Cell Reports Medicine
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A gardener removes weeds among flowers—just like therapies targeting the tumour microenvironment can eliminate cancer cells while sparing healthy ones. Dive into our special issue for expert reviews on immune cell targeting in cancer! Artwork by Justine Reimand.
www.cell.com/issue/S2666-...
6 months ago
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Online now: A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer
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A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer
Advanced microsatellite stable colorectal cancers are particularly difficult to treat due to immune exclusion. Chua et al. identify an NOTUM-high, WNT-inhibitory cancer cell (WICC) state enriched in these tumors that drives reduced CD8+ T cell infiltration. Disruption of the WICC-NOTUM axis restores antitumor immunity and enhances tumor clearance.
http://dlvr.it/TShNJs
about 12 hours ago
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Online now: Reprogramming T cell-myeloid crosstalk overcomes immune resistance in colorectal cancer
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Reprogramming T cell-myeloid crosstalk overcomes immune resistance in colorectal cancer
Mestrallet et al. show that T cell-myeloid interactions determine response to PD-1 blockade in colorectal cancer. Targeting TREM2 macrophages together with LAG3, CTLA4, and PD-1 reprograms the tumor microenvironment and drives antitumor immunity, achieving up to 100% tumor clearance in mismatch repair-deficient and >70% in mismatch repair-proficient models.
http://dlvr.it/TSh8d2
about 19 hours ago
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Online now: Escherichia coli Nissle 1917 alleviates Alzheimer’s disease in mice through OmpA-containing outer membrane vesicles
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Escherichia coli Nissle 1917 alleviates Alzheimer’s disease in mice through OmpA-containing outer membrane vesicles
Xie et al. report that outer membrane vesicles (OMVs) derived from probiotic Escherichia coli Nissle 1917 translocate to the brain and alleviate Alzheimer’s disease pathology by reshaping glia-neuron interactions through OmpA-mediated immunomodulation, identifying a previously unrecognized mechanism of gut-brain communication and a potential OMV-based therapeutic strategy for neurological disorders.
http://dlvr.it/TSgj7h
1 day ago
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Online now: Decoding the human CD4+ T cell epitope repertoire for Lassa fever virus reveals T cell-based pan-mammarenavirus vaccine candidates
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Decoding the human CD4+ T cell epitope repertoire for Lassa fever virus reveals T cell-based pan-mammarenavirus vaccine candidates
Lee et al. identified epitopes via in vitro Lassa peptide exposure, validating them through human Lassa-based vaccination and LCMV infection. Targeting conserved, immunogenic regions optimizes T cell cross-reactivity within Old or New World arenaviruses, ensuring broad population coverage and informing T cell optimization for vaccine design.
http://dlvr.it/TSgMPn
2 days ago
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Online now: Artificial exosomes synergistically reshape sepsis immune homeostasis by modulating neutrophil fate and blocking PD-1/PD-L1
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Artificial exosomes synergistically reshape sepsis immune homeostasis by modulating neutrophil fate and blocking PD-1/PD-L1
Zhang et al. develop an artificial exosome nano-decoy (AT@NV-PD1) that selectively targets senescent-like neutrophils in sepsis. It alleviates the cytokine storm by inducing timely apoptosis of these cells and neutralizing toxins; concurrently, it mitigates immunosuppression by blocking the PD-1/PD-L1 immune checkpoint, ultimately restoring the body’s immune homeostasis.
http://dlvr.it/TSfn6C
2 days ago
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Online now: Integrating speech biomarkers and large language models for adolescent suicide risk detection with mobile application for real-world evaluation
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Integrating speech biomarkers and large language models for adolescent suicide risk detection with mobile application for real-world evaluation
Lei et al. develop a speech-based framework integrating a speech encoder and large language models to detect adolescent suicide risk. Across ten speech tasks, the self-introduction task demonstrates the strongest performance. The framework outperforms conventional baselines and unimodal models and remains effective in mobile application-based external validation.
http://dlvr.it/TSfQHT
3 days ago
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Online now: Synaptophysin autoantibodies mediate synaptic dysfunction in cerebellar ataxia
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Synaptophysin autoantibodies mediate synaptic dysfunction in cerebellar ataxia
Ho et al. identify an autoantibody against the synaptic protein synaptophysin (SYP) in two patients with adult-onset cerebellar ataxia. They observe reduced neuronal activity and SYP mislocalization in neurons exposed to SYP-reactive antibodies. Identification of SYP antibodies and elucidation of their pathogenic activity offer potential for disease stratification and therapeutic intervention.
http://dlvr.it/TSdqnh
3 days ago
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Online now: Understanding and overcoming innate and acquired MAPK inhibition resistance in anaplastic thyroid cancer
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Understanding and overcoming innate and acquired MAPK inhibition resistance in anaplastic thyroid cancer
Using translational genomics and patient-derived models, Zeng et al. find that naporafenib and trametinib overcome resistance to clinically approved RAF/MEK inhibitors in anaplastic thyroid cancer. Further, acquired resistance to naporafenib occurs through compensatory MAST1 mutations. This work provides a rationale for clinical investigation of type II RAF inhibitors in ATC.
http://dlvr.it/TSdT0j
4 days ago
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Online now: Artificial intelligence-driven integration of multi-biofluid omics and clinical phenotype enables stratification of endometrial cancer
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Artificial intelligence-driven integration of multi-biofluid omics and clinical phenotype enables stratification of endometrial cancer
Li et al. develop an AI platform integrating MALDI-TOF MS multi-biofluid omics and clinical data for endometrial cancer stratification. Multilevel models enable sensitive screening, accurate diagnosis, and high-risk subtype detection. Deployed as a web tool, the platform offers scalable decision support for both resource-limited and personalized healthcare settings.
http://dlvr.it/TScsKs
4 days ago
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Online now: Therapeutic activity of a hematopoietic stem cell-delivered cell-penetrating frataxin in Friedreich’s ataxia models
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Therapeutic activity of a hematopoietic stem cell-delivered cell-penetrating frataxin in Friedreich’s ataxia models
Engineered hematopoietic stem cells delivering a secreted, tissue-penetrating frataxin restore mitochondrial function and ameliorate disease features in Friedreich’s ataxia models. This gene and cell therapy approach enables sustained systemic protein delivery, improving motor performance and tissue pathology, and supports a translational strategy for long-term disease stabilization.
http://dlvr.it/TScVcz
5 days ago
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Online now: Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics
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Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics
Noes-Holt et al. develop and apply AAV-encoded PICK1 inhibitors that alleviate inflammatory and neuropathic pain in male and female mice. They identify dorsal root ganglia as the site of action, demonstrate regulation of pain-relevant kinases, and confirm PICK1 expression and target engagement in human DRGs, supporting clinical translation.
http://dlvr.it/TSbvzz
5 days ago
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Online now: Predicting glioma survival and extracellular matrix remodeling through MRI radiogenomics
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Predicting glioma survival and extracellular matrix remodeling through MRI radiogenomics
Bie et al. develop an MRI-based radiomics signature that non-invasively assesses extracellular matrix remodeling in glioma, predicts patient survival, and identifies MMP2 as a key therapeutic target. This approach offers a promising tool for improved clinical management.
http://dlvr.it/TSbYYG
6 days ago
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Online now: Hearing aid effectiveness and probable dementia risk across 33 countries: A pooled analysis of seven cohorts
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Hearing aid effectiveness and probable dementia risk across 33 countries: A pooled analysis of seven cohorts
Jiang et al. pool data from 61,089 hearing-impaired older adults in 33 countries. They find that effective hearing aid use, but not poor use, is linked to reduced probable dementia risk. The association is stronger in middle-income countries, suggesting quality hearing rehabilitation may help reduce the global dementia burden.
http://dlvr.it/TSb2J1
6 days ago
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Online now: Trial-ready external controls for gene therapy: The MATCH cohort in maple syrup urine disease
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Trial-ready external controls for gene therapy: The MATCH cohort in maple syrup urine disease
Brigatti et al. develop MATCH, a prospective natural history cohort designed as a regulatory-ready external control for gene therapy trials in maple syrup urine disease. Using prespecified estimands and Monte Carlo simulations, the authors demonstrate how protocolized data can serve as quantitative evidence supporting ethically defensible single-arm trials.
http://dlvr.it/TSZq1n
7 days ago
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Online now: Traumatic life experiences during critical periods lead to diverse developmental trajectories
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Traumatic life experiences during critical periods lead to diverse developmental trajectories
Morelli et al. showed that exposure to traumatic events during distinct developmental periods in mice and humans produces long-lasting behavioral and molecular changes, revealing critical periods in which stress timing, rather than its nature, shapes adult brain function. The BDNF pathway represents a potential therapeutic target for trauma in young adulthood.
http://dlvr.it/TSZQpB
7 days ago
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Online now: Healthful plant-based diet, gut enterotype, and cognition in a rural Chinese elderly cohort: A longitudinal multi-omics study
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Healthful plant-based diet, gut enterotype, and cognition in a rural Chinese elderly cohort: A longitudinal multi-omics study
Shen et al. report that a healthful plant-based diet is associated with distinct gut microbiome features and a 12-metabolite signature. The diet-cognition association varied by gut microbiome enterotype, with stronger benefits in individuals with non-Prevotella-dominant enterotypes. These findings suggest that gut microbial context may shape diet-cognition associations in later life.
http://dlvr.it/TSZCMY
8 days ago
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Online now: Blunted anticipation, but not consummation, of food rewards in depression
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Blunted anticipation, but not consummation, of food rewards in depression
Schulz et al. show that anhedonia in depression, as measured by a scale often equated with loss of pleasure, reflects reduced anticipation of food rewards rather than impaired enjoyment itself. Linking metabolic signals to reward behavior and depressive symptoms highlights the gut-brain axis as a potential target in depression.
http://dlvr.it/TSYl1X
8 days ago
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Online now: Nectin4-targeted molecular imaging for precise endoscopic diagnosis and image-guided surgery in bladder cancer
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Nectin4-targeted molecular imaging for precise endoscopic diagnosis and image-guided surgery in bladder cancer
He et al. develop NECTIN4-ICG, a Nectin4-targeted fluorescence imaging probe for bladder cancer. In preclinical models and clinical trials, NECTIN4-ICG demonstrates high diagnostic accuracy and improves tumor margin detection compared to conventional white light cystoscopy, enhancing real-time visualization and surgical precision during transurethral resection.
http://dlvr.it/TSYPSc
9 days ago
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Online now: Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome
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Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome
Chen et al. map the multi-kingdom gut microbiome in primary Sjögren syndrome and identify diagnostic microbial signatures, metabolic disruption, and proinflammatory species with potential therapeutic relevance.
http://dlvr.it/TSXqJY
9 days ago
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Online now: Dual-system engineered bacteria and dendritic cells enable precise intratumoral IL-12 delivery and potent antitumor immunity
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Dual-system engineered bacteria and dendritic cells enable precise intratumoral IL-12 delivery and potent antitumor immunity
Deng et al. develop a dual-engineered bacterial-dendritic cell platform that localizes IL-12 delivery to tumors, enhances immune activation, and suppresses colorectal liver metastasis while remaining controllable by antibiotic-mediated clearance.
http://dlvr.it/TSXT05
10 days ago
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Online now: Tumor-microenvironment-modulating microspheres to augment tumor-infiltrating lymphocyte therapy against solid tumors
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Tumor-microenvironment-modulating microspheres to augment tumor-infiltrating lymphocyte therapy against solid tumors
Li et al. develop microspheres co-loaded with hyaluronidase and CXCL9 chemokine for pretreating the tumor microenvironment prior to tumor harvesting. This strategy enhances the number and activity of tumor-infiltrating lymphocytes (TILs), thereby accelerating their ex vivo expansion and improving the overall efficacy of TIL therapy.
http://dlvr.it/TSWvFV
10 days ago
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Online now: Circulating natural killer cells are phenotypically and functionally altered in age-related macular degeneration
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Circulating natural killer cells are phenotypically and functionally altered in age-related macular degeneration
Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness in the world, with neovascular complications. Using a “human-first” approach Brennan et al. identify a distinct, functionally altered NK cell phenotype in AMD and suggest that harnessing NK cell activity represents an immunotherapeutic approach for AMD.
http://dlvr.it/TSWWjP
11 days ago
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Online now: Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment
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Neuroplastic white matter changes in patients with major depression following lysergic acid diethylamide treatment
Avram et al. demonstrate that moderate-to-high doses of LSD, but not low doses, increase white matter fractional anisotropy in patients with major depressive disorder. These structural changes in key fiber tracts correlate with sustained clinical improvement, suggesting that LSD-induced neuroplasticity facilitates its antidepressant effects.
http://dlvr.it/TSVvwz
11 days ago
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Online now: A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer
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A tumor-intrinsic WNT-inhibitory NOTUM program drives immune resistance in microsatellite stable colorectal cancer
Advanced microsatellite stable colorectal cancers are particularly difficult to treat due to immune exclusion. Chua et al. identify an NOTUM-high, WNT-inhibitory cancer cell (WICC) state enriched in these tumors that drives reduced CD8+ T cell infiltration. Disruption of the WICC-NOTUM axis restores antitumor immunity and enhances tumor clearance.
http://dlvr.it/TSVWsV
12 days ago
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Online now: HPK1 inhibitor NDI-101150 as monotherapy and in combination with pembrolizumab in patients with advanced solid tumors: Phase 1/2 trial results
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HPK1 inhibitor NDI-101150 as monotherapy and in combination with pembrolizumab in patients with advanced solid tumors: Phase 1/2 trial results
Braun et al. report a phase 1/2 study evaluating NDI-101150, a potent, selective HPK1 inhibitor in patients with advanced solid tumors. NDI-101150 shows favorable safety as a monotherapy or in combination with pembrolizumab, with monotherapy demonstrating on-target immune activation and durable responses in patients with clear cell renal cell carcinoma.
http://dlvr.it/TSTwHG
12 days ago
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Online now: Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion
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Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion
Onimus et al. find that select cytotoxic therapies induce active HMGB1 secretion and show combinatorial efficacy with anti-TIM-3 antibodies. Taxanes specifically promoted HMGB1 release via TLR4-driven ROS production and DNA damage, which activated the cGAS-STING pathway to promote ER stress, HMGB1 exocytosis, and chemoimmunotherapeutic efficacy.
http://dlvr.it/TSTXqs
13 days ago
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Online now: A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy
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A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathy
Petrova et al. develop a high-throughput human iPSC-derived sensory neuron platform for drug discovery in chemotherapy-induced peripheral neuropathy. They uncover that inhibition of three members of the STE20 kinase family (MAP4K4/MINK1/TNIK) is neuroprotective against paclitaxel-induced axon damage, with validation in primary human and mouse models.
http://dlvr.it/TST13p
13 days ago
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Online now: Reprogramming T cell-myeloid crosstalk overcomes immune resistance in colorectal cancer
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Reprogramming T cell-myeloid crosstalk overcomes immune resistance in colorectal cancer
Mestrallet et al. show that T cell-myeloid interactions determine response to PD-1 blockade in colorectal cancer. Targeting TREM2 macrophages together with LAG3, CTLA4, and PD-1 reprograms the tumor microenvironment and drives antitumor immunity, achieving up to 100% tumor clearance in mismatch repair-deficient and >70% in mismatch repair-proficient models.
http://dlvr.it/TSSnwd
14 days ago
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Online now: An aerosolized dual-action autotaxin inhibitor-PPARÎł agonist for the treatment of pulmonary fibrosis
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An aerosolized dual-action autotaxin inhibitor-PPARÎł agonist for the treatment of pulmonary fibrosis
Matralis et al. present EL244, a dual ATX inhibitor/PPARÎł agonist, developed through drug repositioning and rational design. Inhaled EL244, exhibiting a favorable physicochemical profile, attenuates bleomycin-induced pulmonary fibrosis and prevents fibrosis in human PCLS. Therefore, EL244 emerges as a promising clinical candidate for the inhaled treatment of IPF and ILDs.
http://dlvr.it/TSSQ2c
14 days ago
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Online now: Cross-tissue atlas of mucosa-associated lymphoid tissue lymphomas reveals intratumoral heterogeneity and microenvironmental subtypes
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Cross-tissue atlas of mucosa-associated lymphoid tissue lymphomas reveals intratumoral heterogeneity and microenvironmental subtypes
Kang et al. identify three microenvironmental subtypes of mucosa-associated lymphoid tissue lymphoma through integrated cross-tissue transcriptomic profiling. The resulting framework connects cellular and spatial ecosystem diversity with prognosis, revealing biological heterogeneity in angiogenesis, immune crosstalk, and malignant B cell proliferative states, while informing potential therapeutic stratification.
http://dlvr.it/TSSBNK
15 days ago
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Online now: Escherichia coli Nissle 1917 alleviates Alzheimer’s disease in mice through OmpA-containing outer membrane vesicles
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Escherichia coli Nissle 1917 alleviates Alzheimer’s disease in mice through OmpA-containing outer membrane vesicles
Xie et al. report that outer membrane vesicles (OMVs) derived from probiotic Escherichia coli Nissle 1917 translocate to the brain and alleviate Alzheimer’s disease pathology by reshaping glia-neuron interactions through OmpA-mediated immunomodulation, identifying a previously unrecognized mechanism of gut-brain communication and a potential OMV-based therapeutic strategy for neurological disorders.
http://dlvr.it/TSRk25
15 days ago
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Online now: BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma
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BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma
Zhang et al. demonstrate that BCAT1 consumes α-KG to inhibit prolyl hydroxylase PHD, stabilizing HIF-1α and driving hypoxia-induced metabolic reprogramming that supports hypoxic survival of HCC. Clinically, BCAT1 is over-expressed and correlates with HIF-1α metabolic targets in HCC. BCAT1 inhibitor ERG245 shows therapeutic potential alone or in combination with TKI.
http://dlvr.it/TSRN5X
16 days ago
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Online now: Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy
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Engineering functionality-optimized fully human B7-H3 CAR T cells for enhanced solid tumor therapy
Bajgain et al. report Y111, a fully human B7-H3 CAR designed to minimize immunogenicity associated with non-human-derived binders. Across pancreatic cancer, neuroblastoma, glioblastoma, and rhabdomyosarcoma models, Y111-based CAR T cells demonstrate superior antitumor activity and survival compared with clinical benchmark binders, supporting a next-generation strategy for B7-H3-targeted therapy.
http://dlvr.it/TSQmcZ
16 days ago
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Online now: Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade
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Ferroptotic tumor cells reprogram tumor-associated macrophage antigen presentation to enhance the efficacy of immune checkpoint blockade
Sun et al. demonstrate that inducing tumor ferroptosis activates anti-tumor immunity by potentiating MHC-II-dependent macrophage antigen presentation. A drug-free nano-redox lever selectively targets hypoxic tumor regions to stimulate ferroptosis-mediated immune activation and synergizes with anti-PD-1 therapy, providing a clinically translatable approach to enhance immunotherapy efficacy.
http://dlvr.it/TSQP9s
17 days ago
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Online now: IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration
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IND-enabling safety and efficacy of RPESC-RPE-4W, an adult RPE progenitor cell therapy for dry age-related macular degeneration
Retinal pigment epithelium (RPE) cell replacement holds promise as a treatment for vision decline due to dry age-related macular degeneration. Arduini et al. describe the pathway to IND allowance for an adult RPE stem cell product, a prerequisite to clinical study.
http://dlvr.it/TSPmYL
17 days ago
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Online now: Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis
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Microbiome biomarkers in autism spectrum disorder: Toward prediction, diagnosis, and prognosis
Wong et al. review gut microbiota biomarkers for ASD, detailing gut-brain axis mechanisms, biomarker evolution from taxonomic profiling to multi-omics and multi-kingdom integration, key translational challenges, and actionable research guidelines to boost clinical utility for ASD diagnosis and prognosis.
http://dlvr.it/TSPNkt
18 days ago
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Online now: T cell-engaging bispecific antibodies for myeloid malignancies: Targets, formats, and clinical challenges
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T cell-engaging bispecific antibodies for myeloid malignancies: Targets, formats, and clinical challenges
Paczesny et al. review why bispecific antibodies, successful in other blood cancers, have lagged in acute myeloid leukemia. They highlight how limited tumor specificity and toxicity hinder progress and outline emerging targets and engineering strategies that could enable safer, more effective immunotherapies for this hard-to-treat disease.
http://dlvr.it/TSNmN7
18 days ago
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Online now: An inhalable microbe-oncolytic virus consortium for lung cancer treatment
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An inhalable microbe-oncolytic virus consortium for lung cancer treatment
Ling et al. develop an inhalable microbe-oncolytic virus consortium for lung cancer. Through algal motility and calcium ion competition, the consortium opens tumor tight junctions to facilitate the targeted delivery of oncolytic viruses into deep-seated tumors, providing a promising scheme for eliciting potent oncolytic viral-microbial co-activated antitumor immune responses.
http://dlvr.it/TSNNMl
19 days ago
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Online now: A ketogenic diet sensitizes pancreatic cancer to glutamine metabolism inhibitors
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A ketogenic diet sensitizes pancreatic cancer to glutamine metabolism inhibitors
Hajihassani et al. demonstrate that a ketogenic diet reprograms PDAC metabolism by altering nutrient availability, increasing reliance on glutamine, fatty acids, and ketone bodies to sustain core metabolic pathways. Combining a ketogenic diet with glutamine utilization enhances anti-tumor efficacy without inducing significant toxicity.
http://dlvr.it/TSMmRf
19 days ago
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Online now: Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling
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Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling
Liu et al. find that the TROP2-targeting antibody-drug conjugate (ADC) IMMU132 exerts significant antitumor effects by inducing DNA damage while inhibiting PERK-dependent endoplasmic reticulum stress. Importantly, adding a PERK inhibitor compromises Wnt signaling, creating an enhanced vulnerability that overcomes ADC resistance, offering promising strategies for TROP2-directed ADC-based combination therapies in advanced colorectal cancer.
http://dlvr.it/TSMPB6
20 days ago
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Online now: Macrophage-mimetic photothermal nanotherapeutics regulate mitochondrial homeostasis and inflammatory cascades in lung ischemia-reperfusion injury
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Macrophage-mimetic photothermal nanotherapeutics regulate mitochondrial homeostasis and inflammatory cascades in lung ischemia-reperfusion injury
Haoxiang Yuan et al. develop a macrophage-membrane-coated nanoparticle carrying ginsenoside Rg3, activated by near-infrared light, to precisely target pulmonary ischemia-reperfusion injury. This approach reduces inflammation and oxidative damage while restoring cell energy metabolism, offering a versatile strategy for inflammation-related diseases.
http://dlvr.it/TSLrlj
20 days ago
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Online now: Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians
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Preserved mitochondrial ribosomal protein gene expression marks a youthful transcriptional state in Chinese nonagenarians and centenarians
Xiao et al. analyze transcriptomes of long-lived individuals (≥90 years) and reveal a youthful transcriptional age. This youthful profile is underpinned by the preserved expression of mitochondrial ribosomal protein genes (mRPGs). The sustained expression of these genes may contribute to healthy aging by improving mitochondrial function.
http://dlvr.it/TSLchw
21 days ago
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Online now: A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma
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A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma
Sussman et al. present a longitudinal multiomic study of pediatric high-grade glioma, integrating single-nucleus transcriptomics, epigenomics, genomics, and spatial proteomics across disease progression. This work characterizes malignant cell states, therapy-associated neoplastic and immune programs, and spatial tumor-glial interactions, providing a reference for pediatric brain tumor biology.
http://dlvr.it/TSLCdM
21 days ago
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Online now: Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer
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Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer
Sun et al. reveal that intracellular sclerostin plays a crucial role in promoting TNBC progression and metastasis. Mechanistically, intracellular sclerostin interacts with caprin1 to stabilize CDK1 and Cyclin B1 mRNAs. Targeting intracellular sclerostin might represent a promising therapeutic strategy, particularly for patients who currently lack effective treatment options.
http://dlvr.it/TSKzBM
22 days ago
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Online now: Nano-granulated zoledronate sensitizes innate immune metabolism to enhance vaccine-induced and antitumor immunity
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Nano-granulated zoledronate sensitizes innate immune metabolism to enhance vaccine-induced and antitumor immunity
Chen et al. develop a nano-granulated metabolic modulator that redirects zoledronate to lymph nodes, where it sensitizes and amplifies innate immunity to enhance humoral and antitumor responses and identifies the MVA-CoQ-OXPHOS/pyrimidine metabolism axis as a target for immune-metabolic vaccine adjuvant design.
http://dlvr.it/TSKW4N
22 days ago
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Online now: AAV-based gene therapy with modified HEXB confers lasting therapeutic benefits in GM2 gangliosidosis models
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AAV-based gene therapy with modified HEXB confers lasting therapeutic benefits in GM2 gangliosidosis models
Kitakaze et al. establish proof of concept for treating GM2 gangliosidosis using a single gene therapy encoding a modified lysosomal enzyme. By simplifying gene design and demonstrating efficacy and safety across species, the study provides a foundation for clinical translation in neurodegenerative lysosomal disorders.
http://dlvr.it/TSKBnx
23 days ago
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Online now: Checkpoint blockade-related CNS adverse events are characterized by neurotoxic T helper cells with sustained neuroantigen reactivity
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Checkpoint blockade-related CNS adverse events are characterized by neurotoxic T helper cells with sustained neuroantigen reactivity
Ma et al. identify a unique polyfunctional CD4+ T cell subset (poly6+ Th) in irAEs-CNS. These cells persistently react to neuroantigens (e.g., NMDAR1) and drive neuronal injury, and their abundance correlates with severe neuroinflammation and poor outcomes. IL-17 blockade alleviates pathology, suggesting a targeted therapeutic strategy.
http://dlvr.it/TSJf1W
23 days ago
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Online now: Breastfeeding may lessen socioeconomic disparities in child health through differences in the infant gut microbiome
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Breastfeeding may lessen socioeconomic disparities in child health through differences in the infant gut microbiome
Darlene Dai, Charisse Petersen, Stuart Turvey, and colleagues report that breastfeeding may mitigate the adverse effects of socioeconomic disadvantage on early risk factors for non-communicable diseases. The authors link this effect to differences in infant gut microbiota, including enrichment of Bifidobacterium infantis, highlighting potentially modifiable pathways underlying intergenerational health inequities.
http://dlvr.it/TSJH1W
24 days ago
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Online now: Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small-cell lung cancer
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Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small-cell lung cancer
Wang et al. map combined small-cell lung cancer (cSCLC) with spatial multi-omics, showing that mixed histologies arise from a single clone that diversifies through neuroendocrine plasticity and stromal partitioning. The resulting niche map highlights why microenvironment programs diverge and supports mutation-based detection of cSCLC from small biopsies and blood.
http://dlvr.it/TSHgq1
24 days ago
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Online now: Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial
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Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial
(Cell Reports Medicine 7, 102711; April 21, 2026)
http://dlvr.it/TSHJbz
25 days ago
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