This case report describes a unique presentation of Kelch-like protein 11 antibody-associated paraneoplastic encephalitis in an 81-year-old woman with a high-grade neuroendocrine carcinoma consistent with metastatic Merkel cell carcinoma. ja.ma/4p5Bxc0

"An early and reliable 4R-tau biomarker might help guide the timing of disease-modifying therapies." Read more about copathology in atypical Parkinsonism in this Viewpoint. ja.ma/484tFRX

In patients with AIS-LVO admitted to non-thrombectomy centers after 4.5 hours, IVT before transfer for endovascular therapy was associated with improved 3-month functional outcomes and higher rates of recanalization during transfer. ja.ma/48lPKKQ

Editorial: In a meta-analysis, Malek-Ahmadi and colleagues show that plasma p-tau217 reliably distinguishes biomarker-positive from biomarker-negative individuals without cognitive impairment. ja.ma/3XkDchy

Among published studies involving older adults without cognitive impairment, plasma p-tau217 was shown to reliably differentiate amyloid-positive from amyloid-negative individuals, with a large effect size and high diagnostic accuracy. ja.ma/3XS809z

More than half of the US population experienced health loss due to neurological, neurodevelopmental, metabolic, or infectious disorders in 2021, with #stroke and #dementia ranking among the top causes of disability and death. ja.ma/4aeMH9C

Among US veterans, obstructive sleep apnea was independently associated with an increased risk of developing #Parkinson disease, even after accounting for potential confounders and competing risks. ja.ma/48dURfW

In #pediatric patients with #multiplesclerosis, chronic lesion development begins early in the disease course, even with effective treatment. ja.ma/3Kmxj0q

More than half of the US population experienced health loss due to neurological, neurodevelopmental, metabolic, or infectious disorders in 2021, with #stroke and #dementia ranking among the top causes of disability and death. ja.ma/3M89sC5

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/4ahLJcG

More than half of the US population experienced health loss due to neurological, neurodevelopmental, metabolic, or infectious disorders in 2021, with #stroke and #dementia ranking among the top causes of disability and death. ja.ma/3XP785w

This case report describes a patient with a back-and-forth interhemispheric migration along a bullet’s own trajectory. ja.ma/4ijcakg

Among US veterans, obstructive sleep apnea was independently associated with an increased risk of developing #Parkinson disease, even after accounting for potential confounders and competing risks. ja.ma/4pdP696

Among US veterans, obstructive sleep apnea was independently associated with an increased risk of developing #Parkinson disease, even after accounting for potential confounders and competing risks. ja.ma/48i6hPA

Adults with acute #dengue virus infection had higher odds of developing neurological events—including memory loss, movement disorders, and fatigue—within 90 days compared to uninfected peers. ja.ma/44yhH0C

📢 Are you an early-career neurologist with an interest in publishing? Join the JAMA Neurology editorial team for a 1-year fellowship starting February 2026. Learn the editorial process, contribute to the journal, and grow your academic career. Apply by December 1. 🔗 ja.ma/4onFRTv

Among US veterans, obstructive sleep apnea was independently associated with an increased risk of developing #Parkinson disease, even after accounting for potential confounders and competing risks. ja.ma/4a9bN9O

Interview with John P. Ney, MD, MPH, author of US Burden of Disorders Affecting the Nervous System: From the Global Burden of Disease 2021 Study. Hosted by Cynthia E. Armand, MD. ja.ma/3JHfb18

More than half of the US population experienced health loss due to neurological, neurodevelopmental, metabolic, or infectious disorders in 2021, with #stroke and #dementia ranking among the top causes of disability and death. ja.ma/48fuW7u

Subthalamic nucleus deep brain stimulation may improve motor function, activities of daily living, and reduces dyskinesia and medication needs in #Parkinson patients. ja.ma/4oeScJ1

Long-term adaptive deep brain stimulation (aDBS) provided tolerable, effective, and safe therapy in persons with Parkinson disease whose symptoms were previously stable while receiving continuous DBS. ja.ma/3M2ENGl

Are you interested in receiving hands-on editorial training with an international peer-reviewed medical journal? JAMA Neurology is accepting applications from early-career faculty for its 1-year editorial fellowship program starting in February 2026. Apply by December 1. 🔗 ja.ma/4onFRTv

Home high-intensity aerobic training improved ataxia symptoms, fatigue, and aerobic fitness more effectively than dose-matched home balance training among individuals with cerebellar ataxias. ja.ma/4o8GHTg

Higher levels of fine particulate matter air pollution was associated with increased #dementia severity and increased #Alzheimer disease neuropathologic change. ja.ma/44mGkNJ

JAMA Neurology is accepting applications for its 2026 Editorial Fellowship. This 1-year opportunity offers early-career neurologists hands-on publishing experience, mentorship & a chance to contribute to a leading journal. 🔗Apply by December 1: ja.ma/4onFRTv

From @jama.com: Peripheral neuropathy, defined as damage to the peripheral nerves, affects approximately 1% of adults worldwide. This Review summarizes the pathophysiology, clinical presentation, diagnosis, and treatment of length-dependent peripheral neuropathy. ja.ma/4r0N4Lb

Viewpoint: Routine brain health screening, interdisciplinary teams, and policy reforms addressing neurotoxic exposures may shift neurology toward primary prevention—reducing disease burden across populations. ja.ma/4nYilve

Among patients with AF, surgical occlusion of the left atrial appendage was associated with lower rates of #stroke-related disability and mortality and a decreased proportion of cardioembolic #stroke. ja.ma/481L9xe

Frontotemporal #dementia is comparable in frequency to dementia with Lewy bodies and occurs at higher rates than progressive supranuclear palsy, corticobasal syndrome, and amyotrophic lateral sclerosis. ja.ma/47ZZ0nE

Aneurysm wall enhancement on MRI, particularly circumferential AWE, may be used to predict the risk of instability in unruptured intracranial aneurysms over a four-year period. ja.ma/47Tddmc

📢 Are you an early-career neurologist with an interest in publishing? Join the JAMA Neurology editorial team for a 1-year fellowship starting February 2026. Learn the editorial process, contribute to the journal, and grow your academic career. Apply by December 1. 🔗 ja.ma/4onFRTv

Viewpoint: The updated 2024 McDonald criteria enable MS diagnosis in asymptomatic individuals by incorporating imaging and CSF biomarkers, such as CVS and κ-FLC index, while promoting a single standardized framework. ja.ma/47S9zc9

In patients with supratentorial intracerebral hemorrhage, minimally invasive surgery within 72 hours did not significantly reduce 30-day mortality or improve 180-day disability. PenNeuro ja.ma/4nJ8464

This case report describes a patient with left-sided weakness following transient ischemic attacks who underwent external carotid angioplasty based on findings from ultrahigh-resolution photon-counting computed tomographic angiography (CTA). ja.ma/47r3sN8

Editorial: A probabilistic approach to explicate the role of atherosclerotic and arteriolosclerotic CVD would represent the broader clinical-biological construct more accurately. ja.ma/4o9Xw0h

The VasCog-2-WSO criteria provide updated international guidelines for diagnosing vascular cognitive impairment and #dementia, incorporating recent biomarker advancements. ja.ma/3Lzrj4U

Editorial: The risk of meningiomas increases with progestogen use such as depot medroxyprogesterone acetate (dMPA), especially with prolonged exposure, but overall incidence remains low. ja.ma/4oZ3Zvx

Depot medroxyprogesterone acetate use is associated with an increased risk of meningioma diagnosis, particularly with prolonged exposure and older age at initiation, though the overall clinical risk remains low. ja.ma/4p3S283

Epilepsy incidence among US Medicare beneficiaries aged 65 and older varied tenfold across regions and was associated with insufficient sleep, lack of vehicle access, heat index, physical inactivity, and uninsured rate. ja.ma/4hK4MhL

RCT: Online cognitive training, rehabilitation, and tDCS did not produce superior cognitive or neuropsychological improvements in long #COVID compared to active comparator arms. ja.ma/3WIv5en

📢 Calling all early-career neurologists! If you are looking to learn about medical publishing, receive mentorship from senior editors, and gain hands-on editorial training, we invite you to apply to the 2026 JAMA Neurology Editorial Fellowship. 🔗 Apply by Dec. 1: ja.ma/4onFRTv

Viewpoint: As neurologic disorders remain a leading cause of disability and death, community-engaged research offers a promising approach to close the “know-do gap” between discovery and real-world impact. ja.ma/47Hqiie

This case report describes a 73-year-old man with a type B aortic dissection and quadriplegia. ja.ma/4oSqq5y

📢 Are you an early-career neurologist with an interest in publishing? Join the JAMA Neurology editorial team for a 1-year fellowship starting February 2026. Learn the editorial process, contribute to the journal, and grow your academic career. Apply by December 1. 🔗 ja.ma/4onFRTv

A 12-week remote, automated gamification intervention increased daily steps by 28% among US veterans with Parkinson disease, according to unadjusted analyses. ja.ma/4qIAsIb

While incidence rates for central nervous system cancer remained stable from 1990 to 2021, both mortality and disability-adjusted life-years (DALYs) declined. ja.ma/4oTz3Nu

Case report describes a 65-year-old man with a mobile filling defect detected in his middle cerebral artery during mechanical thrombectomy. ja.ma/3J2Kao4

Case report: a 23-year-old pregnant woman presented with seizures and chronic hepatitis B, with hyperintense lesions discovered in the left caudate nucleus on magnetic resonance imaging. ja.ma/42YCVUN

This case report discusses a patient with vertebral pseudoaneurysm that spontaneously ruptured and led to vertebro-vertebral arteriovenous fistula requiring endovascular therapy. ja.ma/3LbDAvT

Editorial: Recent trials show intravenous thrombolysis provides no clear benefit for patients presenting to the emergency department with mild stroke (NIHSS 0–5), highlighting the need for highly individualized treatment decisions. ja.ma/4oAZZ4q