I know antifa isn't a real organization because I don't get 40 texts a week from them asking for donations.

Is scale all you need? Or is there still a role for incorporating domain knowledge and inductive bias? While I was in Heidelberg, I took some time to write a short essay on this question called "The Bittersweet Lesson". theoryandpractice.org/2025/09/The%... #HLF25

shit ain’t over til it’s over

Excited to share that our paper "LAGOM: A transformer-based chemical language model for drug metabolite prediction" has been accepted in AILSCI! doi.org/10.1016/j.ai... Work led by Sofia Larsson and Miranda Carlsson, with @rbeckmann.bsky.social and Filip Miljković‬ (AZ)! #compchem #chemsky

This is truly an incredible breakthrough IMO. Really exemplifies what you get when deep domain expertise (popgen/evolution/disease genetics in this case) fuses with cleverly crafted ML. What u get r sleek, well thought out architectures that absolutely destroy the behemoths. Wow!! 1/

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance. The regulation of most proteins is dominated by different regulatory mechanisms across cell types. Gratifyingly, this complex regulation defines simple rules ⬇️ www.biorxiv.org/content/10.1...

Time for the world to install a gigawatt of solar power capacity 2004: A year 2010: ~ a month 2015: ~ a week Now: < A day ourworldindata.org/data-insight... 🧪

And a 4th reminder that a transition to 100% WindWaterSolar reduces the annual total tonnes of mining in the world by >84% despite the need for precious metals, which are a trivial component of total mining tonnage.

"In a landmark study, OpenAI researchers reveal that large language models will always produce plausible but false outputs, even with perfect data, due to fundamental statistical and computational limits." www.computerworld.com/article/4059...

I randomly discovered this morning that Zoom on Mac might be recording the content of your screen and audio, even when you're using other applications. (No I don't remember giving Zoom permission to do this.) 1/2

💥 Most law enforcement are now required to publicly display their agency and name or badge number.

💥 Schools are now required to work with families and personnel to develop notification protocols when immigration authorities are present on campus. 💥 Most federal officers are now banned from concealing their faces.

The new laws I just enacted are a direct response to Trump's lawless immigration raids and arrests in California. California is fighting to end this chaos by: 💥 Requiring schools and public hospitals to limit access and implement privacy protocols to protect against Trump’s immigration chaos.

California is putting a stop to secret police. We’re making them take off the damn ski masks.

It also ignores that leaving was a form of influence! Millions sent a clear message about the minimum standards of fairness and respect we believe are foundational for civic conversation. Their obsession with our departure makes clear it was effectively communicated; they just don't like it

Vaccination and health mural by Diego Rivera, 1932, painted to highlight how science helped fight disease (Detroit Institute of Art)

Just a reminder: 10 of the 11 states with the most WindWaterSolar as a % of electricity demand have electricity prices 2 c/kWh or more below the U.S. average web.stanford.edu/group/efmh/j... Wind is the greatest electricity source in 7 of those 11 states. web.stanford.edu/group/efmh/j...

That’s me in the video. And a Fox News host just celebrated me being assaulted by ICE. If ICE will do this to a congressional candidate with a big platform, just imagine what they’re doing to the people they’re kidnapping.

ADD YOUR THOUGHTS ON LIMITING STUDENT VISA TO FOUR YEARS Comment period ends September 29th www.federalregister.gov/documents/20... 1/2

Dudes rock

Of all the stupid things that this regime has done, this is right up near the top. Postdoctoral researchers come to the US on H-1B visas. This will further destroy the US science enterprise. Stupid stupid stupid.

First they came for the Immigrants. And I wrote a memo. Then they came for trans people. And I wrote a memo. Then they came for the comedians. And I wrote a memo. Then they came for me. And there was no one to write a memo for me.

The media allowing Trump plausible deniability on Project 2025 during the campaign is right up there with Iraq War stenography in craven, lazy disgracefulness

They want to kill your kids.

ngl I’m losing faith in this administration

LOST writer-producer Damon Lindelof says he won’t work with Disney unless Kimmel js reinstated. I’m hearing other talent weighing similar pledges.

I want everyone to take a step back for a second, remember why she was fired from New York and juxtapose this w/ all the high profile media folks that have recently lost *their* jobs. *Some* people are allowed to fail upwards. It's mesmerizing.

How the twin-arginine translocase (Tat) system manages to transport folded proteins across membranes without any leaks? To answer this fundamental question we solved the first structure of TatB3C3 complex with bound cargo. Please check out new preprint! t.co/962Kj9pt6F

Let me just say a simple thing. Democrats have no obligation to provide the votes to fund the destruction of our democracy. If you want my vote for a bipartisan budget, there need to be protections to stop Trump's brazen lawlessness.

Please, please read this. Wherever you are. Whoever you are.

Great and nuanced thread. But I think we can expand further. As noted, phage selected for synthesis, and that worked, were significantly less novel. In Fig 4D, there's a very strong correlation between novelty and not working. The phage that worked were much less novel. This is nucleotide ID!

In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com www.chemistryworld.com/opinion/the-...

very cool work and a milestone in synthetic biology. how impressive are the new phage genomes? with generative bioML, i'm always looking at how similar the generated sequences are to known sequences. let's take a look

Not so easy to make a Korean-inspired sauce, is it?!

A free and democratic society cannot silence comedians because the President doesn’t like what they say. This is an attack on free speech and cannot be allowed to stand. All elected officials need to speak up and push back on this undemocratic act.

PIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...

I'd like to commend the lawyers who wrote this complaint on behalf of the professors and employees of the University of California against the Trump administration. It's a sober legal document with strong claims, but also, this is a fight for public opinion, and this reads like the writers know it.

A smart Judith Butler response to @ucberkeleyofficial.bsky.social www.thenation.com/article/soci...

Despite its 162-year-history of service, congressional Republicans tell federal agencies not to seek the advice of the National Academies. www.science.org/content/arti...

Next time someone on the right claims all the political violence in this country is coming from the left, not the right, do please show them this. You're welcome

“When you get older, you learn certain life lessons. You apply that wisdom, and suddenly you say: Hey, I’ve got a new lease on this thing. So let’s go.” A life of art, activism, and heart. R.I.P. Robert Redford. 🕊️💫

Two microbiome metabolites compete for tRNA modification to impact mammalian cell proliferation and translation quality control #rnasky www.nature.com/articles/s41...

this from my piece on charlie kirk is probably the most important takeaway if you want to know why bad faith, right-wing voices in media are treated as just another set of peers

btw Costco seems to have the cheapest updated COVID vax. You can get it without a card at the pharmacy and they do take walk-ins. If you’re also uninsured due to the massive amounts of layoffs this year, they also take this goodrx coupon to lower the cost of www.goodrx.com/comirnaty?sr...

“The goal with the mRNA is for that not to be available to anyone, because no one should be using that one,” Ladapo said, in an apparent reference to the COVID-19 shots. www.tampabay.com/news/florida...

NEW: Reuters asked the Michigan Tax Authority whether Lisa Cook violated any mortgage tax rules for her home in Ann Arbor. They said no. That's in addition to Reuters earlier reporting that nothing was wrong with the documents for her home in Atlanta. www.reuters.com/world/us/no-...

Fifteen years after Citizens United opened the floodgates of corporate and dark political money, the Center for American Progress has figured out how to slam them back shut. CAP published its groundbreaking how-to report today: "The Corporate Power Reset That Makes Citizens United Irrelevant."

Imagine if, in 1946, President Truman had tried to ban Penicillin and other antibiotics on the basis of conspiracy theories and rumor. That’s where we are today, but for mRNA therapies and vaccines.