From an email to one of our faculty members.... Not even Plato can escape censorship at Texas A&M!

I’m very excited to share our new preprint with @arbelharpak.bsky.social! We meta-analyze male-female allele frequency divergences across studies (gnomAD, UKB, AoU) and ask what drives the observed differences. (1/12) www.biorxiv.org/content/10.6...

New preprint alert: we use sign errors as a test of how well TWAS works. Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇

I'm just delighted to announce our new preprint on genome-scale perturb-seq in CD4+ T cells. We learned both general lessons about the power of perturb-seq, and specific lessons about T cell biology. Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.

Come and join me and my colleagues at the Department of Biology, #LundUniversity in #sweden! We have am open position as Senior Lecturer/Associate Professor in Biodiversity. Apply here no later than February 11 2026: https://lu.varbi.com/en/what:job/jobID:848749/type:job/where:4/apply:1

The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31 probgen2026.github.io

Why do I have to read an Irish paper for a feature about this?

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵

Somatic and germline mutational processes across the tree of life https://www.biorxiv.org/content/10.64898/2025.12.28.691837v1

Congrats @jeffgroh.bsky.social et al. Some avocado trees open female-phase flowers in the morning & then male in afternoon. Others show complementary pattern (m->f), to synchronize pollination of two types. Jeff show this to be a >45Mya polymorphism at a transcription factor across 100s of species.

SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the @simonsfoundation.org. Details to follow. Please RT.

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Celebrating the retirement of my wonderful mentor and PhD advisor Doug Bishop @biz3000.bsky.social after more than 30 years at the University of Chicago studying homologous recombination! An incredible mentor to more than 50 grad students, postdocs, and other trainees

I wrote about the bizarre case of Herasight, the embryo selection company going all in on eugenics.

Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model? This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io www.biorxiv.org/content/10.6...

GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:

Our latest collaboration with @jkpritch.bsky.social – led by joint post-doc Mineto Ota – is in @nature.com today: www.nature.com/articles/s41...

On the tragic effects of collective punishment. (gift link) www.nytimes.com/2025/12/04/o...

EEB Postdoctoral Fellowship @ U.Toronto app deadline Jan 15 2026. Opportunity for independent research, encourages collab across labs/disciplines. Lots of great folks to interact with, Come join us! eeb.utoronto.ca/employment-2/

A 6-year-old boy is missing after ICE arrested him and his dad in NYC last week and shipped them off to separate facilities. www.thecity.nyc/2025/12/02/i... @thecity.nyc @gwynnefitz.bsky.social

Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)

Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank! A thread... 🧵 www.medrxiv.org/content/10.1...

I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵

My center at NYU SoM is hiring an Assistant/Associate Professor in human genetics and genomics. It's a wonderful place to do science. Please apply or pass along. apply.interfolio.com/177375

Congratulations to Joe Felsenstein on being awarded the 2026 Mendel Medal!

Congratulations to Richard Durbin on being awarded our Genetics Society Medal!

"What James Watson got wrong about DNA" By the great Sohini Ramachandran (@sramach.bsky.social) and your boy for The Boston Globe (@bostonglobe.com). www.bostonglobe.com/2025/11/14/o...

SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the @simonsfoundation.org. Details to follow. Please RT.

Exciting new study led by @ekerdoncuff.bsky.social and @meaghanmarohn.bsky.social on the evolution of Lactase Persistence in South Asia. www.biorxiv.org/content/10.1...

“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”

I am so excited to share new work on a TE insertion that regulates iridescence in swordtails, led by fantastic grad student @nadiahaghani.bsky.social and with help from many coauthors! In a time that has been so difficult to navigate, this & other projects have kept my spirits up: shorturl.at/NE65A

Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here. www.cam.ac.uk/jobs/faculty...

An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

Very excited for our paper in @nature.com on what genes association studies discover and why. It was a privilege to work closely with @jeffspence.github.io, @jkpritch.bsky.social, and our collaborators.

How do GWAS and rare variant burden tests rank gene signals? In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck! 🧬🧪🧵 www.nature.com/articles/s41...

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

The exciting next instalment of Mutations in Time and Space... Open for registration now

We have TWO post-doctoral fellowships in the Biodiversity Centre at UBC next year! Am happy to chat if you might want to be hosted in my lab. biodiversity.ubc.ca/training-and... Deadline January 15th!

We are now accepting apps for our Simons Postdoctoral Fellowships in Plant Biology awards. Deadline is 12/4/2025: https://www.simonsfoundation.org/applications-for-simons-postdoctoral-fellowships-in-plant-biology-now-open/ #lifesciences

I started a new job in Montpellier, France! Happy about new opportunities, sad about the state of things in the US. abetterscientist.wordpress.com/2025/10/26/w...

The question isn’t "why does Signal use AWS?" It’s to look at the infrastructural requirements of any global, real-time, mass comms platform and ask how it is that we got to a place where there’s no realistic alternative to AWS and the other hyperscalers. 3/

Amazing job opportunity at the @institutimagine.bsky.social, Head of the Genomics Platform. I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below. www.welcometothejungle.com/fr/companies...

Results I'm sad to share but must be told - branching coral are now functionally extinct in Florida - to learn more check out the full study www.science.org/doi/10.1126/... and our personal summary theconversation.com/2-iconic-cor...

We're launching a portal to review federal immigration enforcement in New York after yesterday’s ICE raid on Canal Street. New Yorkers who were present should submit videos or photos, and we will review and investigate any violations of the law.

Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you. More info: www.crg.eu/en/content/t...

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

In Chicago, four vehicles descended and eight ICE agents moved in to kidnap a child. She screams, “I’m 15,” as ICE yanks her from the car and kneels on her neck. This is not about immigration enforcement. It's about terrorizing Americans.

👏 👏 👏 orgchart.mit.edu/letters/rega...

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...