🚀 New preprint! @jacobsenucla.bsky.social x @doudna-lab.bsky.social collaboration: High-activity TnpB (Ymu1-WFR) + a multi-gRNA system in TRV enables heritable, tissue-culture-free multiplex editing in plants. Big potential for plant biotech 🧬🌾🌱 doi.org/10.64898/202...

How do the ancestors of CRISPR-Cas unwind DNA and how can this lead to better genome editing? With our collaboration between @doudna-lab.bsky.social x @jacobsenucla.bsky.social x Zev Bryant's lab x @savagecatsonly.bsky.social we've uncovered the secrets behind TnpB's dynamics!

Check out the latest episode of Rewriting the Code, featuring Jennifer Doudna and #SickleCell patient pioneer Victoria Gray who was cured with a #CRISPR-based treatment in a groundbreaking clinical trial: https://ow.ly/t6FY50XVNO7

Targeted delivery of genome editors in vivo - @doudna-lab.bsky.social @innovativegenomics.bsky.social go.nature.com/4qKp6Tb

New preprint 👉Doudna x Bryant x Jacobsen x Savage collaboration! Work led by @zehanzhou.bsky.social, I. Saffarian-Deemyad, @honglue.bsky.social, T. Weiss We dissect how stepwise DNA unwinding gates TnpB genome editing, revealing how unwound DNA states enhance cleavage www.biorxiv.org/content/10.6...

New in Science Magazine Science Advances from the Doudna Lab, Rubin Lab and Cress Lab —Identification of proteins influencing #CRISPR-associated #transposases for enhanced #GenomeEditing. Read here: https://ow.ly/U0s450XS82n#CRISPR-associated

During my postdoc in @therubinlab.bsky.social, @leosong.bsky.social and I aimed to make CRISPR-associated transposons more efficient for editing bacteria. Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social

🎺New paper alert🎺 Out now in Nature Chemical Biology from IGI's Jennifer Doudna (Doudna Lab) and collaborators: Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap Read here: https://ow.ly/izGo50XAkog

Excited to share our work designing genome editors with machine learning! 🧬💻 Huge thanks to @petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇

A very nice Preview of our work in @cp-cellhostmicrobe.bsky.social this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...

Congrats to IGI's Jill Banfield, Jennifer Doudna, Mary Firestone, Patrick Hsu, Alex Marson, Kris Niyogi, Eva Nogales, Dan Nomura, and Jennifer Puck — each is on Clarivate's Highly Cited Researchers 2025 list for ranking in the top 1% in their field by citations!

Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫

First co-led work from the Doudna lab 🤜🤛 We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social

✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇

Career update: I'm happy to say that I've accepted a postdoc position at UC Berkeley at @innovativegenomics.bsky.social in Jennifer Doudna's lab! I'm looking forward to this exciting new chapter of my scientific career!

We're excited to share our lab's first lead paper! We developed OriGen, a language model trained to generate plasmid origins of replication. 🔄🦠 The model generates sequences that are significantly different from wild type origins and, remarkably, they allow for replication in vivo. Read it here ⬇️

1/2 New from co-first authors @erinedoherty.bsky.social and @jnoms.bsky.social of the @doudna-lab.bsky.social — Bacteria fight off viruses using tiny molecular “alarm signals” made of nucleotides. To survive, viruses must find ways to shut these signals down.

My lab is hiring postdocs! We combine AI, protein structure prediction and comparison, and high-throughput virology to study the virus-host conflict. You can read more about my lab's research here: jasonnomburg.com/research/ Apply here to join us in lovely Vienna! aithyra.onlyfy.jobs/job/0khkxp82

So happy to see this work out! Was such a pleasure to co-lead this effort with Erin. Do you like viral immune evasion, and using protein structure to study immune antagonists? Give it a read!

Work I co-led with @jnoms.bsky.social is now online at @cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity. www.sciencedirect.com/science/arti...

Now online at @cp-cellhostmicrobe.bsky.social from co-first authors @erinedoherty.bsky.social & @jnoms.bsky.social

New in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM

New from the @doudna-lab.bsky.social and first author @owentuck.bsky.social!

Our nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: www.science.org/doi/10.1126/... Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social

I'm hiring a lab technician to help me explore some exciting new questions about virus-host interactions! Biochemistry and/or mammalian cell culture experience is desired.

Apply to work with us! careerspub.universityofcalifornia.edu/psc/ucm/EMPL...

Thank you to the Blavatnik Family Foundation and The New York Academy of Sciences for honoring our research uniting human innate immunity and bacterial anti-phage defense at @danafarber.bsky.social @harvardmicro.bsky.social @harvard.edu bit.ly/4pZUDkF blavatnikawards.org/news/items/t...

Congratulations to my colleagues Omar Yaghi and John Clarke — the two latest UC Berkeley Nobel Laureates! Omar’s development of metal-organic frameworks changed the way we capture carbon, store energy, and harvest water from desert air. shorturl.at/GpBsu 1/2

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

then turned that knowledge into a global movement for conservation. Her work made it impossible to separate what we learn from our obligation to protect it. Generations of researchers have tried to follow that example." 2/2

From IGI Founder Jennifer Doudna: "Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats... 1/2

New paper online at @nature.com from co-leads @erinedoherty.bsky.social + @benadler.bsky.social !

Our story describing the Panoptes bacterial immune defense system is now finally peer-reviewed and published today! www.nature.com/articles/s41...

Bacteria use a decoy defense molecule to set a trap for viruses @doudna-lab.bsky.social @ucberkeleyofficial.bsky.social @ucirvine.bsky.social @aaronwhiteley.bsky.social @colorado.edu @aesully98.bsky.social www.nature.com/articles/d41... www.nature.com/articles/s41... www.nature.com/articles/s41...

Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems. Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here: www.nature.com/articles/s41...

Out today in @nature.com, a new paper from @doudna-lab.bsky.social lab, co-first authors @erinedoherty.bsky.social + @benadler.bsky.social and collaborators at @ucsandiego.bsky.social unveils a powerful new defense strategy in the arms war between viruses + microbes. Read here: ow.ly/mPQI50X5g68

Congrats to Doudna lab postdoc @erinedoherty.bsky.social! 🎊

New pre-print from Doudna lab members @erinedoherty.bsky.social & @jnoms.bsky.social ✨ Here we explore how recurrent adaptation of a single anti-defense protein fold enables evasion of distinct immune systems.

@jenniferdoudna.bsky.social @doudna-lab.bsky.social talks about the history and future of #CRISPR with Cleo Abram! Check out the interview: www.youtube.com/watch?v=0OXa...

In a recent paper, IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and Jill Banfield @banfieldlab.bsky.social collaborate with UCLA's @jacobsenucla.bsky.social to create a new, tiny #CRISPR tool for quicker, easier plant genome editing! Read more in this Q&A with Steve: ow.ly/6Szs50VGElf

‼️ New pre-print from co-leads @owentuck.bsky.social and Jason Hu! Check out this fascinating example of how coevolution enables defense system innovation.

A new Pediatric Center for CRISPR Cures builds on the recent saved life of Baby KJ, who expeditiously had bespoke in vivo base genome editing @jenniferdoudna.bsky.social @doudna-lab.bsky.social @innovativegenomics.bsky.social @chanzuckerberg.bsky.social erictopol.substack.com/p/new-center...

“What we’ve done here is uncover the secret sauce that makes typical #Cas9 — the original Nobel molecule — so efficient and precise." – Co-first author Honglue Shi of the @doudna-lab.bsky.social on his recent paper in Molecular Cell Read here: innovativegenomics.org/uncovering-c...

Thanks to the BBC's The Inquiry program for great conversations with IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and @urnov.bsky.social about Baby KJ, #CRISPR on-demand, and the future of personalized medicine! Listen here: www.bbc.com/audio/play/w... Photo credit: TODAY

Registration is open for the 2025 Computational Structural Virology Symposium, featuring Doudna lab postdoc @jnoms.bsky.social!

Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

US supercomputer named after Nobel laureate Jennifer Doudna @jenniferdoudna.bsky.social @innovativegenomics.bsky.social to power AI and scientific research apnews.com/article/nvid...

Congratulations to Matt on this incredible accomplishment! 🎉This K08 will allow him to continue developing CRISPR based therapies for children with inherited immune diseases.

Elated to share that I was awarded a K08 clinician-scientist research career development award from the National Institutes of Allergy and Infectious Diseases!

Congrats to Doduna lab postdoc @erinedoherty.bsky.social for being selected as a Leading Edge Fellow! @leadingedgeprogram.bsky.social