Milestone of the lab...10000 strains in our collection!

#Klebsiella infections are a serious & growing #PublicHealth threat For #AntimicrobialAwarenessWeek, @josebengoechea.bsky.social discusses the dangers of bacterial infections, antimicrobial resistance & the global efforts to tackle it. @lshtmamrcentre.bsky.social www.lshtm.ac.uk/newsevents/e...

For anyone interested in doing a PhD at the interface of microbiology and immunology focusing on how AMR pathogens subvert host defenses...you may consider applying to our MRC LID DTP project in which we will explore how Klebsiella hijacks the immune checkpoint PD-L1 mrc-lid.lshtm.ac.uk/apply/

So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae. www.nature.com/articles/s41...

Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term www.gov.uk/government/p...

What makes PhD students happy? Good supervision www.nature.com/articles/d41...

Intrinsic resistance pathways & #ResistanceBreaking. Study shows that inhibiting efflux pumps & cell envelope biogenesis sensitizes #bacteria to #antibiotics, but rapid evolutionary recovery may limit long-term effectiveness of resistance-breaking strategies #AMR @plosbiology.org 🧪 plos.io/4huAtvo

Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei @sydneylmiles.bsky.social @katholt.bsky.social 🙏to transformative collaborative effort www.nature.com/articles/s41...

New paper with my (amazing) friend and mentor @jrpenades.bsky.social Really looking forward to see what plasmid aficionados think of this one!! With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others www.cell.com/cell-reports...

#WHO report shows rising #antibiotic resistance in common bacteria @katholt.bsky.social & @josebengoechea.bsky.social explain resistance worryingly high in #Klebsiella & E.coli as 1 in 6 lab-confirmed #bacterial infections in 2023 shown resistant to antibiotics. www.lshtm.ac.uk/newsevents/n...

My nose must be riddled with S. aureus then 🫠

𝘒𝘭𝘦𝘣𝘴𝘪𝘦𝘭𝘭𝘢 𝘱𝘯𝘦𝘶𝘮𝘰𝘯𝘪𝘢𝘦 is a Gram-negative, non-motile, straight rod-shaped bacterium that can divide rapidly, with some strains having a median doubling time of < 30 min, forming biofilms that interfere with both antibiotic and immune clearance

What an incredible week for @julielebris.bsky.social with one published ms in @asm.org #mBio on #capsule phenotypic heterogeneity & a preprint on the modular evolution of a highly exchangeable locus ⏩️capsule 😅 All her hard work is paying off! #ProudPI #microsky @klebclub.bsky.social Check her 🧵👇🏻

Cool work Lindsay, congrats.

#NewResearch This study uses Salmonella strains genetically engineered to express minimal effector subsets and mass cytometry to characterise infection of the spleen, revealing bottlenecks overcome by these effectors #MicroSky www.nature.com/articles/s41...

A good way to think about institutional research culture!

Good opportunity here to work with a super talented new PI.

Maybe I am being grumpy, but can people please stop using poorly curated databases of antibiotic resistance genes (I am looking at you, DeepARG) on shotgun metagenomic data and then present these results without any reflection on their validity, or shortcomings of databases?

New in #JClinMicro! An optimized, streamlined nanopore-only workflow for epidemiologic analysis of bacterial pathogens, enabling outbreak analysis with performance comparable to that of Illumina short-read sequencing. Get the details: asm.social/2wd

Several years of work with several great collaborators, that combined computational biology, molecular microbiology, biochemistry, structural biology and mycology assay culminated in today's publication on discovery of novel bacterial toxins: www.nature.com/articles/s41...

There are half a million cases of invasive non-Typhoidal Salmonella (iNTS) every year and while you might know S. Typhimurim and Enteritidis, you may not have heard of S. Panama 💩 🩸 🧫 💊 Check out our latest in @lancetmicrobe.bsky.social doi.org/10.1016/j.la... and the 🧵 below to find out more 1/n

Are you a physician, nurse, or pharmacist looking to specialise in travel medicine?✈️🌏 Gain the knowledge, practical tools & conceptual framework needed to deliver a modern, evidence-based travel health service with our expertly designed short course. bit.ly/3Qy7Y0O

I provided some comments about the aid cuts in the UK that’s affecting the Fleming Fund today: microbiologysociety.org/news/society...

Journal of Cell Science is published by a not-for-profit charitable organisation (@biologists.bsky.social) that exists to benefit science, not shareholders. We provide Travelling Fellowships, Training Grants, support for ECRs and more. For details, visit: journals.biologists.com/jcs/pages/re...

It's seem like arginine is emerging as a major host cue. So we wrote an IAI minireview on how arginine levels vary between host tissues and affect microbial behavior. The review is online today! journals.asm.org/doi/epdf/10.... @brookeeryan3.bsky.social #microsky

🚨NEW PAPER ALERT!!!🚨 The BBH lab is proud to present the latest www.nature.com/articles/s41... from our collaboration with @joshuasweitz.bsky.social (now at UMaryland), evaluating the importance of alveolar macrophages (AM) for the efficacy of phage therapy against P. aeruginosa Let's dig in (1/6)

🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...

💥 Very excited to share this review in Nature Reviews Microbiology. Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers... www.nature.com/articles/s41... www.nature.com/articles/s41...

I am delighted that our manuscript 'Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut' is now published. www.tandfonline.com/doi/full/10.... Big thank you to all co-authors, particularly @lisalamberte.bsky.social and @halllab.bsky.social

📢 Nearly 600 heat-related deaths expected in UK #heatwave LSHTM & @granthamicl.bsky.social real-time rapid analysis estimates impact of rising UK temperatures as researchers warn risks set to increase @gasparrini.bsky.social #PublicHeath 👉 www.lshtm.ac.uk/newsevents/n...

www.biorxiv.org/content/10.1.... New pre-print of the lab in which we dive deep into Klebsiella-macrophage interface. High structural resolution of the lipid A produced by Klebsiella within the Klebsiella containing vacuole governed bt TLR4 signaling. Superb job led PhD student Toby Bartholomew

Want to be part of a diverse student community making a difference in #GlobalHealth? Our #students & recent graduates tell us why they chose to study with us, from inspiring lecturers to 1st class research, a truly global network & warm welcome 🌎 Find out more👉 www.lshtm.ac.uk/study/intern...

Researchers at @lshtm.bsky.social, led by @josebengoechea.bsky.social, will conduct a £2.2M study funded by UK MRC to investigate how Klebsiella pneumoniae silently colonises the gut before causing deadly infections. 🔬🦠 Read more 👉 bit.ly/4mNSreh

Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight) interpretamr.github.io/AMRrules

Indeed he looks the same as 15 years ago!

🚨New publication🚨 We show that K. Pneumoniae bacteriophages can be incorporated into alginate to create an antibiofilm matrix effective against clinical K. pneumoniae strains academic.oup.com/jambio/artic...

Bacteriophage therapy for MDR infections. www.jci.org/articles/vie...

Delighted to share our last pre print -this one close to my heart- We set to define the rules of lipid A associated with virulence by interrogating the genus Yersinia. www.biorxiv.org/content/10.1...

Good to be back to Belfast!

Landmark paper claxon! 'Evaluating the economic and health impact of proactive genomic epidemiology in a hospital setting' www.medrxiv.org/content/10.1... Significant savings associated with proactive genomic epidemiology.

Somewhat unexpected that no one thought about this before...time is important for plasmid conjugation! journals.plos.org/plosgenetics...

New mechanism of gene transfer! With @tcostalab.bsky.social @imperialcollegeldn.bsky.social, we discovered that cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE

Great work by Dr. Jason Harris and colleagues at Harvard. First true in-depth evaluation of immune response to Klebsiella bacteremia in humans! Antibody responses in Klebsiella pneumoniae bloodstream infection: a prospective cohort study - The Lancet Microbe www.thelancet.com/journals/lan...

Check out our latest Kaptive update for highly sensitive and accurate identification of surface polysaccharide loci from WGS of #AMR pathogens, #Klebsiella and #Acinetobacter baumanii. Led by the awesome @tomstantonmicro.bsky.social 🦠🧫

◢◤P◢◤A◢◤R◢◤A ◢ ◢◤D◢◤I◢◤G◢◤M ◢ ◢◤S◢◤H◢◤I◢◤F◢◤T◢ Joseph Fanous et al Dirk Bumann lab @biozentrum.unibas.ch in 𝘕𝘢𝘵𝘶𝘳𝘦 Starvation-induced general resilience of 𝘚𝘢𝘭𝘮𝘰𝘯𝘦𝘭𝘭𝘢 was the main cause of poor antibiotic clearance, not a small group of highly resistant “persisters” www.nature.com/articles/s41...

New pre print! We establish an ex vivo blood vessel model to investigate the effect of infection on vascular physiology in real time. We show Klebsiella inhibits vasodilation in a T6SS-dependent manner by targeting eNOs. Superb work by @safimicro.bsky.social www.biorxiv.org/content/10.1...

Evidencing three factors for postdoc contribution to future career success (mobility, fellowship, hit paper), a good study to discuss in lab meetings. doi.org/10.1073/pnas...

🔊Online now: Klebsiella pneumoniae emerging anti-immunology paradigms: from stealth to evasion Review by José Bengoechea (@josebengoechea.bsky.social) & colleagues OA link: www.cell.com/trends/micro...

Last work from the lab in @cp-trendsmicrobiol.bsky.social ! We review the most recent evidence on the strategies deployed by Klebsiella to counteract host defences. www.sciencedirect.com/science/arti... The co-evolution with the immune system has taught the bug a couple of tricks!!!

More than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org