Jon Judd
@jonj-udd.bsky.social
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Stanford Genetics PhD. Science Policy Fellow. Just a guy that likes science, policy, and, Quidditch
reposted by
Jon Judd
Jonathan Pritchard
24 days ago
Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model? This work is by the wonderful
@jonj-udd.bsky.social
, and co-mentored by
@jeffspence.github.io
www.biorxiv.org/content/10.6...
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Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes
The classic theory of mutation-selection balance predicts the equilibrium frequency of genetic variation under negative selection. The model predicts a simple relationship between the total frequency ...
https://www.biorxiv.org/content/10.64898/2025.12.05.692665v1
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