Can we simulate realistic evolutionary trajectories and “replay the tape of life”? In this work, we propose a flexible, generalizable deep learning framework for modeling how the entire protein sequence evolves over time while capturing complex interactions across sites. 1/n doi.org/10.64898/202...

New online: Structure and mechanism of antiphage retron Eco2

A beautiful study from the Pausch lab!

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social

Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)

A very nice Preview of our work in @cp-cellhostmicrobe.bsky.social this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...

Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫

My main postdoc paper repost marked as spam - just for the memories. Shame, shame @moderation.bsky.app! 😀

Excited to share our first work on protein design! Huge thanks to the entire team, and especially to @isabelesain.bsky.social, @evandeturk.bsky.social, @doudna-lab.bsky.social, @jacobsenucla.bsky.social, @jhdcate.bsky.social, @banfieldlab.bsky.social, @innovativegenomics.bsky.social!