Maaaaaany graduate students at CSHL have stories. I'll send them your way. I tweeted once about him and was immediately called out by our PR. They sat me down and told me they knew he was problematic but that he brought in too much donor money for us to say anything bad about him.

New paper on everyone’s favourite topic, QC! We show why you should do genotype-level QC on your WGS data www.biorxiv.org/content/10.1... Very real quotes about this paper - “The most exciting, mind-blowing paper of the year!” “On a par with Fisher 1918” “I read it every night. Just so beautiful”

A massive, massive thank you to @hiwwright.bsky.social, @rnbeaumont.bsky.social, @drghawkes.bsky.social who all really drove this project to completion. Without them I would still be twiddling my thumbs shouting to the clouds about QC (I still will, but now you can read about it too!)

A political message all branches of the tree of life can get behind

The names crass, not clash

I am crying I was trying to remember what the RFK fleeing scene reminded me of and

How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

Anyway, if you want to follow people like me who are actively confronting racist pseudoscience and want to hound them into starting a nonprofit that can structure and support this vital work, check out this starter pack from my friend @jowiph.bsky.social bsky.app/profile/jowi...

Its always the economists 🤡

Why do complex traits differ in their genetic architecture? In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits. Thread: journals.plos.org/plosbiology/...

Huge congratulations to @tszfung.bsky.social on successfully defending his PhD! (Co-advised with @charleston.bsky.social ) Plenty of cool insights and methods detailed in his dissertation, "Inferring genetic architecture of complex traits in admixed populations"

The last time new york had an immigrant socialist mayor he campaigned in multiple languages this is merely a retvrn to tradition

Vote

You know upper admin is really getting ready to fuck you over when they start talking about the need for faculty to be "flexible."

harvard medical school got bombed yesterday and it barely made news

DODGERS VINDICATED, LOS ANGELES SPIRITUAL PRIMACY CONFORMED

Yoooooooooo

Kike: Pblbpblbblblblbl

LFG!

I think a key requirement for me in candidates is that I need them to hate Republicans more than they hate Democrats

Buying a six pack at the corner wearing my robe is def a vibe I'm comfortable with

I gotta say. It was pretty magical to be out trick or treating with the kids, the sidewalks packed, with everyone tuned into the game. As soon as dodgers clinched it, folks were cheering, and kids were chanting.

Let’s fucking go, game seven motherfuckers

Let's go dodgers let's go!

I had to

The only acceptable Halloween songs are really just Rocky Horror soundtrack.

Hearing even a *reference* to The Monster Mash ANY time of the year is infuriating. The song absolutely sucks and modern civilization shouldn’t even be aware of it. You should not and cannot and MUST NOT defend it. Let the worms of history finally have their feast.

9YO citizen caught in Idaho FBI raid describes officers breaking car window to detain his father “I felt scared because they were pointing the guns at me. When they broke the window, I had to jump to my mom’s feet. I had glass in my mouth, and I quickly spit it away." www.ktvb.com/article/news...

I mean yes. But this is like the entirety of Buckley philosophy, so no.

That's that

📣 New from @sashagusevposts.bsky.social & co! 📄Discovery of disease-associated cellular states using ResidPCA in single-cell RNA and ATAC sequencing data 🖥️ github.com/carversh/res... 👉 tinyurl.com/357m7s77

Mi receta ... Make this spiced Mexican hot chocolate for Día de Muertos 🌼🌼🌼 via @latimes.com www.latimes.com/food/newslet...

if you get to 20 they let the minotaur out of the labyrinth and onto the field

They’re cooking over on /r/baseball right now

Would appreciate if they stopped aiming for the bleachers and got on base instead

fukuyama was right. history ended. we are stuck inside this game forever

Intentional walks are boooooring

All the hot dog vendors outside still waiting for the crowd...

Just burning pitchers for warmth at this point

There we go there we go. Cmon now, let's tie this bow

Cmon lfg

so cool to be alive at the same time as ohtani

Excited to share this preprint from first author Jon Rosen, a postdoctoral fellow in the @klmohlke.bsky.social lab and my lab. We examine eQTL study sample size and how this affects signal discovery and rates of colocalization with GWAS. www.biorxiv.org/content/10.1...

Adopt me, Ohtani

📣 New from @profsimonfisher.bsky.social & co! 📄Functional characterization of pathogenic SATB2 missense variants identifies distinct effects on chromatin binding and transcriptional activity 👉 tinyurl.com/ym94skym

📣Online now! 📄Splicing and frameshift variants in QSER1 may be involved in developmental phenotypes 👉 tinyurl.com/2ryww2zy

📣 New from @telomeredoc.bsky.social & co! 📄Detailed Assessment of Rare and Common TERT Variation in a Family with a Telomere Biology Disorder 👉 tinyurl.com/3kwnk3zm