A disease, disorder, and syndrome are all different.

#chemsky which brand of septum do you currently use for 14/20 and 24/40 flasks?

im surprised nobody has sponsored the red card. I would love to see a Budweiser(TM) Red Card given

the only way to do chemistry #chemsky

Chirality abounds! And we're on track to a solid year of small molecule approvals with several first in class drugs to be excited about.

"Right now, in some underfunded lab, a scientist is chasing a question that sounds pointless...a century of experience says that funding people to do this work is a good bet. If we stop making that bet, we will pay for it in cures no one will know to miss."

the budweiser logo is a cyclohexane chair #chemsky

can you not buy NP-40 detergent anymore?

A subset of CysDB fragments occupies chemical space with no overlap with approved drugs — likely flat, aromatic, low-complexity chemotypes underrepresented in drug space. The overlapping subset probes cysteine sites with drug-like physicochemistry. sculpturatus.com/surveyorchemscape

"...there are also broad prohibitions against any use of federal funds for collaboration with a whole list of countries, starting with China. Any use at all – paper publication charges, travel, reagents, doesn’t matter." Yikes! The continued dismantling of US science... #Chemsky 🧪

In 1960, 67% of stereocenters in FDA drugs were S. By 2025: 53%. A 65-year erasure of biosynthetic bias by synthetic chemistry — written in R and S. (n=1,212 drugs, RDKit)

Half of FDA-approved drugs are achiral. Of the chiral half, R/S splits 53/47 favoring S — statistically real, but barely. Natural product biosynthetic bias, slowly erased by synthetic chemistry. (n=1,217, RDKit)

eplore the chemical space of drugs for free with zero coding using Surveyor Chemscape. just point, click, and analyze. sculpturatus.com/chemscape/

thia-aza-bicyclooctenone is my new favorite heterocycle. see the full synthesis here. chemistrybydesign.oia.arizona.edu/app/#Sword%2...

it is possible that language and intelligence are inseparable aspects of the same phenomenon. if much of human intelligence is encoded in the ability to model and generate language-like representations, then the rapid progress of llms may suggest they’re on a plausible trajectory toward agi.

Surveyor Chemscape is now available as a webapp. you can begin by uploading your own CSV molecule datasets or by using the available ones (click compute projection). play around, have fun, let me know if you want new datasets. sculpturatus.com/chemscape

organic chemists according to bluesky

Explore the space within chemical universes with Surveyor Chemscape. Here's a video with some of the features, code and sample datasets are available for free here - hit me up with questions or requests. github.com/sculpturatus youtu.be/5ZpamfU1rMk

drug discovery often focuses on proteins that initiate disease, but by the time a patient presents with symptoms, the initiating event may be long gone. in many diseases, the most effective targets are the proteins and pathways that maintain, propagate, or reinforce the disease state.

Want to compare your molecules to FDA-approved drugs or the Enamine 10k library? I made an open-source tool that visualizes physicochemical properties and metrics like Böttcher complexity as 2D/3D PCA or UMAP plots. Fast and easy. Mac only. github.com/sculpturatus...

everything interesting in biology happens after translation. it's the era of the proteoform now and proteoform specific drugs are the future.

Excited to share this paper from @yiechanglin.bsky.social showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. 🎥🌟 #MDsimulations #StructuralBiology doi.org/10.1016/j.bp...

“Academic science is not only about productivity, it is also about deep understanding, exploring creative solutions and training critical thinkers to be the next generation of researchers.” www.nature.com/articles/d41...

the number of clinical trials we would have to do to achieve that goal vastly exceeds the number of patients eligible for those trials

the fundamental unit of the universe is not mass or energy. it's information.

AmPhos Xantphos RuPhos CantPhos DavePhos DontPhos JohnPhos WontPhos MePhos CPhos RedPhos BluePhos

JFC

aging may be the thermodynamic moment when the energetic cost of preserving biological information exceeds the organism’s ability to pay it. entropy is the accumulation of disorder; the enthalpy of aging is the rising energy burden required to hold that disorder back.

there's a Rapamycin Renaissance going on with over 15 current clinical trials

chirality is an emergent property of information itself.

instead of spending an hour on bsky, watch this video. www.youtube.com/watch?v=6MBq...

Now online at JCTC: “Is the Functional Response of a Receptor Determined by the Thermodynamics of Ligand Binding?” Our answer: Yes, it is! And we can use it to predict ligand efficacy. pubs.acs.org/doi/10.1021/...

we teach and are taught that proteins fold to their lowest energy state. but this cannot be true, otherwise they wouldnt do anything. protein features have evolved to be "frustrated", which enables functionality through conservation of structural meta-stability. academic.oup.com/nar/article/...

morning reflections feat. ball

it's amazing to me how many receptor/peptide ligand pairs there are where the ligand is nearly 100% conserved for 450 million years but the receptor has considerable evolution.

one of the reasons i like to photograph reflections in water is because they offer the enantiomers of every day chiral objects.

sun salutations

Happy to share this in its published form! More than any project I've worked on, this was a huge team effort, so thank you so much to that team! Especially @ajrferrari.bsky.social www.nature.com/articles/s41...

This is a painting I made a few years ago. Golden Sky 40x60 acrylic on canvas

Yes, the reason Paul Bracher, Andrew Spaeth and I started the Chemistry Faculty Jobs List is that everyone was so relaxed about finding a tenure-track position

Screen 1M random protein sequences to discover that biology-like folds are accessible from random sequences with surprising frequency www.biorxiv.org/content/10.6...

Wherein I scoop up all the "this new analytical instrument will help us train our AI!" announcements that have landed in my inbox in the past month and present them to you by the armful. cen.acs.org/analytical-c...

wow this is amazing

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity @jem.org rupress.org/jem/article/...

alphafold uses covariation in evolutionary sequence alignments to predict structural contacts. evolution-guided pharmacology uses covariation networks to identify functional hotspots — evolutionarily constrained regions that may be pharmacologically targetable. more soon.

reflections

this paper is one of the clearest demonstrations yet that proteoforms reshape druggability across the proteome. phosphorylation and glycosylation don’t just regulate protein function,they remodel small molecule recognition itself. state-dependent and cell context-rich www.nature.com/articles/s41...

A new framework for visualizing and clustering ultra-large chemical libraries, demonstrated on the REAL database with 9.6 billion molecules. Combines MQN fingerprints, Product Quantization, PQk-Means, and nested TMAPs. pubs.acs.org/doi/10.1021/...

if the internet has taught me anything this year

wow Rachel Entrekin wins cocodona 250 2026! stunning. i think this is a new record and the first time a woman has won overall. congrats! run247.com/running-news...