In this episode of JAMA+ AI Conversations, Editor in Chief Roy Perlis interviews Ajamete Kaykas, Chief eXploration Officer at insitro, a biotech company looking to apply AI to develop new therapeutics. ja.ma/3XeCLVW ja.ma/3XeCLVW

Editor's Note: JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, speaks with insitro’s Chief eXploration Officer, Ajamete Kaykas, PhD, about using machine learning and wet lab research to accelerate new therapeutic development. ja.ma/3LigiEX

Hemorrhoidal disease (hemorrhoids) involves abnormalities in the tissues lining the anal canal. This JAMA Patient Page describes hemorrhoids and their symptoms, diagnosis, and treatment. ja.ma/4qEKABL

🗓️ Friday, Nov 7, at #KidneyWk: ➡️ Attend the “Best of the Journal of the American Medical Association and the New England Journal of Medicine” session moderated by @jama.com Associate Editor Wolfgang Winkelmayer. 📍At 2:00 PM in Grand Ballroom A.

Scabies is caused by a microscopic mite that burrows into the uppermost layer of the skin, causing intense itching and skin rash. This JAMA Patient Page describes scabies, its transmission, signs and symptoms, diagnosis, and treatment. ja.ma/49atWnv

#Medicare beneficiaries assigned to an accountable care organization (ACO) showed reduced mortality but increased spending for TEAM-targeted surgical procedures. ja.ma/49zOhCD

💬 Viewpoint: Increasing patient participation in kidney transplant selection decisions may foster trust and engagement but poses practical and ethical complexities. ja.ma/3LpCTPO

The KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease recommends using equations that include both creatinine and cystatin C for more accurate GFR estimation and risk assessment in CKD. ja.ma/43QS5vy

RCT: Rituximab reduced relapse rates in adults with frequently relapsing or steroid-dependent nephrotic syndrome compared to placebo. ja.ma/493IULY

💡 JAMA Insights: Combining incretin-based therapies with metabolic and bariatric surgery can further improve weight loss and metabolic outcomes in patients with obesity. ja.ma/47Y8X60

#Semaglutide and #tirzepatide effectively target #GLP1 and GIP receptors for obesity treatment, with future therapies exploring further receptor targeting for improved outcomes. ja.ma/4nIE8am

#Hemorrhoidal disease affects 10 million people in the US and accounts for $1.3 billion in annual health care expenditures. 🏥 🩺 This JAMA Review discusses the epidemiology, pathophysiology, diagnosis, and treatment of hemorrhoidal disease. ja.ma/49C9PP3

The JAMA Summit on Firearm Violence gathered experts from medicine, policy, engineering, and community groups to develop a plan for reducing firearm harms by 2040. Learn more in this Special Communication: ja.ma/43hclqa

Yesterday, the JAMA Summit Report on Reducing Firearm Violence was published. @npr.org spoke with authors @josephsakran.bsky.social, MD, MPH, MPA, Sandro Galea, MD, DrPH, and Daniel Webster, ScD, MPH. Read the NPR article:

💡Thinking about submitting your #APHA2025 research to @jama.com or one of our other Network journals? 💻 This video tells you what to expect from the submission and review process: ja.ma/434sQWx

📚 Tracking County-Level Measles Cases in the US, from @jama.com. 🔗Free to read online during #APHA2025. ja.ma/4oxSWtL

📌 Editor’s Choice from this week's issue of #JAMA: ➡️ High #BP in Childhood and Premature #CVD Mortality ➡️ Levodopa Added to #Stroke Rehab ➡️ Review on #Hemorrhoids, and more. ja.ma/4eRp9GH

We are accepting applications for the 2026-2027 Morris Fishbein Fellowship in Medical Editing. Requirements include: ➡ MD or DO degree with completion of residency training ➡ Strong writing skills ➡ 1-year commitment to a full-time position in Chicago Learn more: ja.ma/4mxPDRq

🗓️ Attending #APHA2025? Supplement your schedule with Alcohol Consumption Per Capita and Suicide: A Meta-Analysis, from @jamanetworkopen.com. 🔗 Free to read online. ja.ma/4nzgQUj

Editorial: Inconsistent health insurance coverage harms children's health, highlighting the need for stable, continuous policies like the 2023 Act amid challenges in the US' fragmented insurance landscape. ja.ma/3LkpoAV

An estimated 61% of US children have been enrolled in #Medicaid or CHIP and 42% have experienced periods of uninsurance by age 18, with insurance disruptions being more common in states with restrictive Medicaid policies. ja.ma/47Vjn6y

Among patients receiving inpatient rehabilitation for acute stroke, levodopa added to standardized rehabilitation did not significantly improve motor function at 3 months compared with placebo plus standardized rehabilitation. ja.ma/4nBlNM8

📣 Final day of exhibits at #APHA2025. 📍Find us at booth 915 to get recent articles for your trip home ➡️ Ask about submitting your research presented at the meeting to @jama.com, or one of our other JAMA Network journals. ja.ma/43HUEzY

Viewpoint: The Centers for Medicare & Medicaid Services (CMS)'s WISeR model broadens prior authorization in traditional #Medicare to cut costs and fraud, but raises concerns about transparency, algorithmic bias, and impacts on patient care and clinician burden. ja.ma/3WzhtCe

This week, JAMA published the JAMA Summit Report on Reducing Firearm Violence and Harms, a blueprint for action featuring experts from across sectors committed to advancing evidence-based solutions to reduce firearm-related injury and death. Hear from the experts and read the report: ja.ma/4nz49Jc

📢 JAMA Senior Statistical Editor @rogerjlewis.bsky.social, MD, PhD, @jamaotolaryngology.com EIC Jay Piccirillo, MD, & @jamaotolaryngology.com Statistics Editor Dorina Kallogjeri, MD, MPH, will be speakers at the 2nd Annual Midwest Critical Appraisal Workshop. See flyer for more details. ⬇️

At #APHA2025? @jamahealthforum.com Editorial Fellow Sugy Choi will be at booth 915 in the exhibit hall. 🗓️ Today, Monday, November 3, at 3:30-4:00 PM 📍Stop by to ask questions ➡️ Discuss your research and publishing opportunities with the JAMA Network.

Meet @jamahealthforum.com Editor Sandro Galea at #APHA2025. 📍He will be at booth 915 in the exhibit hall 🗓️ Today, Monday, November 3, at 3:00-3:30 PM ➡️ To answer questions and discuss your research and publishing opportunities with the JAMA Network.

📣 Meet @jama.com Associate Editor Melissa Simon at #APHA2025. 📍 She will be at booth 915 in the exhibit hall 🗓️ Today, Monday, November 3, at 2:00-2:30 PM ➡️ To answer questions and discuss your research and publishing opportunities with the JAMA Network.

The JAMA Summit is an initiative of the JAMA Network that convenes leaders from across sectors to discuss and debate critical issues in medicine and health care. These reports present expert perspectives on topics including clinical trials, #AI, and firearm violence & harms. 🧵

New report that includes two U-M authors: our director John Ayanian and @umich.edu Institute for Firearm Injury Prevention co-director Marc Zimmerman:

💡 JAMA Insights: Combining incretin-based therapies with metabolic and bariatric surgery can further improve weight loss and metabolic outcomes in patients with obesity. ja.ma/47zCC4e

The JAMA Summit on Firearm Violence gathered experts from medicine, policy, engineering, and community groups to develop a plan for reducing firearm harms by 2040. Learn more in this Special Communication: ja.ma/47URrzB

📍Attending #APHA2025? 📚 Supplement your schedule with Human Telephone vs Text Message Counseling and Physical Activity Among Midlife and Older Adults: A Randomized Clinical Trial, from @jamanetworkopen.com. ja.ma/4oJ5o9B

Toward a Safer World by 2040: The JAMA Summit Report on Reducing Firearm Violence and Harms, published today to coincide with #APHA2025 🔗 Free to read online from @jama.com. ja.ma/43CbikB

📢 Attending #APHA2025? 📖 Supplement your schedule with Health Care Costs of Firearm Injury Hospital Visits in the US, from @jamahealthforum.com. Free to read online during the meeting: ja.ma/47hIgsQ

Viewpoint: Addressing the gap between therapeutic investments and unmet medical needs in the US requires strategic alignment through improved data, partnerships, funding, and policies. ja.ma/4nzXMVI

📢 Attending #APHA2025? 📖 Supplement your schedule with Benefit-Risk Reporting for FDA-Cleared Artificial Intelligence−Enabled Medical Devices, from @jamahealthforum.com. Free to read online: ja.ma/47zZPDn

📚 Electronic Nudges to Increase Influenza Vaccination in Patients With Chronic Diseases: A Randomized Clinical Trial, from @jama.com. 🔗 Free to read online during #APHA2025. ja.ma/4nsu98Y

📣 At #APHA2025? Meet @jama.com Associate Editor Melissa Simon, @jamahealthforum.com Editor Sandro Galea, and @jamahealthforum.com Editorial Fellow Sugy Choi. 🗓️ Tomorrow, November 2. 📍At booth 915 in the exhibit hall. ➡️ See the schedule in the image or at our booth.

Nonmelanoma skin cancer, composed primarily of BCC and cSCC, is the most common cancer in the US, with an estimated 5.4 million diagnoses annually. 📌 This Review summarizes the presentation, diagnosis, management, and prevention of keratinocyte carcinomas. ja.ma/49twsFd

📢 Exhibits at #APHA2025 are open. 📍Find @jama.com, @jamahealthforum.com, and @jamanetworkopen.com at booth 915. ✅ Get recent articles, find out when you can meet our editors, and ask us about publishing opportunities and submitting your work. ja.ma/47vpTPQ

H-1B visa–sponsored physicians are twice as prevalent in rural counties and nearly 4 times as common in high-poverty areas, highlighting the potential harm of rising visa costs to health care access. ja.ma/4hIxv6E

📊 Research Summary: Personalized resuscitation targeting capillary refill time modestly improved organ support–free days and composite outcomes in early septic shock, but showed no difference in mortality vs usual care. ja.ma/4qCcT3H

Among patients with early #SepticShock, a personalized hemodynamic resuscitation protocol targeting capillary refill time was superior to usual care for the primary composite outcome, primarily driven by a lower duration of vital support. ja.ma/4oQcysB

📣 Meet @jama.com Associate Editor Melissa Simon, @jamahealthforum.com Editor Sandro Galea, and @jamahealthforum.com Editorial Fellow Sugy Choi. 🗓️ Today at #APHA2025. 📍At booth 915 in the exhibit hall. ✅ See the schedule in the image or at our booth.

"JAMA pulled back the curtain on high-impact publishing in a way that few experiences could." In this Editorial, JAMA editorial fellows share insights from their yearlong experience observing the journal's editorial process. ja.ma/3LBHiz4

In this podcast episode, listen to a roundup of the latest Medical News published in JAMA: ➡️ State Laws Aim to Bring Internationally Trained Physicians to Underserved Areas ➡️ Oral Microbiome Composition Linked to Pancreatic Cancer Risk, and more. ja.ma/47B5Lfx

💬 Viewpoint: The evolving health care landscape necessitates a new clinician-scholar paradigm incorporating humanities and social sciences to address complex challenges and enhance scientific inquiry and health outcomes. ja.ma/4qtBLL0

Uveitis is a condition involving inflammation in the uvea (the middle portion of the eye). 📝 This JAMA Patient Page describes types of uveitis, ages and conditions associated with uveitis, and diagnosis and treatment. ja.ma/439CPK6