Wherein I scoop up all the "this new analytical instrument will help us train our AI!" announcements that have landed in my inbox in the past month and present them to you by the armful. cen.acs.org/analytical-c...

wow this is amazing

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity @jem.org rupress.org/jem/article/...

alphafold uses covariation in evolutionary sequence alignments to predict structural contacts. evolution-guided pharmacology uses covariation networks to identify functional hotspots — evolutionarily constrained regions that may be pharmacologically targetable. more soon.

reflections

this paper is one of the clearest demonstrations yet that proteoforms reshape druggability across the proteome. phosphorylation and glycosylation don’t just regulate protein function,they remodel small molecule recognition itself. state-dependent and cell context-rich www.nature.com/articles/s41...

A new framework for visualizing and clustering ultra-large chemical libraries, demonstrated on the REAL database with 9.6 billion molecules. Combines MQN fingerprints, Product Quantization, PQk-Means, and nested TMAPs. pubs.acs.org/doi/10.1021/...

if the internet has taught me anything this year

wow Rachel Entrekin wins cocodona 250 2026! stunning. i think this is a new record and the first time a woman has won overall. congrats! run247.com/running-news...

Cellular “rejuvenation” may be coming: embryos reset biological age early in development, and scientists can now partially replicate this using epigenetic reprogramming. Early trials are underway—but full-body age reversal remains uncertain. www.nytimes.com/2026/04/27/m...

for almost a hundred million years trees were not biodegradable. they littered the landscape like plastic until microbes figured out how to break them down.

google maps in san francisco be like "2.4 miles, 37 minutes 🚗 "

Today we mourn the passing of our beloved central dogma. It served Crick well. But it is time to let go. www.science.org/doi/10.1126/...

Derek once again equivocating on anti-amyloid antibodies as an Alzheimer's therapy: "I do not see why these antibodies should be on the market." "Do something else! For God's sake, do something else." www.science.org/content/blog...

something we don't often stop to think about! pro tip: spin your stir bar the other way to get the opposite enantiomer. pubs.acs.org/doi/10.1021/...

most “world-changing equations” aren’t independent of one another. rather, they’re different views of the same underlying math. Maxwell → wave equation Black–Scholes → heat equation Schrödinger → complex wave equation Fourier → solves them all Entropy → explains the normal distribution

first in clinic TYK2/JAK1 inhibitor targeting neuro inflammation for parkinson's enters ph II/III ir.biohaven.com/news-release...

Wait, a 400 that doesn't use helium AND is much smaller? Come see for yourself at #ENC26 booth 20!

That pic is decades of osteoporosis, not a few months on Ozempic. Rapid weight loss can nudge bone density a bit—but it doesn’t “shred” bones. Lift weights, eat protein, and skip the fear-bait.

Do you want to hear the exciting and insightful stories behind drug discovery? Lately, Stan Van Boeckel, emeritus professor at @leidenscience.bsky.social and @led3hub.bsky.social , has started a series of #SciComm posts on this topic. (1/4) www.linkedin.com/posts/stan-v...

It's fun having friends who are medical doctors.

Science is good. We should fund it.

super freaking cool

can we do adobe next?

better kinase inhibitors

“People are saying, ‘I refuse to work on this software. You have to find something else for me to do’,” said one senior NHS official who manages data analysts. “They’re calling it a workplace adjustment. “

FDA approves mebendazole for all solid tumors via "Vibes-Based Accelerated Approval." Safety database: one case report and a PDF from a site that also sells ivermectin. Mechanism: convinces the tumor it's a roundworm. $4.12/course. Happy April 1st.

4 drugs. 4 withdrawals. 4 lessons in clinical toxicology. Tienilic acid - reactive thienyl metabolite, CYP2C9 mechanism-based toxicity Phenylbutazone - idiosyncratic agranulocytosis Cerivastatin - rhabdomyolysis, especially with gemfibrozil Lumiracoxib - hepatotoxicity behind clean GI profile

As Q1 2026 closes: 5 FDA-approved small molecules - copper histidinate, difamilast, linerixibat, milsaperidone, and relacorilant. Five targets, five scaffolds, five lessons in med chem. Q2 is at the same point we were this time last year - right on track. #ChemChat #ChemSky

Seems like azides have their own T shirt 😀 #ChemSky

A truly terrible idea, and you can see both where it’s coming from and where it’s going.

Spotted while reading a review.

Watch Director Bhattacharya's performance at CPAC really got to me. I chose to share some of my observations with him. Hold on... 1/11

my daughter: xenon has 54 croutons???? me: PROTONS. 54 protons. i don't think xenon has any croutons.

Metabolism Monday: CYP2D6 deficiency (~8% of European Descendants). Imipramine → toxicity ↑ Codeine → no effect (or fatal in ultrarapid) Tramadol → shifts MOA Same enzyme, 3 outcomes. CYP2D6 handles ~25% of drugs. One-size dosing is over. #Pharmacology

Exercising fathers and metabolic health of offspring, summarized nature.com/articles/s41... www.cell.com/cell-metabol...

Chiral switches usually favor the same enantiomer across a class. PPIs break that rule: Esomeprazole = S, Dexlansoprazole = R. Why? They become achiral at the target—chirality matters in metabolism (CYP2C19), not binding.

Allergy season reminder: Allegra (fexofenadine) only exists because its predecessor, terfenadine, caused fatal heart arrhythmias via QT prolongation. Turns out terfenadine was just a prodrug - fexofenadine was doing all the work. A safer drug was hiding inside a dangerous one. #DrugDiscovery

Dogs have been our friends for a very long time. 🐶 NYT gift link: www.nytimes.com/2026/03/25/s...

glyphosate's not an antibiotic?

Q2 2026 FDA watch list Baxdrostat: first CYP11B2 inhibitor for resistant hypertension Orforglipron: oral GLP-1 agonist Vepdegestrant: first PROTAC estrogen receptor degrader for breast cancer Sparsentan: potentially the first-ever treatment for FSGS Reproxalap: novel RASP modulator for dry eye

this is a really cool advancement with implications in molecular topology and stereochemistry. the transition state energy is high enough that these molecules are separable. americanpeptidesociety.org/research/ins...

Might be the greatest opening paragraph of anything ever.

God grant me the escitalopram to accept the things I cannot change, the methylphenidate hydrochloride to change the things I can, and coffee to know the difference

Exciting to see the approval of linerixibat for cholestatic pruritus—an IBAT inhibitor that targets the underlying bile acid biology driving itch. A great example of basic science translating into real therapies. Curious to see where IBAT inhibitors go next.

#DBfeature The role of Goldilocks protein kinase DYRK1A in embryonic development By Katherine Johnson, Larisa Litovchick, Amanda Dickinson tinyurl.com/4asapuv9