Attachment of ADP-ribose molecules to RNA Polymerase II allows its traffic regulation on transcribed genes in response to oxidative DNA damage 🧬 Insightful #preLight by Élise & @pierrecaron.bsky.social on preprinted work from @gregersenlab.bsky.social⬇️👀 prelights.biologists.com/highlights/o...

Excited to share our new #preprint uncovering how early human forebrain is patterned. Compared to mouse, human dorsoventral and anteroposterior telencephalon patterning is strikingly delayed, which is correlated with SHH and FGF signalling differences. Read it here: www.biorxiv.org/content/10.6...

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. www.biorxiv.org/content/10.6... 1/

New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...

We might be close to obliterating poliovirus, but non-polio enteroviruses are on the horizon. @sergiuppasca.bsky.social & team use a human assembloid model to show how poliovirus, EV A71 & EV D68 disrupt neuromuscular function in different ways. #preLight ⬇️ prelights.biologists.com/highlights/h...

Delighted to share our preprint describing COMET, a new approach to drift correction for #SMLM, which performs exceptionally well in practice. Check out the benchmarking results compared to other methods! :) Thanks to @lreinkensmeier.bsky.social for a superb effort. www.biorxiv.org/cgi/content/...

Meiosis faces a fundamental problem: It must repair hundreds of DNA double-strand breaks while executing a transcriptional programme essential for gamete development. But many of these breaks occur in genes. So how are these two processes reconciled? www.biorxiv.org/content/10.6...

New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵

❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz.bsky.social, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: www.biorxiv.org/content/10.6...

Check out our new preprint and learn about the smart foraging behavior of fly larvae! www.biorxiv.org/content/10.6...

Check out our first lab preprint: A real team effort to understand the Plasmodium GAPM proteins, which form part of a essential bridge between the parasite's cytoskeleton and motility apparatus. Below is a sneak peek of some beautiful microscopy - light and electron! www.biorxiv.org/content/10.6...

Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin1 www.biorxiv.org/content/10.6... Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen. Thanks to @danielhurdiss.bsky.social @utrechtvirology.bsky.social #covid #pais

Posting on behalf of (soon-to-be) Dr. Samira Monshietehadi (not on Bluesky) -- "I’m very excited to announce that my PhD thesis project is now a preprint! www.biorxiv.org/content/10.6.... We show how Müller glia engage with growing retina vasculature in an activity-independent manner."(1/11)

How do you kill a MRSA superbug armed with 15 different anti-phage defense systems? You make a smarter phage. Check out our latest preprint on overcoming bacterial immunity using defense-guided engineering to build durable therapeutic phage cocktails! Led by Sarah Voss. doi.org/10.64898/202...

1) The Herzik lab is excited to announce our newest preprint in collaboration with the Grotjahn lab! We have developed a surfactant cocktail that seeks to overcome one of the more nefarious problems in #cryoEM, Air-water interface (AWI)-induced damage and preferred orientation (PO).

🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...

Inside super-enhancers, a few classical enhancers do the real work 💪 Siddharth Singh covers a recent #preprint proposing a hierarchy inside super-enhancers; from the group of Biswajyoti Sahu #UofHelsinki #UofOslo #preLight ⬇️👀 prelights.biologists.com/highlights/c...

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

Preprint Editors – Development's next step into the preprint landscape In this Editorial, @reinierprosee.bsky.social, @amjeve.uk and @jamesbriscoe.bsky.social announce a call for Preprint Editors in Development. Apply by 30 March. doi.org/10.1242/dev....

Check out our February issue's preLights in disease biology highlights: journals.biologists.com/dmm/article/... With featured preLight from Manuel Lessi & Riccardo Nagni on a CRISPRi screen for schizophrenia-associated genes prelights.biologists.com/highlights/h... @prelights.bsky.social

Getting involved as an organiser of one of our Workshops is easy. We focus on the logistics, so you can focus solely on the science. Watch this video to hear from some of our previous organisers. The call for proposals for 2028 programme runs until 29 May. www.youtube.com/watch?v=eShr...

New spotLights Short! This episode features #preLighter Anubhav Prakash (@prakash-patterns.bsky.social), who shares some thoughts on his #preprint about junctional heterogeneity & epithelial morphospace. #DevBio Big story, covered in under 2 minutes 👇 www.youtube.com/shorts/GjyRQ...

Happy to have written a piece with @prelights.bsky.social covering two preprints looking at funding and publications! A data science approach to analysing #funding decisions and #publications in #biosciences. (1/3) prelights.biologists.com/highlights/t...

In my @prelights.bsky.social post, I highlight a preprint in which T. Gabr et al. shows that small-molecule agonists of TREM2 💊 can reprogram microglia and protect synapses in human Alzheimer’s models, uncovering promising therapeutic strategies for neurodegeneration. Check it out 👇

Mirror mirror on the wall, what is the fairest funding call? @jontytownson.bsky.social covers two #preprints (@kristine-willis.mstdn.science.ap.brid.gy & team) using data & social science to analyse how significant biological discoveries are made #preLight⬇️ prelights.biologists.com/highlights/t...

🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process. www.biorxiv.org/content/10.6...

New preprint on the limits of detecting higher-order interactions in microbial communities. www.biorxiv.org/content/10.6... We find that the dominance of additive and pairwise interactions on community function may not reflect biological simplicity, but fundamental limits of statistical detection.

Excited to share this preprint that describes my latest work on using GPUs to accelerate processing of RNA-seq data. The title says it all: "RNA-seq analysis in seconds using GPUs" now on biorxiv www.biorxiv.org/content/10.6... and github github.com/pachterlab/k... Figure 1 shows they key result

A new preprint with Matthew Schmitt, @kiseokmicro.bsky.social and Vincenzo Vitelli makes a huge step forward in learning functional groups of components in complex biological systems. It's dimension reduction that speaks to biological function. www.biorxiv.org/content/10.6...

Had an absolutley brilliant time at #KSEmbryology26 a few weeks ago and was really inspired by all the great talks and posters there 🤩 Here's a list of the #preprints I noticed from presenters 👇 - check it out and please let me know if I've missed any! prelights.biologists.com/prelists/key...

The soft and flowing will prevail: fly extraembryonic tissue actively softens to keep the embryo from tearing itself apart. 🪰 Another insightful post by Ruoheng Li on work from Yu-Chiun Wang (yuchiunwang.bsky.social) & team #preprint #DevBio #preLight ⬇️ prelights.biologists.com/highlights/c...

First preprint from the lab! Using intracellular recordings & analysis of 2-photon imaging data, we show that spiking & neuromodulatory input during experience drive a reorganization of visuomotor inputs in V1 layer 2/3 neurons, consistent with enhanced visuomotor cancellation - bioRxiv link below.

Another preprint is out from the Neal Lab! 🎉 Excited to share the first systematic side-by-side comparison of ERAD Derlin paralogs, revealing distinct cellular functions for Derlin-1, Derlin-2, and Derlin-3. www.biorxiv.org/content/10.6...

Highlighting preprint stories from within the preLights community 📽️ Here, Teodora narrates her preprint showing that functional decline in the ageing retinal epithelium results from a change in the mechanical balance of the tissue due to natural cell loss! #Short ⬇️ www.youtube.com/shorts/CWYRX...

We are inviting experienced researchers to apply to become Preprint Editors, a new type of editorial role responsible for handling our 'In preprints' articles and forging links with preprint literature. #prepints Learn more and apply before 30 March 2026: journals.biologists.com/dev/pages/pr...

New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology Join our community & shape the future of research journals.biologists.com/dev/article/...

New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version! It has new data about our progress and highlights from a massive user survey. 1/n www.biorxiv.org/content/10.1...

New preprint out on bioRxiv! www.biorxiv.org/content/10.6... Can conjugative plasmids be used to control plasmid and pathogen spread? Follow me down the rabbit hole that led to this story 🧵

How to make a 4-cell square ascidian embryo? Cytoplasmic pulling rotates centrosomes, cortical forces lock the plane. Corentin Mollier & Shivani Dharmadhikari highlight a #preprint from Silvia Caballero-Mancebo & team @rdumollard.bsky.social #preLight ⬇️ prelights.biologists.com/highlights/c...

Leaf pavement cells may look simple, yet their shapes encode developmental history & environmental response. @srobertgroup.bsky.social show that a MYB transcription factor contributes to fine-tuning this process in aspen. #preprint #preLight by Jeny Jose ⬇️ prelights.biologists.com/highlights/a...

1/5 Happy by a recent biorxiv pre-print about DARNA (PD-T7-3) anti-phage defense system. This system is activated by binding to ssDNA, presented by phage SSB, to cleave tRNA in the anti-codon loop. www.biorxiv.org/content/10.6...

Environment is vital: #development of in vitro mouse embryos lag behind their in vivo counterparts 🐁 New post from Heather Pollington on a recent #preprint from Huanhuan Yang. Includes an insightful discussion with the author. #preLight ⬇️ prelights.biologists.com/highlights/c...

Newest collaborative paper out now on biorxiv - new genome and VSG arrangements in T. congolense, excellent work by Marija! In the words of @scotomorph.bsky.social T. congolense ≠ T. brucei www.biorxiv.org/content/10.6... @rmc9z.bsky.social @keithrmatthews.bsky.social

Greenland sharks & the Quest for cardiac immortality ❤️ 🦈 Theodora Stougiannou highlights fascinating new work from Elena Chiavacci & colleagues studying a shark living in the abyss where temperatures are around 2°C! #preprint #preLight ⬇️ prelights.biologists.com/highlights/r...

How do #sponges coordinate their bodies despite lacking neurons and true muscles? We show that sponges use monoamines to control water flow in their canals — reminiscent of how adrenaline regulates blood vessels. My PhD story, now on BioRxiv: www.biorxiv.org/content/10.6... #Evolution

New preprint @biorxiv-devbio.bsky.social by Harshath Amal and colleagues from our lab @uni-muenster.de shows how a BMP #morphogen gradient is translated into graded junctional permeability by tuning adhesion and actomyosin contractility in #Drosophila See tinyurl.com/yhbwd9xh @sfb1348.bsky.social

FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇 www.biorxiv.org/content/10.6...

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4 Preprint: www.biorxiv.org/content/10.6... Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

PPAR excellence: microglial transcription factor shows potential as a therapeutic target for Alzheimer’s disease. #neuroscience 🧠 Isabel Paine highlights work from Jacob S. Deyell & colleagues #preprint #preLight ⬇️ prelights.biologists.com/highlights/p...