@jtrendbio.bsky.social, @clarkinbonebiol.bsky.social & co used synchrotron X-ray computed tomography to characterise the distribution and structure of intracortical canals and #osteocyte lacunae, helping identify molecular drivers of age-related cortical porosity. Read: doi.org/10.1242/dmm....

For International Day of Women & #GirlsInScience revisit this editorial from Editorial Board Member Kirsten Sadler on the shifting culture of the scientific workforce doi.org/10.1242/dmm.... #WomenInScience #WomenInSTEM #EveryVoiceInScience

Jing-Fu Bao, Youhua Liu, Aiqing Li & co developed two methods to simulate human uremic #cardiomyopathy, compared these approaches across several #RatModel and#MouseModel, and identified CCR-2 as a potential therapeutic target. Read doi.org/10.1242/dmm....

Esther Becker, Simone Mayer and @lenakutscher.bsky.social teamed up to summarise current approaches for generating #cerebellar #organoids and advocate for the establishment of rigorous quality control standards to ensure reproducible, high-quality research. Read doi.org/10.1242/dmm....

Congratulations to our Editor-in-Chief, Liz Patton, on receiving the 2026 Christiane Nüsslein-Volhard Award for the pioneering work using #zebrafish for #melanoma research. She will give a CNV Award Lecture at the 2026 @ezsociety.bsky.social meeting www.ezsociety.org/cnv-awardee-... #WomenInScience

DMM is supporting the Developmental origins of #PaediatricCancer symposium. Discover the latest cutting-edge research on the modelling, biology and treatment in the field. Abstract submission until 28 Feb 2026 Info www.cclg.org.uk/information-... Registration www.tickettailor.com/events/cclg/...

Brand new review by Emily Troemel, Patricija van Oosten-Hawle & Michalis Barkoulas explores discoveries from C. elegans that elucidate connections between immune responses and #proteostasis doi.org/10.1242/dmm.... #Celegans #immunity

This new paper from Luo Ting Huang, @nictitate.bsky.social & co @bcchresearch.bsky.social used genetic engineering to facilitate magnetic-activated cell sorting enrichment of insulin-producing stem cell-derived β cells with implications for cell-replacement therapy doi.org/10.1242/dmm....

Meet Priyanka Tibarewal, 1st author of new paper with Bart Vanhaesebroeck & co @ucl.ac.uk presenting a mouse model of human PTEN variants to elucidate associations with tissue overgrowth, #autism spectrum disorder and #cancer Interview & article: 🥼 doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

Join Cancer Genomics in Essen, Germany (12-14 May 2026) to discover the latest breakthroughs in cancer genomics, multiomics and computational biology: bit.ly/47xVTo7 @helloeacr.bsky.social

This new paper from Bäumges, Lübke & co combined translational readthrough therapy & degradation of release factors to restore FUCA1 in an in vitro model of a #LysosomalStorageDisease doi.org/10.1242/dmm....

Our latest #EditorsChoice from Dileep, Sharma, Hasan & co uncovers early warning signs of #ParkinsonsDisease inside the cell’s powerhouse EC highlight & article: ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm.... #Drosophila #mitochondria

Our December issue marked the end of #biologists100 with a cover highlighting many of the scientists in our community, some of the featured #100biologists, as well as our Editors & in-house team! Thank you everyone for helping us celebrate @biologists.bsky.social 100-year anniversary in style 🎉

Meet Nayeli Reyes-Nava, 1st author of #EditorsChoice paper with @edwardmarcotte.bsky.social, @jbwallingford.bsky.social & co who used #Xenopus to study #Cilia motility disturbances in primary ciliary dyskinesia #PCD Interview & article: doi.org/10.1242/dmm.... doi.org/10.1242/dmm....

This study from Shin, Park & co demonstrates that PDGFRα+ fibroblast ablation worsens #asthma pathology by elevating neutrophil numbers and activation, highlighting fibroblast–immune crosstalk in asthma pathogenesis doi.org/10.1242/dmm....

Meet Chaitali Khan, 1st author of resource paper with Nasser Rusan @NIH that established reproducible #Drosophila metastatic tumour models, enabling organ-specific metastasis tracking & the study of tumor–host interactions Interview & article: doi.org/10.1242/dmm.... doi.org/10.1242/dmm....

Julien Debbache, Lukas Sommer & co generated a novel sporadic #MouseModel of Nf1 wild-type malignant peripheral nerve sheath tumours, driven by conditional expression of oncogenic BrafV600E and loss of Pten in the glial lineage. #sarcoma Read doi.org/10.1242/dmm....

Check out this new #preLight post on the influence of macrophages on human #kidney organoids! With a bonus response from the authors of the #preprint

In this new paper from Schuster-Winkelmann, Aszodi & co they show that a humanized mouse model engrafted with PBMCs from a patient with rheumatoid arthritis mirrors pathology & treatment response, enabling translational studies of disease mechanisms & novel therapies doi.org/10.1242/dmm....

Cassandra Diegel, @bartwilliams.bsky.social & co generated mice carrying an Lrp5 allele lacking the class A repeats and observed reduced bone mass and retinal vascularisation, suggesting an essential role for these repeats in normal #LRP5 function. Read doi.org/10.1242/dmm....

Meet Camille Lacarrière-Keïta, 1st author of paper with Steve Jean & co that shows #autophagy inhibition in #Drosophila intestinal stem cells increases enteroendocrine cell differentiation Interview & article below: 👩🏼‍🔬https://doi.org/10.1242/dmm.052770 📰https://doi.org/10.1242/dmm.052214

Caiqin Zhang, Yangchao Don, Changhong Shi, & co developed a humanised STAT2 #MouseModel of Japanese #encephalitis #virus, which exhibited a phenotype resembling clinical human infections, characterised by elevated viral load and increased proinflammatory cytokines. Read doi.org/10.1242/dmm....

Check out this new paper from Gineste, Reiss & Laporte that shows there is no improvement in muscle phenotype observed in recessive Ryr1-linked centronuclear myopathy mice following tamoxifen administration doi.org/10.1242/dmm....

Elizabeth Apsley, Esther Becker & co used CRISPR-based gene editing in cerebellar #organoids to model specific aspects of early human cerebellar development, with a particular focus on the role of the previously understudied FOXP2. #cerebellum #CRISPR Read doi.org/10.1242/dmm....

To celebrate our publisher's (@dmmjournal.bsky.social) 100-year anniversary in 2025, we looked back over our comparably short history as a journal, highlighting our support for ECRs, including Conference Travel Grants doi.org/10.1242/dmm....

Robin Karge, Stefan Wolking & co used #Drosophila to model a rare form of developmental and epileptic #encephalopathy associated with genetic defects in AP2M1 and investigated the relationship between seizures and clathrin-mediated endocytosis. #epilepsy Read doi.org/10.1242/dmm....

In this interview with Margaret (Peggy) Goodell @goodell-lab.bsky.social we discussed her impressive career, the parallels between ageing and cancer in the blood, and the lessons we can learn from stem cell biology to understand and mitigate disease. doi.org/10.1242/dmm....

In this new paper, Pair, Yacoubian & co show that phosphorylation of 14-3-3θ protein disrupts its interactome in mouse brain and causes dysregulation of axonal trafficking, which may impair clearance of aggregated proteins in neurodegenerative disorders doi.org/10.1242/dmm....

Our latest editorial from sergemostowylab.bsky.social & @kateduncan.bsky.social discusses the global problem of antimicrobial resistance & emerging solutions. This is in our collection of articles celebrating the 100-year anniversary of @biologists.bsky.social doi.org/10.1242/dmm....

We are pleased to be a media partner for the @embo.org Workshop: Brain (epi)genome, 21 - 24 Apr 2026, EMBL Heidelberg and Virtual. Abstract deadline today! Abstract submission: 13 Jan 2026 Registration (On-site): 10 Mar 2026 Registration (Virtual): 14 Apr 2026 t.co/sWwIh4rQZT

Meet Astrid Baattrup, 1st author of paper with @kimbakjensen.bsky.social & co showing that transcription factor ETV1 regulates emergence of hormone-producing subtypes of enteroendocrine cells Interview & article below: 👩🏼‍🔬https://doi.org/10.1242/dmm.052698 📰https://doi.org/10.1242/dmm.052610

New paper from Minzi Mao, Jianjun Ren & co reveals distinct immune dynamics in orthotopic vs subcutaneous HPV-positive oropharyngeal cancer models, helping refine preclinical cancer immunology studies doi.org/10.1242/dmm....

In their paper, Sarah Gerstner, Hanna Berger-Santangelo, Silke Pauli, Annette Borchers & co used the #Xenopus model to study a rare syndrome with #Craniofacial malformations caused by truncating variants in fibrosin-like 1, which they identified in 2020. #RareDisease Read doi.org/10.1242/dmm....

Meet Ronan Smith and Nicole Reyne, 1st authors of new paper from Martin Donnelley & co tracking lung tumor burden by assessing changes to ventilation with Xray velocimetry imaging Interview & article below: 👨🏻‍🔬👩🏼‍🔬https://doi.org/10.1242/dmm.052735 📰https://doi.org/10.1242/dmm.052559

In 2025, we celebrated the 100-year anniversary of our not-for-profit publisher @biologists.bsky.social 🥳 In this article we look back on our year of celebrations and look forward to the next 100 years! journals.biologists.com/dmm/article/...

Sankalpa Chakraborty, Viswanathan Rajagopalan & co used the ZSF1 #RatModel to investigate early and severe age-related heart failure with preserved ejection fraction and showed novel noncoding and coding markers in early- and/or late-ageing-related hypothyroid #HFpEF. Read doi.org/10.1242/dmm....

John Hellicar, Dominic Lenz, Martin Lowe & co used #fibroblasts from individuals with #CALFAN syndrome, which affects the nervous system and liver, and revealed an accumulation of the secretory cargo procollagen type I in the #EndoplasmicReticulum #RareDisease Read doi.org/10.1242/dmm....

Abigail Poff, Nicole Moss & @debbysilver.bsky.social generated a #MouseModel of the #DDX3XSyndrome and demonstrated that missense and loss-of-function variants have similar effects on #corticogenesis but act through distinct molecular targets. #RareDisease Read doi.org/10.1242/dmm....

DMM is supporting the Developmental origins of #PaediatricCancer symposium. Discover the latest cutting-edge research on the modelling, biology and treatment in the field. Abstract submission until 28 Feb 2026 Info www.cclg.org.uk/information-... Registration www.tickettailor.com/events/cclg/...

Biqin Zhang, Hrvoje Augustin & co used #Drosophila model of PLA2G6-associated #neurodegeneration and showed that treatment with decanoic acid significantly extends the lifespan, reduces bang sensitivity and improves resistance to heat shock stress. #RareDisease More details doi.org/10.1242/dmm....

In December's #EditorsChoice, Nayeli Reyes-Nava, @edwardmarcotte.bsky.social, @jbwallingford.bsky.social & co use #Xenopus model to study #Cilia motility disturbances in primary ciliary dyskinesia #PCD ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

In November's #EditorsChoice, Katerina Yamamoto, @cswormlab.bsky.social & co investigate the connection between #InnateImmunity and #LipidMetabolism, using the worm model #Celegans ⚡ doi.org/10.1242/dmm.... 📰https://doi.org/10.1242/dmm.052357

Anam Naseer, Pranoy Toppo, Mahmood Akbar, Aamir Nazir investigate the mechanistic aspect of mitochondrial #sirtuins in modulating age-associated #neurodegeneration, specifically #ParkinsonsDisease, using #Celegans Read doi.org/10.1242/dmm....

In October's #EditorsChoice, Kenneth Katschke, Marion Jeanne & co investigate the role of #HTRA1 in age-related retinal degeneration #AMD. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

In September's #EditorsChoice, Victor Tapia, Catherine Lawrence, Paul Kasher & co investigate #cholesterol homeostasis connection to #COVID19 in #zebrafish and #CellCulture models. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

In August's #EditorsChoice, Gianna Maggiore, @haozhulab.bsky.social & co showed strong clinical potential in reducing #HepatocellularCarcinoma by targeting the actin-binding protein anillin via #siRNA knockdown in #MouseModel. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

December Issue's #EditorsChoice highlights an article that uses the #Xenopus cell model to study vertebrate motile #cilia and the involvement of LRRC56 protein in #PrimaryCiliary Dyskinesia #PCD #RareDisease Read the short, simple retelling here doi.org/10.1242/dmm.... Details in the thread.

In July's #EditorsChoice, Kamila Karimjee, Richard J. Piercy & co develop long-term, age-associated activity quantification for dog model of #DuchenneMuscularDystrophy #DMD ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....

Yeon Ja Choi, Jiang Chen & co developed a genetically engineered mouse model expressing a mutant Wdpcp gene, implicated in several ciliopathies, including Bardet-Biedl syndrome. This model provides new insights into WDPCP’s structure–function relationships. Read doi.org/10.1242/dmm....

In June's #EditorsChoice, Laetitia Pinte, Ludovic Vallier & co investigate the function of EHF transcription factor in #LungHomeostasis and #LungDisease. ⚡ doi.org/10.1242/dmm.... 📰 doi.org/10.1242/dmm....