Cell Reports Medicine
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A gardener removes weeds among flowersājust like therapies targeting the tumour microenvironment can eliminate cancer cells while sparing healthy ones. Dive into our special issue for expert reviews on immune cell targeting in cancer! Artwork by Justine Reimand.
www.cell.com/issue/S2666-...
3 months ago
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Online now: The Ca2+ sensor STIM1 promotes neuronal ferroptosis by regulating iron homeostasis to exacerbate brain injury after intracerebral hemorrhage
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The Ca2+ sensor STIM1 promotes neuronal ferroptosis by regulating iron homeostasis to exacerbate brain injury after intracerebral hemorrhage
Zhang et al. reveal that STIM1 promotes neuronal ferroptosis and exacerbates brain injury by interacting with the iron uptake protein TFR1 after intracerebral hemorrhage. S-IN-1 inhibits STIM1-TFR1 binding and exhibits neuroprotective effects, offering a promising therapeutic strategy.
http://dlvr.it/TQvV2M
about 7 hours ago
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Online now: Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis
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Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis
In this multicenter longitudinal study, Fleischer et al. show that enlargement of the choroid plexus, a key gateway between the blood and cerebrospinal fluid, signals early neuroaxonal injury and predicts silent progression in MS. Their findings suggest that volumetric changes at this barrier contribute to neurodegeneration and clinical disability in MS.
http://dlvr.it/TQv4b7
about 14 hours ago
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Online now: TNF-āŗ-mediated myeloid-instructed CD14+CD4+ T cells are associated with poor survival in lung adenocarcinoma
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TNF-āŗ-mediated myeloid-instructed CD14+CD4+ T cells are associated with poor survival in lung adenocarcinoma
Marceaux et al. uncover a TNF-Ī±-driven mechanism of immune suppression in lung cancer. Their spatial multi-omics analysis shows that myeloid-T cell interactions generate hybrid immune cells that weaken anti-tumor responses, revealing how inflammatory signaling rewires the tumor microenvironment to promote disease progression.
http://dlvr.it/TQtN9N
1 day ago
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Weāre excited to share a preview of the scientific program for @CellSymposia #CSCellDeath26 taking place in Hangzhou, China, Oct 22ā24, 2026
http://dlvr.it/TQtCVZ
1 day ago
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Online now: Synergistic mechanical and therapeutic modulation of engineered tumor cell-derived microparticles for enhanced cancer treatment
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Synergistic mechanical and therapeutic modulation of engineered tumor cell-derived microparticles for enhanced cancer treatment
Zhang et al. engineer soft Rh2-modified tumor-derived MP that enhance tumor accumulation, deep penetration, and clathrin-mediated CSC uptake, while Rh2 concurrently suppresses stemness to potentiate doxorubicin. These dual mechanical-pharmacological effects enable efficient CSC eradication, CTC neutralization, and strong inhibition of tumor growth and metastasis.
http://dlvr.it/TQsyHN
1 day ago
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Online now: Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis
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Preoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis
Preoperative exercise (PEx) prevents surgical stress-promoted liver metastasis by enhancing anti-tumor immunity. Zhang et al. demonstrate that PEx-induced gut microbiota-derived butyrate accumulates in Kupffer cells, where it inhibits HDAC3 to upregulate CXCL9. This chemokine then recruits and activates CXCR3+ CD8+ T cells, thereby suppressing surgical stress-promoted colorectal cancer liver metastasis.
http://dlvr.it/TQsFgp
2 days ago
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Online now: The effect of dual antiplatelet therapy in different patterns of watershed infarction: Subgroup analysis of the INSPIRES trial
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The effect of dual antiplatelet therapy in different patterns of watershed infarction: Subgroup analysis of the INSPIRES trial
Liu et al. explore the effectiveness and safety of clopidogrel-aspirin in patients with different patterns of watershed infarction (WI). They find a higher risk of recurrent stroke in WI than in non-WI. The effect of clopidogrel-aspirin appears consistent across WI subgroups but might be more effective in patients with IWI.
http://dlvr.it/TQp6g6
6 days ago
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Online now: Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors
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Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors
Hao Zhang et al. develop CAR-iNEV, a cell-free therapy from engineered iPSC-NK vesicles, which targets solid tumors, modulates the microenvironment, and activates macrophages, acting alone or with CD47 blockade to strengthen antitumor responses and showing efficacy in diverse tumor models.
http://dlvr.it/TQnLs4
6 days ago
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Online now: Unsafe drinking water and human health: A global umbrella review of disease outcomes, intervention effectiveness, and policy implications
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Unsafe drinking water and human health: A global umbrella review of disease outcomes, intervention effectiveness, and policy implications
Li et al. synthesize global evidence on risks from unsafe drinking water and related interventions. They find variable statistical robustness in attributing health risks; however, interventions such as filtration consistently demonstrate clear benefits. The results highlight the need to shift policies toward implementing proven water safety solutions.
http://dlvr.it/TQm8Wn
7 days ago
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Online now: Proteomics landscape of early T-cell precursor acute lymphoblastic leukemia reveals deficient oxidative phosphorylation signatures
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Proteomics landscape of early T-cell precursor acute lymphoblastic leukemia reveals deficient oxidative phosphorylation signatures
Liu et al. identify mitochondrial dysfunction as a hallmark of ETP-ALL. Restoring oxidative phosphorylation with dichloroacetate effectively suppresses leukemic proliferation through ROS-mediated ER stress activation, and CD109 is identified as a diagnostic and therapeutic target, defining a subset with enhanced ETC suppression and heightened metabolic vulnerability to dichloroacetate.
http://dlvr.it/TQljhV
8 days ago
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Online now: Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury
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Acutely denervated muscle EVs reshape neuronal mitochondrial metabolism via retrograde signaling to rescue peripheral nerve injury
Liu et al. find a retrograde signaling axis wherein acutely denervated muscle rescues peripheral nerve injury by delivering IDH2 and CS to injured neurons. These metabolic enzymes are shuttled via extracellular vesicles to boost neuronal mitochondrial metabolism and restore redox balance, thereby driving axon regeneration.
http://dlvr.it/TQky44
8 days ago
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Online now: Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
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Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution and promoting immune escape. Their work highlights how long-term infections in immunocompromised individuals can generate variants with enhanced resistance to neutralizing antibodies, shaping SARS-CoV-2ās evolutionary trajectory.
http://dlvr.it/TQkW31
9 days ago
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Online now: Efficacy and safety of autologous CD5-KO anti-CD5 CAR-T cells in relapsed/refractory CD5+ hematological malignancies
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Efficacy and safety of autologous CD5-KO anti-CD5 CAR-T cells in relapsed/refractory CD5+ hematological malignancies
Cheng et al. report a phase 1 trial of autologous CD5-targeting CAR-T cells with CD5 gene deletion (CT125A) in seven patients with relapsed/refractory CD5+ malignancies. CT125A achieves an 85.7% response rate but causes prolonged immunosuppression, infections, and autoimmune events, highlighting the need for safety optimization strategies.
http://dlvr.it/TQjlVW
9 days ago
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Online now: A pan-cancer single-cell transcriptomic atlas of human bone metastases
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A pan-cancer single-cell transcriptomic atlas of human bone metastases
This study constructs a pan-cancer single-cell atlas of human bone metastases, revealing niche-specific stromal and immune programs that drive tumor proliferation and immunotherapy resistance. Combined anti-PD-1/TIGIT therapy effectively suppresses tumor growth and enhances T cell cytotoxicity in mouse models.
http://dlvr.it/TQhKm2
11 days ago
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Online now: An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals
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An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals
Ying et al. demonstrate that intranasally delivered ChAd-Texas H5 vaccine elicits robust systemic and mucosal immunity that confers protection against homologous H5N1 challenge in rodents. Intranasal immunization outperforms intramuscular delivery and is effective even with pre-existing immunity from seasonal influenza vaccines, highlighting its potential as a vaccine strategy against H5N1.
http://dlvr.it/TQgqdz
11 days ago
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Online now: Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia
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Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia
Li et al. explore functional connectome dynamics underlying propofol-induced unconsciousness using high-density electroencephalogram. Propofol anesthesia disrupts alpha-band connectivity between parietal, occipital, and subcortical regions, marking the key transition from consciousness to unconsciousness. These findings highlight the importance of functional networks for understanding the physiology underlying anesthesia-induced changes in consciousness.
http://dlvr.it/TQgYsw
12 days ago
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Online now: Synthetic cleavage-resistant TREM2 boosts macrophage efferocytosis to treat inflammatory diseases
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Synthetic cleavage-resistant TREM2 boosts macrophage efferocytosis to treat inflammatory diseases
To restore TREM2 signaling during inflammation, Dong et al. engineer a cleavage-resistant synthetic TREM2 receptor (CRT). In situ generated CRT macrophages via the LNP-mRNA system resist ADAM17 proteolysis, amplify TREM2 signaling, enhance efferocytosis, and reduce apoptotic cell accumulation and inflammation in mouse models of MASH and atherosclerosis.
http://dlvr.it/TQg2L9
12 days ago
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Online now: Liver metastases dampen IL18-driven Ī³Ī“ T cell activity and immunotherapy responsiveness in colorectal cancer
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Liver metastases dampen IL18-driven Ī³Ī“ T cell activity and immunotherapy responsiveness in colorectal cancer
van Renterghem et al. investigate the impact of liver metastases on immunity in MMR-d/MSI-hi patients treated with ICB. They show that IL18 activates liver-derived VĪ“1+ T cells and predicts ICB benefit selectively in LM patients. Tumor cells counteracted this response by secreting IL18BP; blockade of IL1BP restores VĪ“1+-mediated tumor killing.
http://dlvr.it/TQfdHK
13 days ago
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Online now: An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk
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An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk
Recently, it has become possible with mass spectrometry to measure thousands of endogenous and exogenous biochemicals in human plasma. Lancaster et al. systematically documented metabolites in umbilical cord plasma from >500 babies. They identified metabolites predictive of newborn health and illness, including those from the diet and microbiome.
http://dlvr.it/TQdxGK
13 days ago
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Online now: Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
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Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
Govindarajan et al. leverage N-glycoproteomics and PDX models to decode the in vivo cancer cell surfaceome and establish Glyco PDXplorerāa target discovery platform. The identification and validation of FAT2 as a previously undescribed, actionable antigen demonstrates the utility of Glyco PDXplorer for uncovering therapeutic vulnerabilities.
http://dlvr.it/TQdWTF
14 days ago
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Online now: Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
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Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
Wang et al. systematically annotate orphan non-coding RNAs (oncRNAs), cancer-emergent small RNAs, across 32 cancers. The study demonstrates that oncRNAs are informative of cancer types and have functional roles in cancer progression. Importantly, circulating oncRNAs are predictive of clinical outcomes in breast cancer patients, holding potential for liquid biopsy applications.
http://dlvr.it/TQcpJX
14 days ago
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Online now: CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL
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CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL
Mikami et al. perform serial single-cell analysis of CAR-T cells in patients with BCP-ALL who receive tisagenlecleucel. The abundance of CAR-T cells with a specific phenotype correlates with long-term treatment response. These cells have metabolic characteristics indicating low adenosine production and gene expression similar to that of memory T cells.
http://dlvr.it/TQcPHF
15 days ago
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Online now: Pipe dream to pipeline: Journey of cancer vaccines and the road ahead
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Pipe dream to pipeline: Journey of cancer vaccines and the road ahead
Onkar et al. discuss the current landscape of therapeutic cancer vaccines in the context of recent clinical trials, with a special focus on neoantigen vaccines. They also highlight challenges and scope for improvement such as the need for enhanced strategies for target identification, validation, and immune-monitoring practices.
http://dlvr.it/TQbj3w
15 days ago
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Online now: Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions
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Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions
Masi et al. synthesize how gut microbiome-derived functions shape obesity risk, metabolic dysfunction, and therapeutic response. The review highlights converging microbial signatures across dietary, surgical, and pharmacological interventions, underscoring opportunities for microbiome-informed and personalized strategies to enhance long-term obesity care.
http://dlvr.it/TQbHgC
16 days ago
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Online now: Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity
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Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity
(Cell Reports Medicine 6, 102079; April 15, 2025)
http://dlvr.it/TQZcCS
16 days ago
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Online now: Gut microbiota and metabolic disease risk in youth
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Gut microbiota and metabolic disease risk in youth
Xie et al. review genetic and environmental factors underlying the rising incidence of obesity and type 2 diabetes in children and young people and the evidence connecting gut microbiota to stages of disease progression and treatment. Gut microbiota-based interventions during developmental window hold promise for early detection and disease reversal.
http://dlvr.it/TQZCFG
17 days ago
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Online now: Design of a bispecific peptide-nanozyme conjugate for cancer immunotherapy
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Design of a bispecific peptide-nanozyme conjugate for cancer immunotherapy
Gao et al. develop a PD-L1 and CXCR1/2-targeting bispecific peptide-nanozyme conjugate (BsPNEC) that reduces immunosuppressive myeloid cell infiltration, activates cGAS-STING via ROS to enhance CD8+ T cell tumor infiltration, and validates efficacy in an anti-PD-L1-resistant pancreatic cancer model.
http://dlvr.it/TQYc6V
17 days ago
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Online now: UniCAS: A foundation model for cervical cytology screening
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UniCAS: A foundation model for cervical cytology screening
Jiang et al. present UniCAS, a foundation model pre-trained on 48,532 whole slide images for cervical cytology screening. By functioning as a unified encoder for multi-scale analysis, UniCAS enables various clinical analysis tasks with state-of-the-art performance, thereby addressing the inefficient and fragmented workflows of conventional approaches.
http://dlvr.it/TQYLXX
18 days ago
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Online now: Microbiota-metabolome interplay in depression: Metabolic insights and diagnostic potential
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Microbiota-metabolome interplay in depression: Metabolic insights and diagnostic potential
The study by Zhao et al. reveals that specific gut microbiota and metabolites are altered in first-episode depression and can be partially restored by antidepressants. Metabolites mediate microbiota-depression links and enable accurate diagnosis, highlighting serum and gut microbial metabolism as key targets for understanding and managing depression.
http://dlvr.it/TQXtcS
18 days ago
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Online now: Multimodal hybrid nanozymes with antioxidant catalytic and antibiotic-free antibacterial activities for enhanced multi-target sepsis therapy
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Multimodal hybrid nanozymes with antioxidant catalytic and antibiotic-free antibacterial activities for enhanced multi-target sepsis therapy
Zhu et al. develop Ce-baicalein nanozymes (Ce-BE NZs) with broad-spectrum antibacterial and redox enzyme-mimicking activities. These Ce-BE NZs show multi-target therapeutic efficacy in sepsis models, thus offering a strategy for the treatment of sepsis and other infectious diseases.
http://dlvr.it/TQXcYY
19 days ago
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Online now: Longitudinal body mass index exposure-based threshold to prevent mortality for populations with type 2 diabetes mellitus
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Longitudinal body mass index exposure-based threshold to prevent mortality for populations with type 2 diabetes mellitus
Hu et al. show that the āhealthyā body mass index for middle-aged and elderly individuals with type 2 diabetes needs to be refined. The threshold for increased mortality risk is sustained exposure to a body mass index ā„27 kg/m2.
http://dlvr.it/TQX34h
19 days ago
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Online now: Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma
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Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma
Wang et al. engineer A. muciniphila-derived vesicles to co-deliver PD-L1 siRNA and sonodynamic MOF. The nanoparticles trigger pyroptosis, induce trained immunity in tumor-associated macrophages, enhance cytotoxic T cell infiltration, and achieve potent antitumor efficacy in HCC models.
http://dlvr.it/TQWdtZ
20 days ago
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Online now: CAR-T triggers TAM reeducation and adaptive anti-tumor response via TREM2 deficiency or CD40 agonist
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CAR-T triggers TAM reeducation and adaptive anti-tumor response via TREM2 deficiency or CD40 agonist
Ting Liu et al. show that TREM2+ macrophages drive resistance to GPC3-CAR-T therapy in hepatocellular carcinoma. Targeting TREM2āor using a CD40 agonistāovercomes resistance by triggering TAM reeducation and adaptive anti-tumor response, proposing a promising combination strategy to boost CAR-T efficacy.
http://dlvr.it/TQVxN2
20 days ago
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Online now: Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML
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Sequence-dependent splicing dysregulation drives therapy resistance in pediatric AML
Huang et al. show that 36% of pediatric AML patients harbor sequence-dependent splicing defects that resemble those driven by splicing factor mutations in adult AML. They identify U2AF2 downregulation as the key driver linked to treatment resistance and highlight PRMT inhibition as a potential strategy to restore splicing dysregulation.
http://dlvr.it/TQVWn0
21 days ago
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Online now: Multimodal profiling of pancreatic cancer reveals a TIMP-1-dominated secretory profile determining pro-tumor immunoinstruction in human cancers
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Multimodal profiling of pancreatic cancer reveals a TIMP-1-dominated secretory profile determining pro-tumor immunoinstruction in human cancers
By multiomic profiling across human cancers, FrƤdrich et al. discover a secretory profile linking malignant evolution to immunosuppression and poor patient survival. In pancreatic cancer, this profile is shaped by TIMP-1-dependent NK cell suppression and proves targetable through clinically approved kinase inhibitors, highlighting exploitable prognostic and therapeutic potential.
http://dlvr.it/TQTqMV
21 days ago
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Online now: c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors
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c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors
Balke-Want et al. show that B7-H3 is an actionable CAR target in SCLC and thoracic SMARCA4-deficient UTs. However, in thoracic SMARCA4-deficient UTs, TGF-Ī²1 suppresses their activity. By engineering CRISPR knockin c-JUN+B7-H3 CAR T cells with combined expression of type I/II cytokines, the authors overcome TGF-Ī²1-mediated suppression.
http://dlvr.it/TQTPlk
22 days ago
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Online now: CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance
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CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance
Immunotherapies only provide benefit for a subset of individuals with cancer, highlighting the need for biomarkers of response. Using whole-genome CRISPR-Cas9 screens, Watterson et al. map genetic dependencies in the context of four cytokines and tumor-reactive T cells, identifying CHD1 and MAP3K7 as mediators of resistance to IFN-Ī³-induced cancer cell death.
http://dlvr.it/TQSjCS
22 days ago
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Online now: A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein
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A potently neutralizing and protective human antibody targeting antigenic site V on RSV and hMPV fusion glycoprotein
Abu-Shmais et al. isolate and characterize respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) cross-neutralizing antibodies. Structural analysis reveals one antibody, RM 5-1, binds an epitope that spans sites Ć, II, and V on the fusion glycoprotein. RM 5-1 has potential for translational development.
http://dlvr.it/TQP0Yf
26 days ago
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Online now: Evolutionary proteogenomic landscape from pre-invasive to invasive lung adenocarcinoma
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Evolutionary proteogenomic landscape from pre-invasive to invasive lung adenocarcinoma
(Cell Reports Medicine 5, 101358; January 16, 2024)
http://dlvr.it/TQLMGc
29 days ago
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Online now: BCG vaccination induces antibacterial effector functions among VĪ“1/3 T cells that are associated with protection against tuberculosis
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BCG vaccination induces antibacterial effector functions among VĪ“1/3 T cells that are associated with protection against tuberculosis
Maerz et al. report that in response to protective BCG vaccination, VĪ“1/3 T cells in humans and non-human primates undergo clonal expansion, upregulate pro-inflammatory and cytotoxic effector functions, and accumulate in the airway. Further, cytokine-producing VĪ“1/3 T cells in the airway correlate with protection against tuberculosis.
http://dlvr.it/TQJYQs
about 1 month ago
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Online now: Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain
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Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain
Ram and Gopalakrishnan et al. demonstrate that peripheral cytokine modulation alters the brainās inflammatory environment and immune response to retroviral infection. These results demonstrate that a favorable central nervous system environment can be induced by intravenous administrations of antibodies. This work will inform and guide therapeutic strategies for HIV-associated neurocognitive disorder.
http://dlvr.it/TQGmr9
about 1 month ago
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Online now: Molecular and cellular composition changes after neoadjuvant letrozole and palbociclib in early luminal breast cancer
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Molecular and cellular composition changes after neoadjuvant letrozole and palbociclib in early luminal breast cancer
Cottu et al. report the translational analysis of the NeoPAL trial. They show that neoadjuvant letrozole-palbociclib and chemotherapy yield comparable reductions in proliferation, enhanced immune activity, and stromal remodeling in early luminal breast cancer. Low-ROR scores predict favorable survival. These data support chemotherapy-sparing approaches for patients with high-risk luminal disease.
http://dlvr.it/TQGV2J
about 1 month ago
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Online now: Mutational landscape of normal breast tissues adjacent to invasive breast cancer
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Mutational landscape of normal breast tissues adjacent to invasive breast cancer
Suwalska et al. show that cancer-adjacent normal breast tissues share genomic alterations with cancer, and many changes in cancer-relevant genes arise from specific combinations of germline polymorphisms. This supports gradual mutation-driven malignant transformation of normal cells and suggests context-dependent co-oncogenic function for common and rare germline polymorphisms.
http://dlvr.it/TQFxrz
about 1 month ago
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Online now: ĪNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
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ĪNp73 isoform defines a TP53-mutant-like poor-risk subgroup of acute myeloid leukemia
Pereira-Martins et al. identify an AML subgroup with poor prognosis marked by elevated ĪNp73, an oncogenic TP73 isoform. This isoform lacks a transcriptional activation domain and competes with TP53 for specific targets. ĪNp73 expression is regulated by CEBPA via binding to an intragenic enhancer, which is amendable to pharmacological targeting.
http://dlvr.it/TQFXvD
about 1 month ago
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Online now: Closed-loop modulation of sleep in children undergoing intracranial recordings
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Closed-loop modulation of sleep in children undergoing intracranial recordings
Phase-targeted auditory stimulation during sleep enhances slow-wave activity in children with epilepsy, with direct intracranial evidence of large-scale thalamocortical network engagement. This non-invasive approach significantly reduces epileptiform discharges during sleep and improves next-day cognitive performance on response inhibition tasks.
http://dlvr.it/TQDrt1
about 1 month ago
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Online now: Model confrontation and collaboration: A debate intelligence framework for enhancing medical reasoning in large language models
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Model confrontation and collaboration: A debate intelligence framework for enhancing medical reasoning in large language models
Sun et al. introduce model confrontation and collaboration (MCC), a humanized intelligence framework that integrates advanced LLMs from multiple vendors into a dynamic, debate-driven roundtable. MCC achieves strong performance across diverse medical tasks, serving as a clinical decision-support tool that can potentially improve diagnostic accuracy and reduce clinician cognitive load.
http://dlvr.it/TQBd4T
about 1 month ago
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Online now: 5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation
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5-HT reuptake blockade induces pyroptosis in BRAFV600E-mutated melanomas via remodeling histone serotonylation
Li et al. demonstrate that paroxetine hydrochloride, an FDA-approved antidepressant, induces pyroptosis in melanoma and drives anti-tumor immunity. This occurs as 5-HT reuptake inhibition reduces H3Q5ser at DNA repair gene promoters, thereby impairing DNA damage repair, triggering genomic instability, disrupting proteostasis, and ultimately leading to pyroptosis.
http://dlvr.it/TQBD32
about 1 month ago
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Online now: Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy
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Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy
Zeng et al. engineer an inorganic nano-immunotherapy that precisely reprograms the immune landscape within atherosclerotic plaques. The therapy mitigates plaque progression, enhances stability, and preserves systemic safety. Mechanistic analyses reveal immune rewiring and crossācell communication across four key immune populations, illuminating a translational path for immune modulation in atherosclerosis therapy.
http://dlvr.it/TQ9YX5
about 1 month ago
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Online now: Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
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Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer
Zhan et al. demonstrate that elevated cathepsin D (CTSD) expression promotes immune evasion in colorectal cancer (CRC) by driving MHC class I degradation via lysosomal pathways. Targeting CTSD potentiates the anti-PD-1 response, providing a promising strategy to enhance the efficacy of CRC immunotherapy.
http://dlvr.it/TQ7q3V
about 1 month ago
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Online now: A randomized controlled trial of precision bezlotoxumab treatment for Clostridioides difficile infection
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A randomized controlled trial of precision bezlotoxumab treatment for Clostridioides difficile infection
Psarrakis et al. describe the BEYOND score for the early prediction of unfavorable outcomes in Clostridioides difficile infection. BEYOND integrates data of blood hemoglobin, urea, and interleukin-8 levels; G alleles of rs2091172; and stool carriage of specific bacterial species. Patients with high-risk BEYOND scores received 82% relative protection from bezlotoxumab treatment over placebo.
http://dlvr.it/TQ7YMr
about 1 month ago
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