Very excited to share the latest work from our lab in @insight.jci.org, highlighting a role for the #septin #cytoskeleton in protecting against "leaky gut", by recruiting non-muscle myosin II and stabilizing the tight junction. Credit to @dominikrobak.bsky.social for the stunning cover image!

London interdisciplinary #PhD position now open with myself, @sergemostowylab.bsky.social, & @gmknght.bsky.social on #phage -bacteria-host immune dynamics for WHO priority bacterial pathogens #Klebsiella, #Shigella, and #Staph. Combines cellular microbiology, genomics, & mathematical modelling.

also worthwhile checking out the highlight commentary by @kewright.bsky.social and @sergemostowylab.bsky.social: No guts, no glory: IL-26 in host-microbiota interactions www.embopress.org/doi/full/10....

No guts, no glory: IL-26 in host-microbiota interactions @embojournal.org www.embopress.org/doi/full/10....

Don't let the bug's virulence fill you with dread, When gourmet French dining awaits you instead. So pack up your notes and your best, clever wits, To discuss all the bug's crafty cellular tricks! @ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social

We hire! The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities. More details here: cytomorpholab.com/index.php/jo...

Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei @sydneylmiles.bsky.social @katholt.bsky.social 🙏to transformative collaborative effort www.nature.com/articles/s41...

Attention #Septin Fans! Serge Mostowy's lab @sergemostowylab.bsky.social published a wonderful #openacces short report in #CYTOSKELETON.Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death. onlinelibrary.wiley.com/doi/full/10....

This year's Crick @crick.ac.uk PhD programme is open for applications - £27,715 tax-free student stipend per year for 4 years - Tuition fees paid - Student visa fee & health surcharges covered Deadline 5 Nov We have a project available. For all the details visit: www.crick.ac.uk/careers-stud...

The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1

Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social

A great opportunity to attend the #Shigella meeting April 20-24, 2026! Abstract submissions are open! @shigellameeting.bsky.social #Microsky

Come and join us in Paris 2026 to talk all about Shigella!

Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky www.shigella2026.conferences-pasteur.org/home

We will be talking about our favorite microorganism #Shigella at the @shigellameeting.bsky.social in April 2026! 🦠 🧫 @ksbakes.bsky.social @sergemostowylab.bsky.social @marteynlab.bsky.social

Why not follow our @shigellameeting.bsky.social starterpack of people who are speaking at and attending the conference - please message to be added to the starter pack if you're planning on coming or we haven't found you yet! go.bsky.app/6Vbwhjc

💫Don't miss the N&V💫 📰Organoid models advance dysentery control. By Sydney L. Miles & Serge Mostowy. ⬇️ www.nature.com/articles/s41...

Last day of #SeptSRC begins with Marc Fivaz from reMYND with the most exciting septin advance of the year - a septin targeting compound that reverses Alzheimer’s symptoms in mice and patients

Super exciting talk @ #SeptSRC by Friederike Arlt on septin autoantibodies linked to rare and inexplicable neurological disorder symptoms with cancer history. Possibly generated through immune response to cancer cells. So inspiring and motivating for future of septin use in medicine!

Back from coffee break with the latest septin fan and #SeptSRC newbie @nanigrotjahn.bsky.social on septins and mitochondria with amazing cryo ET and super resolution imaging. Breathtaking views of septin filaments on mitochondria.

#SeptSRC pathogenesis session continues with Serge “cageman” Mostowy @sergemostowylab.bsky.social presenting compelling new data on septins as a unique cytoskektal system that curtails Shigella infection.

It is a great pleasure to think about your study and the impact it will have, congratulations

Thrilled to share our work is finally out at @natgenet.nature.com ! rdcu.be/eqGgf Combining a scalable human gut organoid model with TraDIS and statistical modeling, we mapped how Shigella colonizes the intestine at genome-wide resolution.

Congratulations on your transformative work

Lots of exciting work to do at this interface between #ubiquitin and #ADP-ribosylation! In the coming months, @michaelnadbio.bsky.social and I hope to be recruiting new team members to explore this space. Here is a thread of other exciting opportunities to check out!

The Montpellier Institute of Molecular Genetics is recruiting group leaders (open rank). IGMM studies fundamental mechanisms underlying cellular processes and their links to human pathologies. Montpellier 🇨🇵 is an absolutely wonderful place to live. Deadline 31st October. jobrxiv.org/job/montpell...

April 20-24, 2026 Save the date!

Zoom into a human cell infected by Shigella, the bacteria behind dysentery. Using cryo-EM, @leaswistak.bsky.social and team revealed how it pierces cells with molecular syringes. Stunning science at the nanoscale. @enningalab.bsky.social @jytinevez.bsky.social @nanoimaging.bsky.social #CryoEM

5 days left to register at discounted rate, and 3 weeks left from Sunday for FASEB - Septins: spatial regulators of cell biology. An exciting program of over 50 talks. Daily meet the speakers luncheons/dinners Career development sessions Poster prizes & a killer dance party mix in the making!?!

I'm looking for a postdoc in computational evolutionary phage genomics, with the goal to better understand how protein innovation arises in viruses, at @jagiellonskiuni.bsky.social in Krakow (Poland). Drop me a line if it sounds cool! Deadline: 20.06. Link here: mcb.uj.edu.pl/documents/15...

After nearly 2 years of striving for research independence, I’m thrilled to share that my work and I have found a home at @warwicklifesci.bsky.social. Today was my first day as Assistant Professor — excited for what’s ahead! 🤩 🐠🔬🦠 Deep thanks to all the mentors who’ve supported me on the way

How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z

Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection @cgmargarida.bsky.social

1/ Today we spotlight @sanchoshimizu.bsky.social, a postdoc in our Paris branch from 2006-12 and now Reader/Associate Professor at @imperialcollegeldn.bsky.social in the department of infectious diseases and head of both of a lab there and a satellite lab at the @crick.ac.uk

3/ It is gratifying to be acknowledged for our lab’s 30-year journey exploring the fundamental role that human genes play in determining who becomes seriously ill and who remains healthy when infected with the same virus, bacterium, fungus, or parasite. novonordiskfonden.dk/en/news/unra...

Join the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩 Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭! Please visit my lab's webpage for details about the position and how to formally apply.

Thank you for highlighting our work, I am grateful for the community Liverpool is putting together!

New role for macrophages in Shigella infection control @cgmargarida.bsky.social @lshtm.bsky.social @cp-cellreports.bsky.social www.cell.com/cell-reports...

I’m delighted to share my final project with @sergemostowylab.bsky.social at @lshtm.bsky.social: Shigella-trained zebrafish macrophages are more pro-inflammatory and have enhanced antibacterial activity 🐠🦠🔬🛡️ www.cell.com/cell-reports... Thank you for all your help Dominik! More news to follow 🤩

FASEB Septins - June 15-19, Niagara Falls, New York. Abstracts for posters and short talks STILL ACCEPTED until early/mid May (despite April 20 website deadline). REGISTER NOW: events.faseb.org/event/septin... Program and attendance looking great so far - 40% non US participation

APRIL 20 Abstract Deadline has been extended for another two weeks. Submit your septin work now for a poster and chance to give a short talk in one of the 8 exciting sessions of the conference.

Two months left for FASEB Conference - Septins: Spatial regulators of cell biology Register now: events.faseb.org/event/septin... Come find out what these filaments do at the interface of the actin and microtubule cytoskeletons and cell membranes. You'll be hooked for life.

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!

🔊 Empowering women in science means amplifying voices, breaking barriers, and driving change. Ahead of #IWD2025, we celebrate Dr. Sydney Miles, whose career is a testament to perseverance, passion, and the power of representation in science. 🔗 bit.ly/4kwlPVl

How is extrusion of infected host cells related to ERK (extracellular signal-regulated kinase) activity? Hi, I’m @hundsdorfer.bsky.social from the @effiebastounis.bsky.social lab. Let’s follow the recent development of bacterially-infected cell extrusion & mechanochemical ERK activity waves.

Finally, in 2025, we found that ERK activity waves are crucial for CICE. This mechanism isn’t pathogen or cell-line specific: Shigella-infected zebrafish tails extrude infected cells in an ERK-activity dependent manner (Thanks to the @sergemostowylab.bsky.social lab). bsky.app/profile/epim...

Had a fantastic time sharing my work funded by @researchireland.bsky.social and listening to awesome science at the @biologists.bsky.social conference! Thanks to @sergemostowylab.bsky.social and @kateduncan.bsky.social for organising a great day on interdisciplinary approaches to combatting #AMR