Severe infections have been linked to increased risk of #Dementia. However, it has been unclear whether this assoc is explained by other coexisting, non-infectious diseases that predispose people to both infections & dementia. Learn More @plosmedicine.org 👉 journals.plos.org/plosmedicine...

INTERESTING RESEARCH from @ki.se! Older people with a genetic risk of #AlzheimersDisease did not experience the expected increase in cognitive decline and #Dementia risk if they consumed relatively large amounts of meat. Learn More @jamanetworkopen.com ➡️ jamanetwork.com/journals/jam...

A NEW STUDY by Chris Greene, Declan Brennan, Colin Doherty, Matthew Campbell, et al. has identified a leaky #BloodBrainBarrier (BBB) as the primary mechanism linking repetitive head injuries to long-term cognitive decline in retired athletes. Learn More @science.org 👉 www.science.org/doi/10.1126/...

In this prospective cohort study by Hui Chen, Gulisiya Hailili, Lu-sha Tong, et al., greater adherence to the #MINDDiet was associated w/ slower brain structural atrophy, particularly regarding grey matter loss & ventricular enlargement. Learn More at jnnp.bmj.com 👉 jnnp.bmj.com/content/earl...

In a new study, @dukemedschool.bsky.social researchers Vincent D’Anniballe, Sarah Kim, John Finlay, Bradley Goldstein, et al. show that a quick, outpatient nasal swab can pick up early biological changes linked to #Alzheimers. Learn More in Nature Communications 👉 www.nature.com/articles/s41...

A NEW STUDY by Francisco José López-Murcia, Nils Brose, et al. has identified a molecular pathway in the brain that is crucial for the proper functioning of working memory. @unibarcelonathe.bsky.social @maxplanck.de Learn More in @cp-cellreports.bsky.social 👉 www.cell.com/cell-reports...

Rodrigue Brossaud, Michel Neunlist, Moustapha Cissé, et al. investigated possibility Aβ accumulates in both brain & gut of patients w/ #Alzheimers, which can also damage connections that promote healthy digestion, contributing to AD progression. Molecular Psychiatry www.nature.com/articles/s41...

Researchers @meredithbraskie.bsky.social, et al. have ID'd important differences in how early #AlzheimersDisease -related brain changes appear across racial & ethnic groups. LEARN MORE @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

FANTASTIC! Researchers Wouter De Coster, Marleen Van den Broeck, Matthew Baker, @joannambi.bsky.social, Rosa Rademakers, et al. have ID'd a major genetic risk factor for rare form of #FrontoTemporalDementia. @uantwerpen.be @viblifesciences.bsky.social @mayoclinic.org 👉 www.nature.com/articles/s41...

I am so proud and grateful to have been selected to receive the Society for Brain Mapping & Therapeutics' 2026 Golden Axon Leadership Award. It is a wonderful honor. Thank you Dr. Babak Kateb and the World Brain Mapping Foundation Boards.- Dr. Giulio Maria Pasinetti

A new study by researchers Ahrum Son, Hyunsoo Kim, Jolene Diedrich, John Yates III, et al. suggests #AlzheimersDisease may be detectable through subtle shape changes in proteins found in the blood. Learn More in Nature Aging | @natureportfolio.nature.com 👉 www.nature.com/articles/s43...

Researchers Melanie Campbell, et al are leading development of fast, non-invasive & affordable diagnostic tool that could help doctors quickly distinguish btwn similar #NeurodegenerativeDiseases w/ remarkable accuracy. @alzassociation.bsky.social👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

In this study, Vincent Prevot, et al. show that specialized hypothalamic cells called tanycytes clear tau by shuttling it from cerebrospinal fluid of the brain to the blood. In patients w/ #Alzheimers, tanycytes are fragmented & dysfunctional. @cellpressblue.bsky.social www.cell.com/cell-press-b...

Interesting Article! China is waging war on #Alzheimers. What can its approach teach the rest of the world? China is facing a coming wave of #Dementia for its ageing population, & is investing in research into drugs, diagnostics & even surgery. @nature.com ➡️ www.nature.com/articles/d41...

TERRIFIC STUDY! To reduce the frequency of treatment & potentially improve the efficacy of the new generation of #Alzheimers drugs, an anti-amyloid therapy, researchers Yun Chen, et al. @washumedicine.bsky.social engineered a new cellular immunotherapy. @science.org www.science.org/doi/10.1126/...

Is α-synuclein pathology differentially associated with tau accumulation in women and men across the #AlzheimersDisease continuum? LEARN MORE in a NEW STUDY by Elijah Mak, Angela Fought, Heather Wiste, Kejal Kantarci, et al. @mayoclinic.org! @jamanetworkopen.com 👉 jamanetwork.com/journals/jam...

Researchers Nilüfer Ertekin-Taner, et al. @mayoclinic.org ID'd specific DNA-level changes in brains of people w/ #Alzheimers. Team mapped alterations in brain’s regulatory landscape that may help explain why AD presents & progresses differently from person to person. 👉 www.nature.com/articles/s41...

In NEW STUDY, researchers Nalini Rao, et al. @feinberg.northwestern.edu pinpointed when & where toxic proteins accumulate w/in brains of #Alzheimers patients, & discovered an @fda.gov approved drug that can stop accumulation process before it begins. @science.org 👉 www.science.org/doi/10.1126/...

Researchers, led by Dr. Sonia Villapol at Houston Methodist, found short-term antibiotic treatment significantly reduced #Neuroinflammation & #Neurodegeneration following #TraumaticBrainInjury by altering #Gut #Microbiome in animal models. @commsbio.nature.com 👉 www.nature.com/articles/s42...

In a NEW STUDY, Ahmed Disouky, Mark A. Sanborn, K. R. Sabitha, Jalees Rehman, Orly Lazarovet, al. found SuperAgers produce between two and two and a half times more new neurons than their healthy peers and peers with #Alzheimers, respectively. Learn More @nature.com 👉 www.nature.com/articles/s41...

Amaryllis Tsiknia, @meredithbraskie.bsky.social, et al. @keckmedicineusc.bsky.social found subtle shifts in how blood moves thru brain & how brain cells receive oxygen may be closely connected to risk of #Alzheimers. @alzdemjournals.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers Gregor Bieri, Saul Villeda, et al. at UCSF "have discovered a mechanism that could explain how exercise improves cognition by shoring up the brain’s protective barrier of blood vessels." @ucsfaging.bsky.social FULL STUDY @cellcellpress.bsky.social 👉 www.cell.com/cell/fulltex...

Findings by Kellen Petersen, Marta Milà-Alomà, Yan Li, Suzanne Schindler, et al. suggest time until onset of #Alzheimers symptoms can be estimated using single blood test w/in margin of error that is acceptable for use in clinical trials. @naturemedicine.bsky.social 👉 www.nature.com/articles/s41...

"To systematically uncover cellular factors controlling accumulation of tau aggregates in human neurons, Avi Samelson, Martin Kampmann, et al. conducted a genome-wide CRISPRi screen in induced pluripotent stem cell (iPSC)-derived neurons." @cellpress.bsky.social 👉 www.cell.com/cell/fulltex...

In new study, researchers Yanling Deng, et al.'s findings suggest #AirPollution contributes to #AlzheimersDisease mostly through direct pathways rather than through other chronic health conditions. at @emoryuniversity.bsky.social Learn More in @plos.org Medicine 👉 journals.plos.org/plosmedicine...

An int'l group of #Dementia specialists, along w/ people affected by dementia, evaluated 80 existing medications. Their goal was to ID which ones showed greatest promise for treating or preventing #Alzheimers. Alzheimer's Research and Therapy | Springer Nature Link link.springer.com/article/10.1...

NEW FINDINGS: "adults age 65 & older who completed 5 to 6 weeks of cognitive speed training, & who had follow-up sessions about 1 to 3 years later, were less likely to be diagnosed w/ #Dementia up to 2 decades later." @alzassociation.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Here, Sung Kyun Park, et al. @umich.edu investigated prospective assoc btwn lead exposure & incident #Alzheimers & all-cause #Dementia in nationally-representative US populations.
 They found high bone lead levels can triple your risk. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Here, Nicholas Tonks, et al. @cshlnews.bsky.social found deleting or inhibiting a protein tyrosine phosphatase enzyme, PTP1B, improved cognitive behaviors & reduced Aβ burden in an #Alzheimers mouse model. Learn More @pnas.org 👉 www.pnas.org/doi/10.1073/... Overview 👉 www.cshl.edu/researchers-...

Knowledge of modifiable factors influencing age at onset of #AlzheimersDisease remains limited. In this study, Yi-Ju Li, Eden Martin, et al. utilized genetic information to uncover such factors. FULL STUDY @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

In this study, Bhakta Prasad Gaire, Yosef Koronyo, Jean-Philippe Vit, et al. show Chlamydia pneumoniae can reach retina & trigger immune responses linked to inflammation, nerve cell death & cognitive decline. @cedarssinaihsu.bsky.social @natureportfolio.nature.com 👉 www.nature.com/articles/s41...

Alison Warren, @phdleigh.bsky.social, et al.'s new, scoping review is shedding light on the growing evidence that #Gut #Microbiome imbalances may play a key role in development & progression of #MCI & #Alzheimers. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Here, researchers Sarah Shipley, Caswell Barry, et al. investigated how disruptions in hippocampal reactivations relate to place cell stability and spatial memory deficits in #AlzheimersDisease mouse model. @ucl.ac.uk @currentbiology.bsky.social @cellpress.bsky.social 👉 www.cell.com/current-biol...

In this study, researchers Rachael Layden, Jenna Groh, Annalise Miner, et al. examined the independent contribution of #CTE neuropathology w/ #Dementia & cognitive symptoms. @alzdemjournals.bsky.social @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

In new genetic study, Liv Tybjærg Nordestgaard, et al. analyzed data from large populations in Denmark and the U.K., and found that #Obesity & #HighBloodPressure may play a direct role in causing #Dementia, not just increasing the risk. Learn More in #JCEM 👉 academic.oup.com/jcem/advance...

Researchers Brenna Hagan, Ali Ozdemir, Andrew Budson, et al. say that measure derived from EEG combined w/ transcranial magnetic stimulation can distinguish people w/ #Alzheimers from healthy older adults by detecting reduced brain response complexity. Learn More 👉 academic.oup.com/nc/article/2...

In a NEW STUDY, researchers Barbara Brott, Aram Raissi, Carla Shatz, et al. report new evidence that amyloid beta & inflammation may act through same molecular pathway. This insight may have important implications for future #AlzheimersDisease therapies. @pnas.org 👉 www.pnas.org/doi/10.1073/...

Here, Michael Pomirchy, Pascal Geldsetzer, et al. found that vaccination against #Herpes zoster ( #Shingles ) was tied to significantly less #Dementia risk. @stanfordpress.bsky.social @mcmasteruniversity.bsky.social Learn More @thelancet.com 👉 thelancet.com/journals/lan...

INTERESTING! Can #Cancer affect #Alzheimers progression? Here, Youming Lu, et al. at Huazhong University find that a molecule produced by cancer cells can shield brain from AD in mice. Overview @nature.com 👉 www.nature.com/articles/d41... Study @cellpress.bsky.social 👉 www.cell.com/cell/abstrac...

Here, researchers Dylan Williams, Sami Heikkinen, Mikko Hiltunen, et al. estimated extents to which clinically diagnosed #Alzheimers (AD), AD neuropathology & all-cause #Dementia attributable to common APOE alleles in four large studies. @ucl.ac.uk npj | dementia www.nature.com/articles/s44...

Here, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, et al. investigated frequency of APOE genotypes in #SuperAgers compared to middle‐aged and older adults. Learn More in #Alzheimers & #Dementia | Journal of @alzassociation.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The cPLA2 enzyme is a critical mediator of inflammatory lipid signaling pathways. Here, Anastasiia Sadybekov, et al. at USC investigated therapeutic potential of novel cPLA2 inhibitors in modulating #Neuroinflammation in #Alzheimers. Learn More in npj Drug Discovery 👉 www.nature.com/articles/s44...

Researchers @unmhsc.bsky.social have shown OTULIN, an enzyme known for regulating immune activity, plays major role in producing tau. Disabling OTULIN stopped tau production & removed existing tau from neurons @uthsc.bsky.social @genomicpress.bsky.social👉 genomicpress.kglmeridian.com/view/journal...

"Darkness cannot drive out darkness; only light can do that… the time is always right to do what is right”. - Dr. Martin Luther King Jr. On January 19th, celebrate the life and legacy of Dr. Martin Luther King Jr., a great American hero!

Brian Kennedy, et al. of National University of Singapore report calcium alpha-ketoglutarate (CaAKG), naturally occurring & well studied metabolite linked to healthy aging, can reverse several memory related brain functions disrupted in #Alzheimers Aging Cell👉 onlinelibrary.wiley.com/doi/10.1111/...

Researchers Victoria Garfield, et al. report new evidence suggesting sharp increases in blood sugar following meals may raise #Alzheimers risk. Overview 👉 www.sciencedaily.com/releases/202... Learn More in #Diabetes #Obesity & #Metabolism 👉 dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

An international research effort combining brain imaging and memory testing from thousands of adults is offering a clearer picture of how age-related brain changes affect memory. @andersfjell.bsky.social Learn More in Nature Communications @natureportfolio.nature.com 👉 www.nature.com/articles/s41...

In this study, Qiwen Cheng, Rosa Krajmalnik-Brown, Diego Mastroeni, et al. @arizonastateuni.bsky.social aimed to characterize gut proteome and #Microbiome differences associated with #AlzheimersDisease. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers Xingyu Su, et al. at Waseda University sought to determine if elevated levels of bone morphogenetic proteins, or BMPs, in brains of #AlzheimersDisease patients are assoc w/ impaired neurogenesis & play a role in sex differences observed in AD. Learn More link.springer.com/article/10.1...

Your daily rhythm may matter more for #BrainHealth than previously thought. Research by Wendy Wang, et al. points to the body clock as possible early warning sign for cognitive decline. @aanbrainhealth.bsky.social 👉 www.neurology.org/doi/10.1212/... ScienceDaily👉 www.sciencedaily.com/releases/202...