In October's #EditorsChoice, Kenneth Katschke, Marion Jeanne & co investigate the role of #HTRA1 in age-related retinal degeneration #AMD. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

In September's #EditorsChoice, Victor Tapia, Catherine Lawrence, Paul Kasher & co investigate #cholesterol homeostasis connection to #COVID19 in #zebrafish and #CellCulture models. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

In August's #EditorsChoice, Gianna Maggiore, @haozhulab.bsky.social & co showed strong clinical potential in reducing #HepatocellularCarcinoma by targeting the actin-binding protein anillin via #siRNA knockdown in #MouseModel. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

December Issue's #EditorsChoice highlights an article that uses the #Xenopus cell model to study vertebrate motile #cilia and the involvement of LRRC56 protein in #PrimaryCiliary Dyskinesia #PCD #RareDisease Read the short, simple retelling here doi.org/10.1242/dmm.... Details in the thread.

In July's #EditorsChoice, Kamila Karimjee, Richard J. Piercy & co develop long-term, age-associated activity quantification for dog model of #DuchenneMuscularDystrophy #DMD ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

Yeon Ja Choi, Jiang Chen & co developed a genetically engineered mouse model expressing a mutant Wdpcp gene, implicated in several ciliopathies, including Bardet-Biedl syndrome. This model provides new insights into WDPCP’s structure–function relationships. Read doi.org/10.1242/dmm....

In June's #EditorsChoice, Laetitia Pinte, Ludovic Vallier & co investigate the function of EHF transcription factor in #LungHomeostasis and #LungDisease. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

In May's #EditorsChoice, Stephanie May, Tom Bird & co explore targeted radiation in #LiverCancer ablation ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

In April's #EditorsChoice, @daniyaljafree.bsky.social & co explore microvascular abnormalities that arise early in polycystic #KidneyDisease ⚡https://doi.org/10.1242/dmm.052437 📰 doi.org/10.1242/dmm.... #PCKD

Christian Gonzalez, @simonytanglab.bsky.social & co show that a chronic high-fat diet and impaired β-cell function mouse model more accurately captures the multifactorial inflammatory microenvironment of intervertebral disc degeneration induced by #Type2Diabetes #T2D Read doi.org/10.1242/dmm....

In March's #EditorsChoice, Griffin, Saint-Jeannet & co come face to face with a new #Xenopus model for a rare #SplicingDisorder ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm.... #CraniofacialDevelopment

In February's #EditorsChoice Thornton, Sharma & co turn #HIV treatment up a Notch(3) ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

Roza Masalmeh, @margaretframe.bsky.social & co uncover a FAK–ROCK-driven mechanism that links #ExtracellularMatrix mechanical cues to the rewiring of energy #metabolism, affecting mitochondrial function and malignant behaviour. #mitochondria #cancer Read doi.org/10.1242/dmm....

In January's #EditorsChoice, Wu, @richardbartfai.bsky.social & co de-liver insights into improving organoid-derived #hepatocyte culture by analysing transcription factor networks ⚡https://doi.org/10.1242/dmm.052296 📰 doi.org/10.1242/dmm....

This month's Editor's Choice highlights an article on the connection between #InnateImmunity and #LipidMetabolism, investigated using the worm model #Celegans Read the short, simple retelling here journals.biologists.com/dmm/article/... More details in the thread. @cswormlab.bsky.social

The tiny hero behind advances in developmental biology, toxicology, immunology & genetics? The #Zebrafish, a key model for human disease. Researchers now urge standardised reporting to boost #reproducibility @aburger2009.bsky.social @khaichung.bsky.social journals.biologists.com/dmm/article/...

In this issue, we focus on #foreverchemicals, #pollutants that build up in the environment and living organisms, resist removal, and are increasingly tied to developmental and health issues. Details about the featured articles are collected in the thread. journals.biologists.com/dmm/issue/18...

In our latest editorial, @labliston.bsky.social celebrates the perseverance behind the 2025 #NobelPrize in Physiology or Medicine. Learn how regulatory T cells act as the immune system's 'brakes', and how immunology and genetics came together to uncover these elusive cells.

DMM is supporting the Developmental origins of #PaediatricCancer symposium. Discover the latest cutting-edge research on the modelling, biology and treatment in the field. Abstract submission until 28 Feb 2026 Info www.cclg.org.uk/information-... Registration www.tickettailor.com/events/cclg/...

Max Gijsbertsen, Jeroen van de Peppel & co established three patient-derived iPS cell lines for in vitro modelling of #craniosynostosis syndromes, #congenital conditions in which the baby's skull bones fuse earlier than they should. Read bit.ly/48kjGYS #raredissease @erasmusmc.bsky.social

Read about the disease-focused expansion of The Mammalian Phenotype Ontology and its improved alignment with the Human Phenotype Ontology in a recently published article by Susan Bello, Cynthia Smith & co: bit.ly/4amknlO @modcur.bsky.social @jacksonlab.bsky.social @mousegenome.bsky.social

Learn about the inspiration behind Kaitlyn Rutter's 1st-author paper with Susan Brockerhoff & co, which uses #ZebrafishModel to explore links between de novo purine synthesis enzyme mutations and cone photoreceptor degeneration. #retinopathy Interview bit.ly/3MmoeW1 Paper bit.ly/4ixBIdt

Kaitlyn Rutter, Susan Brockerhoff & co generated a #ZebrafishModel carrying mutations in the enzyme required for de novo purine synthesis, then examined how these mutations affected cone photoreceptor degeneration, a process that typically results in blindness. #retinopathy Read more bit.ly/4ixBIdt

@cpschaaf.bsky.social & his team developed two new mouse models of the Bosch-Boonstra-Schaad optic atrophy syndrome, carrying patient-specific Nr2f1 variants and capturing key aspects of the #BBSOAS, offering insights into genotype-phenotype links underlying the syndrome. #raredisease bit.ly/4rsjQVC

In a new paper from Braunreiter, Kabadi & co @sarepta.com humanized mouse model of #DuchenneMuscularDystrophy displays molecular & functional deficits of #DMD that were restored by human-targeted therapy confirming its suitability for developing new treatments journals.biologists.com/dmm/article/...

In a #Drosophila model of #spinocerebellar ataxia 3 Animesh Banerjee, Sherry Shiying Aw & co @astar-gis.bsky.social show that tremor primarily arises from GABAergic dysfunction within the adult ventral nerve cord, identifying a subset of ~30 impaired neurons 📰https://bit.ly/4oMz8CM

Meet Lucie Perillat, 1st author of paper with Ronald Cohn & co that characterized the long-term effects of a Becker #MuscularDystrophy (BMD)-like deletion of Dmd exons in mice. This sheds light on BMD pathology and mechanisms 👩🏽‍🔬https://bit.ly/4o8aFXk 📰http://bit.ly/49wQ6jP

We have a fantastic line up of speakers for our 2026 Journal Meeting organised by @amatrudalab.bsky.social, @bandolab.bsky.social, @banitolab.bsky.social and Elaine Mardis @nationwidekids.bsky.social! 🚨Register your interest now so you're first to get updates🚨 www.biologists.com/meetings/dmm...

This paper from Minakawa, Seki & co generated 2nd generation transgenic marmoset models of #Spinocerebellar ataxia 3 that replicated progressive motor deficits and neuropathology & provides a powerful platform for studying this disease journals.biologists.com/dmm/article/...

A new #DMMPerspective from Wenqing Xu & @aleprigio.bsky.social explores increasing evidence of #neurodevelopmental aspects in #HuntingtonsDisease & early interventions that might lead to prevention or delay of the disease pathology journals.biologists.com/dmm/article/...

Our latest #EditorsChoice from Katschke, Jeanne & co @genentech.bsky.social investigated the role of HTRA1 in samples from patients with age-related macular degeneration & mouse models EC highlight & article: ⚡https://tinyurl.com/ze3czu7r 📰 tinyurl.com/ynhhw5b4

The Tumour Ecosystem conference in Bergamo, Italy (17-19 Mar 2026) is an opportunity to gain a deeper understanding of the latest exciting breakthroughs on multiple aspects of the tumour microenvironment: bit.ly/4owGcUm @helloeacr.bsky.social

Meet Jack Barrington, 1st author of paper with Stuart Allan & co showing complex IL1 functions during acute intracerebral #haemorrhage. Jack also received a DMM grant to present this at an international conference 🧑🔬https://tinyurl.com/3fmra89p 📰https://tinyurl.com/y5tcmajm

We are pleased to be a media partner for the @embl.org Conference: The new cardiobiology: engineering, vascular, and molecular insights, 16 - 19 Feb 2026 Abstract submission: 17 Nov 2025 Registration (On-site): 5 Jan 2026 Registration (Virtual): 9 Feb 2026 bit.ly/43BGa4V

In our latest Editorial, members of the COST Action TEATIME CA20135 welfare group advocate for automation in animal research alongside advances in AI and machine learning to enhance rigor, robustness and translatability of animal studies journals.biologists.com/dmm/article/...

New Review from James Amos-Landgraf & colleagues @umissouripress.bsky.social provides guidance on selecting suitable animal models for specific disease aspects of #COVID19 to improve translatability of studies journals.biologists.com/dmm/article/...

This new Resources & Methods paper from Gyanu Lamichhane & co at John Hopkins establishes a cost-effective BALB/c mouse model of #Mycobacterium abscessus #LungInfection for preclinical drug evaluation and facilitating the development of new treatments journals.biologists.com/dmm/article/...

For our #InfectiousDisease Special Issue we interviewed Dr Sifumba Zolelwa who discusses how her experience as a #tuberculosis survivor, along with her training as a medical doctor, complements her work as a #PatientAdvocate journals.biologists.com/dmm/article/...

This Perspective from Dilys Santillo, Evangelos Bellos & Vanessa Sancho-Shimizu explores common gut immunity functions in multisystem inflammatory syndrome in children, #IBD & Kawasaki disease to inform prevention & treatment @imperialcollegeldn.bsky.social journals.biologists.com/dmm/article/...

Check out this Review for our Special Issue from Rachael Dangarembizi, Amalia Awala & Anja de Lange from the University of Capetown on #neuroinflammation during #fungal infection, which is an essential host defence but also contributes to neuropathology journals.biologists.com/dmm/article/...

In this Resources & Methods paper, Victoria Ektnitphong, @michaelshiloh.bsky.social & co developed a humanized lung-on-a-chip model that revealed early immune responses to a non-tuberculous #mycobacterium relevant for drug discovery journals.biologists.com/dmm/article/...

For our #InfectiousDisease Special Issue we interviewed the marvelous @harmitmalik.bsky.social ! We discussed the #viral arms race, how to support mentees and the beauty of basic science 🔬 journals.biologists.com/dmm/article/...

Two closely related fungi – Cryptococcus deneoformans (Cd) and Cryptococcus neoformans (Cn) – can cause serious infections. Charles-Niño & co explore how Cd and Cn respond to temperature and how they interact with human tissues, including infection. doi.org/10.1242/dmm....

Caroline Beltran & co describe a novel and unbiased 3D imaging approach that visualises how the lung granulomas that are characteristic of TB infection form, evolve & spatially organise. 🐭 🫁 doi.org/10.1242/dmm.... #Tuberculosis #Granuloma

Bats can carry deadly viruses without getting sick. Now, Ng & Wang give a timely & fascinating #DMMPerspective on the possible translation of discoveries from bats to humans, in the context of treating and preventing #infectiousdiseases. 🦇🧫 doi.org/10.1242/dmm....

Biological conduction bridges skip a beat. ❤️ #preLight (from Theodora Stougiannou) of a study generating stem-cell derived AVN-like pacemaker cells + demonstrating their functionality for biological conduction bridge applications in vivo. @uhnresearch.ca prelights.biologists.com/highlights/h...

The G307D variant of TOM1, an endosomal adaptor protein, is linked to inborn errors of immunity. Ryhänen & co use patient cells to show that this mutation disrupts the interaction of TOM1 with TOLLIP, impairing cargo trafficking & autophagy regulation. doi.org/10.1242/dmm....

Using a zebrafish model & human brain tissue, Tapia & co find that high levels of CH25H and 25HC are linked to small brain bleeds following COVID-19 infection. They show that 25HC can damage endothelial cells, especially when cholesterol levels are low. doi.org/10.1242/dmm....

The deadline to submit to our Special Issue 'In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery' is tomorrow.🚨 We look forward to receiving your next submission for this exciting special issue! #OpenAccess bit.ly/4h1092r

Save the date and register for abstract updates for @dmmjournal.bsky.social's 2026 Journal Meeting. 'Innovative Preclinical Models for Pediatric Cancer Research'. biologists.com/meetings/dmm... #DMM2026cancer