Cedric Boeckx (@cedricboeckx.bsky.social)

How did DNA changes that alter protein structures impact evolution on the branch that led to modern humans? As we demonstrate today in Science Advances, biobanking initiatives offer ways to directly assess biological effects of rare archaic variants in living people, & (re)evaluate their roles. 🧬🧪

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Evaluating the effects of archaic protein-altering variants in living human adults Promise and pitfalls of using large biobanks to study impacts of archaic protein-coding variants in living humans. https://www.science.org/doi/10.1126/sciadv.ads5703