In this study, researchers Rachael Layden, Jenna Groh, Annalise Miner, et al. examined the independent contribution of #CTE neuropathology w/ #Dementia & cognitive symptoms. @alzdemjournals.bsky.social @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

In new genetic study, Liv Tybjærg Nordestgaard, et al. analyzed data from large populations in Denmark and the U.K., and found that #Obesity & #HighBloodPressure may play a direct role in causing #Dementia, not just increasing the risk. Learn More in #JCEM 👉 academic.oup.com/jcem/advance...

Researchers Brenna Hagan, Ali Ozdemir, Andrew Budson, et al. say that measure derived from EEG combined w/ transcranial magnetic stimulation can distinguish people w/ #Alzheimers from healthy older adults by detecting reduced brain response complexity. Learn More 👉 academic.oup.com/nc/article/2...

In a NEW STUDY, researchers Barbara Brott, Aram Raissi, Carla Shatz, et al. report new evidence that amyloid beta & inflammation may act through same molecular pathway. This insight may have important implications for future #AlzheimersDisease therapies. @pnas.org 👉 www.pnas.org/doi/10.1073/...

Here, Michael Pomirchy, Pascal Geldsetzer, et al. found that vaccination against #Herpes zoster ( #Shingles ) was tied to significantly less #Dementia risk. @stanfordpress.bsky.social @mcmasteruniversity.bsky.social Learn More @thelancet.com 👉 thelancet.com/journals/lan...

INTERESTING! Can #Cancer affect #Alzheimers progression? Here, Youming Lu, et al. at Huazhong University find that a molecule produced by cancer cells can shield brain from AD in mice. Overview @nature.com 👉 www.nature.com/articles/d41... Study @cellpress.bsky.social 👉 www.cell.com/cell/abstrac...

Here, researchers Dylan Williams, Sami Heikkinen, Mikko Hiltunen, et al. estimated extents to which clinically diagnosed #Alzheimers (AD), AD neuropathology & all-cause #Dementia attributable to common APOE alleles in four large studies. @ucl.ac.uk npj | dementia www.nature.com/articles/s44...

Here, Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, et al. investigated frequency of APOE genotypes in #SuperAgers compared to middle‐aged and older adults. Learn More in #Alzheimers & #Dementia | Journal of @alzassociation.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The cPLA2 enzyme is a critical mediator of inflammatory lipid signaling pathways. Here, Anastasiia Sadybekov, et al. at USC investigated therapeutic potential of novel cPLA2 inhibitors in modulating #Neuroinflammation in #Alzheimers. Learn More in npj Drug Discovery 👉 www.nature.com/articles/s44...

Researchers @unmhsc.bsky.social have shown OTULIN, an enzyme known for regulating immune activity, plays major role in producing tau. Disabling OTULIN stopped tau production & removed existing tau from neurons @uthsc.bsky.social @genomicpress.bsky.social👉 genomicpress.kglmeridian.com/view/journal...

"Darkness cannot drive out darkness; only light can do that… the time is always right to do what is right”. - Dr. Martin Luther King Jr. On January 19th, celebrate the life and legacy of Dr. Martin Luther King Jr., a great American hero!

Brian Kennedy, et al. of National University of Singapore report calcium alpha-ketoglutarate (CaAKG), naturally occurring & well studied metabolite linked to healthy aging, can reverse several memory related brain functions disrupted in #Alzheimers Aging Cell👉 onlinelibrary.wiley.com/doi/10.1111/...

Researchers Victoria Garfield, et al. report new evidence suggesting sharp increases in blood sugar following meals may raise #Alzheimers risk. Overview 👉 www.sciencedaily.com/releases/202... Learn More in #Diabetes #Obesity & #Metabolism 👉 dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

An international research effort combining brain imaging and memory testing from thousands of adults is offering a clearer picture of how age-related brain changes affect memory. @andersfjell.bsky.social Learn More in Nature Communications @natureportfolio.nature.com 👉 www.nature.com/articles/s41...

In this study, Qiwen Cheng, Rosa Krajmalnik-Brown, Diego Mastroeni, et al. @arizonastateuni.bsky.social aimed to characterize gut proteome and #Microbiome differences associated with #AlzheimersDisease. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers Xingyu Su, et al. at Waseda University sought to determine if elevated levels of bone morphogenetic proteins, or BMPs, in brains of #AlzheimersDisease patients are assoc w/ impaired neurogenesis & play a role in sex differences observed in AD. Learn More link.springer.com/article/10.1...

Your daily rhythm may matter more for #BrainHealth than previously thought. Research by Wendy Wang, et al. points to the body clock as possible early warning sign for cognitive decline. @aanbrainhealth.bsky.social 👉 www.neurology.org/doi/10.1212/... ScienceDaily👉 www.sciencedaily.com/releases/202...

Here, Cleveland Clinic's Noah Lorincz-Comi & Feixiong Cheng introduce a general Bayesian method which returns posterior probabilities that a gene is only assoc w/ #Alzheimers or additionally assoc w/ other phenotypes @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Scientists @ki.se & RIKEN Center for Brain Science have uncovered two somatostatin receptors, known as SST1 & SST4, that help regulate how #Amyloid beta is broken down, a process disrupted in #AlzheimersDisease. Learn More in Journal of Alzheimer’s Disease journals.sagepub.com/doi/10.1177/...

Lindsay Farrer, et al. @bumedicine.bsky.social, studying #Alzheimers in African Americans, have uncovered a striking genetic clue that may cut across racial lines and open the door to new treatment strategies. @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

May the New Year bring you joy, happiness, peace and good health! 🎉

Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social www.cell.com/cell-reports...

Experimental drug dvlpd @nufeinbergmed.bsky.social has demonstrated promise as early intervention for #Alzheimers. CHECK OUT: Identification of a glia-associated amyloid β oligomer subtype & the rescue from reactive astrogliosis by inhibitor NU-9👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The #PasinettiLab’s family wishes you and your loved ones an AMAZING HOLIDAY filled with #Peace, #Joy, #Love and #Happiness! Most importantly, we wish you the best of HEALTH. Please #StaySafe as you gather for holiday festivities.

Researchers Huntington Potter, et al. @cuanschutz.bsky.social discovered while brain neuron changes may begin in early life, sargramostim might be repurposed to slow damage, offering new hope for those w/ #Alzheimers & other cognition issues @cp-cellreports.bsky.social www.cell.com/cell-reports...

IN CASE YOU'VE MISSED IT, the #PasinettiLab is excited to share that its new manuscript, "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression", is OUT NOW in Molecular Neurobiology. CHECK IT OUT 👉 link.springer.com/article/10.1...

Researchers Nicole F. O. Green, Gavin Sutton, Irina Voineagu, et al. at UNSW have revealed so-called “junk DNA” contains powerful switches that help control brain cells linked to #AlzheimersDisease. Learn More In Nature Neuroscience @natureportfolio.nature.com 👉 www.nature.com/articles/s41...

NEW RESEARCH from Jo Mhairi Hale, et al. 👉 Disentangling #SocialIsolation, #Loneliness & later-life cognitive function for older adults in United States: Evidence from causal inference modeling. @uniofstandrews.bsky.social @emoryuniversity.bsky.social FULL STUDY ➡️ academic.oup.com/psychsocgero...

The #PasinettiLab is excited to share its REVIEW "Role of dietary polyphenols in NAD+-dependent deacetylase SIRT 1 in stress-induced depression" ➡️ OUT NOW in Molecular Neurobiology👉 link.springer.com/article/10.1... @mountsinainyc.bsky.social @ufabcoficial.bsky.social @deptvetaffairs.bsky.social

Society for Brain Mapping & Therapeutics's 23rd Annual Neurotech Conference is COMING UP FAST🚀 Looking forward to connecting w/ Rudolph Castellani, George Perry & Christopher Wheeler to discuss latest #Neurotech innovations in #Alzheimers & #Dementia. JOIN US! Register Now👉 www.worldBrainMapping.org

Here, Ana Royo Marco, et al. investigated whether promoting brain lymphatic drainage recuperation following #TBI via trtmnt w/ lymphangiogenic factor vessel endothelial growth factor C (VEGFC) mitigates ability of TBI to exacerbate tauopathy @cp-cellreports.bsky.social www.cell.com/cell-reports...

In this study, Matias Pizarro, Ruben Gomez-Gutierrez, et al. investigate the effects of infusing blood from young and old wild-type mice into transgenic mice that model #AlzheimersDisease brain amyloidosis. Learn More in Aging 👉 www.aging-us.com/article/206319

Researchers Chiron Bang, et al. @floridaatlantic.bsky.social have dvlped deep learning model that analyzes #Electroencephalography brain activity to detect both type & severity of #Dementia, specifically #AlzheimersDisease & #FrontotemporalDementia Learn More 👉 www.sciencedirect.com/science/arti...

Researchers Cyrus Raji, et al. @washumedmir.bsky.social have conducted 1st study evaluating impact of #Obesity on #Alzheimers blood #Biomarkers. BBM values increased up to 95% faster in individuals w/ obesity vs. non-obese individuals. Learn More @rsnasky.bsky.social 👉 www.rsna.org/media/press/...

This review by Kamal Dua, Muralikrishnan Dhanasekaran, et al. explores the emerging link between #Microplastics exposure & development of #NeurodegenerativeDiseases, particularly #Alzheimers & #ParkinsonsDisease. Learn More in Molecular and Cellular Biochemistry 👉 link.springer.com/article/10.1...

Scientists Erzsebet Szatmari, Ryohei Yasuda, et al. @mpfneuro.bsky.social w/ @eastcarolinauniv.bsky.social & @floridaatlantic.bsky.social 👉 genetically eliminating Centaurin-α1 can lessen many of cognitive deficits & brain damage caused by #Alzheimers in mice. eNeuro www.eneuro.org/content/12/1...

Why do neurons die in #Dementia & can this process be slowed down? Study by researchers Svenja Lorenz, Marcus Conrad, et al. provides the first molecular evidence that #Ferroptosis can drive #Neurodegeneration in the human brain. Learn More @cellpress.bsky.social www.cell.com/cell/fulltex...

Large population analysis by Min Xie, Pascal Geldsetzer, et al. @stanforduniversity.bsky.social strengthens growing evidence that viral infections may play an important and previously underappreciated role in #NeurodegenerativeDisease. Learn More @cellpress.bsky.social 👉 www.cell.com/cell/fulltex...

What a fantastic day at #RSNA25 connecting w/ so many incredible professionals in our field. It was particularly a pleasure to exchange insights w/ DeepHealth's Dr. Greg Sorensen, RadNet's Norman Hames & SBMT CEO, Dr. Babak Kateb @rsnasky.bsky.social Learn More 👉 events.siemens-healthineers.com/rsna

Here, Xun Sun, Debasis Saha, Xue Wang, Jinghui Luo, et al. describe the distinct modulation by spermine on #AlzheimersDisease Tau & #ParkinsonsDisease α-synuclein, elucidating their condensation behaviors in vitro & in vivo. Learn More in Nature Communications 👉 www.nature.com/articles/s41...

Whether you are traveling or relaxing at home, spending the day with friends and/or family, from the #PasinettiLab family to yours, ENJOY a WONDERFUL, HAPPY and SAFE #Thanksgiving2025!

ACCEPTED for PUBLICATION! The #PasinettiLab is excited to share that its new manuscript has been accepted for publication by Molecular Neurobiology. COMING SOON 👉 "Role of dietary #Polyphenols in NAD+-dependent deacetylase SIRT 1 in #Stress-induced #Depression".

According to new study by Shea Andrews, Kristine Yaffe, et al. at UCSF, while genes account for about half risk of developing #Dementia & cannot be changed, other half is determined by factors which can be addressed. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Researchers at Kindai University have discovered that oral administration of arginine, a naturally occurring amino acid, can suppress amyloid β (Aβ) aggregation & alleviate neurological symptoms in animal models of #Alzheimers. In Neurochemistry International ➡️ www.sciencedirect.com/science/arti...

Researchers Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Benjamin Deneen, et al. @bcmhouston.bsky.social discovered natural mechanism that clears existing #Amyloid plaques in brains of mouse models of #Alzheimers & preserves cognitive function. Nature Neuroscience 👉 www.nature.com/articles/s41...

A MUST READ! Zaven Khachaturian offers a unique perspective & terrific account of the history of Alzheimer Movement in the United States as well as the origins & future of Alzheimer's Disease Research Centers (ADRC). @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

People w/ lower incomes & people from racial & ethnic historically underrepresented groups in clinical studies are more likely to have modifiable risk factors for #Dementia, factors that could be changed to lower their risk. Learn More @greenjournal.bsky.social 👉 www.neurology.org/doi/10.1212/...

Researchers Tomomi Takahashi, Rei Kurita, et al. at Tokyo Metropolitan University have turned to concepts from polymer physics to better understand a central feature of #Alzheimers: the formation of tau protein fibrils. Learn More @elsevierconnect.bsky.social 👉 www.sciencedirect.com/science/arti...

Once again, congratulations to @mountsinainyc.bsky.social's Pinar Ayata, Jessica Crowle, Matthew Challman, John Crary, Alison Goate, Anne Schaefer, et al., as well as, all of the contributing researchers from other institutions! Very exciting work.