We really appreciate the time and work that @orestissavva.bsky.social put into preparing the PreLights article, and his thoughtful questions were a nice avenue for Charlotte to expand on her work. Thanks to BioRxiv for highlighting this resource.

Cats: the ultimate pets and scientific heroes. 🐱 Studying feline viruses to identify innovative solutions to prevent human infections. #preprint by @cb99-lewis.bsky.social, @dbhella.bsky.social & team #microbiology #preLight by @orestissavva.bsky.social: prelights.biologists.com/highlights/i...

Cryo-EM ligand building using AlphaFold3-like model and molecular dynamics pubmed.ncbi.nlm.nih.gov/40788932/ #cryoem

Cool and collected: Advances in sample preparation for cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/40784122/ #cryoem

Human ribosome interactions reframe neomycin toxicity www.biorxiv.org/content/10.1101/2025.07.22.666027v1 #cryoem

We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design! github.com/martinpacesa...

Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach www.nature.com/artic...

New research shows that simply changing how a reaction vessel is positioned on a magnetic stirrer can significantly change a reaction's speed and product quality, influencing the reproducibility of results. #ChemSky #ScienceSky #EduSky

Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strains pubmed.ncbi.nlm.nih.gov/40490363/ #cryoem

A great read on how flexibility and air–water interface interactions impact SPA cryo-EM data quality! Congratulations @isobelhirst.bsky.social @stemuench.bsky.social @scarfflab.bsky.social and the team!

Illuminating ubiquitination mechanisms: How cryo-EM has shed light on Cullin RING E3 ligase function pubmed.ncbi.nlm.nih.gov/40311545/ #cryoem

Missed any of the Fragment-Screen webinars with @instruct-eric.bsky.social? Take a look at them here, with talks from @ceitec.eu, @ebi.embl.org, IBM Research and FFULisboa! fragmentscreen.org/news-and-eve...

Protein structure prediction via deep learning: an in-depth review pubmed.ncbi.nlm.nih.gov/40248099/ #cryoem

Unraveling the proton-sensing mechanisms of G protein-coupled receptors: Insights from cryogenic electron microscopy studies pubmed.ncbi.nlm.nih.gov/40250408/ #cryoem

The code & camera-ready version of our #ICLR2025 paper on "Multi-domain Distribution Learning for De Novo Drug Design" are now available 📚 Paper: openreview.net/forum?id=g3V... 💻 Code: github.com/LPDI-EPFL/Dr... (1/4)

The structural diversity of psychedelic drug actions revealed pubmed.ncbi.nlm.nih.gov/40108183/ #cryoem

Structure-guided design of partial agonists at an opioid receptor pubmed.ncbi.nlm.nih.gov/40082451/ #cryoem

Protein bL38 facilitates incorporation of uL6 during assembly of the 50S subunit in Flavobacterium johnsoniae pubmed.ncbi.nlm.nih.gov/39997215/ #cryoem

"Norovirus replication, host interactions and vaccine advances" www.nature.com/articles/s41...

HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria pubmed.ncbi.nlm.nih.gov/39913204/ #cryoem

Beautiful work! 🧬🧶 www.science.org/doi/10.1126/...

The binding of RbgA to a critical 50S assembly intermediate facilitates YphC function in bacterial ribosomal assembly pubmed.ncbi.nlm.nih.gov/39658043/

Apparently, everyone is moving to Blue Sky now...