Oh boy, by Camron, but replaced with the Mickey Mouse "oh boy!"

This is an insane silent bug that's been in GCP since March and which has been impacting my scientific workflows. Think you're copying over 3+ files? No you are not, you're just getting the first two. github.com/GoogleCloudP...

PhyKIT v2.2.0 is out! PhyKIT has been rigorously profiled and optimized across the entire codebase, resulting in speedups ranging from ~1.0x to 16.6x, with a geometric mean of 2.0x Python 3.10 through 3.13 is also supported

Five minute time lapse at Yosemite Valley. While there were a few shooting stars that night, all the streaks here are satellites.

Yosemite is breathtaking.

Damn solid game. Not the outcome I wanted but damn good game

Polytoken 0.4.0-unstable.6 out. Adds Neuralwatt as a provider, addresses a few weird random issues that I wanted to take care of before 0.4.0. Which, I think, will probably be tomorrow (based on unstable.6). brew install polytoken/tap/polytoken-unstable docs.polytoken.dev/installation/

one of my more unpopular on Bluesky opinion is that I'm pro some form of national service. I did americorps and I think some form of that (or peace corps, serving in mil, etc) being the norm for young people is good, actually.

Merged a few updates that had been sitting in the pipeline into genoio for v0.3.0. The biggest change is all metadata is now handled via arrows, which eliminates memory overhead when handing off to python from rust. github.com/mancusolab/g...

I’m going to waste tokens making agents hide secret CLI commands that play chiptunes. Gen Z will never know the thrill of launching a warez/cracker app and immediately getting hit with maniacal chiptunes just to play some game for free.

Anyone have a recommendation for tracking and organizing AI agent work on a codebase? Linear.app? Ideally with an emphasis on organization.

Is codex running like molasses for folks today?

Absolutely heart broken to learn that kei trucks can't be registered in CA 😭 💔

1/2 🚨 New commentary in @pnas.org "Maynard Smith’s protein-space analogy, realized" Here, we invoke Maynard Smith's protein space to discuss a study proposing that evolution has explored a tiny fraction of functional protein sequences, chiefly b/c of common ancestry: www.pnas.org/doi/10.1073/...

It's not a coincidence that unitary executive theory as propounded by Scalia arose at a time when Republicans had a streak of winning more presidential elections than not, but hadn't held the House in decades.

Twitter is going kind of crazy about crime and genetics right now (What's new?). My next post is a deep dive into a paper behind a widespread claim that brutal execution in Medieval Europe selected for reduced aggression, allowing civilization to develop. The title says it all, really.

even more impressive — the huge improvement in treating kids with cancer we can cure many now, precisely because of painstaking research and clinical trials over decades ourworldindata.org/db734210-96b...

Steak sangwich with chimichurri for dinner!

Stiff competition but this is a serious contender for funniest quote I’ve ever received on a post.

Any AoU folks using the new workbench having issues with GCP failing after ~1-2 hours?

Please keep me in your thoughts and prayers. I have deleted my micromamba env and embraced brew + uv

Oooo keeping an eye on this. Sparse AD Jacobians via graph coloring for JAX: github.com/adrhill/asdex

Seeing that jax-metal (Apple's GPU backend for JAX) is kind of dead, long live github.com/tillahoffman...

The new All of Us servers are going well, I see

Genoio has a v0.2.0 release. Performance is better across the board, beating most other libraries or matching highly performance ones (but with a single interface in Python now). Check it out mancusolab.github.io/genoio/

For (co-)dominant selection, Stolyarova, @gcbias.bsky.social, and @mollyprz.bsky.social showed in a really nice paper that most strongly selected LoFs are only a handful of generations old, and so equilibrium is reached really quickly. doi.org/10.1073/pnas...

Excited to see @jonj-udd.bsky.social's fantastic work out @genetics-gsa.bsky.social. Selection in _heterozygotes_ is the primary force shaping allele frequencies of loss-of-function mutations in humans, even in genes only associated with purely recessive diseases. 🧪🧬 doi.org/10.1093/gene...

I am closely monitoring the ongoing Boyle Heights warehouse fire affecting our SGV communities. If you're in an affected area, please follow local air quality guidance and stay indoors to protect yourself from the smoke.

Step dad and I got each other the exact same stud finder for father's day, to replace the same shitty stud finders we each had 😆

Advertise your Bsky account with a Simpsons gif

this is also specifically why government IT overhaul/revamping to bring everything in house should be a major part of the democratic program. get rid of elon, get rid of palantir, get rid of the contractors

who thought it would be a good idea to reuse rsid for multi-allelic sites, rather than diff rsid for diff alt alleles?

Zensical Studio v0.1.1 just dropped, and it brings a wide range of improvements for highlighting! Update your VS Code extension, or enable auto-update to immediately benefit from future improvements. github.com/zensical/stu...

Asking the Ai for some copium as I do a really risky and heavy lift to detangle and modularize SpliceCraft. From a 131,000 lines of code monolith into very robust modules that fit into open source LLM context windows. Specifically designed to work if I ever lose Claude access.

Widow's Bay is -very- good. Strikes the perfect balance between humor and horror of the absurdities occuring.

Today, we're launching Zensical Studio, the missing productivity layer for Docs-as-Code. The idea is simple: Refactor documentation like code. Rename headings safely. Catch [broken links] instantly. Works with Zensical and MkDocs projects. zensical.org/studio/

I lay awake at night super stressed bc they still haven't made a sequel to Nice Guys

@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease. Details below careersearch.stanford.edu/jobs/computa... Plz RT

KNICKS IN FIVE! The New York Knicks rallied to win Game 5 in San Antonio, beating the Spurs 94-90 to win New York's first NBA championship since 1973. https://wapo.st/4uEvvBd

when the knicks won everyone yelled and my cat threw up

Yoooo omg

Tapping the sign again in light of recent grant discourse

this is disgusting and outrageous and i hope everyone involved gets heatstroke and worse

Me, naive teen: Spy Game is a serious spy thriller and is one of best in the genre Me, re-watching Spy Game for the first time since then: lol this is the corniest thing I've ever seen and is still one of the best in the genre. I love it.

Bro just one billion more parameters, no bro you don't understand. Bro the cell atlas,

I legitimately love Teen Titans Go and have so much fun watching it with my kids. The episode about writing for TV/Hollywood that had an exposition about expositions is 🧑‍🍳 👌

Lifes a gas