New study by researchers Kei Igarashi, et al. demonstrates dopamine deficiency in lateral entorhinal cortex drives early memory impairment in #Alzheimers. @ucirvine.bsky.social Nature Neuroscience ➡️ www.nature.com/articles/s41... Overview from Tohoku University ➡️ www.tohoku.ac.jp/en/press/dop...

A range of exposures across the #Lifespan interact w/ genetic factors to shape one's neurocognitive phenotype. Deciphering how this complex web of influences shapes individual brain–behaviour phenotypes comes w/ substantial challenges. Nature Reviews Neuroscience 👉 www.nature.com/articles/s41...

A long-term study by Daniel Wang, et al. @harvard.edu found that drinking two to three cups of coffee a day was linked to a much lower risk of #Dementia, especially before age 75. Learn More @jama.com 👉 jamanetwork.com/journals/jam...

People who carry protective APOE2 variant are more likely to live to advanced age & are partly protected against #Alzheimers, scientists have struggled to explain why. Study by Lisa Ellerby, et al. @buckinstitute.org offers a mechanistic answer. Aging Cell 👉 onlinelibrary.wiley.com/doi/10.1111/...

The Rockefeller University's Junyue Cao's Laboratory of Single-Cell Genomics and Population Dynamics has produced two new tools and concepts for studying the molecular changes, gene expression, and intercellular dynamics of aging. Overview @rockefeller.edu 👉 www.rockefeller.edu/news/39664-t...

Here, @amandaanderssonr.bsky.social & @hansclevers.bsky.social outline limitations & challenges of current organoid systems, highlight recent advances aimed at increasing their complexity & discuss innovations that support their translation into clinical applications 👉 www.nature.com/articles/s41...

Long-term MRI study by Iris Shai, et al. @bengurionuniv.bsky.social demos lower accumulation of #VisceralFat over years associated w/ significant slowing of brain atrophy, preservation of key brain structures & better cognitive performance in late midlife 👉 www.nature.com/articles/s41...

In a first of its kind study, Susan dos Reis, Huifeng Yun, et al. found older adults in the U.S. were less likely to develop #Dementia if they received the recombinant subunit Zoster (#Shingles) vaccine (Shingrix). @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Research from Stephen Safe, et al. @tamuvetmed.bsky.social suggests compounds in coffee may work, in part, by activating receptor in body known as NR4A1, a protein increasingly recognized for its role in #Aging, #Stress response & disease. @mdpiopenaccess.bsky.social 👉 www.mdpi.com/2072-6643/18...

Interesting Article! "Tracking the turning point in #AlzheimersDisease | A #Blood #Biomarker reveals the mechanistic shift from #Amyloid to tau pathology - Bart De Strooper and Henrik Zetterberg. Learn More @science.org 👉 www.science.org/doi/10.1126/...

A recent study by researchers Yoshitaka Nagai, et al. at Kindai University found that naturally occurring #AminoAcid, arginine, can reduce buildup of harmful Aβ proteins in animal models of #Alzheimers. @sciencedirect.bsky.social | Neurochemistry International 👉 www.sciencedirect.com/science/arti...

The POINTER Imaging Ancillary Study's Susan Landau, et al. explored whether lifestyle modifications could alter brain changes associated w/ #AlzheimersDisease #CerebrovascularDisease & #Neurodegeneration, & the potential impact on global cognition. @jamaneurology.com jamanetwork.com/journals/jam...

Through a study using mice & simulations, C. Spencer Garborg, Beatrice Ghitti, Qingguang Zhang, Patrick J. Drew, et al. @pennstateuniv.bsky.social found potential biological mechanism underlying why exercise is thought to benefit brain health. Nature Neuroscience 👉 www.nature.com/articles/s41...

On April 17, the World Brain Mapping Foundation held its 23rd Annual Gathering for Cure Awards Gala. I was so proud to receive the SBMT Golden Axon Leadership Award. Here, I am w/ Nobel laureate Professor Thomas C. Südhof, recipient of the Pioneer in Medicine Award. Thank you again, Dr. Babak Kateb!

#AlzheimersDisease is best addressed as early as possible. To enable early, accurate risk prediction both for individuals & whole populations, a team centered at MIT has released FINGERS-7B, first AI foundation model built to make #Alzheimers preventable. Learn More 👉 picower.mit.edu/news/mit-bas...

Fantastic Work! Study by Haitham Amal, et al. @hebrewuniversity.bsky.social suggests #NitricOxide can sometimes trigger cascade of changes inside neurons that may play a role in some forms of #Autism. Learn More in Molecular Psychiatry @natureportfolio.nature.com 👉 www.nature.com/articles/s41...

Some brains resist #Alzheimers, even when the disease is already present. Evgenia Salta, et al. have found that this likely depends on how specific brain cells, immature neurons, respond to damage caused by the disease. Learn More @cp-cellstemcell.bsky.social 👉 www.sciencedirect.com/science/arti...

In a preclinical study using human #Alzheimers brain cells, researchers Stuart Lipton, et al. @scripps.edu have ID'd a molecular switch, & potential drug target, responsible for driving chronic inflammation in #AlzheimersDisease. Learn More @cp-cellchembiol.bsky.social www.cell.com/cell-chemica...

A NEW STUDY by Simon Cork, et al. at Anglia Ruskin University found comprehensive evidence that ‘weight-loss’ GLP-1 receptor agonists such as semaglutide are effective in tackling the biological drivers of #AlzheimersDisease. @elsevierconnect.bsky.social www.sciencedirect.com/science/arti...

NEW STUDY by Kaveh R. Khalilpour, et al. at UTS shows links between #AlzheimersDisease & #Gut #Health can lead to prevention. Learn More @alzdemjournals.bsky.social ➡️ alz-journals.onlinelibrary.wiley.com/doi/10.1002/... Overview from University of Technology Sydney ➡️ www.uts.edu.au/news/2026/04...

New study by Nate Fillmore, Jaime Ramos-Cejudo, et al. shows high neutrophil to lymphocyte ratio could ID patients at risk of dvlping #Alzheimers & related #Dementias before they exhibit signs of cognitive impairment. @alzdemjournals.bsky.social👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

An incredible audience w/ fantastic feedback at my last talk at 23rd Annual Society for Brain Mapping & Therapeutics Neurotech Conference: "Late Onset of #AlzheimersDisease computational modeling"! As the conference nears its end, thank you SBMT & Dr Babak Kateb for organizing such an amazing event.

On Friday, April 17, the World Brain Mapping Foundation held its annual "Gathering for Cure" Awards Gala. It was a fantastic event! I was so proud and humbled to have been selected to receive the 2026 Golden Axon Leadership Award. It is a wonderful honor. Thank you Dr. Babak Kateb & SBMT!

Researchers Akhmetzada Kargazhanov, Romy Aiken, Kenneth Hawkins, et al. @ucf.bsky.social have uncovered evidence some movement-related symptoms of #Alzheimers may originate outside the brain. Alzheimers & Dementia | @alzassociation.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

LANDMARK STUDY from researchers Ashok Shetty, et al. @tamu.bsky.social suggests the inflammatory tide responsible for brain aging and brain fog might actually be reversible. @tamuvetmed.bsky.social Learn More in Journal of Extracellular Vesicles 👉 isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

NEW RESEARCH by Justin Golub, et al. finds that two common & treatable causes of conductive hearing loss are associated with higher odds of #Dementia. Learn More from the American Academy of Otolaryngology - Head and Neck Surgery Foundation aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1002/...

The primary aim of this study was to examine plant-based dietary patterns and their change over time in relation to #AlzheimersDisease and related #Dementias. Learn More in Neurology www.neurology.org/doi/10.1212/... Overview @neurosciencenews.bsky.social neurosciencenews.com/plant-based-...

Jeremy Herskowitz, et al. at UAB discovered tau “seeds” travel primarily along an individual’s unique, natural communication pathways confirming personal neuronal wiring dictates how fast & far #Alzheimers advances, providing definitive target for antibody therapies. 👉 www.cell.com/neuron/fullt...

NEW STUDY from Praveen Rao, et al. @uwaterloo.ca investigated potential of combining antibody treatments with natural small molecule inhibitors known for their anti-amyloid properties, specifically #Resveratol and #Curcumin. Learn More in ACS Chemical Neuroscience pubs.acs.org/doi/10.1021/...

MORE INTERESTING RESEARCH! Led by Marilyn Rampersad Mackiewicz @osuscience.bsky.social, a team of researchers have uncovered real-time insights into a chemical process linked w/ #Alzheimers, paving the way toward better drug designs. Learn More in ACS Omega news.oregonstate.edu/news/researc...

Older adults who received a high-dose inactivated influenza vaccine had a lower risk of incident #AlzheimersDisease dementia compared with those who received a standard-dose shot, U.S. claims data showed. Learn More in Neurology www.neurology.org/doi/10.1212/...

GREAT PAPER! In a new study, Thomas Shoff, Maxence Derbez-Morin, Peishan Cai, and Ryan Julian @ucriverside.bsky.social offer a "unifying theory" that resolves some conflicting ideas about #AlzheimersDisease. Learn More @pnasnexus.org 👉 academic.oup.com/pnasnexus/ar...

Society for Brain Mapping & Therapeutics's 23rd Annual Neurotech Conference is 2 WEEKS AWAY! Looking forward to connecting w/ Rudolph Castellani, George Perry & Christopher Wheeler to discuss latest #Neurotech innovations in #Alzheimers & #Dementia. JOIN US! Register Now 👉 www.worldBrainMapping.org

Interesting Research! Alzheimer’s has long been considered “undruggable” because the proteins involved lack a fixed shape for traditional drugs to latch onto. Researchers @kobeuniv.bsky.social have found a solution. Learn More in ChemEurJ ➡️ chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Different #Neurodegenerative conditions can present w/ similar symptoms, making it difficult to distinguish btwn them. Now, researchers Jacob Vogel, Lijun An, et al. have dvlpd an #AI model capable of detecting multiple diseases at once. Learn More in Nature Medicine 👉 www.nature.com/articles/s41...

The #GutBrainAxis has long been known for its indirect chemical signaling, but a groundbreaking study by Arash Grakoui, et al. @emoryuniversity.bsky.social suggests a much more direct interaction. Learn More @plosbiology.org 👉 journals.plos.org/plosbiology/...

MISSED IT? Study by Eun-Jeong Yang, Giulio Maria Pasinetti, et al. reveals regulatory T cells, crucial components of immune system, might also influence #AlzheimersDisease type neuropathology & cognitive functions. CHECK OUT this #PasinettiLab study @pnasnexus.org 👉 academic.oup.com/pnasnexus/ar...

A great day at Making the Impossible Possible (MIPO) Youth Summit. Metropolitan College of New York (MCNY) was proud to be represented by @weillcornell.bsky.social's Dr. Greta Strong & Dr. Hamilton Raymond w/ special recognition to MCNY MBA alumna NY State Assemblymember Monique Chandler-Waterman.

Severe infections have been linked to increased risk of #Dementia. However, it has been unclear whether this assoc is explained by other coexisting, non-infectious diseases that predispose people to both infections & dementia. Learn More @plosmedicine.org 👉 journals.plos.org/plosmedicine...

INTERESTING RESEARCH from @ki.se! Older people with a genetic risk of #AlzheimersDisease did not experience the expected increase in cognitive decline and #Dementia risk if they consumed relatively large amounts of meat. Learn More @jamanetworkopen.com ➡️ jamanetwork.com/journals/jam...

A NEW STUDY by Chris Greene, Declan Brennan, Colin Doherty, Matthew Campbell, et al. has identified a leaky #BloodBrainBarrier (BBB) as the primary mechanism linking repetitive head injuries to long-term cognitive decline in retired athletes. Learn More @science.org 👉 www.science.org/doi/10.1126/...

In this prospective cohort study by Hui Chen, Gulisiya Hailili, Lu-sha Tong, et al., greater adherence to the #MINDDiet was associated w/ slower brain structural atrophy, particularly regarding grey matter loss & ventricular enlargement. Learn More at jnnp.bmj.com 👉 jnnp.bmj.com/content/earl...

In a new study, @dukemedschool.bsky.social researchers Vincent D’Anniballe, Sarah Kim, John Finlay, Bradley Goldstein, et al. show that a quick, outpatient nasal swab can pick up early biological changes linked to #Alzheimers. Learn More in Nature Communications 👉 www.nature.com/articles/s41...

A NEW STUDY by Francisco José López-Murcia, Nils Brose, et al. has identified a molecular pathway in the brain that is crucial for the proper functioning of working memory. @unibarcelonathe.bsky.social @maxplanck.de Learn More in @cp-cellreports.bsky.social 👉 www.cell.com/cell-reports...

Rodrigue Brossaud, Michel Neunlist, Moustapha Cissé, et al. investigated possibility Aβ accumulates in both brain & gut of patients w/ #Alzheimers, which can also damage connections that promote healthy digestion, contributing to AD progression. Molecular Psychiatry www.nature.com/articles/s41...

Researchers @meredithbraskie.bsky.social, et al. have ID'd important differences in how early #AlzheimersDisease -related brain changes appear across racial & ethnic groups. LEARN MORE @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

FANTASTIC! Researchers Wouter De Coster, Marleen Van den Broeck, Matthew Baker, @joannambi.bsky.social, Rosa Rademakers, et al. have ID'd a major genetic risk factor for rare form of #FrontoTemporalDementia. @uantwerpen.be @viblifesciences.bsky.social @mayoclinic.org 👉 www.nature.com/articles/s41...

I am so proud and grateful to have been selected to receive the Society for Brain Mapping & Therapeutics' 2026 Golden Axon Leadership Award. It is a wonderful honor. Thank you Dr. Babak Kateb and the World Brain Mapping Foundation Boards.- Dr. Giulio Maria Pasinetti

A new study by researchers Ahrum Son, Hyunsoo Kim, Jolene Diedrich, John Yates III, et al. suggests #AlzheimersDisease may be detectable through subtle shape changes in proteins found in the blood. Learn More in Nature Aging | @natureportfolio.nature.com 👉 www.nature.com/articles/s43...

Researchers Melanie Campbell, et al are leading development of fast, non-invasive & affordable diagnostic tool that could help doctors quickly distinguish btwn similar #NeurodegenerativeDiseases w/ remarkable accuracy. @alzassociation.bsky.social👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...