loading . . . A harmless-to-harmful switchable and spatiotemporally activated nano-CRISPR hierarchically amplifies ferroptosis in melanoma Gong et al. develop ARCHER, a switchable and spatiotemporally activated nano-CRISPR system. Under tumor-specific conditions and laser irradiation, ARCHER sequentially amplifies ferroptosis sensitivity via CRISPR/Cas9-mediated GPX4 suppression, iron ions, and ROS, which triggers a synergistic ferroptosis storm, achieving 60% tumor ablation with minimal off-target effects in vivo. http://dlvr.it/TRtY9j
