Nucleolar reorganization on stress depends on physicochemical changes due to nascent rRNA synthesis https://www.biorxiv.org/content/10.64898/2026.01.03.697456v1

mRNAbow: A versatile gene expression system for multiplexed fluorescent imaging using optimized in vitro transcribed mRNA https://www.biorxiv.org/content/10.64898/2026.01.02.697412v1

'Zipper' Grammar of CTD Governs the Spatial Programing of the Transcription Cycle of RNA Polymerase II https://www.biorxiv.org/content/10.64898/2026.01.02.697396v1

Proteolytic processing of Argonautes in multiphase condensates promotes transgenerational epigenetic inheritance https://www.biorxiv.org/content/10.64898/2026.01.01.697165v1

SpatialDINO: A Self-Supervised 3D Vision Transformer that enables Segmentation and Tracking in Crowded Cellular Environments https://www.biorxiv.org/content/10.64898/2025.12.31.697247v1

Unraveling Subcellular Ultrastructure with Cyclically Multiplexed Expansion Microscopy https://www.biorxiv.org/content/10.64898/2026.01.01.697161v1

Altered Cohesin Dynamics During Cellular Differentiation https://www.biorxiv.org/content/10.64898/2026.01.01.697310v1

The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication https://www.biorxiv.org/content/10.64898/2026.01.02.697337v1

Local translational program at the muscle-tendon junction endows domain identity in muscle syncytia https://www.biorxiv.org/content/10.64898/2026.01.01.697307v1

Single cell RNA-sequencing reveals an association between testosterone treatment and reduced hormone signaling in the human mammary gland https://www.biorxiv.org/content/10.64898/2025.12.31.697241v1

Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization https://www.biorxiv.org/content/10.64898/2025.12.31.696872v1

Selective estradiol sensitivity in 12Z human endometriotic epithelial cell line https://www.biorxiv.org/content/10.64898/2025.12.31.697205v1

Acute deletion of PLIN5 in brown adipocytes causes mitochondrial dysfunction and cold intolerance https://www.biorxiv.org/content/10.64898/2025.12.31.697198v1

Fibrotic substrate stiffness enhances endometriotic epithelial cell motility https://www.biorxiv.org/content/10.64898/2025.12.31.697209v1

GCL pruning of PIP3 establishes the soma-germline boundary https://www.biorxiv.org/content/10.64898/2025.12.30.697122v1

Protective IFIH1 variant reduces immune-mediated islet stress and dysfunction in a type 1 diabetes genetic background https://www.biorxiv.org/content/10.64898/2025.12.30.697107v1

The Hippo Pathway Regulates Corneal Endothelial Regeneration https://www.biorxiv.org/content/10.64898/2025.12.30.697046v1

Identification and Regulation of a Hepatic Lipogenic Metabolon https://www.biorxiv.org/content/10.64898/2025.12.30.696908v1

Spatial inhibition of RhoA by RhoGAP15B promotes protrusive activity during collective cell migration https://www.biorxiv.org/content/10.64898/2025.12.30.694567v1

The biochemical nature of senile plaques: intracellular destabilized-lysosome-enriched neural processes catabolizing extracellular hemorrhagic amyloid materials https://www.biorxiv.org/content/10.64898/2025.12.30.696965v1

Validation of diffusion and exchange imaging biomarkers via simultaneous real-time NMR and optical microscopy https://www.biorxiv.org/content/10.64898/2025.12.30.697003v1

A conserved mitochondrial role for cyclin C in mediating oxidative stress-induced cell death in yeast https://www.biorxiv.org/content/10.64898/2025.12.30.696989v1

3'to 5'translation of linear mRNAs? https://www.biorxiv.org/content/10.64898/2025.12.29.696803v1

A novel dephosphorylation peptide inhibits 17β-HSD1 enzyme activity in ovarian granulosa cells and breast cancer cells https://www.biorxiv.org/content/10.64898/2025.12.29.696806v1

mRNA transcription in skeletal muscle drives growth and determines nuclear accretion https://www.biorxiv.org/content/10.64898/2025.12.29.696842v1

Paclitaxel induces NM2-dependent cellular contraction independent of microtubule acetylation in live cells https://www.biorxiv.org/content/10.64898/2025.12.29.696873v1

A brief exposure to rotenone alters microtubule dynamics resulting in aberrant elongation of primary cilia with impaired function https://www.biorxiv.org/content/10.64898/2025.12.29.696880v1

Optogenetic SH3 nanoclustering of SRC and HCK uncovers the functional specificity of these redundant kinases in macrophages. https://www.biorxiv.org/content/10.64898/2025.12.27.692121v1

Temporal Dynamics of Kidney Mitochondrial Dysfunction in Type 2 Diabetes: Analysis of the Goto-Kakizaki Model. https://www.biorxiv.org/content/10.64898/2025.12.27.696702v1

TMPO promotes cellular dissemination and metastasis in circulating tumor cells https://www.biorxiv.org/content/10.64898/2025.12.27.696673v1

Automated Image-Based Cell Sorting by Targeted Photopolymerization https://www.biorxiv.org/content/10.64898/2025.12.27.693999v1

A minor muscle stem cell population functions as metabolic Trojan horse fueling systemic aging by succinate induced epigenetic reprogramming https://www.biorxiv.org/content/10.64898/2025.12.26.696560v1

Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine https://www.biorxiv.org/content/10.64898/2025.12.25.696514v1

Transcriptomic Profiling Reveals Key Molecular Events and Pathways Driving Acquired Chemotherapy Resistance in Relapsed Acute Myeloid Leukemia https://www.biorxiv.org/content/10.64898/2025.12.24.696467v1

BMP9-mediated regulation of endothelin-1 requires integrated SMAD1/5 and SMAD2/3 signaling https://www.biorxiv.org/content/10.64898/2025.12.24.696445v1

Unraveling the molecular mechanisms underlying spontaneous multipolar mitosis through CIN-seq https://www.biorxiv.org/content/10.64898/2025.12.24.696383v1

Beta hydroxybutyrate alters beta cell identity and function in human islets https://www.biorxiv.org/content/10.64898/2025.12.24.696385v1

Laser-driven VHEE pulsed fast fractionation (PFF): second-scale inter-pulse timing differentially modulates normal tissue and tumour toxicity https://www.biorxiv.org/content/10.64898/2025.12.24.696225v1

MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state https://www.biorxiv.org/content/10.64898/2025.12.24.696404v1

The pore-forming protein APOL7C ruptures Leishmania major-containing parasitophorous vacuoles in dendritic cells to promote IL-12 production and the induction of T helper type 1 immunity https://www.biorxiv.org/content/10.64898/2025.12.24.696354v1

Astrocytic glycolysis attenuates mitochondrial efficiency to preserve cognition https://www.biorxiv.org/content/10.64898/2025.12.24.696355v1

The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases https://www.biorxiv.org/content/10.64898/2025.12.25.696450v1

The conserved NUS-1/DHDDS complex links N-glycosylation to lipid and lysosomal homeostasis in C. elegans https://www.biorxiv.org/content/10.64898/2025.12.25.696488v1

Lung derived extracellular vesicles have distinct pro-repair effects, depending on the age of their source tissue https://www.biorxiv.org/content/10.64898/2025.12.23.694250v1

Absence of MBP 3' UTR in Mice Disrupts mRNA Transport, Myelination, and Motor Learning https://www.biorxiv.org/content/10.64898/2025.12.23.696264v1

Development of an organotypic brain slice culture model using tissues collected from geriatric mice https://www.biorxiv.org/content/10.64898/2025.12.23.696302v1

Residual blinking-driven channel alignment for multicolor single-molecule localization microscopy https://www.biorxiv.org/content/10.64898/2025.12.23.696332v1

Genomic stress drives activation of interferon signaling and innate immune pathways during SMA Type II myoblasts differentiation https://www.biorxiv.org/content/10.64898/2025.12.23.696216v1

Self-Supervised Missing Wedge Correction in Soft X-Ray Tomography: Towards Accurate Cellular Morphology and Volume Quantification https://www.biorxiv.org/content/10.64898/2025.12.23.696166v1

Compromised ESCRT signalling is sufficient for resistance to the Target of Rapamycin Complex inhibitor Torin1 in fission yeast https://www.biorxiv.org/content/10.64898/2025.12.23.696270v1