Cell Reports Medicine
@cp-cellrepmed.bsky.social
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A gardener removes weeds among flowers—just like therapies targeting the tumour microenvironment can eliminate cancer cells while sparing healthy ones. Dive into our special issue for expert reviews on immune cell targeting in cancer! Artwork by Justine Reimand.
www.cell.com/issue/S2666-...
8 months ago
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Online now: A functional antiplatelet nanomotor for tri-modal ablation of acute arterial thrombus
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A functional antiplatelet nanomotor for tri-modal ablation of acute arterial thrombus
Wu et al. present a functional antiplatelet nanomotor composed of a photothermal photosensitizer (DiR), a nitric oxide donor (BNN6), and ticagrelor (TGL). Under near-infrared laser irradiation, the nanomotor achieves efficient thrombolysis through photothermal/mechanical/antiplatelet tri-modal synergy and reduces the risk of thrombus recurrence.
http://dlvr.it/TTR0Zw
about 12 hours ago
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Online now: From generalization to precision: A large domain-specific pretrained model for specialized medical tasks
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From generalization to precision: A large domain-specific pretrained model for specialized medical tasks
Li et al. develop USPEC, a novel domain-specific model pretrained on 875,947 unlabeled ultra-widefield fundus images using self-supervised learning. USPEC outperforms general-purpose foundation models across multiple UWF-based diagnostic, few-shot learning, and segmentation tasks, with superior label and training efficiency, demonstrating that modality-matched pretraining advances precision in specialized medicine.
http://dlvr.it/TTQQLn
1 day ago
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Online now: Preventative semaglutide and tirzepatide treatment does not alter disease progression in the 5xFAD mouse model of Alzheimer's disease
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Preventative semaglutide and tirzepatide treatment does not alter disease progression in the 5xFAD mouse model of Alzheimer's disease
Vear et al. report that chronic semaglutide or tirzepatide treatment does not slow the progression of Alzheimer's disease neuropathology in two distinct mouse models, the 5xFAD mouse or lipopolysaccharide-treated mice. This guides the design of future preclinical investigations testing next-generation incretin mimetics for brain diseases.
http://dlvr.it/TTQ3zm
1 day ago
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Online now: Core gastric microbiota linked to pathogenesis and preserved across age-stratified cohorts
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Core gastric microbiota linked to pathogenesis and preserved across age-stratified cohorts
Huang et al. identify a core gastric microbial network established in early childhood. They show that imbalance within this antagonistic network is associated with pediatric peptic ulcer and is exacerbated by Helicobacter pylori. This ecological framework predicts gastric disease risk across age groups, providing potential targets for precision microbiome medicine.
http://dlvr.it/TTPTtc
2 days ago
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Online now: Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer
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Differential T cell clonal dynamics underlie outcomes to frontline chemoimmunotherapy in advanced gastric cancer
Wright et al. use serial single-cell RNA/TCR sequencing to show that durable benefit from gastric cancer chemo-immunotherapy associates with persistence of putative tumor-reactive progenitor-exhausted T cells, circulating TCR clones that infiltrate tumors after immunotherapy, increased B cell abundance after chemotherapy, and B cell interactions that support T cell persistence.
http://dlvr.it/TTLSmj
6 days ago
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Online now: Transplantation tolerance versus immune evasion: Mechanistic divergences and therapeutic frontiers for islet cell replacement
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Transplantation tolerance versus immune evasion: Mechanistic divergences and therapeutic frontiers for islet cell replacement
Deuse et al. review emerging strategies to overcome the toxicities of chronic immunosuppression that limit allogeneic islet transplantation. This review contrasts fragile recipient-centric tolerance induction—vulnerable to destabilization by infections, heterologous immunity, and inflammation—with robust product-centric immune evasion engineered for hypoimmunity, highlighting its transformative potential for islet cell replacement therapy.
http://dlvr.it/TTL7xn
6 days ago
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Online now: Targeted DNA triplex-forming oligonucleotide liposome for pulmonary fibrosis gene therapy
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Targeted DNA triplex-forming oligonucleotide liposome for pulmonary fibrosis gene therapy
Xu et al. develop a targeted DNA triplex-forming oligonucleotide liposome (tLipo-TFO1) for pulmonary fibrosis gene therapy to accelerate the clearance of deposited extracellular matrix. Downregulation of plasminogen activator inhibitor 1 (PAI-1) activates the fibrinolysis and attenuates the fibrosis of pulmonary-fibrosis-bearing mice.
http://dlvr.it/TTKYMg
7 days ago
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Online now: Targeting cytokine-like protein FAM3D alleviates atherosclerosis
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Targeting cytokine-like protein FAM3D alleviates atherosclerosis
Shirong Zhu et al. found that elevated circulating FAM3D levels are associated with the incidence of atherosclerosis in humans. FAM3D exacerbates atherosclerosis through both lipid-dependent and lipid-independent mechanisms. Treatment with FAM3D antibodies significantly alleviates atherosclerosis in mice, highlighting FAM3D as a promising therapeutic target for combating atherosclerosis.
http://dlvr.it/TTK9w4
7 days ago
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Online now: Metabolomic and lifestyle profiles refine BMI-metabolic phenotypes in older adults
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Metabolomic and lifestyle profiles refine BMI-metabolic phenotypes in older adults
Chen et al. apply large-scale metabolomics to develop machine learning models that accurately classify metabolic dysfunction within each BMI category, derive a BMHS that independently predicts mortality beyond BMI-metabolic phenotypes, and, when combined with lifestyle factors, further refine metabolic risk stratification, offering scalable precision management for older adults.
http://dlvr.it/TTJbBR
8 days ago
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Online now: High-dose furmonertinib as first-line treatment for untreated EGFR-mutated advanced NSCLC with central nervous system metastases: A phase 2 trial
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High-dose furmonertinib as first-line treatment for untreated EGFR-mutated advanced NSCLC with central nervous system metastases: A phase 2 trial
Yan et al. demonstrate that high-dose furmonertinib delivers promising intracranial efficacy for untreated EGFR-mutated NSCLC patients with CNS metastases. This phase II study reports a median progression-free survival of 16.59 months, significant early molecular clearance in plasma and cerebrospinal fluid, and manageable safety.
http://dlvr.it/TTJCyt
8 days ago
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Explore AI-guided biomaterial design, generative AI, smart scaffolds, drug delivery systems, and more with Joseph C. Wu, Cesar de la Fuente, and Kam W. Leong. July 16, 12:00 p.m. ET.
http://dlvr.it/TTJ8Gl
9 days ago
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Online now: Microglial IL-27 modulates depression-like behaviors induced by postnatal immune activation
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Microglial IL-27 modulates depression-like behaviors induced by postnatal immune activation
Qiao et al. identify IL-27 as a key regulator of aberrant microglial phagocytosis following postnatal immune activation. Through microglial STAT1-Trem2 signaling, IL-27 preserves synaptic integrity and alleviates depression-like behaviors, highlighting a potential immunomodulatory avenue for mood disorders.
http://dlvr.it/TTHcC5
9 days ago
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Online now: Case of complete response to immunotherapy in MMR-deficient prostate cancer associated with NK-like and CD4+CD8+ T cells
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Case of complete response to immunotherapy in MMR-deficient prostate cancer associated with NK-like and CD4+CD8+ T cells
Tsai et al. identify that CD56+ “NK-like” and CD4+CD8+ “double-positive” T cells were associated with a complete response to immunotherapy in a patient with high-grade MMR-deficient prostate cancer. These unique lymphocytes also expanded in other immunotherapy-responsive patients with diverse tumor types. These studies uncover possible conserved mechanisms of immunotherapy efficacy.
http://dlvr.it/TTHGRS
9 days ago
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Online now: Multi-omics profiling unveils biological and clinical insights into pulmonary sarcomatoid carcinoma
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Multi-omics profiling unveils biological and clinical insights into pulmonary sarcomatoid carcinoma
Sun et al. provide a rich multi-omics dataset for pulmonary sarcomatoid carcinoma (PSC), revealing detailed genomic, transcriptomic, proteomic, phosphoproteomic, and scRNA-seq landscapes. Their work defines distinct molecular subtypes, uncovers potential therapeutic targets, and elucidates mechanisms of immunotherapy resistance, offering critical biological and clinical insights into PSC.
http://dlvr.it/TTGkGt
10 days ago
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Online now: GPNMB+ macrophages promote osteogenic differentiation of nucleus pulposus cells through PDGF signaling in intervertebral disc degeneration
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GPNMB+ macrophages promote osteogenic differentiation of nucleus pulposus cells through PDGF signaling in intervertebral disc degeneration
Intervertebral disc degeneration involves altered differentiation of nucleus pulposus cells. Jiang et al. identify an osteoblast-like NP cell population whose osteogenic fate is driven by GPNMB+ macrophages through PDGF signaling. Blocking this pathway reduces disc degeneration, highlighting a potential therapeutic strategy.
http://dlvr.it/TTGPbw
10 days ago
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Online now: Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors
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Design optimization of antibody-ligand motifs to enhance CAR-T redirection activity against solid tumors
Wang et al. designed a sCAR-T to overcome solid tumor heterogeneity and the tumor microenvironment. The fusion of scFv with ligands enables coordinated targeting of multiple antigens. Optimization of switches and CAR hinges facilitates IS formation and exhibits potent antitumor efficacy and controllable safety in both syngeneic and xenogeneic in vivo models.
http://dlvr.it/TTFwxT
11 days ago
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Online now: A S.C.O.R.E. framework for evaluating open-ended responses from large language models in healthcare
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A S.C.O.R.E. framework for evaluating open-ended responses from large language models in healthcare
Tan et al. proposed a S.C.O.R.E. framework to evaluate clinical responses from large language models (LLMs) in terms of Safety, Consensus & Context, Reproducibility, and Explainability. S.C.O.R.E. supports clinical LLM validation by providing structured, actionable insights to guide model optimization and refinement.
http://dlvr.it/TTFkpY
11 days ago
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Online now: Advancing CAR-NK cell therapy in solid tumors: Current landscape and future directions
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Advancing CAR-NK cell therapy in solid tumors: Current landscape and future directions
CAR-NK cells offer a scalable and safer alternative to CAR-T therapy, with growing clinical success in hematologic malignancies. Here, Manzar et al. examine emerging engineering strategies and translational approaches aimed at overcoming key barriers in solid tumors and unlocking the broader therapeutic potential of CAR-NK therapy.
http://dlvr.it/TTFNMW
12 days ago
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Online now: A radiopharmaceutical enhances CAR T cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling
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A radiopharmaceutical enhances CAR T cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling
Rodriguez et al. demonstrate that VLA-4-targeted low-dose radiopharmaceutical therapy enhances CAR T cell activity and drives tumor regression in neuroblastoma mouse models. Mechanistically, RPT promotes tumor cell killing and TNF-α-mediated T cell activation in radio-sensitive tumors, while it remodels the myeloid compartment and fosters CAR T cell niches in radio-resistant tumors.
http://dlvr.it/TTF9cF
12 days ago
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Online now: Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor
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Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor
Zhang et al. demonstrate that C. acnes isolated from the skin of AD patients have undergone genomic shifts that impair their ability to produce ILA. Topical application of ILA restores epidermal barrier function and mitigates AD symptom by activating AhR in both mice and humans.
http://dlvr.it/TTDl9F
13 days ago
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Online now: Spatial architecture contributes to failure of bulk biomarker-guided neoadjuvant immunotherapy selection in bladder cancer: The DUTRENEO study
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Spatial architecture contributes to failure of bulk biomarker-guided neoadjuvant immunotherapy selection in bladder cancer: The DUTRENEO study
Grande et al. show that prospective selection of bladder cancer patients for neoadjuvant immunotherapy based on a bulk tumor inflammation score does not enrich for responders. Spatial transcriptomics points to CD8-tumor proximity, checkpoint niches, and fibroblast exclusion as spatial correlates of response, and signal is retained at ≥77 genes and ≥3-mm sampling.
http://dlvr.it/TTDQVp
13 days ago
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Online now: Safety and efficacy of GZR18, a long-acting GLP-1 analog, in Chinese patients with type 2 diabetes: A randomized, double-blind, phase 1b/2a trial
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Safety and efficacy of GZR18, a long-acting GLP-1 analog, in Chinese patients with type 2 diabetes: A randomized, double-blind, phase 1b/2a trial
Ming Liu et al. report a randomized, double-blind, placebo-controlled phase 1b/2a trial evaluating once-weekly GZR18. In Chinese adults with type 2 diabetes, GZR18 demonstrates robust HbA1c reductions (up to −1.81%) and is generally safe and well tolerated. These findings support its further clinical development.
http://dlvr.it/TTCsPS
14 days ago
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Online now: Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes
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Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes
(Cell Reports Medicine 4, 101074; June 20, 2023)
http://dlvr.it/TTCVt5
14 days ago
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Online now: Light-driven thermotropic hydrogel with nanomodulator enables lipid intervention and cavity delivery for postsurgical tumor therapy
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Light-driven thermotropic hydrogel with nanomodulator enables lipid intervention and cavity delivery for postsurgical tumor therapy
Zhong et al. develop a light-driven thermotropic hydrogel targeting the fatty acid-rich milieu in the tumor microenvironment for preventing postsurgical tumor recurrence. By coordinating lipid intervention strategy and enhancing cavity delivery, this approach successfully inhibits tumor recurrence in melanoma and breast cancer models, providing robust strategy for tumor postsurgical management.
http://dlvr.it/TTBwhl
15 days ago
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Online now: ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development
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ABO: A 3D stroma-supported culture platform enabling full human B-lymphopoiesis for disease modeling and gene therapy development
Braams et al. establish 3D aggregate cocultures (ABOs) generating functional B cells from hematopoietic stem and progenitor cells (HSPCs). ABOs recapitulate the B cell developmental arrest of RAG1-deficient HSPCs, which is rescued by RAG1 gene correction, and thus provide a valuable tool to study B cell immunodeficiencies and test gene therapy strategies.
http://dlvr.it/TTBZzX
15 days ago
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Online now: Negative effects of semaglutide on bone in obese mice
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Negative effects of semaglutide on bone in obese mice
While GLP1ra’s are effective at causing weight loss, there is concern that these drugs reduce lean mass. Eisner et al. demonstrate that treatment with the GLP1ra semaglutide causes reductions in bone mass and strength, an effect that reverses when the drug is discontinued. These findings highlight potential negative consequences of GLP1ra’s.
http://dlvr.it/TTB1HJ
16 days ago
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Online now: A predictive corticospinal model for pain perception
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A predictive corticospinal model for pain perception
Lin et al. present a neuroimaging biomarker integrating brain and spinal cord activity to decode pain. This corticospinal model outperforms traditional brain-only signatures, effectively tracking pain relief from neuromodulation and predicting chronic pain severity and treatment outcomes.
http://dlvr.it/TT9fpQ
16 days ago
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AI-assisted biomaterials advancement webinar w/ Joseph Wu @stanfordmedicine.bsky.social @greenstonebio.bsky.social, Cesar de la Fuente @upenn.edu & Kam Leong @columbiauniversity.bsky.social.
http://dlvr.it/TT9f3n
16 days ago
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Online now: Self-assembly of tumor-related vascularized colorectal tumoroid-on-a-chip for precision medicine drug testing
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Self-assembly of tumor-related vascularized colorectal tumoroid-on-a-chip for precision medicine drug testing
Dai et al. develop a biomimetic vascularized colorectal tumoroid-on-a-chip featuring self-assembled, tumor-associated vessels. This platform demonstrates high concordance with clinical drug responses, serving as a functional in vitro model for evaluating tailored therapeutic strategies and advancing personalized oncology for colorectal cancer.
http://dlvr.it/TT95W0
17 days ago
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Online now: The IMMUNO-BIOMAP trial in NSCLC: An adaptive multimodal framework for biomarker-guided care
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The IMMUNO-BIOMAP trial in NSCLC: An adaptive multimodal framework for biomarker-guided care
Tumor heterogeneity and evolution constrain NSCLC immunotherapy, leading to variable and often short-lived responses. This commentary discusses the ARPA-H ADAPT program and IMMUNO-BIOMAP trial, which longitudinally profile tumors and the microenvironment to identify resistance mechanisms in real time and enable adaptive, biomarker-guided, personalized treatment strategies.
http://dlvr.it/TT8lyb
17 days ago
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Online now: Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma
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Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma
Mukherjee et al. show that a ketogenic diet enhances the antitumor effects of mebendazole and devimistat in juvenile high-grade glioma models. Nutritional ketosis reduces tumor invasion, slows progression, prolongs survival, and enables lower drug doses, supporting a metabolically informed press-pulse strategy targeting glycolysis and glutaminolysis.
http://dlvr.it/TT8G4q
18 days ago
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Online now: STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer
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STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer
Pei et al. develop an activable nanoplatform NiS@ALB for co-delivery of Ni2+ and H2S to initiate metalloimmunotherapy and modulate STAT3 signaling-mediated lipid metabolism, which synergistically potentiates the chemosensitivity and immunogenicity of breast cancer. The combination with chemotherapy and αPD-1 elicits potent systemic immune response and suppresses breast tumor progression and metastasis.
http://dlvr.it/TT84C6
18 days ago
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Online now: Type I interferon signaling in hematopoietic cells impairs neutrophil antibacterial function in the middle ear during viral co-infection
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Type I interferon signaling in hematopoietic cells impairs neutrophil antibacterial function in the middle ear during viral co-infection
Shaw et al. investigate how immune modulation by viruses worsens bacterial infection in the middle ear, the most common site of childhood infection. In a pathway distinct from lung co-infections, virus induction of a type I interferon response targets myeloid cells, impairing middle ear neutrophil antibacterial function.
http://dlvr.it/TT7kPn
19 days ago
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Online now: Salmonella vector creates de novo parvovirus that reduces solid tumors and forms antitumor immune memory
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Salmonella vector creates de novo parvovirus that reduces solid tumors and forms antitumor immune memory
Khanduja et al. demonstrate that virus-delivering Salmonella (VDS) carries the H-1 parvovirus genome directly into cancer cells, enabling de novo virion formation, potent tumor regression, and durable antitumor immunity. VDS overcomes systemic OV delivery barriers, reshapes the tumor microenvironment, and generates tumor-specific immune memory that prevents re-implantation.
http://dlvr.it/TT7WRL
19 days ago
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Online now: Emerging therapeutic strategies for mitochondrial DNA-related diseases
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Emerging therapeutic strategies for mitochondrial DNA-related diseases
In this review, Shi et al. discuss emerging therapeutic strategies for mitochondrial DNA-related primary mitochondrial diseases, including gene editing, pharmacological modulation of heteroplasmy, mitochondrial donation, and mitochondrial transplantation. It highlights recent progress toward targeted interventions for disorders that currently have limited disease-modifying treatment options.
http://dlvr.it/TT75NY
20 days ago
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Online now: Comprehensive mapping of human CD4+ T cell epitopes for Nipah and measles as prototype Paramyxoviruses
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Comprehensive mapping of human CD4+ T cell epitopes for Nipah and measles as prototype Paramyxoviruses
Tarke et al. systematically map CD4+ T cell epitopes in measles and Nipah viruses, revealing broad and overlapping immune targets. They define conserved T cell epitope regions (CTERs) that drive cross-reactive T cell responses across Paramyxoviruses, providing a framework for vaccine strategies that enhance population coverage and pandemic preparedness.
http://dlvr.it/TT6nGw
20 days ago
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Online now: Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy
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Metabolically engineered probiotic OMVs as nanovaccine mediating sequential immunomodulation for chronic bone infection immunotherapy
Lei et al. screen Lactococcus lactis OMVs (Lac-OMVs) and develop a metabolically engineered NAD+-Lac-OMV nanovaccine with potent tissue-repair therapeutic effects. NAD+-Lac-OMVs sequentially activate dendritic cells by membrane components and reprogram inflammatory macrophages for anti-inflammation and bone repair by interior nicotinamide metabolites.
http://dlvr.it/TT6DKN
21 days ago
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reposted by
Cell Reports Medicine
Cell Press Events
about 1 month ago
Cell Symposia is now Cell Press Symposia. Our meetings have always been shaped by Cell Press editors—this name simply makes that connection clearer. Read more:
http://dlvr.it/TSr7FK
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Online now: Pro/synbiotics reduce systemic inflammation and improve gut health in Kenyan infants: An open label, randomized, 4-arm, phase II trial
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Pro/synbiotics reduce systemic inflammation and improve gut health in Kenyan infants: An open label, randomized, 4-arm, phase II trial
In this open-label, randomized trial in 600 vulnerable infants in western Kenya, Otiti et al. find that chronic systemic inflammation occurs at age 6 months in 43% controls but in
http://dlvr.it/TT5sfh
21 days ago
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Online now: Druggable β-catenin palmitoyl-switch coordinates immune evasion via immunogenic ferroptosis resistance and PD-L1-mediated immunosuppression
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Druggable β-catenin palmitoyl-switch coordinates immune evasion via immunogenic ferroptosis resistance and PD-L1-mediated immunosuppression
Zhang et al. identify a druggable palmitoylation switch on β-catenin at C466, mediated by ZDHHC5, which displaces inhibitory S-nitrosylation. This switch coordinates immune evasion in colorectal cancer by upregulating SLC7A11 and PD-L1 to block immunogenic ferroptosis and inhibit T cells, and pharmacological inhibition reactivates anti-tumor immunity and suppresses tumor growth.
http://dlvr.it/TT5H2K
22 days ago
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Online now: Sustained mucosal delivery of SAMT-247 via an intravaginal ring reduces the risk of SIVmac251 acquisition in vaccinated macaques
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Sustained mucosal delivery of SAMT-247 via an intravaginal ring reduces the risk of SIVmac251 acquisition in vaccinated macaques
Rahman et al. demonstrate that intravaginal rings delivering SAMT-247 reduce vaginal SIVmac251 acquisition risk in ΔV1-SIV-vaccinated macaques. Correlates of risk include IL-10-producing mucosal dendritic cells (DC10) and macrophages; CD73+mDC-derived adenosine, which fortifies the mucosal barrier; IL-17+NKp44+ ILCs that maintain mucosal integrity; and V2-specific ADCC responses.
http://dlvr.it/TT4vtz
22 days ago
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Online now: TIGIT-targeted IL-12 fusion protein engages NK and CD8+ T cells for potent tumor immunotherapy
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TIGIT-targeted IL-12 fusion protein engages NK and CD8+ T cells for potent tumor immunotherapy
Maoxing et al. design and construct an immunocytokine comprising IL-12 fused to an anti-TIGIT antibody, serving as a multipronged therapy strategy. Results show that it preferentially targets and activates NK and CD8+ T cells inside the tumor and potently curbs the growth of cold tumors and greatly eliminates metastasis.
http://dlvr.it/TT4JpN
23 days ago
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Online now: Intervening in aging and related diseases with gene therapy techniques
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Intervening in aging and related diseases with gene therapy techniques
Jiang et al. review gene therapy strategies, including genome editing, RNA modulation, epigenetic reprogramming, and engineered delivery platforms, for targeting aging and age-associated diseases. They highlight key genetic entry points, translational opportunities, and safety challenges, offering a roadmap for future precision geroprotective interventions.
http://dlvr.it/TT3MhB
24 days ago
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Online now: Subretinal rAAV2-based VEGF-Trap gene therapy for neovascular age-related macular degeneration: Preclinical assessment and phase 1 trial results
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Subretinal rAAV2-based VEGF-Trap gene therapy for neovascular age-related macular degeneration: Preclinical assessment and phase 1 trial results
Li et al. present the preclinical development and phase 1 trial results of LX102, an rAAV2-based gene therapy designed for sustained VEGF-Trap secretion. LX102 achieved long-term efficacy in animal models and shows a favorable safety profile with durable clinical benefits in patients with nAMD in this phase 1 study.
http://dlvr.it/TT2Hjj
25 days ago
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Online now: Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer
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Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer
Hao et al. develop a non-genetic reprogramming strategy using IFNγ training and Abraxane arming to create meta-neutrophils, which sustain antitumor phenotype and enable potent chemo-immunotherapy against lung metastatic triple-negative breast cancer (TNBC), overcoming cell source limitations.
http://dlvr.it/TT1wLZ
26 days ago
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Online now: Psilocybin restores behavior and 5-HT2A signaling while reducing microglial density after chronic traumatic brain injury in rats
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Psilocybin restores behavior and 5-HT2A signaling while reducing microglial density after chronic traumatic brain injury in rats
Allen et al. show that a single psilocybin injection administered one year after traumatic brain injury restores behavioral function and normalizes 5-HT2A receptor signaling, while reducing microglial density in the prefrontal cortex in rats, highlighting its potential for patients with chronic TBI symptoms.
http://dlvr.it/TT1hg2
26 days ago
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Online now: Toward generalizable prediction of cancer signal using a cell-free DNA language model
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Toward generalizable prediction of cancer signal using a cell-free DNA language model
Xu et al. analyze patterns in cell-free DNA fragments to detect cancer signals from very low sequencing input across cancer types and clinical settings. The approach supports early detection, treatment monitoring, and post-treatment risk assessment while reducing sequencing demands across assay types.
http://dlvr.it/TT1Fll
27 days ago
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Online now: Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction
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Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction
Zhong et al. map the spatiotemporal dynamics of zinc and copper following myocardial infarction. They develop a sequential Zn-Cu therapy, delivered via an epicardial device, that matches physiological needs. This targeted approach enhances cardiac repair and improves ventricular function by regulating the circadian gene PER2.
http://dlvr.it/TT0w4P
27 days ago
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Online now: Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma
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Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma
Park et al. show that patient-derived glioblastoma organoids faithfully recapitulate parental tumor features and predict clinical responses to temozolomide more accurately than current biomarkers, including MGMT status. This platform reveals heterogeneous resistance mechanisms and enables personalized drug screening, identifying lazertinib as a promising therapeutic option for temozolomide-resistant glioblastoma.
http://dlvr.it/TT0Jr8
28 days ago
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Online now: Human primary antibody response to vaccination follows a partially sequential class-switching program with a checkpoint at IGHG2
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Human primary antibody response to vaccination follows a partially sequential class-switching program with a checkpoint at IGHG2
Using the SARS-CoV-2 mRNA vaccine as a model immune challenge, Montamat-Garcia et al. describe how antibody class-switch recombination (CSR) during a primary human response is partially sequential, but with checkpoint at the IGHG2 locus. Moreover, CSR is influenced by the B cell subset and VDJ gene usage.
http://dlvr.it/TSwXZ8
about 1 month ago
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