I described our internships but it is best to hear from one of our interns how much it has helped! From @astbury-bsl.bsky.social to @embl.org Heidelberg, thank you @simonemattei.bsky.social for sharing your expertise with Instruct interns By the way call now open! instruct-eric.org/submit-call/...

Join tomorrow for the webinar on "Current state of data standards, repositories, and interpretation approaches for structural modelling with mass spectrometry data", presented by Frank Sobott of @universityofleeds.bsky.social, part of Instruct-UK! events.teams.microsoft.com/event/4e785b...

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

Very happy that our group has been able to contribute to this fantastic study. @astburycentre.bsky.social @astbury-bsl.bsky.social

Are you an enthusiastic and ambitious scientist looking for a challenging project? Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance! Apply by 11 JAN www.jobs.ac.uk/job/DPU715/r...

We’re excited to open applications for Cryo-EM in Structural Biology 2026, part of the Wellcome/MRC-funded national cryo-EM training programme! ❄️ 🗓️ Registration is open until 12 January 2026 All the details (and the registration link) are can be found here: astbury.leeds.ac.uk/facilities/w...

A snapshot from our FBS Facilities Christmas gathering yesterday - good food, easy chats, and a nice atmosphere. Thanks to Louie for sorting the food, and to Ruth for taking the photo! It was great to catch up and spend some time together before the holiday break! 🎄 @bioscienceleeds.bsky.social

📆Save the date: 20-21 April 2026 #AstburyConvo26 is back with a bold new theme: Designing Biology. Expect cutting-edge talks and the chance to shape the future of molecular science. Register now: astburyconversation.leeds.ac.uk @astburycentre.bsky.social @universityofleeds.bsky.social

Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects. If you’re at the conference, come say hi before it wraps up!! 👋

🚨 Abstract submission extended to Oct 21! Join us for the Austrian Cryo-EM Symposium (Nov 11–12) at @istaresearch.bsky.social / ISTA 🇦🇹 Explore cutting-edge cryo-EM, meet top speakers, and visit beautiful Vienna. 👉 cryoem-symposium.pages.ist.ac.at

Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead! #OpenSoftwareAcceleratesScience www.biorxiv.org/content/10.1...

Was lucky to see this presented at the NYC cryoEM meeting earlier this year - super cool stuff!

🚨 We’re hiring! 🚨 We’re looking for a Correlative Imaging Scientist to join our EM team at ABSL! You will be developing and supporting cryo-EM & cryo-CLEM workflows across multiple imaging platforms (FIB-SEM, cryo-confocal, cryo-EM). Any questions? Get in touch! jobs.leeds.ac.uk/Vacancy.aspx...

Delighted to see our publication with industry partners out! 🎉 Huge shoutout to @jbrwhite.bsky.social and @oksana-degtjarik.bsky.social for their contributions to the structural work! Many thanks to @chingshinhuang.bsky.social & the whole team for an excellent collaboration! #CryoEM #drugdiscovery

We are proud to share our latest preprint: "(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation". www.biorxiv.org/content/10.1...

🚨 Applications now open! Join us in Leeds for the Wellcome-MRC Cryo-EM Training Course 📅 1–4 Sept 2025 | 🧊 Beginners tailored 🔬 Hands-on single-particle cryo-EM 👉 More info and to apply: forms.office.com/e/QHYmbcsZ33

A great read on how flexibility and air–water interface interactions impact SPA cryo-EM data quality! Congratulations @isobelhirst.bsky.social @stemuench.bsky.social @scarfflab.bsky.social and the team!

Wonderful #PintOfScience evening with @maddie-gilbert.bsky.social and @richardallenart.bsky.social making sense of memory loss! The memory test results may already have slipped our minds…😅 Huge thanks to our own @c-hawksworth.bsky.social for helping organise such a great event!🍺

Beautiful and inspiring talk by Sheena Radford of the @radford-lab.bsky.social at the Astbury Centre for Structural Molecular Biology (@astbury-bsl.bsky.social) from the University of Leeds (@universityofleeds.bsky.social) at our annual Bijvoet Symposium!

The perfect gift doesn’t exi… Oh wait! Those tiny replicas of our Titan Krios microscopes are absolutely adorable! 🥹❄️ Thank you so much @snowentific.bsky.social! Wishing you all the best in your next adventure - you will be missed!

“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩‍💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬

Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium! Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.

Huge shout out to @jenkinsjj.bsky.social for his excellent talk on the #cryoET structure of Tau filaments from human brain tissue at CCPEM Spring Symposium in Nottingham! #cryo-EM @diamondlightsource.bsky.social @ccpem.bsky.social

It's great to be at the CCPEM conference in Nottingham this week, with talks from many Instruct facilities including @astburycentre.bsky.social, @astbury-bsl.bsky.social, @diamondlightsource.bsky.social, and @ox.ac.uk! Find out more about the Instruct-UK centre - instruct-eric.org/centres/inst...

Another week, another training course wrapped up ✅ Huge thanks to our fantastic participants for sticking with us through the reschedule, and to our amazing lecturers & tutors for making it a success: @leicstructbio.bsky.social @diamondlightsource.bsky.social @uofglasgow.bsky.social & Birkbeck, UoL

I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.

🔬 Exciting to see our custom time-resolved cryo-EM device featured in Nature! A groundbreaking look at the swinging lever mechanism of myosin in action! Huge congrats to @scarfflab.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social and everyone involved! #cryoEM

#CryoSPARC v4.7 is out! 🚀  Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more! Full changelog: cryosparc.com/updates #cryoEM

🔬Sibling rivalry alert! Our Krios 2 is finally catching up with Krios 1 with a shiny new Selectris energy filter! ⚡ Exciting times ahead! Huge thanks to @thermofishersci.bsky.social for the upgrade! 🙌 #cryoEM #cryoET

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes. rdcu.be/edRwF

🎉 And that’s a wrap! The Wellcome-MRC Cryo-EM in Structural Biology 2025 course in Leeds was a fantastic week of learning, hands-on training, and great discussions. Huge thanks to our amazing instructors, speakers & enthusiastic participants for making it such a success! #CryoEM

📢 4-year funded PhD opportunity at the Aston Institute for Membrane Excellence, starting in October 2025. The project will focus on studying protein-lipid interactions in mechanosensitive channels📢 📅 Application deadline: 7th April 2025 @astonaime.bsky.social tinyurl.com/4arujyaw

Really pleased to share this story in collaboration with our fantastic industry partners @chingshinhuang.bsky.social !

Our methods paper made it to bioRxiv: doi.org/10.1101/2025... Full #cryoET workflows for #plant tissues. Plus some general tricks and tweaks on serial Lift-Out and cryo-FLM. 🧪🧵1/5 #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM #CLEM

📢 Registration is now open for 'Wellcome-MRC Cryo-EM in Structural Biology 2025'! 📅 Join us online March 3-7 at @diamondlightsource.bsky.social @universityofleeds.bsky.social for lectures & demos in #CryoEM & #CryoET: sample prep, SPA, model building & more!🧬 🔗 www.diamond.ac.uk/Instruments/...

Great to see it's out! 😍

Take a look at our new paper! We show that YbiO can achieve a conductance equivalent to MscL, the largest known gated ion channel. We also show the presence of several subconducting states. One state is consistent with a structure we determine using cryoEM. www.cell.com/structure/fu...

Interested in learning to process cryo-ET data in the latest version of Warp? I'll be running a workshop on April 22nd in central London, UK details+registration: forms.gle/FLDr3ZWtVGXs... Hope to see you there!

Hello Bluesky! Excited to make our debut with our first lift-outs on the new Hydra Bio PFIB. A chunk of brain tissue has been mounted with the needle onto the finger of a half-moon grid and is now ready for milling to create a thin lamella for further analysis. Stay tuned for more updates! #FIBSEM