At the Centre for Regenerative Medicine #UoE, ECRs discuss preprints + now publish their discussions on #preLights! First #preprint they highlight brings membrane lipids & their spatial organization to the spotlight. @epfl-brainmind.bsky.social #preLight ⬇️ prelights.biologists.com/highlights/t...

Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...

A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams. www.biorxiv.org/content/10.1...

Just published: "Planetary microbiome structure and generalist-driven gene flow across disparate habitats" by @podlesny.bsky.social @chanyeong-kim.bsky.social and @jonas-bio.bsky.social www.cell.com/cell/fulltex... See the quoted post below for a thread on the preprint!

🚨Preprint alert🚨 How does chromatin “architecture” form at CTCF sites? Our new preprint with @voslab.org and @andersshansen.bsky.social shows CTCF dimerization promotes nucleosome oligomerization on chromatin. tinyurl.com/CTCF-nucleos...

Neurons contain “hotspots” for mitochondrial biogenesis at distal branch points. #preprint First #preLight posted by Lorena Olifiers - take a look! ⬇️👀

New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos. www.biorxiv.org/content/10.6...

Discussing #arXiv preprint 'Kosmos: An AI Scientist for Autonomous Discovery' 🤖 Manuel Lessi & @ramadio.bsky.social share their excitement and worries + discuss possible uses of Kosmos. Includes a lovely graphic created by Theodora M Stougiannou #preLight⬇️ prelights.biologists.com/highlights/k...

Our new preprint is live!🎉 Cytosolic factors govern vimentin network architecture and mechanics. Cytosolic components shape vimentin IF networks & mechanics - beyond minimal reconstitutions. On bioRxiv now! Congrats @dyuthisreekumar.bsky.social www.biorxiv.org/content/10.6...

A new algorithm called BOUQUET maps which genes interact with transcriptional condensates by integrating 3D genome topology and protein binding data. The approach identifies "3D-super-enhancers"—exceptionally protein-rich regulatory... https://www.biorxiv.org/content/10.1101/2024.02.01.578210

Delighted to speak with @reinierprosee.bsky.social @prelights.bsky.social about the work that we do at the Journal of Emerging Investigators. Check it out here!

Time for a thread on our Christmas preprint “Origin and evolution of acrocentric chromosomes in human and great apes”. I had so much fun with this project and paper. It will be hard to summarize in a thread, but I’ll try www.biorxiv.org/content/10.6... [1/21]

New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

🧬📄 Preprint update (v2): We added new biochemical experiments that clarify how IWS1 associates with the transcription elongation complex and further define competition between IWS1 and RECQL5. 🧪⚙️ www.biorxiv.org/content/10.1... Structural model is already available in the PDB (9MLC).

Mitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing. We explore this link in our new preprint. 🔗 www.biorxiv.org/content/10.6...

New preprint! We show how mesoscopic nonequilibrium fluctuations in active gels emerge from the breaking of detailed balance at the molecular scale. Warning: Long technical paper ahead! Enjoy! @mpipks.bsky.social @ub.edu @ubics.bsky.social @icreacommunity.bsky.social arxiv.org/abs/2601.20483

Friends! I am so happy to share our new preprint! Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago. How do animals like C. elegans sense it fast and escape? www.biorxiv.org/content/10.6... Thread 1/

Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...

The threefold way an epithelium copes with cell misplacement: pulling them up, killing them less, and removing the unwanted. Ruoheng Li discusses a #preprint from @florisbosveld.bsky.social & colleagues @ybellaichelab.bsky.social Check out the #preLight ⬇️👀 prelights.biologists.com/highlights/t...

In preprints: shedding light – chemogenetic induction of menstruation in mice Aishwarya V. Bhurke and Ripla Arora from @aroralab.bsky.social discuss the recent preprint by @cagricevrim.bsky.social, @karalmckinley.bsky.social and colleagues on the X-mens menstruation model. doi.org/10.1242/dev....

Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development! @ijmonod.bsky.social www.biorxiv.org/content/10.6...

A new extreme of meiotic evolution: ✔️ 𝗻𝗼 crossovers ✔️ 𝗻𝗼 gene conversion ✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴. more about it: www.biorxiv.org/content/10.6...

The cell cortex behaves like a sorting hat: it groups membrane proteins by how tightly they bind to dynamic actin. 🪄🎩 Insightful post from Teodora Piskova covering recent work of the #MayorLab & team @ncbsbangalore.bsky.social #CellBio #preprint #preLight ⬇️ prelights.biologists.com/highlights/a...

The extended version of my thesis procrastination project/subcortex visualization package is out now in both Python and R, now that I’ve graduated 🤠 This figure shows the 9 atlases included (and counting)! Preprint: www.biorxiv.org/content/10.6... Website: anniegbryant.github.io/subcortex_vi...

Our latest preprint on how regional cellular, molecular, and other forms of heterogeneity shape macroscopic wave dynamics is now out: www.biorxiv.org/content/10.6... For a full thread, see: x.com/_victorbarne...

preLighter Stefan Friedrich Wirth covers a #preprint from Dr Raychoudhury & team #DBS_IISERM It concludes that the isolation mechanisms preventing mating between different species of parasitoid Nasonia wasps remain a mystery 🔮 #zoology #evolution #preLight⬇️ prelights.biologists.com/highlights/m...

10/ Thanks to Manuel Lessi for highlighting a preprint of the study prelights.biologists.com/highlights/d...

We’re excited to share our latest preprint on the mechanism of excised linear intron stabilization in yeast! This work was led by PhD student @glennli.bsky.social and was a wonderful collaboration with @maxewilkinson.bsky.social. Link: www.biorxiv.org/content/10.6... (1/4)

Kanishka Parashar #UNIL has uploaded a #postLight. 👀 Here, Kanishka revisits work from @matteoall.bsky.social & team originally posted as a #preprint, highlighted as a #preLight and now published in @jcellsci.bsky.social #postLight ⬇️👀 prelights.biologists.com/highlights/p...

Outsmarting brain tumours with engineered immune cells. Dina Kabbara highlights a #preprint in which Ali Turhan & team show that CAR-macrophages can be engineered 🧬 to fight glioblastoma cells while sparing healthy cells! #oncology Check out the #preLight👇 prelights.biologists.com/highlights/a...

Immune cells for nephron development; tweaking the organoid recipe! Theodora mixes science writing & visuals to highlight recent work from Filipa Lopes, Susan Kimber & team #FBMH_UoM #preprint #DevBio Check out the #preLight + author response ⬇️👀 prelights.biologists.com/highlights/h...

I’m back here to share our new pre-print! 🔬 🧬 😃 Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia Flow cytometry+Imaging+RNA-seq+Proteomics Preprint available on bioRxiv [link in comments]

Happy to share the pre-print on GEMMIFER, a novel ERF required for the initiation of gemma in Marchantia. One of the coolest phenotypes that I have ever seen. Congratulations to Yuki and Go, who led this research. #PlantScience @biorxiv-plants.bsky.social www.biorxiv.org/content/10.6...

"I would risk over-heating just to be with you" - Male red-sided garter snake🔥🐍 Tshepiso Majelantle highlights recent work on thermoregulatory behaviour. #preprint #zoology Includes an insightful response from @drhubert.bsky.social #OregonState #preLight ⬇️ prelights.biologists.com/highlights/t...

Today in #JournalClub we discussed a new preprint that uses in situ cryo-ET and molecular dynamics simulations to study biomolecular condensate formation. Very beautiful data and interesting insights. Check it out! www.biorxiv.org/content/10.6...

We were delighted to be featured in the latest issue of #BlueSci (@bluescicam.bsky.social) & spotlight a few University of Cambridge students active as part of our community sites @the-node.bsky.social @focalplane.bsky.social Read BlueSci Issue 62, 'Unseen Worlds', here: www.bluesci.co.uk/issue/

Preprints without borders 🌎 Carolina Tanigushi explains how @scielo.org & SciELO Preprints boost #OpenScience across Latin America & beyond, increase visibility for regional research + what (early-career) researchers can do to benefit. Read the interview: prelights.biologists.com/news/preprin...

Happy to share our recent preprint: "DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity" www.biorxiv.org/content/10.6... @spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

Preprints of pandemic potential - new historical piece from me on the history of bioRxiv/medRxiv, their role in the pandemic, and the way forward. 1/n journals.asm.org/doi/10.1128/...

Environment & evolution take centre stage at January’s #DevPres 📅 14 January 15:00 GMT/UTC Three talks, three unique stories. Told by @ethanewe.bsky.social @maxfarnworth.bsky.social @sonyawiden.bsky.social Chair: @pritiagarwal.bsky.social 🔗Learn more & register: us02web.zoom.us/webinar/regi...

KANK2 plays a dual role – dictating cells when to move and when to stick! @vibhasingh.bsky.social covers recent work from Nikolina Stojanović & colleagues – includes a lovely discussion with the author team. #preLight ⬇️ prelights.biologists.com/highlights/k...

Mind the GAP 🚧🕳️🚧 Excited to share the latest preprint from the Fromme Lab (@fromme-lab.bsky.social), showing that the DENN domain protein Avl9 functions as an Arf-GAP, revising long-standing assumptions about DENN protein function, 🧵: www.biorxiv.org/content/10.6...

Unconventional mechanisms of antibiotic action: Stacking and disorganizing. #biochemistry Leonie Brüne talks to William Stuart & Nicholas J. Harmer #UoEBiosciences about their recent #preprint Check out the #preLight + insightful discussion ⬇️ prelights.biologists.com/highlights/c...

In preprints: understanding leaf form for better crop designs Neha Bhatia from @slcuplants.bsky.social discusses two preprints on soybean leaf development by Chancelor Clark & colleagues and Bishal Tamang & colleagues doi.org/10.1242/dev....

I'm excited to share that our preprint is now available on bioRxiv! Our study challenges the widespread use of molecular genetic diversity as a predictor adaptive potential, with important implications for how genetic data is used to inform conservation decisions. www.biorxiv.org/content/10.6...

From uniform beginnings, junctional heterogeneity and cell-specific mechanics choreograph the stunning diversity of sensory epithelia. Bhaval Parmar discusses recent work from Anubhav Prakash @prakash-patterns.bsky.social & colleagues. #DevBio #preLight ⬇️ prelights.biologists.com/highlights/j...

Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are 🔥 👇 "Single-cell map of the female brain across reproductive transitions" www.biorxiv.org/content/10.6...

Last but certainly not least, our final extraordinary biologist featured is Saanjbati Adhikari, a @dev-journal.bsky.social Reviews Editor, a Cross-Title Features Editor for our 100-year anniversary and a former preLighter @prelights.bsky.social. #100biologists

Two more recent preLights were written by Vibha Singh @vibhasingh.bsky.social 🙌 One that discusses Taxane-induced conformational changes in the microtubule lattice. #preprint from Joyce Meiring @joycemeiri.bsky.social and colleagues #UniUtrecht. #preLight ⬇️ prelights.biologists.com/highlights/t...