Petr Skopintsev
@petrskopintsev.bsky.social
π€ 158
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Postdoc @ UC Berkeley
reposted by
Petr Skopintsev
Yun S. Song
about 1 month ago
Can we simulate realistic evolutionary trajectories and βreplay the tape of lifeβ? In this work, we propose a flexible, generalizable deep learning framework for modeling how the entire protein sequence evolves over time while capturing complex interactions across sites. 1/n
doi.org/10.64898/202...
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https://doi.org/10.64898/2026.02.19.706898
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reposted by
Petr Skopintsev
Nature Structural & Molecular Biology
about 1 month ago
New online: Structure and mechanism of antiphage retron Eco2
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Structure and mechanism of antiphage retron Eco2
Nature Structural & Molecular Biology, Published online: 18 February 2026; doi:10.1038/s41594-026-01754-2This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein production and stops phage replication.
http://dlvr.it/TR2Dls
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A beautiful study from the Pausch lab!
add a skeleton here at some point
about 1 month ago
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reposted by
Petr Skopintsev
Phil Holliger
about 2 months ago
New paper from my group in
@science.org
: "A small polymerase ribozyme that can synthesise itself and its complementary strand"
www.science.org/doi/10.1126/...
Outstanding work by
@edogia.bsky.social
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reposted by
Petr Skopintsev
Patrick Bryant
about 2 months ago
Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. π§΅π (1/5)
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reposted by
Petr Skopintsev
Erin Doherty
4 months ago
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino!
www.cell.com/cell-host-mi...
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Viral enzymes degrade to evade
Across all domains of life, immune systems rely on nucleotide-based signaling molecules to activate defense responses. In a recent Cell Host & Microbe study, Doherty, Nomburg, and colleagues identify ...
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00472-X
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Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! π«
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4 months ago
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My main postdoc paper repost marked as spam - just for the memories. Shame, shame
@moderation.bsky.app
! π
4 months ago
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Excited to share our first work on protein design! Huge thanks to the entire team, and especially to
@isabelesain.bsky.social
,
@evandeturk.bsky.social
,
@doudna-lab.bsky.social
,
@jacobsenucla.bsky.social
,
@jhdcate.bsky.social
,
@banfieldlab.bsky.social
,
@innovativegenomics.bsky.social
!
add a skeleton here at some point
4 months ago
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