In a new paper, Jahmel Fowler, Michelle Gray & co show that mutant huntingtin expression in somatostatin-expressing interneurons contributes to anxiety-like behavior in male mouse model of #HuntingtonsDisease doi.org/10.1242/dmm.... #UABMedicine

We are delighted to be media partners with @dmmjournal.bsky.social for our 4th Metabolism in Health & Disease Conference on 10-13 October. Check out their Metabolic Disorders subject collection: journals.biologists.com/dmm/collecti...

Check out this new review from Roger Smith and Marc Mendillo @feinberg.northwestern.edu on the role of heat shock transcription factors in #development, #NeurodegenerativeDisease and #cancer, and their emerging therapeutic potential doi.org/10.1242/dmm....

Our Reviews Editor, Dr Dina Mikimoto, is attending #Vaccinology : A New Era in #VaccineDesign, this May in Killarney with @keystoneSymposia.bsky.social Looking forward to big ideas, bold science, and great conversations. keysym.us/KSVaccines26 #KSVaccines26

In a new paper in our #InVitroModelling Special Issue, @amylucassen.bsky.social, Heiko Locher & co develop human #iPSC derived inner ear #organoids that reveal ototoxicity in response to cisplatin and gentamicin doi.org/10.1242/dmm....

The money question comes up often in conversations with scientists, so our journals chose to address it directly and be transparent about the cost of publishing. Our latest Editorial breaks down exactly where that money goes.

In a new Resources & Methods paper in our #InVitroModelling Speical Issue, Rahmana, Hapangama & co develop an in vitro model of peritoneal #endometriosis using patient-derived cells to accelerate understanding of disease onset & development of novel treatment options doi.org/10.1242/dmm....

The latest #EditorsChoice is from Miller, Halloran & co @uwmadison.bsky.social as they show that inhibition of chemokine receptor (Cxcr4) signaling improves habituation learning and increases cAMP signaling in a #zebrafish model of neurofibromatosis #NF1 doi.org/10.1242/dmm....

Don't miss the @fusionconf.bsky.social 4th Metabolism in Health & Disease conference. For all those investigating individual molecules, to those carrying out population studies & clinical trials: 📆Talk submission: 13 April 💰Grants & discounts available See website for details: bit.ly/4brQTC6

Our new Special Issue has launched with a fascinating interview with @hansclevers.bsky.social where he discusses the future of #organoid and #StemCell research "My personal opinion is that the strength of the organoids is their simplicity." doi.org/10.1242/dmm.... @hubrechtinstitute.bsky.social

Harb, @WangLysolab & co present a comprehensive natural history of a Pompe disease mouse model - comprising a human-relevant mutation - that recapitulates key disease features and can be used in preclinical therapeutic testing doi.org/10.1242/dmm....

In a new Resources & Methods paper Mele, Johnson & co present an easy-to-use, open-access & customisable tool to analyse #Drosophila larval movements, enabling rapid assessment of organism behaviour without specialised equipment or coding expertise doi.org/10.1242/dmm....

As today is #WorldTBDay we urge you to read this powerful interview with Dr Zolelwa Sifumba highlighting how her experience as a #tuberculosis survivor, alongside her training as a medical doctor, complements her work as a patient advocate for TBProof in South Africa doi.org/10.1242/dmm....

This new article from Paul Iyyanar, Nirpesh Adhikari, Yu Lan & Rulang Jiang shows that ALX1 is a crucial transcription factor acting upstream of the gene regulatory network that controls cranial mesoderm patterning and craniofacial #muscledevelopment doi.org/10.1242/dmm....

This Saturday is #IntlForestDay 🌳 DYK that we plant a tree in our forest in the UK for every paper we publish & we preserve a piece of ancient woodland for every peer-reviewer?! forest.biologists.com

Check out our February issue's preLights in disease biology highlights: journals.biologists.com/dmm/article/... With featured preLight from Manuel Lessi & Riccardo Nagni on a CRISPRi screen for schizophrenia-associated genes prelights.biologists.com/highlights/h... @prelights.bsky.social

Mirror mirror on the wall, what is the fairest funding call? @jontytownson.bsky.social covers two #preprints (@kristine-willis.mstdn.science.ap.brid.gy & team) using data & social science to analyse how significant biological discoveries are made #preLight⬇️ prelights.biologists.com/highlights/t...

DMM is supporting the Developmental origins of #PaediatricCancer symposium. Discover the latest cutting-edge research on the modelling, biology and treatment in the field. The abstract submission deadline has been extended to 20 March 2026 - in 2 days! Info www.cclg.org.uk/information-...

We're proud to be sponsoring the Tumour Ecosystem conference @helloeacr.bsky.social in Bergamo that is starting today: eacr.org/conference/t... Our Reviews Editor Dr Dina Mikimoto is there and will be happy to chat about all thing DMM!

Here's a quote from our first person interview with Helen Molteni @chopresearch.bsky.social: "DMM has a thorough review process that provides constructive feedback, which I found especially helpful as an early-stage researcher" Read the full interview here: doi.org/10.1242/dmm....

Check out our latest issue with thought-provoking Editorial & Perspective articles & cutting-edge Research, Resources & Methods papers! On the cover we have a scanning electron microscopy image of zebrafish larva 🐟️ 📗 journals.biologists.com/dmm/issue/19/2

In this issue we have 2 Research papers on mucopolysaccharidosis type IVA - a rare, progressive, inherited #LysosomalStorageDisorder caused by a deficiency of the GALNS enzyme. It causes severe skeletal dysplasia, short stature, joint, respiratory, and heart issues 🧵 Research papers below

New paper from Xiao, Xia & co shows that MAP3K1 colocalizes to F-actin & centrosomes & that its overexpression hyperactivates MAPK and WNT signaling, causing broad developmental and sexual differentiation defects in a mouse model 📰 doi.org/10.1242/dmm....

This new paper from Kimberley Evason @huntsmancancer.bsky.social & co provides insights into mechanisms of hepatocellular carcinoma, with findings suggesting that microRNA-21 is a target of activated β-catenin that mediates some of its effects during liver tumorigenesis 📰 doi.org/10.1242/dmm....

Our new Editorial from EiC Liz Patton @uoe-igc.bsky.social urges you to CITE IT RIGHT! Citations hold immense power in shaping the history of a field & the success of careers. Accurate & CONSIDERATE citation of the literature is vital! doi.org/10.1242/dmm....

Celebrate #InternationalWomensDay with us and read interviews with women leaders in disease biology research: Peggy Goodell on stem cells and ageing in the blood: doi.org/10.1242/dmm.... Sadaf Farooqi on investigating the genetics underpinning obesity: doi.org/10.1242/dmm....

@miguelrmphd.bsky.social, Douglas Watt Allan, Amritpal Mudher & co model Tau-induced neurotoxicity in the #Drosophila wing, enabling a rapid, genetically tractable in vivo system for #tauopathies studies. Read doi.org/10.1242/dmm.... @sotonbiosciences.bsky.social @unisouthampton.bsky.social

Join @helloeacr.bsky.social Cancer Genomics in Essen, Germany (12-14 May 2026) to discover the latest breakthroughs in cancer genomics, multiomics and computational biology: Travel Grant & abstract submission deadline: 16 March 2026 Registration deadline: 13 April 2026

@tsoelter.bsky.social @emmafjones.bsky.social @bnlasse.bsky.social & co quantified gene and splice junction expression from single-nuclei RNA-seq data from the #cerebral cortex and #kidney in atypical Schinzel‑Giedion syndrome–variant and wild‑type mice. #RareDisease Read: doi.org/10.1242/dmm....

In their Perspective, Lori Forster and @gutmannlab.bsky.social apply the nested ecosystems concept to #glioma, clarify how diverse risk factors shape CNS oncobiology, and highlight new opportunities for targeted disease‑mitigation strategies. Read: doi.org/10.1242/dmm....

Registration is open for @dmmjournal.bsky.social 2026 meeting 'Innovative Preclinical Models for Pediatric Cancer Research' organised by James Amatruda amatrudalab.bsky.social, Pratiti (Mimi) Bandopadhayay, bandolab.bsky.social, Ana Banito & Elaine Mardis. Find out more bit.ly/46r84Ca #DMM2026cancer

I'm excited to be heading to Wellcome Genome Campus next week for #Microbiome26 @eventswcs.bsky.social Please come chat to me if you're interested in publishing with @dmmjournal.bsky.social & joining our microbiome collection of articles: journals.biologists.com/dmm/collecti... #MicrobiomeSky

Luo Ting Huang, Yaser Tahamtani, @nictitate.bsky.social & co explored the possibility of magnetic selection of insulin-expressing stem cell‑derived β‑cells using a CRISPR/Cas9 technology and transmembrane glycoprotein CD19 as a marker. @bcchresearch.bsky.social Read: doi.org/10.1242/dmm....

Registration is open for @dmmjournal.bsky.social 2026 meeting 'Innovative Preclinical Models for Pediatric Cancer Research' organised by James Amatruda amatrudalab.bsky.social, Pratiti (Mimi) Bandopadhayay, bandolab.bsky.social, Ana Banito & Elaine Mardis. Find out more bit.ly/46r84Ca #DMM2026cancer

Jingyi Long, Kevin Lüthy, Mireia Coll-Tané, Annette Schenck & co used #Drosophila scRNA-seq to refine an #epilepsy gene co-expression network, reproducing seizures for 4 genes, identifying 2 new candidates and finding 3 genes whose knockdown was protective. Read doi.org/10.1242/dmm....

Timothy Shaw, Mercedes Gonzalez-Juarrero & co investigated Mycobacterium avium complex isolate-dependent differences in #PulmonaryDisease, quantified them and added novel insights into #lung immune cell profiling and whole-body plethysmography in prolonged infection. Read doi.org/10.1242/dmm....

Mireia Moreno-Estellés, Pascual Sanz & co improved their astrocytic model of #LaforaDisease by maturing #astrocytes, showing that they accumulate larger and granular PGBs (insoluble glycogen form), recapitulating key characteristics of the disease. Read doi.org/10.1242/dmm.... @ibv-csic.bsky.social

#apaperaday Today's pick is by Wang et al published in @dmmjournal.bsky.social on a Duchenne rat model with a deletion of exon 45 in rat dystrophin gene (one of the most common deletions in human dystrophin gene). Obviously I had to make an origami rat to decorate the paper. doi: 10.1242/dmm.052578

DMM is supporting the Developmental origins of #PaediatricCancer symposium. Discover the latest cutting-edge research on the modelling, biology and treatment in the field. Just 3 days left before the abstract submission deadline on 28 Feb 2026 Info www.cclg.org.uk/information-...

Simona Totaro, Valentina Massa, @vaccarilab.bsky.social & co showed that somatic STAG2 variants occur in #glioblastoma and #medulloblastoma, and that reducing SA1 during fly brain development disrupts neural stem cell differentiation and drives tumorigenesis. Read doi.org/10.1242/dmm....

Rebekah Niewoehner, Rolf Stottmann & co found that pathogenic Ttc21b variants, the primary #cilia gene, contribute to primary #microcephaly, with homozygous #mouse mutants showing severe #microcephaly due to impaired neural progenitor proliferation and differentiation. Read doi.org/10.1242/dmm....

Tao Wang, Cynthia Daoud, Abbass Jaber, Isabelle Richard & co generated a new #RatModel of #DuchenneMuscularDystrophy with an exon 45 deletion using CRISPR/Cas9, recapitulating the most-frequent single-exon deletion and key features of #DMD. Read: doi.org/10.1242/dmm....

Do you have a DMM-related workshop idea but need support with logistics or funding? Our annual call for topics is now open, and if your idea is selected, you can bring it to life. #BiologistsWorkshops Details: www.biologists.com/workshops/pr...

Arístides López-Márquez, Cecilia Jiménez-Mallebrera & co used CRISPR/Cas9 to generate the first #MouseModel of a pathogenic variant that involves glycine substitutions in the triple helical domain of collagen VI alpha chains and leads to congenital #MuscleDisease. Read doi.org/10.1242/dmm....

This year, DMM is supporting the 'Integrating Multi-Modal, Multi-Scale Models of Cardiovascular Disease Mechanisms' workshop organised by Jennifer Davis, Christine Mummery & Beth Pruitt. Application deadline 8 May 2026 www.biologists.com/workshops/no... #CardiovascularDisease

Check out the #FirstPerson interview with Mrudula Dileep and Anamika Sharma, the collaborators behind our January issue #EditorsChoise research article on the connection between mitochondrial stress and #ParkinsonsDisease. Read doi.org/10.1242/dmm....

@jtrendbio.bsky.social, @clarkinbonebiol.bsky.social & co used synchrotron X-ray computed tomography to characterise the distribution and structure of intracortical canals and #osteocyte lacunae, helping identify molecular drivers of age-related cortical porosity. Read: doi.org/10.1242/dmm....

For International Day of Women & #GirlsInScience revisit this editorial from Editorial Board Member Kirsten Sadler on the shifting culture of the scientific workforce doi.org/10.1242/dmm.... #WomenInScience #WomenInSTEM #EveryVoiceInScience

Jing-Fu Bao, Youhua Liu, Aiqing Li & co developed two methods to simulate human uremic #cardiomyopathy, compared these approaches across several #RatModel and#MouseModel, and identified CCR-2 as a potential therapeutic target. Read doi.org/10.1242/dmm....

Esther Becker, Simone Mayer and @lenakutscher.bsky.social teamed up to summarise current approaches for generating #cerebellar #organoids and advocate for the establishment of rigorous quality control standards to ensure reproducible, high-quality research. Read doi.org/10.1242/dmm....