In women with multiple sclerosis, disease-modifying therapy management during pregnancy increased relapse risk, particularly in patients receiving natalizumab with prolonged interruption or fingolimod. ja.ma/3KOHJGd

Editorial: Plasma p-tau217 is a promising yet complementary #Alzheimer biomarker, aiding diagnosis and trial efficiency but not fully replacing CSF and PET, especially in those without cognitive impairment. ja.ma/499PIaL

Across the JAMA Network, we seek submission of manuscripts describing original research that examines the application of #AI in clinical settings. 🔗 Learn more about submission criteria: ja.ma/48p3TbH

Using tau PET and plasma p-tau217 biomarkers may refine #Alzheimer trials by tracking disease progression in real-time and anticipating cognitive changes prior to impairment. ja.ma/46SoIv2

From @jama.com: #Microplastics are increasingly detected in human tissues, with potential links to cognitive, cardiovascular, and inflammatory outcomes. 📌 Learn more: ja.ma/4qgfSyQ

HHV-6 was identified as a rare cause of fulminant acute hemorrhagic leukoencephalitis in an immunocompetent adult. #NeuroSky ja.ma/4nbe87b

Lower posttreatment amyloid plaque after donanemab was correlated with slower clinical decline and reduced AD-related plasma biomarkers in TRAILBLAZER-ALZ 2. ja.ma/4ogkUJN

From @jama.com: After mechanical thrombectomy for acute LVO stroke, intra-arterial alteplase increased the rate of excellent 90-day functional outcomes without raising symptomatic intracranial hemorrhage. ja.ma/4h5gRxo

General anesthesia improved 90-day disability outcomes and increased the rate of successful reperfusion compared with moderate sedation in patients undergoing endovascular thrombectomy for acute ischemic stroke. ja.ma/4930oI2

Viewpoint: The APOE4 allele is associated with an increased risk of #Alzheimer disease and earlier onset, but more longitudinal studies with diverse populations are needed to accurately estimate this risk. ja.ma/4nJX5Ko

In patients with post-dural puncture headache who do not respond to conventional treatment, iatrogenic CSF-venous fistula should be considered as it may necessitate different treatment. ja.ma/48ecrCd

Brain arteriovenous malformations, also known as AVMs, are high flow cerebrovascular lesions with great potential to cause intracranial hemorrhage and epilepsy. Learn more in this episode with author Helen Kim, PhD, and JAMA Neurology Web Editor Cynthia Armand. ja.ma/4o6JIE3

The annual rate of first intracranial hemorrhage from unruptured brain AVMs was 1.4% in a multinational cohort, lower than commonly cited estimates. ja.ma/3KzOqM6

Editorial: The ATIS-NVAF trial shows adding antiplatelet therapy to OAC in stroke patients with AF and atherosclerotic disease increases major bleeding without significant reduction in ischemic events. ja.ma/48Pm6PK

In patients with ischemic stroke and concurrent nonvalvular atrial fibrillation and ASCVD, adding an antiplatelet agent to anticoagulant therapy offered no net clinical benefit over anticoagulant monotherapy. ja.ma/4nCGhoF

The VasCog-2-WSO criteria provide updated international guidelines for diagnosing vascular cognitive impairment and #dementia, incorporating recent biomarker advancements. ja.ma/4mOsJVY#dementia

Case report: brain imaging of 2 patients with a disease course suggestive of autoimmune glial fibrillary acidic protein astrocytopathy. ja.ma/42IlRT1

Case report: a patient with X-linked FHL1-related myofibrillar myopathy and Charcot-Marie-Tooth disease type 1A, a dual pathology revealed by imaging and genetic testing. ja.ma/3VXzdad

"The book is not closed on a more expansive view of the entire menopausal transition." Learn more in this Editorial. ja.ma/46o48SW

In this study, menopause was not the primary driver of multiple sclerosis clinical progression in women at midlife. ja.ma/4mD3GoK

OTOF gene therapy (GT) offers rapid improvements in auditory and speech performance, outperforming cochlear implantation (CI) in speech in noise and music perception. ja.ma/4gFTgmQ

Local visual interpretations of clinical amyloid-PET scans closely matched central quantitative assessments, supporting the reliability of visual reads in real-world clinical settings. ja.ma/48CkQPT

CT perfusion and CT angiography showed less than optimal accuracy for confirming death by neurologic criteria. ja.ma/46wTeKR

Long-term adaptive deep brain stimulation (aDBS) provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving continuous DBS. ja.ma/4pEY5RF

Laser interstitial thermal therapy may be considered as a treatment option for durable seizure control and quality of life improvements in patients with mesial temporal lobe epilepsy. ja.ma/47LKm4W

Editorial: A probabilistic approach to explicate the role of atherosclerotic and arteriolosclerotic CVD would represent the broader clinical-biological construct more accurately. ja.ma/3VTF4Nw

The VasCog-2-WSO criteria provide updated international guidelines for diagnosing vascular cognitive impairment and #dementia, incorporating recent biomarker advancements. ja.ma/4nhczpg#dementia

Zero-degree head positioning for acute LVO patients is a protective maneuver to maintain clinical stability in the pre-thrombectomy phase while awaiting definitive treatment. ja.ma/3Kbk2r5

Case report: the appearance of autosomal recessive limb-girdle muscular dystrophy in a 30-year-old man with lower limb weakness, asymmetric atrophy of thigh muscles, and wasting of calf muscles. ja.ma/48f1UXa atabisneuro

A 62-year-old man presented with progressive limb weakness and involuntary movements. Take the Clinical Challenge. What is your diagnosis? ja.ma/4mdDmRS

Subthalamic nucleus deep brain stimulation may improve motor function, activities of daily living, and reduces dyskinesia and medication needs in #Parkinson patients. ja.ma/46lMq14#Parkinson

Viewpoint: Empowering primary care practitioners to manage common neurological conditions may improve access, reduce delays, and enhance care quality. ja.ma/462qhpJ

Plasma p-tau217 is a useful stand-alone marker and, when combined with confirmatory PET or CSF testing, may enhance precision in identifying cognitively unimpaired individuals with amyloid β pathology for preclinical #Alzheimer disease trials. ja.ma/41P4tvo

Home high-intensity aerobic training improved ataxia symptoms, fatigue, and aerobic fitness more effectively than dose-matched home balance training among individuals with cerebellar ataxias. #ANA2025 ja.ma/3Ig7Dl8

While attending #ANA2025, explore new research from @jamaneurology.com: Higher levels of fine particulate matter air pollution was associated with increased #dementia severity and increased #Alzheimer disease neuropathologic change. ja.ma/46CNxLa

At #ANA2025? Consider these articles from @jamaneurology.com: Frontotemporal #dementia is comparable in frequency to dementia with Lewy bodies and occurs at higher rates than progressive supranuclear palsy, corticobasal syndrome, and amyotrophic lateral sclerosis. ja.ma/4pkpNCO

Looking for more to discuss at #ANA2025? In patients with supratentorial intracerebral hemorrhage, minimally invasive surgery within 72 hours did not significantly reduce 30-day mortality or improve 180-day disability compared to medical management alone. ja.ma/41SDBuj

While at #ANA2025, dive into recent research from @jamaneurology.com: Women receiving depot medroxyprogesterone acetate had a greater relative risk of subsequent meningioma diagnosis. ja.ma/41MZgnO

At #ANA2025? 🩺 Don't miss these timely articles from JAMA Neurology, selected to enhance your conference takeaways: 👇 MRI aneurysm wall imaging may be used for predicting the risk of aneurysm instability. ja.ma/48lUJwm