesting paper 'Evolutionary selection of trimethoprim-resistant dfrA genes in lytic phages affects phage and host fitness during infection' www.science.org/doi/10.1126/...

www.nature.com/articles/s41... #phagesky #phage defence

www.biorxiv.org/content/10.1... #microsky

A global view of morphogenetic peptidoglycan synthases across the domain Bacteria Open Access @femsjournals.bsky.social microLife by Francisco García-del Portillo et al academic.oup.com/microlife/ad...

Okay so I definitely need a CRISPR system and the only real path forward is the OpenCrispr protein. A friend donated a human optimized plasmid, so first is retooling for plants. If anyone wants access to it early, help me pay for the synthesis. DM's open. 💚

www.science.org/doi/10.1126/... #microsky

www.nature.com/articles/s41... #microsky

The ESCMID AMR Action Subcommittee has organised a series of online events leading up to #WAAW, 18 - 24 Nov 2025. These webinars cover topics under the theme of rethinking our response to #AMR in different ways. Learn more & register: ow.ly/46rb50X0L59#WAAW,#AMR#IDSky #clinmicro

www.nature.com/articles/s44... #microsky #phagesky #synbio

You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry @science.org www.science.org/doi/10.1126/...

Protein labeling made simple. Self-labeling tags like HaloTag® let you visualize proteins in real time with the dye or ligand of your choice. Find out how these systems expand your experimental toolkit. 🔗 Read the blog:

Multidrug resistance efflux pumps drive C. parvum virulence differences - showing how gut microbiome protects against pathogen colonization, and how antibiotics can disrupt this defense. 🦠💊 #microsky #microbiomesky #Mevosky 🧪 www.cell.com/cell-host-mi...

www.biorxiv.org/content/10.1... #phagesky jumbo #phage

www.biorxiv.org/content/10.1... #phagesky #phage defence

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org! It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance. Huge congrats to Wendy & colleagues! shorturl.at/WbFQC

www.biorxiv.org/content/10.1... #microsky but feels more like Horrible Histories!

www.biorxiv.org/content/10.1... #microsky #phagesky Among the adaptations found in wound-adapted Pseudomonas aeruginosa to compensate for other pre-engineered mutations, there’s the expanded number of Pf6 prophage copies.

A new #CryoET study shows that the protein ZapD helps organise FtsZ filaments into stable ring-like structures in building bacterial division machinery. buff.ly/saLPqJM

The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.

One for you @brockhurstlab.bsky.social ! Functional phages, and cocktails that work (caveat - have only looked at abstract) www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1... #microsky

www.nature.com/articles/s41... #phagesky #phage

www.biorxiv.org/content/10.1... #microsky #microbiome #synbio

And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs (superb collaboration) ComFB, a widespread family of c-di-NMP receptor proteins www.pnas.org/doi/10.1073/...

Want to understand why PAM-relaxed Cas9 variants like SpRY are inefficient? Check out this paper and the associated plasmids!

Fascinating! 🤔 I wonder whether bacteria with simpler single-membrane envelopes (like Chloroflexota) could be more “permissive” to HGT of membrane systems (from both bacteria and archaea)? 🦠🔀🧪 #microsky

www.biorxiv.org/content/10.1... #phagesky #phage Anecdotally, a few years ago a very trigger-happy temperate had infected a strain of E. coli of mine and caused significant lysis. The release of enzymes in the medium degraded a sugar into a different form which could be used by the other cells.

www.biorxiv.org/content/10.1... #microsky

www.biorxiv.org/content/10.1... #microsky #synbio

Volatile organic compounds from Bacillus velezensis FZB42 remodel Arabidopsis root architecture by an auxin-dependent mechanism -in Plant Cell Reports (Springer) link.springer.com/article/10.1...

QuickVariants 🦠🧬🧪- a genetic variant identification tool developed for microbes, now on Bioconda! 🚀 • 9× faster median speed vs bcftools • Higher accuracy for both SNPs & indels bioconda.github.io/recipes/quic... bmcbiol.biomedcentral.com/articles/10.... #microsky #microbiomesky

Genome evolution of Acinetobacter baylyi ADP1 during laboratory domestication: acquired mutations impact competence and metabolism #ApplEnvironMicrobiol from Jeff Barrick journals.asm.org/doi/10.1128/...

academic.oup.com/nar/article/... #phagesky #phage OLDie but goodie

www.biorxiv.org/content/10.1... #phagesky #phage

www.nature.com/articles/s41... #microsky #genomics #phagesky #phage defense

Life in academia according to autobiographies of Nobel laureates

www.pnas.org/doi/10.1073/... #microsky #sialic acid STM1128 is a Neu5Ac transporter of the sodium-solute symporter (SSS) superfamily, which @gavinhthomas.bsky.social, Arthur Hosie & I identified 15 years :-)

www.biorxiv.org/content/10.1... #phagesky #phage

www.cell.com/cell/fulltex... #microsky #microbiome

www.cell.com/cell-host-mi... #microsky #microbiome

www.biorxiv.org/content/10.1... #phagesky #phage

journals.asm.org/doi/10.1128/... #phagesky #phage