DMM is proud to sponsor this meeting and publish important #Drosophila research, which you can find in our 'Drosophila as a Disease Model' subject collection. journals.biologists.com/dmm/collecti...

We are still welcoming submissions for our exciting special issue on #InVitroModels of #HumanDisease. We're looking forward to receiving your next paper by 3 November 2025. Editors: @vivianlilab.bsky.social, @ausmith.bsky.social & Joseph Wu #OpenAccess #DiseaseModelling #CallforPapers

Stuti Bakshi & co develop a hypomorphic mouse model of carbamoyl phosphate synthetase 1 deficiency, allowing for the assessment of the effects of mild hyperammonemia on development, with potential applications in new therapeutic advancements. 🐭 doi.org/10.1242/dmm.... #Hyperammonemia

It’s about who you know, not what you know. Uh Oh. In this new post on the Node, Umaymah Ahmad discusses the importance of speaking to others, asking questions and making connections. thenode.biologists.com/its-about-wh...

Did you know that authors that submit to DMM can now include a translation of the manuscript's abstract in their chosen language? journals.biologists.com/dmm/pages/news

Issue 8 is done and dusted! On the cover: A whole-mount mouse cochlea at postnatal day 16, labelled with anti-MSRB3 (a methionine sulfoxide reductase family member) antibody (green) and phalloidin (red). bit.ly/48rXYm0

Dr Sevda Boyanova (UK DRI at UCL) explores two mutations associated with frontotemporal dementia and ALS in her latest study. She delves into her research on behavioural analysis of dementia mouse models in a Q&A with @dmmjournal.bsky.social 👉 buff.ly/nyTmFrS

For #NPAW2025, read our interview with Claudia Charles-Niño, a postdoc in Luis Martinez's lab at the University of Florida, USA, investigating medical mycology, pathogenesis & immunology, focussing on understanding the molecular interactions between pathogens and host. doi.org/10.1242/dmm....

For #NPAW2025, read our interview with Victor Tapia, a postdoc in the labs of Catherine Lawrence & Paul Kasher at @manchester.ac.uk, investigating the causes & neuroprotective mechanisms of intracerebral hemorrhage using in vitro and animal experimental models. doi.org/10.1242/dmm.... #LovePostdocs

At DMM, we #LovePostdocs and for #NPAW2025, we are highlighting remarkable postdocs from our 'First person' series. Sevda Boyanova, a postdoc in the Wiseman lab at UCL, UK, is investigating behavioural analysis of mouse models of aspects of dementia. doi.org/10.1242/dmm.... @ukdri.ac.uk

Chronic recurrent multifocal osteomyelitis (CRMO) affects bone tissue & causes osseous inflammation. Huo & co reveal the immune cell landscape of CRMO-like mice by single-cell transcriptomics & identify a new potential therapeutic target for this disease. doi.org/10.1242/dmm....

Narayanan & co show, for the first time, that presymptomatic and postsymptomatic ALS mice exhibit lymph transport dysfunction and an association between inflammation and lymphatic marker upregulation in key affected tissues in the disease. doi.org/10.1242/dmm.... #ALS

September is #AFibAwarenessMonth. Atrial fibrillation is the most common progressive arrhythmia & is associated with stroke & heart failure. van Wijk & co show that different lamin variants trigger distinct molecular pathways that drive arrhythmogenic effects in #Drosophila. doi.org/10.1242/dmm....

Early embryos develop... and eliminate threats @estebanhoijman.bsky.social & co recently discovered that early embryos can eliminate bacterial infections before immune cells are formed. Take a look at the dynamics of their first encounter with microbes. thenode.biologists.com/early-embryo...

Well deserved, Owen Sansom @osansom.bsky.social , our DMM Monitoring Editor. 👏

Margherita Romeo & co generate the first transgenic C. elegans strain as a model of immunoglobulin light chain amyloidosis to investigate the mechanisms underlying the cardiac-specific toxicity occurring in the disease. doi.org/10.1242/dmm.... #ALAmyloidosis

Jun-yi Zhu & co identify endoplasmic reticulum stress as the converging point for synergy between APOL1-G1 and HIV-1 Nef in kidney cells. #HIV doi.org/10.1242/dmm....

Nguyen & co generate & characterise a novel mouse line containing one of the disease-associated DHDDS variants found in human RP59 patients to better understand the underlying mechanism leading to the human disease. 🐭 doi.org/10.1242/dmm....

📢Call for papers - submission deadline: 3 November 2025. Submit your latest research to our upcoming special issue on #InVitroModels of #HumanDisease. Editors: @vivianlilab.bsky.social , @ausmith.bsky.social & Joseph Wu journals.biologists.com/dmm/pages/in... #CallforPapers

preLighters go live! A light and lively face-to-face conversation between the preLighters @fadelvalle.bsky.social & Vibha Singh and the researchers probablycarmen.bsky.social & Eva Mejia-Ramirez will be hosted at the @focalplane.bsky.social webinar. 4 Sept, 14.00-15.00 BST Tune in!

We have received wonderful feedback from authors who have benefitted from Read & Publish agreements arranged by their institutional libraries. To read what authors have to say about fee-free Open Access publishing in DMM, visit bit.ly/4asqWRv.

Vanessa Gomez & co develop a Drosophila-based functional model that allows testing of the impact of individual human PEX variants in vivo, highlighting the value of using #Drosophila as a model to functionally test human mutations and refine genotype−phenotype correlations. doi.org/10.1242/dmm....

Jun-yi Zhu & co indicate that Nef and APOL1-G1 act synergistically to induce nephrocyte cell death through the endoplasmic reticulum stress pathway, providing a potential therapeutic target for HIV-1- and APOL1-associated nephropathies. doi.org/10.1242/dmm....

#FocalPlaneFeatures meets @prelights.bsky.social @fadelvalle.bsky.social & Vibha Singh have picked 2 fantastic #cellbio preprints & will be presenting their preLights alongside research talks from @probablycarmen.bsky.social & Eva Mejia-Ramirez. Register: focalplane.biologists.com/2025/08/20/f...

👀 Do you have an idea for a post on the Node that you have been postponing writing for a while? This is your chance to publish your piece at last for a chance to win £200. Submit your post by 30 September 2025. 📝 thenode.biologists.com/the-node-wri... #devbio #stemcell

Minou Verhaeg, Rosanne Govaarts & Maaike van Putten describe central nervous system involvement in a subset of individuals with Duchenne muscular dystrophy, as well as the behavioural alterations & brain pathology observed in humans & mice. 🧬 doi.org/10.1242/dmm.... #DMD

Sanja Rogic & co discuss their experience with the Canadian Rare Diseases: Models and Mechanisms (RDMM) Network and the emerging RDMM International network, which aim to accelerate functional research on rare disease genes and promote global collaborations. 🌍 doi.org/10.1242/dmm....

In our July cover, Bakshi et al. show a wild-type liver section of carbamoyl phosphate synthetase 1 (CPS1; red). A CPS1-deficient mouse model 🐭 was used to investigate the effects of CPS1 deficiency on ammonia metabolism and urea cycle function. Explore Issue 7 here: bit.ly/4mJRZgu

Sign up to our table of contents alerts so you won't miss our latest articles. journals.biologists.com/dmm/pages/al...

Looking for a home for your paper on viruses, and innate and cellular immunity? Our expert Academic Editor Sumana Sanyal (based at @ox.ac.uk), is committed to handling articles on this topic so send your article our way. Find out more at: journals.biologists.com/dmm/pages/ab...

Aaron Gibson and co develop an anti-DWORF antibody capable of recognising the canine protein and revealed reduced DWORF expression in #DuchenneMuscularDystrophy (DMD) dogs, laying the groundwork for DWORF-based gene therapy to treat DMD. doi.org/10.1242/dmm....

We are committed to improving equity, diversity and inclusion (EDI) in all our activities. Click on the image to read why we have adopted the C4DISC Joint Statement of Principles, and are signatories of the Joint commitment for action on inclusion and diversity in publishing. @c4disc.bsky.social

Kenji Sakakibara and colleagues establish a noninvasive and efficient in vitro drug screening technique based on morphology-based phenotypic analysis using a muscle cell model of spinal and bulbar muscular atrophy. doi.org/10.1242/dmm....

Montfries & co provide insight into mechanisms leading to eye malformation in fzd5 #zebrafish mutants & highlight the importance of considering multiple genetic defects when searching for the molecular aetiology of ocular malformations in humans. 🐟 👁️ doi.org/10.1242/dmm....

📢Call for papers - Submission deadline: 3 November 2025. Submit your latest research to our upcoming special issue on #InVitroModels of #HumanDisease. Editors: @vivianlilab.bsky.social, @ausmith.bsky.social & Joseph Wu journals.biologists.com/dmm/pages/in... #CallforPapers

ONLINE NOW in @biologists.bsky.social "Disease Models & Mechanisms:" from CRI's @haozhulab.bsky.social about siRNAs for liver cancer prevention ⬇️ read more #relentlessdiscovery 🧪 journals.biologists.com/dmm/article/...

We have received wonderful feedback from authors who have benefitted from Read & Publish agreements arranged by their institutional libraries. To read what authors have to say about fee-free Open Access publishing in DMM, visit bit.ly/4asqWRv.

Would you like to be the Node’s new Community Manager? If you're interested in #SciComm and passionate about #DevBio, apply to join the @dev-journal.bsky.social & @biologists.bsky.social team. Find out more about what the role entails: bit.ly/4otQ2GL #JobOpportunity

Are you an early-career researcher using Drosophila in your research? Sign up to be matched with a mentor as part of FlyCROSS 2025-26. Apply by 1 September 2025 thenode.biologists.com/mentees-flyc...

Zhe Chen & co show that human #tumours with similar metabolic signatures to #fruitfly tumours have lower mutational load. They highlight that depletion of key metabolites may be an evolutionarily ancient driving force for tumourigenesis. doi.org/10.1242/dmm....

Wallén & co expose #embryonicstemcells to alcohol during germ layer differentiation to study the effects of alcohol on the transcriptome, methylome and metabolome of embryonic germ layer cells during the developmentally crucial #gastrulation stage. doi.org/10.1242/dmm.... #PrenatalAlcoholExposure

In this Review, Kathleen Hudson, Logan Dameris, Rebecca Lichtler & Michael Cowley discuss findings that assess the effects of #developmentalexposure to #cadmium, followed by an exploration of dysregulation & dysfunction in major organs & organ systems. doi.org/10.1242/dmm.... @ncstate.bsky.social

Epilepsy is a chronic neurological disease affecting ∼70 million people worldwide. So-Hyun Lee & co create a #zebrafish model with a loss-of-function mutation in slc25a22a that can help us understand #epilepsy and find better treatments in the future 🐟 . doi.org/10.1242/dmm....

Samantha Thompson, @mrobichaux.bsky.social & co investigate how rod photoreceptor synapses are impacted during diseases like retinitis pigmentosa by using a mouse model where mislocalised rhodopsin can be seen at the synapse. 🐭 👁️ doi.org/10.1242/dmm.... #Rhodopsin #Photoreceptors

📢Call for papers - new submission deadline: 3 November 2025. Submit your latest research to our upcoming special issue on #InVitroModels of #HumanDisease. Editors: @vivianlilab.bsky.social, @ausmith.bsky.social & Joseph Wu journals.biologists.com/dmm/pages/in... #CallforPapers

Variants in AARS1 have been associated with multi-system recessive phenotypes & dominant axonal peripheral neuropathy. Kuo & co use a humanised yeast model to test the functional consequences of 16 AARS1 missense variants reported in recessive diseases. doi.org/10.1242/dmm....

Our next extraordinary biologist is Norbert Perrimon, a @dmmjournal.bsky.social Editorial Advisory Board member and author of one of @dev-journal.bsky.social's most cited papers. #100biologists @perrimonlab.bsky.social

Pinte et al. investigated the role of EHF in lung homeostasis & disease by differentiating human induced pluripotent stem cells into lung airway epithelial cells & seeding them in an air–liquid interface culture system that mimics aspects of the respiratory tract environment. doi.org/10.1242/dmm....

Namal Coorey & co develop a new model system that enables genomic and proteomic analyses to identify genes, proteins and pathways integral to the bioactivity of MTDIA, a potent anti-cancer transition-state analog and inhibitor of human MTAP. doi.org/10.1242/dmm.... #TransitionStateAnalogs #cancer

Issue 6 is complete! Explore the issue: bit.ly/45a3yrg On the cover: Monfries et al. show the eye of a maternal-zygotic frizzled 5 mutant zebrafish 5 days post-fertilisation, revealing tissue architecture with phalloidin-FITC (actomyosin cortical cytoskeleton, grey) & Sytox-Orange (nuclei, blue).