Among US adults, women had up to 44% higher odds of chronic rhinosinusitis without polyps and 37% lower odds of the polyp-associated form compared to men. ja.ma/4aZ2JoJ

Early palliative care for head and neck cancer may provide more cost-efficient end-of-life care but not facilitate home deaths, for which a coordinated team-based approach may be required. ja.ma/45NCqOD

#AI-based imaging classification of extranodal extension in HPV-positive oropharyngeal carcinoma predicted worse outcomes and surpassed radiologist accuracy. ja.ma/49O3IH1

A rapid 5-item mobile app olfactory test had 74% sensitivity and 86% specificity for olfactory dysfunction, supporting its use as a reliable, scalable screening tool for adults. ja.ma/49sqPp9

In adults receiving #cochlear implants, gains in positive affect and reductions in negative affect corresponded with improvements in quality-of-life scores across listening, communication, and participation domains. ja.ma/49rqFyj

In this podcast, Paul Bryson, MD, MBA, speaks with Yael Bensoussan, MD, MSc, and Victoria Sanchez, AuD, PhD about why hearing health is a critical and overlooked component in voice biomarker research. 🎧 Listen now: ja.ma/3LraJnU

Early palliative care for head and neck cancer may provide more cost-efficient end-of-life care but not facilitate home deaths, for which a coordinated team-based approach may be required. ja.ma/4pmiERq

A 31-year-old female presented with a progressively enlarging left submandibular mass and history of pleomorphic adenoma of the left submandibular gland. What is your diagnosis? ja.ma/4q7hPx3

Individualized prognostic counseling using an online model was linked to reduced decisional conflict and regret and more active decision-making in #HNSCC patients. ja.ma/4pr1rq3

Strategic sponsor decisions and poor accrual are the leading reasons for early termination of #HNSCC clinical trials, especially in industry-funded and phase 1 studies. ja.ma/3N0G7tZ

Fourteen cancer-testis antigens were validated as tumor-specific immunotherapy targets in head and neck squamous cell carcinoma. ja.ma/3L9ktmK

Deep transfer learning using presurgical brain MRI features predicted post–cochlear implant language improvement in children with >92% accuracy, outperforming traditional ML. ja.ma/4azapxG

Medicare reimbursement for #ThyroidSurgery decreased 38.7% between 2000 and 2023, with total #thyroidectomy reimbursement falling nearly 48% after adjusting for inflation. ja.ma/4qrNN6H

Systematic review and meta-analysis: Active surveillance for low-risk papillary thyroid microcarcinoma was consistently associated with equal or better health-related quality of life compared with surgery across multiple thyroid-specific domains. ja.ma/4qt0q1G

Fourteen cancer-testis antigens were validated as tumor-specific immunotherapy targets in head and neck squamous cell carcinoma. ja.ma/4qjgaEc

💬 Viewpoint: Recent evidence shows that routine contralateral tonsillectomy in p16-positive tonsillar OPSCC offers minimal oncologic benefit and increases morbidity, suggesting practice change may be warranted. ja.ma/493tIwE

The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025, and did other readers agree? 🔗 ja.ma/4pZhcWm

Patients with head and neck cancer and a greater number of barriers were less likely to initiate timely postoperative radiation therapy, as were those with a perioperative adverse effects–related barrier. ja.ma/4p64hAn

The numbers are in. The numbers are in. This year's most popular JAMA Network content spans a range of topics, from #fluoride to #Parkinson disease to #GLP-1s. What was your favorite article in 2025 -- and did other readers agree? 🔗 ja.ma/497aSVw

Early palliative care for head and neck cancer may provide more cost-efficient end-of-life care but not facilitate home deaths, for which a coordinated team-based approach may be required. ja.ma/4qr99Bt

"What is the correct number of practicing head and neck surgeons? Are the right people caring for patients with head and neck cancer?" Read this Viewpoint by former AHNS President, William Lydiatt, MD, EMBA. ja.ma/4at3tSC

In a cohort of patients with head and neck cancer, preexisting psychiatric comorbidities were found to be associated with increased odds of receiving opioid prescriptions and long-term opioid therapy. ja.ma/4s7J0ZY

Head and neck #cancer is the seventh most common cancer worldwide. This @jama.com Review summarizes the epidemiology, clinical presentation, diagnosis, and treatment of head and neck squamous cell carcinomas (#HNSCC) of the upper aerodigestive tract. ja.ma/4sbX19a

Unilateral transoral surgery is a safe approach for HPV-positive tonsillar squamous cell carcinoma; prophylactically resecting the contralateral tonsil may add patient harm without any clear benefits. ja.ma/4pGOdWY

Among adults with papillary thyroid carcinoma and ipsilateral lateral neck node metastases, thyroid lobectomy combined with neck dissection offered similar 5- and 10-year survival and recurrence outcomes. ja.ma/4qiNV8O

The BRIGHT program, a brief cognitive behavioral treatment, effectively reduced body image distress across multiple domains in head and neck cancer survivors. ja.ma/48OmjCs

Among adults with mucosal #HNSCC receiving neoadjuvant immune checkpoint inhibition, pooled analysis demonstrated that partial and major pathologic responses correlated with improved disease-free survival, but not overall survival. ja.ma/3KS44mw

Systematic review and meta-analysis: Omitting contralateral elective extracapsular tonsillectomy in tonsillar SCCa is safe, with low metachronous contralateral second primary tumor rates and no difference in survival outcomes. ja.ma/4pK6mmZ

"We need to strengthen our communities—not just the American Head and Neck Society (ANHS), but all our communities, to reverse the trend of distrust." Learn more in this Viewpoint from former AHNS President, William Lydiatt, MD, EMBA. ja.ma/3KUYfVp

Advanced cancer stage and receiving multiple treatment modalities were the strongest predictors of high health care costs in patients with head and neck cancer. ja.ma/4aiDAVF

Patients with #HPV-negative head and neck squamous cell carcinoma who are deemed pathologic responders to neoadjuvant nivolumab may have improved survival outcomes compared to those who are low or nonresponders. ja.ma/3YeqBgx

ctHPVDNA detectability early after surgery is associated with greater burden of nodal disease but demonstrates poor predictability at 2 weeks after surgery. ja.ma/3KX5oEE

Laryngeal histoplasmosis can mimic cancer in immunocompetent adults, requiring biopsy and fungal staining for diagnosis. ja.ma/4aOqa3N

Both over- and underprescribing opioids at discharge elevate refill risk after otolaryngology–head and neck surgery. ja.ma/3KX0tU7

In this podcast, Paul Bryson, MD, speaks with Molly Huston, MD, associate professor at Wash U Medicine, and Will Strober, MD, resident physician at Wash U Medicine, about treating inducible laryngeal obstruction. Listen now: ja.ma/44hTThG

Both biofeedback and standard therapy offered modest, similar improvements for inducible laryngeal obstruction in this randomized trial. ja.ma/4q6l5sb

High MetaboScore values were associated with greater recurrence and reduced survival in #OCSCC, supporting the use of serum metabolomics for prognostic stratification. ja.ma/4ry7R8S

Among patients with #HNSCC treated with radiotherapy, each additional week of treatment interruption was associated with decreased three-year locoregional control and survival, regardless of p16 status. ja.ma/48t3aED

Use of glucagon-like peptide-1 receptor agonists (#GLP1RA) in adults with type 2 #diabetes was associated with an increased risk of new chronic cough compared with other second-line diabetes medications. ja.ma/3LZtgrs

Model-based analysis of ECAPs in #CochlearImplant users showed stronger auditory nerve responses and plasticity in younger recipients, highlighting the value of early implantation. ja.ma/4pfDcMb

Head and neck cancee is a collective term for cancers affecting the oral cavity, pharynx, larynx, salivary glands, and other sites in the head and neck region. This Review discusses immunotherapy within the salvage setting for locally advanced, recurrent disease. ja.ma/4prUd5q

Use of glucagon-like peptide-1 receptor agonists (#GLP1RA) in adults with type 2 #diabetes was associated with an increased risk of new chronic cough compared with other second-line diabetes medications. ja.ma/4rnkMKU

This Special Communication explores how mental training techniques found in sports psychology may be used by otolaryngologists to optimize surgical performance and surgeon well-being. ja.ma/48hIfEB

On December 1 at 10 AM ET, JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new @who.int guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/4akt7sB

Use of glucagon-like peptide-1 receptor agonists (#GLP1RA) in adults with type 2 #diabetes was associated with an increased risk of new chronic cough compared with other second-line diabetes medications. ja.ma/3M2FsYm

Up-front percutaneous ultrasound-guided core-needle biopsy offers a high diagnostic yield for neck lesions, effectively reducing the need for excisional biopsy, even when lymphoma is considered. ja.ma/48wGLaN

Among patients with oropharyngeal squamous cell #carcinoma, proton therapy for head and neck cancer was associated with a higher 3-year incidence of osteoradionecrosis compared with intensity-modulated radiation therapy. ja.ma/4pCTH4N

On December 1 at 10 AM ET, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, will co-chair a public, live-streamed webinar discussing a new WHO guideline concerning #GLP-1 therapy and adults with #obesity. Register for the webinar: ja.ma/4pwD8Y7

Use of glucagon-like peptide-1 receptor agonists (#GLP1RA) in adults with type 2 #diabetes was associated with an increased risk of new chronic cough compared with other second-line diabetes medications. ja.ma/3XfGfHV

Partial laryngeal radiotherapy was associated with potentially favorable oncologic outcomes and toxic effects profiles compared to whole laryngeal radiotherapy. ja.ma/4rmjDmE