We found a new brain shuttle! Mucins on brain endothelium mediate transcytosis of cargo linked to mucin-binding “C domain”. Congratulations Sophia Shi, now a Roland Fellow @harvard.edu, and longtime collaborator Tony Wyss-Coray @stanfordmedicine.bsky.social www.biorxiv.org/content/10.6...

Fantastic new resource for glycoproteomics from @nmriley.bsky.social and coworkers #glycotime

I defended my PhD 10 years ago today. That was the least remarkable thing that happened that day. Sharing something I wrote about it last year. Since then "the horrors persist but so do we." And with dignity.

Walk with Me: Meet Paul Mischel, who studies how cancer cells grow, evolve, and resist treatment. His lab has uncovered key drivers of aggressive cancers. Discover what led him to this work — and his favorite comfort meal. youtu.be/SlPd-Pdvs-k?... @stanford-cancer.bsky.social

With immortal bass lines like California Girls and Good Vibrations 🙏

Born 24 March 1935 - Carol Kaye, one of the most prolific bass guitarists, who has played on an estimated 10,000 recordings in a career spanning over 50 years. Kaye was the bassist on many Phil Spector and Brian Wilson productions in the 1960s and 1970s. She is 91 years old today. #CarolKaye

Great piece on @corsello.bsky.social and coworkers’ exciting new discovery @stanfordmedicine.bsky.social

Damon Runyon Clinical Investigator Steven M. Corsello, MD, and his colleagues at Stanford have discovered a drug that can degrade nuclear pores—the passageways by which mRNA leaves the nucleus—in cancer cells, effectively inducing cell death. Read more: https://bit.ly/3NCJeZJ

Highly recommend watching open.substack.com/live-stream/... if you are interested in a scientific discussion of the origin of COVID-19 and some of the politics about pushing particular narratives.

Chemist/physician Dr. Maud Menten co-authored the seminal paper 𝘋𝘪𝘦 𝘒𝘪𝘯𝘦𝘵𝘪𝘬 𝘥𝘦𝘳 𝘐𝘯𝘷𝘦𝘳𝘵𝘪𝘯𝘸𝘪𝘳𝘬𝘶𝘯𝘨, 1931. This intro'd the Michaelis–Menten equation (image). It remains a cornerstone of #biochemistry, used in drug design, metabolic studies & enzyme engineering. She was born #OTD in 1879. #WomenInSTEM

You could say that Rock n Roll was born 111 years ago today in Arkansas, but probably not where you'd think. Before there was a Chuck Berry or Little Richard, there was those who wanted to be like her. Rosetta Nubin better known as Sister Rosetta Tharpe, the godmother of Rock was born on this day

Compare this to the sunny propaganda Jay Bhattacharya shared at Tuesday's appropriations hearing. www.statnews.com/2026/03/19/n...

@saveamericamvmt.bsky.social @standupforscience.bsky.social and @27unihted.bsky.social are co-sponsoring an event covering this lecture with the first NIH Freedom From Science lecture with scientists who have actually worked to find evidence and unravel the origin of COVID-19 #NIHFFS 2/3

@statnews.com conducted a national survey of NIH-funded researchers and found that, a year after Trump's return, many scientists are reeling, with some closing labs entirely. ‘This is like the Titanic,' one respondent told me. For full details, see our special report www.statnews.com/2026/03/19/n...

We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)

Another unbearable read but do not look away

A simple celebratory post about completing my PhD went viral for all the wrong reasons. Here’s how I managed the backlash and used the attention to promote my research, says Juliet Turner go.nature.com/4sQu3uX

“This is not efficiency. This is not streamlining. This is the systematic elimination of scientific stewardship at the world’s largest biomedical research funder.”

Note the analysis on the discordance between the health and economic burden of endometriosis vs relative federal investment in research. TL:DR, very bad. www.owlposting.com/p/endometrio...

"How could this not be your life goal to work on? To reduce how awful maladies, and the awful solutions to those maladies, are? What else is there really? Better prediction markets? What are we talking about?"

Watch. Learn.

A point of contrast.

Another informative and thought provoking piece by @dereklowe.bsky.social

Exciting new discovery from @jimwellsucsf.bsky.social and coworkers, a new class of potential cancer antigens flipped onto the cell surface via autophagy-associated exocytosis, featuring first author and former PhD student Corleone Delaveris! #proudofalumni

Meet Steven Artandi, a physician-scientist who studies cancer biology. His work helps uncover the mechanisms that enable cancer to grow and persist. Learn what he wanted to be when he was a kid — and the quote he lives by. youtu.be/UWwT5owtCdc?... @stanford-cancer.bsky.social

Pleased to share our native glycomics workflow preserving O-acetylation, detecting this labile modification in rat (53%) and mouse (9%) serum N-glycans. Integrally, O-acetyls are invisible under standard reductive conditions. Now published at Molecular Omics. Link: academic.oup.com/molecular-om...

ACTION ITEM-----ACTION ITEM Because of overwhelming demand, NIH has new links for the Strategic Plan webinars March 16, 2026 12:30 - 1:30 pm | www.scgcorp.com/strategicpla... April 8, 2026 2:30 - 3:30 pm | www.scgcorp.com/strategicpla... NOTE: YOU HAVE TO RE-REGISTER IS YOU REGISTERED BEFORE

In honor of international Women's Day I am going to tell you a story about Ellen Ash Peters, the first female professor at Yale Law and the first female Justice on the Connecticut Supreme Court.

This International Women’s Day 2026, we celebrate the women shaping India’s scientific research landscape! Explore inspiring insights from women in science across the country, along with a curated collection of research articles published in ACS journals: buff.ly/XBGH2NZ #IWD2026

So proud of him.

We can save science, protect health and defend this democracy, but we have to act NOW. Hit the streets! Make yourself seen and heard! Join us on the streets at rallies nationwide on March 7th! Don't sit this out. standupforscience.net/march7 #ItsUpToUs #standupforscience #rally #March7 #science

For those in the SF Bay area, please consider attending the SUFS rally this Saturday, March 7 at SF City Hall from 1-3 pm #standupforscience @standupforscience.bsky.social fight2win.standupforscience.net/SF-March/

My weekly update on NIH funding This includes awards made through 2/27/26 Warning: This thread contains data compiled by a known deranged_activist™. Do not read while operating heavy machinery. 1/9

Excited to share our new study using engineered immune proteins to quench inflammation in aged brains!! Congratulations to Paloma Navarro and the entire team! Fantastic collaboration with Chris Garcia's lab, Tony Wyss-Coray's lab, and Saul Villeda's lab! www.cell.com/immunity/ful...

I just tried to register. The March date is already listed as Full! I did register for the April date. You have a chance to enter questions. I don't know if there will be another opportunity to do this.

Meet Sergiu Pasca, a neuroscientist whose work explores the biological basis of brain disorders such as autism and schizophrenia. Discover a favorite “aha” moment and the place he seeks out when he’s not in the lab. youtu.be/6QOptRJUH8k

Check out this cool #glycotime conference @vai.org in May 2026, co-organnized by Sharon Pitteri @stanfordbiosci.bsky.social alongside Ginny Shapiro, Brian Haab, and Richard Drake. www.vai.org/event/cancer...

MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics. A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social 1/10

Congratulations to Grant Rotskoff and Steven Banik on being named 2026 Sloan Research Fellows - honoring outstanding early-career scientists shaping the future of chemistry and discovery! 🎉 #SloanResearchFellows chemistry.stanford.edu/news/chemist...

Get to know biomedical researchers @stanfordbiosci.bsky.social @stanfordchemistry.bsky.social @stanford-chemh.bsky.social through our new “walk with me” series stanmed.stanford.edu/we-are-stanf...

Fascinating discovery by team @stanfordbiosci.bsky.social www.cell.com/cell/abstrac...

New essay on LLMs and brain rot: "LLMs do not inevitably corrode thinking. They amplify whatever epistemic posture you bring..." sbgeoaiphd.github.io/rotating_the...

My thoughts from last spring on Surgeon General nominee Casey Means' push for continuous glucose monitoring as a way of improving metabolic health: www.bloomberg.com/opinion/arti...

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

A lot of those on SI...

Great to see our work to engineer AbLecs as a new immunotherapy modality featured in @natrevdrugdiscov.nature.com! www.nature.com/articles/d41...

Professor Kevan Shokat (UCSF) will present a Student Hosted Colloquia on “Overcoming the Undruggable Nature of the Most Common Human Oncogene: K-Ras.” Join us today at 3PM in STLC 114. (Student Host: Kaan Tarhan) chemistry.stanford.edu/events/stude...

www.theguardian.com/environment/... “On climate, the hour for collective action has already arrived. The science is here. What we need now is courage – courage scaled to the enormity of the task – so we may gift the next generation not only carbon capture, but a planet worthy of their hopes,”

Deep, well sourced, moving, and enraging story from the NYT [Gift Link] www.nytimes.com/2026/02/23/o...