Interesting piece in The Lancet www.thelancet.com/action/showP...

If humans had descended from carnivores we wouldn't have ended up with the pharmacopoeia we have today.

do any of my chemist friends on here know where i can get a new or used ozonolyzer?

Anyone from the University of Montreal here? Please DM. Please RT.

weather

if anyone has previously used the MISTIC2 web server to do covariation analysis (it's been down for a long time) I wrote my own code to do the same thing. it'll be on gihub eventually but for now you can DM me if you want it. rp if you want

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Needful Things in 4th grade 👀

I always thought it would be cool to reconstruct the evolutionary history of natural products like with proteins. While it's likely not possible, I put together a chart of inferred best guesses at when classes of natural products evolved within a greater biological context.

A short video about some of my research. m.youtube.com/watch?v=QRVB...

morning

one of the single best deals in streaming. i've been paying for PBS Passport for years. it rules

Politico has it correct: "Can you ever trust a jobs report again?" www.politico.com/newsletters/...

Vinegar does no good, nor do other acids. Baking soda does no good, nor do other bases.The three tear gases are not neutralized by any of them. Milk does no good either. You need soap/detergent and water for skin and clothing, and always only plain water for the eyes. Lots of it. That’s it.

Whoa. You can do that?!

Lots of talk today about the demise of BlueSky. For whatever it's worth, it's been a boon to indie publishers like us. Twitter and Facebook have pretty much silenced us, so the engagement here has, and continues to be, wonderful.

He's right. "Nothing short of devastating" By @holdenthorp.bsky.social @science.org www.science.org/doi/10.1126/...

i have to dry and purify mCPBA (i know, i know...) and this is how much water is in ten grams of the commercially available 70% stuff.

Many plants produce toxins to deter herbivores. Over time, herbivores evolved ways to detoxify them. Carnivores didn’t need to—meat lacks such toxins. Humans are omnivores descended from herbivores; dogs are omnivores descended from carnivores. That’s why some foods safe for us are toxic to dogs.

what have you done in the name of science? as an undergrad i was doing a work up at 10 PM on a saturday night when we ran out of dry ice. i rode my bike in the rain to the grocery store, open til midnight, who has a butcher and bought 5 lb of dry ice for the rotovap

Along with the Top 200 Drugs of 2024, the Njardarson lab has also released the Top 200 Small Molecule Drugs of 2024! Free high res download at the link below. bpb-us-e2.wpmucdn.com/sites.arizon...

Njardarson Lab (my alma matre) has released the Top 200 Drugs of 2024! Once again biologics continue to grow in their domination. Free high res download below. bpb-us-e2.wpmucdn.com/sites.arizon...

action shots courtesy of the university, med chem S2025.

norse is not a word

Natural products (toxic secondary metabolites) were the original immune system.

handsome dog

sunrise feat. cattle dog and a puddle

I posted a list of books that changed the way I think about science for my students, figured I would post here. Chaos - James Gleick The Information Dancing Naked in the Mind Field Oxygen Power Sex Suicide The Transformed Cell PiHKAL and TiHKAL The Emperor of All Maladies Song of the Cell

🚨🚨🚨 BREAKING: controversy as new Pope endorses CHN analysis as primary purity determination method 🚨🚨🚨

very cool, i'm a big fan of this kind of outreach

if anyone uses verizon make sure to opt out of their new privacy settings

i think i took a wrong turn

200%? No sleep til 400%

work work work

dog

we stop at red lights

this is one of the wildest molecules i've ever seen

Here’s your chance to ask the new NIH director some questions. Don’t be shy!

Here are the structures of the food dyes that have just been banned (FD&C = food, drug, cosmetics) A few years ago I set out to do a structural analysis on all approved food dyes, but I never ended up publishing it. I'll post the rest of the structures in the comments.

I love that NCBI is so inclusive for alternative spellings.

dog

Excited to teach this upper division pharmaceutical sciences major course that I developed where students will learn about the evolution and modern use of natural products.

Thank you very much for this great analysis!! And for confirming what I have been saying all along, AF3 is comparable at PPI prediction, they just sample more in the original publication

In Brief: US FDA approves the first RNAi drug for treating heart failure caused by amyloidosis. Alnylam gets the nod for #Amvuttra (vutrisiran) to treat transthyretin amyloid cardiomyopathy caused by sporadic or hereditary ATTR, expanding the drug’s label www.nature.com/articles/s41... rdcu.be/ehRIa

This!!! I hope someone in Washington is listening www.wsj.com/tech/biotech...