Gladstone researcher Alex Marson and his collaborators at Stanford University developed a genomic mapping technique that helps close the gap in understanding why certain genetic variants are tied to disease. @marsonlab.bsky.social @stanford.edu @nature.com

Today we celebrate Nobel Prize Day by honoring Jennifer Doudna and Shinya Yamanaka—two Gladstone scientists whose groundbreaking discoveries in #CRISPR gene editing and iPS cell technology continue to drive innovation and transform the future of medicine.

#YearInReview: A discovery about the consequence of neuron overactivity could lead to new methods of treating or preventing #Parkinsons disease. Read more about this study: https://bit.ly/4fYanzV

Gladstone Wrapped is here! This year, our scientists published more than 170 publications in scientific journals! Read the full thread for more highlights from the year.

A memorable moment from earlier this year—San Francisco Mayor Daniel Lurie's visit to Gladstone! #YearinReview Take a look at more highlights from his visit: https://bit.ly/4oAYt1C

Our scientists are pushing boundaries with AI approaches similar to large language models. By teaching machines to understand biological patterns, we're accelerating the discovery of new treatments for devastating diseases. The future of medicine is happening right here at Gladstone!

What a day at the 2025 Ogawa–Yamanaka Stem Cell Prize Ceremony! We honored Rudolf Jaenisch for his groundbreaking contributions to stem cell biology and epigenetics. Thank you to everyone who joined us and helped make the celebration special!

Today is J. David Gladstone's birthday—the man behind our name. His generosity paved the way for our journey. Discover more about his inspiring story: https://bit.ly/2ENrx5M

Congratulations to our six Gladstone scientists recognized as 2025 Highly Cited Researchers by Clarivate! Their groundbreaking work places them among the world’s most influential researchers, highlighting a decade of excellence and impact in their fields. 🌟👏

Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns. https://bit.ly/4imbtqv

Deepak Srivastava explains groundbreaking research in cardiac regenerative medicine. Scientists have discovered how to reprogram adult cells using specific master genes, potentially offering new treatments for heart failure. https://www.youtube.com/watch?v=3mnHLTqwKHA

Jon Muncie-Vasic explains why it’s still crucial to get to the root of congenital heart defects and how understanding early heart development is key to preventing congenital heart defects and reducing their lifelong impact.

🚨 🚨 NEW PUBLICATION 🚨 🚨 "The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2" from @theottlab.bsky.social in @elife.bsky.social

A new study from Gladstone could influence how gene therapies are designed for many genetic diseases.

Introducing 2025 Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research recipient Nalini Rao, PhD, of the @gladstoneinst.bsky.social, who will research “Elucidating how aging impairs brain proteostasis and protein clearance.” Learn more here: www.afar.org/grantee-prof...

This month, we're revisiting some of our top stories from 2025. In this Q&A from January, Virologist Melanie Ott shared scientific insights into the virus that prompted California Gov. Gavin Newsom to declare a state of emergency. Read more: https://bit.ly/4jm7aLO

Tomorrow! Join this TikTok live and get an inside look at an HIV cure research lab. Meet meet the scientists bringing us closer to ending HIV. @theottlab.bsky.social

Tomorrow! We're honoring Rudolf Jaenisch with the 2025 Ogawa-Yamanaka Stem Cell Prize. Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬 Register: https://bit.ly/4gNhf3z

Bruce Conklin and his team demonstrate that manipulating DNA repair pathways in nondividing cells can direct outcomes and improve efficiency of #CRISPR genome editing.

Scientists at Gladstone and @ucsanfrancisco.bsky.social have discovered a new way to outsmart COVID-19. Their study reveals that the molecule AVI-4206 blocks a key viral protein called Mac1—stopping the virus from hiding from our immune system. @theottlab.bsky.social https://bit.ly/3Xi6ldm

🧡🍁 Happy Thanksgiving from Gladstone! 🧡🍁 We’re grateful for the scientists, trainees, staff, collaborators, and supporters who drive discovery every day.

Scientists from Alex Marson’s lab have mapped the regulatory elements that control the FOXP3 gene, which is implicated in maintaining balance in the immune system.

Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments. Read more about this new study on our website: https://bit.ly/4nUtpcT

In honor of World AIDS Day, take an inside look at an HIV cure research lab to meet the scientists bringing us closer to ending HIV. Join the live tour on TikTok on December 1.

What does the fox say? 🦊 Dr. Alex Marson (@marsonlab.bsky.social) and scientists have the answer! Using CRISPR-based gene silencing technology, they mapped the network of genetic switches that immune cells use to fine-tune FOXP3 levels. @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social

Researchers discovered why #CRISPR behaves differently in neurons, revealing repair patterns.

Exciting news! We're honoring Rudolf Jaenisch with the 2025 Ogawa-Yamanaka Stem Cell Prize on December 1. Join us as we celebrate his groundbreaking work in epigenetics and stem cell biology. Don't miss his scientific lecture! 🧬🔬 Register: https://bit.ly/4gNhf3z

In our November newsletter, a new study could impact how gene therapies are designed, scientists explain how they identified a gene driving heart defects in Down syndrome, and find out how to register for the 2025 Ogawa-Yamanaka Stem Cell Prize Award Ceremony. https://bit.ly/44jCdC7

Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments. https://bit.ly/4oc6dXU

From her home on Potrero Hill to her lab just a few blocks away, Katie Pollard is using AI to teach computers how to read DNA — with the goal of predicting disease risk long before symptoms show up.

🚨 🚨 NEW STUDY 🚨 🚨 "CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology"

New from IGI's @bruceconklin.bsky.social!

Lennart Mucke reflects on how Alzheimer’s research has evolved since the founding of the Gladstone Institute of Neurological Disease. #AlzheimersAwarenessMonth

New research from the Gladstone reveals that the mitochondrial protein CHCHD2 may play a key role in triggering Parkinson’s disease, highlighting a new direction in understanding how the disease begins.

🚨 NEW PUBLICATION 🚨 "Characterizing and controlling #CRISPR repair outcomes in nondividing human cells" @natcomms.nature.com @ucberkeleyofficial.bsky.social @ucsanfrancisco.bsky.social @innovativegenomics.bsky.social#CRISPR https://go.nature.com/4plheqJ

Characterizing and controlling CRISPR repair outcomes in nondividing human cells @natcomms.nature.com @gladstoneinst.bsky.social www.nature.com/articles/s41...

The secret to Gladstone’s impact? A tight-knit community of top scientists, a laser focus on disease, and partnerships that stretch around the world. Dive in at gladstonenow.org.

Gladstone Investigator Ken Nakamura led a study that strengthens the links between energy breakdown in cells and the onset of Parkinson’s, potentially illuminating new paths for treatment.

A new study by scientists from Gladstone, Innovative Genomics Institute, and UC Berkeley could influence how gene therapies are designed for many genetic diseases. @innovativegenomics.bsky.social @ucberkeleyofficial.bsky.social

FOXP3—identified decades ago in work that won this year's @nobelprize.org—prevents autoimmune disease. Now @marsonlab.bsky.social & colleagues at @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social have mapped how immune cells fine-tune FOXP3 levels. gladstone.org/news/researc...

New from IGI's @marsonlab.bsky.social!

Researchers from Gladstone were part of a team that discovered a way to efficiently deliver therapeutic messenger RNA into heart muscle cells.

Discover how Gladstone scientists combined stem cells, gene editing, and AI to uncover a gene linked to heart defects in Down syndrome—and restored normal heart development in mice, opening doors to new treatments.

Azalea grew out of collaborative research conducted at the Innovative Genomics Institute in Jennifer Doudna’s lab and in Justin Eyquem’s lab as part of the Gladstone-UCSF Institute of Genomic Immunology. @j-eyquem.bsky.social @innovativegenomics.bsky.social

🚨NEW PUBLICATION 🚨 "FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry" @cp-immunity.bsky.social @ucsanfrancisco.bsky.social @parkerici.bsky.social @innovativegenomics.bsky.social @arcinstitute.org https://bit.ly/4paigFO

New from IGI's Alex Marson!

FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry www.cell.com/immunity/ful... @cp-immunity.bsky.social @gladstoneinst.bsky.social

Scientists learn to fine-tune a gene that is centrally involved in regulating the immune system, offering potential clues for future autoimmunity and cancer treatments. @cp-immunity.bsky.social @ucsanfrancisco.bsky.social @parkerici.bsky.social @innovativegenomics.bsky.social https://bit.ly/4nUtpcT

Discover the future of medicine as Gladstone President Deepak Srivastava takes the stage at the Global Wellness Summit! Don’t miss his insights on groundbreaking cures. Learn more: https://bit.ly/3Jna8mn

Virtual cell models hold potential to transform biomedicine, and Gladstone's Christina Theodoris has been at the forefront with her platfom for predicting gene interactions. https://bit.ly/49esW1C