Using fluorescence live imaging and an in vitro implantation model, we show that human embryo attachment begins with direct cell fusion via syncytin-2–MFSD2A interaction. With @hansclevers.bsky.social. Great work by @tnoordzij.bsky.social & @martinacelotti.bsky.social www.biorxiv.org/content/10.6...

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

Brain diseases are tough to treat because of the blood-brain barrier. For decades, it stumped drug delivery. At Roche pRED, we challenged that! Our Brainshuttle™ technology safely transports drugs across, opening new doors for CNS therapies. Learn more: www.roche.com/stories/clev...

Exciting #organoids meeting in Glasgow, just after the summer!

🔬 Developing next-generation Antibiotics: @Roche we are pioneering the discovery and development of novel antibiotics that can fight resistant bacteria, aiming for future generations to have effective treatments. Visit our #AMR hub:https://www.roche.com/stories/antibiotics

@NatureMedicine invited me to reflect on leading research in academia vs. industry. In the end, all -academia, biotech & pharma- is needed to translate scientific breakthroughs into scalable treatments. rdcu.be/elPt8 @_hubrecht @Roche

Snake venom gland organoids. Study by Yorick Post and collaborators. www.sciencedirect.com/science/arti... Image credit: Anne Rios

a human liver organoid

#Lgr5+ gut #stemcells don't divide asymmetrically. They simple divide and then compete for space: This is called neutral competition. Stem cell numbers are set by the available space between the #Panethcells. Paper: Hugo Snippert et al. Cell (2010). www.cell.com/action/showP...

📢Roche's Institute of Human Biology seeks 2 visionary scientific leaders: Head of Computational Biology & Head of Exploratory Biology. Drive pioneering research, shape scientific strategy and lead innovation at the crossroad of academia and industry!🔗https://go.roche.com/ls0un #organoids #TeamIHB

Ik was in Basel voor een interview met @hansclevers.bsky.social “Het is een proces van eindeloze een-tweetjes. En bij de start van de eerste fase van het klinisch onderzoek moet je al in je hoofd hebben wat voor patiëntengroep je over zes jaar wilt behandelen.” www.newscientist.nl/blogs/een-me...

Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. www.cell.com/cell/fulltex... New #organoid protocol allows the seemingly indefinite expansion of human fetal pancreatic Lgr5+ stem cell 1/

trying out to post an animation: #organoids in #Matrigel dome

Excited to join BlueSky! Will share insights in #intestine #stemcells #cancer #organoids #drugdevelopment and others. Blue image credentials: Luminal surface of the small intestine, Anne Rios. Goblet cells red, enterocytes blue