📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.

Do you know your congressional district? Who your House Representative and Senators are? Are you registered to vote? Do you know when your primary election is? I’m always surprised how few people can answer these questions. The responsibility of the privilege of democracy, is civic engagement.

Renewables are the future but Trump is dragging US backwards. He's attacked climate research, blocked wind & solar, rolled back fossil-fuel regulation and expanded extraction - even as the Strait of Hormuz crisis shows why this makes no sense My new post christinapagel.substack.com/p/while-the-...

Someone sent me this.

the trump administration is selling this country wholesale to rapacious, extractive industries that will destroy our collective resources for private profit morethanjustparks.substack.com/p/breaking-t...

If preparing figures please consider "colorblind friendly" approaches (www.nature.com/articles/d41...). I am missing the long-wave opsin, which manifests in strange ways: I can't discern red vs. black. This dichromacy is rare and severe, but ~300 million have more common forms addressed in link.

Never mind that I died inside when I heard Gorsuch say in Trump v Barbara arguments that there weren't any immigration laws in the 1860s. Taps new book 👇 in which I document the over a century of first colonial then state-level international and domestic migration laws before federalization.

Excellent Bouie piece on the birthright case. Especially how it points out that every academic backing Trump has either explicitly rejected Trump’s take in the past or somehow written extensively on the 14A without raising it (and implicitly rejecting it)… and have no new evidence now. Gift link:

Let's learn about James Harrison, the "man with the golden arm". Born 1936 in NSW, Australia, he required a pneumonectomy (lung-removal) at age 14. This involved transfusing 6 liters of donor blood (13 units) & a three month hospital stay. That's when he developed his magical blood.

SCOTUS hears arguments about Trump's EO on birthright citizenship today, a dispute no more valid than "can the President prohibit the free exercise of religion?" Anything other than 9-0 against Trump is a grave injury to the very idea of having a written Constitution, to the very idea of America.

Why bioRxiv

Yes it reads like I'm being asked to give a deposition by an attorney representing the local owl community, but it's actually just an email from a fact-checker inquiring about what will be a very fun forthcoming news story that I'll share when published.

A single vote for Trump in the birthright citizenship case would be as bad as anything the Court has done since Bush v. Gore. This issue has been settled for more than a century. It is the jurisprudential equivalent of asking what 2+2 is. Any answer other than 4, something is deeply, deeply wrong.

Some longer thoughts on this, because no matter how long the war lasts, its outcome is no longer in doubt.

New #preprint 😍‼️ led by 2 incredible postdocs @ninizhani.bsky.social & Ranj Papareddy: transforming #UFMylation from a local ribosome rescue pathway to systems level regulator of mRNA splicing www.biorxiv.org/content/10.6... A short 🧵

My main gripe with the alphafold example is how it shows you need decades and decades of high quality data, well structured, open and accessible to train a model -- and yet they always gloss over it and pretend it's just AI and magic. No, we need to continuously invest in real data and FAIR data.

Having cozy source relationships with evil people makes your journalism worse and degrades your personality

The whole thing about Democrats searching for a winning message for the midterms is infuriating because it is staring them in the face: Rule of Law — People who do illegal shit should face consequences. For insider trading. For illegal wars. For ignoring court orders. For being a pedophile.

Travel writer Rick Steves on Washington's newly signed "Millionaires Tax"

At my alma mater in MN giving the Ford Lecture in Science Literacy! Some of the faculty who taught me 32 years ago were in the audience! 😭. That building behind me is a bauhaus masterpiece of Marcel Breuer and that wall so the largest stained glass one in the world.

Two-year-old Kaleth is being locked away at the Dilley trailer prison. He is getting sicker with each passing day. He will not eat the food CoreCivc serves, which detainees have said sometimes has mold and worms. He now has a fever.

"We were praying! Loudly! Did everyone hear our performative prayer? Be sure you write down that you heard us praying! It was very sincere. Be sure to write that too.:"

70 yo insomniac here, this is a great start but we must also drop the glam pub reward effects during critical evaluation of researchers for promotion and research support. It's easier to get off the glam train once you've arrived. Alternative transportation is necessary.

The latest on #CRISPR in #ClinicalTrials, including testing treatments for high cholesterol, lupus, GI cancer, sepsis, hemophilia, and many many more. Read here: https://ow.ly/s4c150YzswO

Iswar Hariharan @hariharanlab.bsky.social would like a word. mattbaker.blog/2018/06/25/t...

"DNA codes for RNA codes for proteins codes for phenotype." I just don't understand it - how do you get the VC for a biotech startup when you've only read the Ladybird Book of Biology? But judging from Trump's science advisers, this is the future of biology. www.techradar.com/pro/every-li...

Project Hail Mary is a beautiful brilliant film. But molecular biologists be warned there's a deeply disturbing scene midway through when Ryan Gosling's scientist places two eppendorfs directly next to each other in an otherwise empty unbalanced microcentrifuge & sets it spinning with wild abandon.

"The third No Kings protests were an unmistakable display of political force..." "Two-thirds of participants live in suburban, small town or rural areas, a 40% increase over last time in protesters from outside big cities..." www.usatoday.com/story/news/p...

Sharing a birthday today: Reps. Jasmine Crockett (D-Texas) and Ted Lieu (D-Calif.) - two people who consistently show a fire we need in all Congressional Democrats.

There’s an important update on the Duke-UConn game, just click this link. diddukewin.com

Over eight million Americans took to the streets today, which makes No Kings 3 the biggest single day of protest in the history of our country. #NoKings

Yes - though I suspect the thinking here, to the extent that there is any at all, is that AI will do all the biology.

"World Athletics’ mandatory genetic test for women athletes is misguided. I should know – I discovered the relevant gene in 1990". www.mcri.edu.au/news/insight...

Again, the first Tea Party rallies in April 2009 -- heavily promoted in advance by Fox News -- only had about 300,000 attendees across 750 cities, but the media treated it like the Second American Revolution. There will be multiple *individual* No Kings rallies today that have more people at them.

idk guys, but I think they have to start taking @standupforscience.net seriously now...right?

“The fact that organized protest can break the spiral of silence, and correct our impressions of what other Americans think, is one of the most immediate and important values of protesting in the first place. Scientists have [shown] protests update our impressions of what other citizens believe.”

Here’s where NYT put No Kings coverage on the home page of its iOS app

Sandra Wong, the great granddaughter of Wong Kim Ark, is preparing to march at the #NoKings Rally in San Francisco. Today is the 128th Anniversary of the SCOTUS decision affirming birthright citizenship.

One-hundred-and-twenty-eight years ago today. United States v. Wong Kim Ark, 169 U.S. 649 Decided March 28, 1898 supreme.justia.com/cases/federa...

We are estimating more than 200,000 people at the flagship No Kings rally in the Twin Cities. #NoKings

Donald Trump would love nothing more than for us to be scared, be afraid, & be silent while he wrecks our democracy. But as millions of Americans are showing today, we will not be scared, we will not go away, & we will say loudly: NO KINGS! 📍Laurel, MD

Beyond thrilled to see the continuation of my grad school work in the Leemor Joshua-Tor lab at CSHL. Huge thanks and congratulations to Ankur Garg, for spearheading the sequel and the whole crew (Leah Braviner, and Armend Axhemi) for getting the work to this point. youtu.be/VzaQUsB1Jlg

850 Tomahawk missiles could be $3,060,000,000... That is 3 billion sixty million US dollars. That is 1224 5 year biomedical research grants. Literally, over 6 millennia of biomedical research.

In 2025, two U.S. states met >100% of grid + behind-the-meter electricity demand with WindWaterSolar. 14 states met 50-124% of demand with WWS 7 were dominated by wind 3 by solar 4 by hydro U.S. average: 25.72% WWS web.stanford.edu/group/efmh/j...

Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation. www.biorxiv.org/content/10.6...

Goooooooood morning! This is fascism! @standupforscience.net is here to fight.

Trump’s outright bigotry against an entire ethnic minority continues to stain this country. It’s gutter racism with real consequences; the government itself has been ordered to target this minority group for special disfavor.

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

My lab released a new preprint today. The work is the culmination of a long term project led by Peren Coskun, Ph.D., who investigated the biological role of the C. elegans glp-1 3'UTR in its endogenous context. Please join me in congratulating Peren! www.biorxiv.org/content/10.6...