Excited to share a new chapter of my scientific journey in Chris Russo's group — developing a way to freeze proteins faster than they diffuse, paving the way for cryo-EM without air–water interface damage.

❄️ NEW PRE-PRINT ❄️ Happy to see our latest work online. Here we present a super simple solution to the preferred orientation problem in single particle cryo-EM: the use of ultrasonic excitation during vitrification! Details in the 🧵 below... #cryoEM #structuralbiology

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

I submitted my thesis today!!! 4 years of work in 1 pdf 🤯

Keeping me company whilst I write 🐓 #phd #chicken

Michelle Agyemang takes the trophy for best young player of the tournament, and well deserved! #England would not be in this final without her magic. #WOSO #WEURO #EURO2025 #WEURO2025 #FOOTBALL

Lending Keira Walsh a helping hand to make a fan’s dream come true 🤝🥹 #WEURO2025 || #Lionesses

Nice!!

Angélique-Marguerite du Coudray was a famous 18th century French midwife who designed various teaching aids to train midwives about anatomy and obstetrics. Her work saved many lives in the age #WomensArt

The Euro semi-final stage is set. Who is winning it all? 🏆 📸: WEURO2025

Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...

Trans youth deserve healthcare, not courtroom cruelty. Now, the highest court has sided with bans - against research showing this care improves mental health and saves lives. 💔 We stand with them. We demand science, dignity, and compassion. zurl.co/QejZr

🧵 Activists have broken into British Airforcs Base & carried out sabotage to try to help save Palestinian lives & prevent war crimes. ‘RAF Brize Norton military planes damaged as activists break into base ahead of flight.’ [1]

Really enjoying this review of time-resolved cryoEM 😊 especially this lovely summary figure ✍️ www.cell.com/structure/fu...

Great to see the conversation in the US around how gender-blind design leaves girls out of parks. Also great to see Brickfield Park in Bath mentioned – co-created with teenage girls, alongside inspiring examples from Vienna. Awareness is growing! nextcity.org/urbanist-new...

Some good news. Tentatively. HIV protection with just two shots a year: FDA approves Gilead drug www.statnews.com/2025/06/18/f... via @statnews.com

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

Proteins operate on a short timescale — on the order of a millisecond, or even faster https://go.nature.com/4l7qAEm

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩 www.sciencedirect.com/science/arti...

"I am hesitant to comment broadly on what it’s like for scientists now in America because I have only limited information about what is going on outside of this detention center. What I do know is that my colleagues, many of whom are, like me, foreign scientists, are terrified"

Okay hear me out, what if building your protein model was a first person horror survival experience?? #MolecularNodes #b3d #GeometryNodes 🧪

Young Londoners deserve opportunities across the EU. A youth mobility scheme would strengthen ties with our neighbours, boost our economy and open doors for the next generation at a time of global uncertainty.

Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium! Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.

Huge shout out to @jenkinsjj.bsky.social for his excellent talk on the #cryoET structure of Tau filaments from human brain tissue at CCPEM Spring Symposium in Nottingham! #cryo-EM @diamondlightsource.bsky.social @ccpem.bsky.social

Thank you for this whole thread!🙏 I occasionally worry I invest too much time making figures, but this one post makes 100s of hours seem worth it!

Diversity: www.albany.edu/offcourse/is...

In case you wondered what it looks like "in real life" when the FluScreen of a Krios cryoEM is retracted/inserted: here you go. ❄️🔬

📢 Submissions are now open for the CellMap Segmentation Challenge. Build the best method for segmenting cellular organelles in vEM using our 289 annotated volumes, 40 organelle classes, and 22 diverse cell and tissue types. 🔗 hhmi.news/410evJQ

Saw some cows and sheep doing a kind pseudosymmetry thing on my run the other day 😊

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

Check out this brand new album from Berlin-based punk-ska band Dafffke out now on your favourite music streaming platform 🤩🤩 some motivational political music to get you in the Xmas spirit 😎

Nudibranch cruising like a ship over a grainy sea

AlphaFold3 still tends to overfit regions that AF2 multimer predicts to be disordered. Almost all disordered regions become helices in AF3.

Quote: "It is very hard to interpret big data in ecology in meaningful ways if you do not know anything about who the organisms are and what they do in the environment." onlinelibrary.wiley.com/doi/full/10....

Pleased to share that Foteini and I each got second place for our talks at the White Rose DTP Winter Symposium! Foteini about her placement at Yorkshire Cancer Research and me about some research on sample preparation for #cryoem 🥳

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social! tinyurl.com/setd2

The birth of fruit fly's central nervous system imaged with multicolor #adaptive #lightsheet microscopy. The microscope self-aligns to a signal that appears during imaging. www.nature.com/articles/nbt...

🌍🧪 Want to do something different and have fun? Try Skype a Scientist! It's an amazing chance to connect with a classroom anywhere in the world 🌎 and share your journey as a scientist. 👩‍🔬 The new 2025 volunteer form is out 🥳 Let’s inspire the next generation! 💡✨ #PhDSky #AcademicSky #MedSky

Our #CryoET paper on ciliary rootlet ultrastructure from mouse retina is now out in @elife.bsky.social! Have a peek with this video or dive deeper at bit.ly/3ZJzhgc. Big thanks to @carter-lab.bsky.social and #teamtomo. #CryoET #CryoEM #Cilia #Rootlet #Centriole #Research #Science

Beautiful !

Large language models surpass human experts in predicting neuroscience results @natureportfolio.bsky.social "The researchers say this highlights their potential as powerful tools for accelerating research, going far beyond just knowledge retrieval." Open Access www.nature.com/articles/s41...

Cladonia, a lichenized fungus, seems almost otherworldly sometimes. 🍄📷 #fungifriends #lichen #macrophotography

PDB structures of HIV molecules provide hope for development of new vaccines and methods to rid an infected individual of the latent virus. #WorldAIDSDay pdb101.rcsb.org/brow...#WorldAIDSDay

Happy Holliday Junction for those who celebrate

I am so excited for the #Christmas season. I want to do a #podcast episode for #kids about the #science of the #holidays. I would love to hear some ideas from #parents about what intrigues your kids the most. What are the holiday "why" questions you hear every year? I'd enjoy answering them. 👩‍🔬🍎🥽🧪❄️