Among patients with recurrent/metastatic adenoid cystic carcinoma, amivantamab provided disease stabilization in most cases, although objective tumor responses were rare. ja.ma/3OGMvaz

In pediatric vocal fold immobility after cardiothoracic surgery, standardized protocols and injection laryngoplasty were associated with more frequent oral diet advancement at discharge. ja.ma/4st3YSD

Systematic review and meta-analysis: Thyroid lobectomy provided oncologic outcomes comparable to total thyroidectomy for select patients with sporadic medullary thyroid cancer. ja.ma/3OZzjgX

Among patients with recurrent/metastatic adenoid cystic carcinoma, amivantamab provided disease stabilization in most cases, although objective tumor responses were rare. ja.ma/3OYmt2w

Laryngeal histoplasmosis can mimic cancer in immunocompetent adults, requiring biopsy and fungal staining for diagnosis. bit.ly/3OmJ8oS

A 62-year-old man with submandibular salivary duct history, alcohol use disorder, and facial flushing after minimal alcohol presents with lower extremity numbness, dysesthesia, and impaired proprioception. What is your diagnosis? bit.ly/45Li3BY

Among adults with papillary thyroid carcinoma and ipsilateral lateral neck node metastases, thyroid lobectomy combined with neck dissection offered similar 5- and 10-year survival outcomes as total thyroidectomy plus radioactive iodine in select cases. ja.ma/4s36Fd9

Among patients with head and neck cancer younger than 65 years, immunotherapy prescriptions increased only marginally from 2017 to 2022, with pembrolizumab dominating the prescribing market. ja.ma/4ruGE6x

This JAMA Otolaryngology–Head & Neck Surgery Patient Page describes what to expect with skin cancer reconstruction. 🔗 ja.ma/4ruKUTS

Among patients with head and neck cancer younger than 65 years, immunotherapy prescriptions increased only marginally from 2017 to 2022, with pembrolizumab dominating the prescribing market. ja.ma/4qQPs5U

Both over- and underprescribing opioids at discharge elevate refill risk after otolaryngology–head and neck surgery. bit.ly/4kfQXZr

Both biofeedback and standard therapy offered modest, similar improvements for inducible laryngeal obstruction in this randomized trial. ja.ma/4cE4IiL

Among adults with mucosal #HNSCC receiving neoadjuvant immune checkpoint inhibition, pooled analysis demonstrated that partial and major pathologic responses correlated with improved disease-free survival, but not overall survival. bit.ly/4kiD8JH

Among patients with head and neck cancer younger than 65 years, immunotherapy prescriptions increased only marginally from 2017 to 2022, with pembrolizumab dominating the prescribing market. ja.ma/4rtuXxa

Both biofeedback and standard therapy offered modest, similar improvements for inducible laryngeal obstruction in this randomized trial. bit.ly/4caHxMS

Among adults undergoing total #thyroidectomy, selective calcium and calcitriol supplementation triggered by low postoperative PTH was not superior to routine supplementation for preventing symptomatic or biochemical hypocalcemia. ja.ma/3OoxPwH

Among patients with head and neck cancer younger than 65 years, immunotherapy prescriptions increased only marginally from 2017 to 2022, with pembrolizumab dominating the prescribing market. ja.ma/4rY1VW6

Use of glucagon-like peptide-1 receptor agonists (#GLP1RA) in adults with type 2 #diabetes was associated with an increased risk of new chronic cough compared with other second-line diabetes medications. bit.ly/4koi9We

Systematic review and meta-analysis: Active surveillance for low-risk papillary thyroid microcarcinoma was consistently associated with equal or better health-related quality of life compared with surgery across multiple thyroid-specific domains. bit.ly/3ZOgaAP

Among patients with oropharyngeal squamous cell #carcinoma, proton therapy for head and neck cancer was associated with a higher 3-year incidence of osteoradionecrosis compared with intensity-modulated radiation therapy. bit.ly/4qhb4Yy

Radiomics is a field that establishes associations between quantifiable imaging biomarkers and histopathological characteristics or clinical outcomes. 🔗 Learn more in this Review: ja.ma/4kHwddt

Model-based analysis of ECAPs in #CochlearImplant users showed stronger auditory nerve responses and plasticity in younger recipients, highlighting the value of early implantation. bit.ly/3NVvI3a

A unified #SGC staging system using LN count and extranodal extension improves prognostic accuracy for both major and minor salivary gland carcinomas and aligns with WHO histologic risk groups. ja.ma/3ZA7Ogj

Persistent cochlear microphonic amplitude drops during #CochlearImplant surgery were associated with reduced residual hearing, supporting real-time automated #Electrocochleography monitoring. bit.ly/4qYAUSm

This JAMA Otolaryngology–Head & Neck Surgery Patient Page describes what to expect with skin cancer reconstruction. 🔗 ja.ma/4riOhgu

Radiomics is a field that establishes associations between quantifiable imaging biomarkers and histopathological characteristics or clinical outcomes. 🔗 Learn more in this Review: ja.ma/4aNMEkY

A unified #SGC staging system using LN count and extranodal extension improves prognostic accuracy for both major and minor salivary gland carcinomas and aligns with WHO histologic risk groups. ja.ma/4bMYGw3

Narrative review: Large language models (#LLMs) can structure clinical notes, automate phenotyping, and augment decision support in otolaryngology but require validation beyond feasibility and secure, open-source deployment. bit.ly/4kohuUK

Systematic review and meta-analysis: Thyroidectomy in adults ≥65 years showed small absolute increases in nerve injury, hematoma, and mortality, but similar rates of hypocalcemia and wound complications compared to younger adults. bit.ly/3ZeqEtb

In patients with #OSA who received hypoglossal nerve stimulation (#HGNS), smaller necks, BMI <30, and AHI ≤30 predicted highest #HGNS response rates in #OSA, while greater values and comorbidities were linked to lower likelihood. bit.ly/4tef3Il

💬 Editorial: JAMA Otolaryngology–Head & Neck Surgery upholds transparency, rigorous peer review, and conflict-of-interest management to ensure research credibility. bit.ly/3M6x1vE

While balloon sinuplasty was performed in just 2.7% of newly diagnosed Medicare patients with chronic or recurrent acute rhinosinusitis, 1.5% of otolaryngologists performed nearly half of all procedures. ja.ma/4qSDFEH

This case report describes a patient who presented with isolated left-sided conductive hearing loss. ja.ma/3LYrcAn

Intratumoral NBTXR3 followed by #Radiotherapy showed feasibility and promising response rates in cisplatin- or cetuximab-ineligible patients with locally advanced #HNSCC. ja.ma/4rqPx0v

Systematic review and network meta-analysis: Diltiazem, esmolol, dexmedetomidine, labetalol, and clonidine reduced bleeding during #ESS, with comparable safety and flexibility for individualized management. ja.ma/4ap4smc

Intratumoral NBTXR3 followed by #Radiotherapy showed feasibility and promising response rates in cisplatin- or cetuximab-ineligible patients with locally advanced #HNSCC. ja.ma/4qRuIvC

Among patients with head and neck #MerkelCellCarcinoma, sentinel lymph node biopsy identified occult nodal disease in more than half of cases but showed reduced accuracy compared to other sites. ja.ma/4qRv0Te

Among patients with head and neck #MerkelCellCarcinoma, sentinel lymph node biopsy identified occult nodal disease in more than half of cases but showed reduced accuracy compared to other sites. ja.ma/4sRUlhe

Intratumoral NBTXR3 followed by #Radiotherapy showed feasibility and promising response rates in cisplatin- or cetuximab-ineligible patients with locally advanced #HNSCC. ja.ma/3Z66txu

Persistent, unexplained hyponatremia in a young, healthy patient led to the diagnosis of SIADH caused by a low-grade olfactory neuroblastoma of the maxillary sinus. ja.ma/4k3dmco

This case report describes a patient who presented with isolated left-sided conductive hearing loss. ja.ma/4qDhxhA

While balloon sinuplasty was performed in just 2.7% of newly diagnosed Medicare patients with chronic or recurrent acute rhinosinusitis, 1.5% of otolaryngologists performed nearly half of all procedures. ja.ma/3M77ylB

A 13-year-old male presented with a 7-month history of a painless, progressively enlarging mass in the right parotid region. What is your diagnosis? ja.ma/49XmOcU

In patients with locally advanced #HNSCC, ctDNA-based minimal residual disease positivity after treatment completion was associated with higher recurrence and worse survival, supporting its use as a prognostic biomarker. ja.ma/3NDeM1m

A healthy 25-year-old female presented with an 8-month history of a painful right mandibular lesion. What is your diagnosis? ja.ma/4rfVIVp

A 36-year-old man with a 4-year history of Crohn disease who was receiving maintenance therapy with infliximab presented with 6 months of progressive left mandibular pain and swelling. What is your diagnosis? ja.ma/4k0uuzA

A 69-year-old woman was referred due to widespread gingival swelling, which had been worsening over the preceding 3 months and was unresponsive to antibiotic treatment. What is your diagnosis? ja.ma/4pUWsxS

Systematic review and meta-analysis: #AIFRS incidence among immunocompromised patients has risen since 2013, but mortality rates declined with advances in antifungal therapy, surgical techniques, and diagnostic imaging. ja.ma/3NxY03y

💬 Viewpoint: Oral #nicotine pouch use nearly doubled among US youths from 2023 to 2024, raising concerns about oral health risks. ja.ma/3Zt143y

In patients with locally advanced #HNSCC, ctDNA-based minimal residual disease positivity after treatment completion was associated with higher recurrence and worse survival, supporting its use as a prognostic biomarker. ja.ma/45ij5Fi