New from MBoC: CRISPR disruption of centriolin/Cep110 (CNTRL) causes cell cycle arrest and apoptotic death in rhabdomyosarcoma cells in vitro. A centrosome protein emerges as a potential therapeutic vulnerability. Read more: https://www.molbiolcell.org/doi/10.1091/mbc.E25-08-0365

How do cellular forces shape development and aging? Join the MBoC Highlight webinar Forces On and Within Cells with keynote by ASCB President Rong Li. April 23, 6–7 pm ET https://www.ascb.org/ascb-meetings/mboc-highlight-forces-on-and-within-cells-with-keynote-by-ascb-president-rong-li/

New from MBoC: Motor protein tails may not be simply disordered linkers. Emerging structural data reveal conditionally ordered motifs that regulate cargo binding and activation. Read the Perspective: https://www.molbiolcell.org/doi/10.1091/mbc.E25-07-0359

Editor Spotlight: Avery August, Cornell University Research: tyrosine kinase signaling and immunity “MBoC publishes well-supported advances regardless of trends, with fair reviews at the pace of the busy scientist.” Explore molbiolcell.org

Editor Spotlight: Avery August Cornell University Research areas: Tyrosine kinase signaling and immunity “MBoC publishes well-supported scientific advances regardless of trends, with fair reviews delivered at the pace of the busy scientist. ” molbiolcell.org

Step-by-step protocol and reproducibility Generate iPSC-derived 3D neurospheres for neuron–glia studies. Date: March 25 | Time: 12:00 pm ET Free Register: https://www.ascb.org/ascb-meetings/3d-human-multi-cell-type-meurospheres-from-ipscs/

DORA has launched an introductory course on responsible research assessment! 🤩 🤓 What is it? A free online self-paced course ❓ Who is it for? Anyone who wants to learn more about the basics of research assessment, regardless of career level or discipline 🌐 Explore the course 👉 bit.ly/DORA-Intro-C...

New from MBoC: ZNF787 binds a conserved MIR repeat motif and recruits the NuRD complex to repress nearby genes. A new example of repeat-directed epigenetic regulation. Read more: https://www.molbiolcell.org/doi/10.1091/mbc.E25-07-0347

Last chance to help shape Cell Bio 2026! Scientific session proposals are due February 22. Don’t miss your opportunity to lead a session. https://www.ascb.org/cellbio2026/

New from MBoC: A previously unknown subset of mitochondrial-derived vesicles enables inter-mitochondrial communication. TOMM70-positive MDVs expand our understanding of mitochondrial signaling and quality control. Read more: https://www.molbiolcell.org/doi/10.1091/mbc.E25-04-0188

Advocate for science policy and research funding. Join ASCB’s Texas Virtual Capitol Hill Day on April 22. Free for ASCB members. No travel required. Register: https://www.ascb.org/ascb-meetings/ascb-texas-virtual-capitol-hill-day-2/

New from MBoC: Ligand-induced clustering of the copper transporter CTR1 alters membrane mechanics to drive its own endocytosis. A novel self-regulatory mechanism for an ion channel. Read more: https://www.molbiolcell.org/doi/10.1091/mbc.E25-04-0159

The American Society for Cell Biology’s journal CBE—Life Sciences Education is recruiting a Sr. Editor for Special Issues. Lead & mentor editors while shaping the field. Deadline: March 11, 2026 https://www.ascb.org/society-news/call-for-senior-editor-special-issues-cbe-life-sciences-education-lse/

Editor Spotlight: Derek Applewhite Reed College Research areas: Cell biology, cytoskeleton, cell motility “MBoC provides high-quality, peer-reviewed articles and advocates for the cell biology community.” Learn more about the journal and how to submit your work at molbiolcell.org.

From MBoC… RhoGEF Trio strengthens endothelial barriers by promoting tensile, linear junctions via F-actin organization and Rap1-dependent tension. A potential therapeutic target in vascular disease. https://www.molbiolcell.org/doi/10.1091/mbc.E24-09-0405-T

From MBoC… This study shows how the LINC complex and microtubule motors control nuclear number and positioning in cells of the Drosophila blood–brain barrier. https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0518

MBoC Highlight webinar: Forces On and Within Cells Keynote by ASCB President Rong Li + lightning talks from early-career scientists. April 23, 6–7 pm ET Register: https://www.ascb.org/ascb-meetings/mboc-highlight-forces-on-and-within-cells-with-keynote-by-ascb-president-rong-li/

We’re excited to share that CBE—Life Sciences Education (LSE) is now on Bluesky. If you care about evidence-based teaching and learning in the life sciences, be sure to follow.

How respiratory viruses breach cellular defenses: this article explores viral strategies that target the nuclear pore complex and nuclear transport pathways. https://www.molbiolcell.org/doi/10.1091/mbc.E25-07-0322

From genome biology to AI, imaging, and new tools—Cell Bio 2026 welcomes sessions across the full spectrum of cell biology. Submit your scientific session proposal by February 22. https://www.ascb.org/cellbio2026/

Webinar alert Learn how to generate 3D human multi-cell type neurospheres from iPSCs without necrotic core formation. Featuring Stefan Wendt, PhD (UBC) Date: March 25 | Time: 12:00 pm ET Free for all Register here: https://www.ascb.org/ascb-meetings/3d-human-multi-cell-type-meurospheres-from-ipscs/

How do cells generate, sense & resist force? MBoC highlights recent advances in mechanobiology in its Forces on and within Cells collection — spanning cytoskeletal dynamics, membrane mechanics, and beyond. 🔗 https://www.ascb.org/science-news/exploring-the-forces-that-shape-cells/

From cartoon models to quantitative structural maps: learn how cryo-electron tomography is reshaping studies of cellular organization. Danielle Grotjahn, Ph.D., shares where cryo-ET excels, its challenges, and how it fits into today’s imaging toolbox.

Want to organize a Minisymposium, Workshop, or Special Interest Subgroup? Now’s your chance to lead at Cell Bio 2026. 🗓 Scientific session proposals due February 22 https://www.ascb.org/cellbio2026/

From MBoC… A systematic comparison of auxin-inducible degradation tools in yeast identifies optimal component combinations for fast, efficient protein depletion with low basal effects. https://www.molbiolcell.org/doi/10.1091/mbc.E25-12-0571

From MBoC… Founded by graduate students, the Puerto Rico Cancer Research Meeting builds inclusive, collaborative research networks and strengthens Puerto Rico’s cancer research community. https://www.molbiolcell.org/doi/10.1091/mbc.E25-10-0481

From MBoC Lipid-induced membrane curvature stress recruits the PML-II protein to the inner nuclear membrane, activating pathways that help restore membrane integrity under metabolic stress. https://www.molbiolcell.org/doi/10.1091/mbc.E25-09-0443

From MBoC… In fly neurons, the protein Kenny recruits the phagophore to damaged, ubiquitinated mitochondria, enabling mitophagy in vivo and linking Drosophila biology to optineurin-related human disease. https://www.molbiolcell.org/doi/10.1091/mbc.E25-05-0235

NIH has paused new human embryonic stem cell line submissions and ended NIH-funded research using human fetal tissue, reversing long-standing biomedical research policy. https://www.ascb.org/science-policy/white-house-halts-use-of-human-embryonic-stem-cells-and-human-fetal-tissue/

Cell Bio 2026 is built by scientists, for scientists—and it starts with your ideas. Submit a scientific session proposal and help shape the program. 🗓 Deadline: February 22, 2026 https://www.ascb.org/cellbio2026/

From MBoC… Researchers reveal how TNIP1 and autophagy receptors organize STING-associated membranes and help regulate innate immune signaling, uncovering new control points in the STING pathway. doi.org/10.1091/mbc....

Molecular Biology of the Cell (MBoC) hit a new high in 2025 with 3.49M full-text views—the most in its history! Explore the top-read articles shaping cell biology today:

Curious about cryo-electron tomography but not sure how it fits into your research? This ASCB webinar with Danielle Grotjahn, Ph.D., breaks down what cryo-ET can do, where it shines, and how it works alongside other imaging methods.

How can cryo-electron tomography connect molecular structure to cellular function? Join Danielle Grotjahn, for an ASCB webinar exploring how cryo-ET reveals macromolecules in their native environment and complements other nanoscale imaging approaches. Register for free: www.ascb.org/ascb-meeting...

From MBoC… How do bacteria maintain their shape? Chaitanya Athale (IISER Pune) shows how internal pressure and cell envelope mechanics control E. coli cell width—and explains why cells bulge when that balance is disrupted. www.molbiolcell.org/doi/full/10....

From LSE… This study shows that racially marginalized and minoritized students who perceive their mentors as culturally aware experience more inclusive lab climates, stronger science identity, and greater motivation to pursue STEM careers. www.lifescied.org/doi/10.1187/...

Scientific trends come and go—but the future of cell biology is built by those willing to look beyond them. Read ASCB President Rong Li’s reflection on creating the next frontier in cell biology: www.ascb.org/society-news...

From MBoC… Manual synapse reconstruction is time-consuming and limits discovery. This article introduces SynapseNet, a deep-learning tool that automates synapse segmentation in EM images—making large-scale, data-driven analysis possible. www.molbiolcell.org/doi/10.1091/...

From LSE… This article reexamines the learning theory behind ungrading and argues that self-regulated learning falls short of ungrading’s emancipatory aims. www.lifescied.org/doi/10.1187/...

We’re excited to announce a new ASCB–Bio-protocol webinar partnership. From Bench to Breakthrough: Cutting-Edge Tools for Cell Biology will deliver detailed, practical methods talks from the scientists who developed them, plus live Q&A & on-demand access. Learn more: www.ascb.org/society-news...

From MBoC… Strong cell attachments are critical in early development. Guy Tanentzapf (University of British Columbia) shows that inside–out integrin activation helps cells survive and proliferate during early mammalian embryogenesis. www.molbiolcell.org/doi/full/10....

From LSE… Who shapes instructional change in STEM departments? This study finds that tenure-track, teaching-focused faculty are influential across instructional domains—and especially within DEI networks—positioning them as key departmental change agents. www.lifescied.org/doi/10.1187/...

From MBoC… Cells move cargo in clever ways. John Salogiannis (University of Vermont) reveals how the protein AcbdA helps peroxisomes hitchhike on early endosomes—connecting intracellular transport with fatty acid metabolism. www.molbiolcell.org/doi/full/10....

From LSE… This scoping review examines mentorship interventions in postgraduate STEMM settings and finds major gaps in evidence, inclusivity, and program design—while offering clear guidance for building more effective, equitable mentorship programs. www.lifescied.org/doi/10.1187/...

From MBoC… How do heart muscle cells get their structure just right? Dylan Burnette (Vanderbilt University) shows that alpha-actinin-1 plays a key role in strengthening cell adhesions needed for proper sarcomere assembly in cardiac cells. www.molbiolcell.org/doi/10.1091/...

From LSE… What makes students feel included in introductory STEM courses? An analysis of nearly 2,000 student responses shows that teaching practices, policies, and classroom interactions matter. www.lifescied.org/doi/10.1187/...

From MBoC... Perihan Nalbant, et al., used optogenetics to boost the Rho activator GEF-H1 in mouse melanoma cells. The result: stronger contraction dynamics, expanding tumor spheroids, and single cells escaping—pointing to a role for Lbc GEFs in driving invasion. www.molbiolcell.org/doi/10.1091/...

From LSE… This Research Methods Essay explores how critical disability frameworks—like DisCrit—can help biology education researchers design more inclusive, accessible studies that truly center disabled voices. Practical strategies + tools included.

Join us in supporting the next generation of cell biologists. Your gift helps sustain meetings, publications, and outreach that keep our community thriving. Every contribution matters. www.ascb.org/donate/

From LSE... Do AntiBias statements reduce gender bias in teaching evaluations? A study finds mixed results—suggesting simple fixes aren’t enough. Read more: www.lifescied.org/doi/10.1187/...