@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

"Only 20 left in stock" for my book on Amazon -- that's kind of gratifying. And thanks to the two lovely people who rated the book 5 stars. a.co/d/09cT0Y4C

Today, I'm introducing my wealth tax — and more than 50 members of Congress are joining me. It’s time for the government to start working for American families, not just the ultra-rich.

A deep dive without first defining what they mean by #epigenetics. But that's OK, nice thought-provoking ideas. Gedankenexperiment: if you replace the word "epigenetics" throughout with "transcriptional regulation", now how does it look?

Failure to understand that the fundamental principle of Mendelian randomization (MR) is of gene-environment equivalence contributes to the flood of nonsense MR papers that are appearing; Shah Ebrahim, Gib Hemani and I explain why in this short commentary. journals.plos.org/plosmedicine...

Happy St. Patrick's Day, New York.

Lá Fheile Pádraig sona daoibh! Today we emigrants celebrate our Irish pride. I am involved in the New York Celtic Medical Society. Founded in 1891, it was a way for Irish doctors to counter anti-Catholic bias in #NYC. Now we exist to pay our good fortune forward. www.celticmedsocnyc.org

Sad to hear of the passing of the great Dolores Keane. I will have this on repeat tomorrow in celebration of what she has left us. music.youtube.com/playlist?lis...

We need to move on from the era of extractive population genetics. The model needs to start benefiting study participants, with data privacy the *bare minimum* as a deliverable. www.theguardian.com/science/2026...

arXiv to spin out as an independent non-profit. They are seeking a CEO jobs.chronicle.com/job/37961678...

RIP Irish athletic hero Ronnie Delany Very odd running style but it got him a gold Olympic medal youtu.be/u696YRFCfFg

Unusual to see serial measurements of epigenetic ageing clocks. But then the problems arise: multiple clocks, a choice of age versus acceleration, no real biological hypothesis or way of interpreting the meaning of the results. I don't see the value of these studies. www.nature.com/articles/s41...

A reminder that we are actively recruiting a geneticist to the Department of Genetics at Albert Einstein College of Medicine careers-einstein.icims.com/jobs/17847/a...

The @newyorkcrd.bsky.social at @einsteinmededu.bsky.social Rare Disease Day 2026 #RDD26 is underway! #rarediseases #bronx #nyc

This is really important in terms of understanding what families in #NYC deal with, why free buses resonate so strongly, for example, and why when I ask all my patients “Are you under any financial stress?” so much private information can reveal itself. Kudos and thanks to the authors.

Register to be a snow shoveller in #NYC, make a few bucks and help your neighbours www.nyc.gov/assets/dsny/...

An important new report on wealth & health in NYC by demographic characteristics “White & Chinese respondents reported the highest median net worth ($142,000 & $320,000)” Puerto Rican: $160 Dominican: $300 African American: $500 American Indian/Alaska Native: $1000 www.nyc.gov/site/doh/abo...

Very thoughtful and gently-handled discussion about a decision that causes a lot of emotion for many parents. Thank you @nytimes.com My First Child Has a Genetic Syndrome. Can I Use I.V.F. to Spare My Second? Gift link below: www.nytimes.com/2026/02/14/m...

If they come saying: * Longevity * Wellness * Supplements * Peptides * Light therapy ...they will be effective at taking your money, but they will not be effective in making you healthier. Walk away. @theatlantic.com gift link: www.theatlantic.com/health/2026/...

The culmination of a lot of excellent work, @marlmatos.bsky.social defending her PhD thesis today. Co-mentored by @tuuliel.bsky.social, exceptional insights into molecular quantitative trait loci in CD4+ T cells @einsteinmededu.bsky.social

Rare disease piece in @theatlantic.com, how carriers of recessive conditions can have medical problems, making them more than 'carriers'. Gift link below. www.theatlantic.com/health/2026/...

Really well put: “The developing organism accretes information as it builds itself.” Increasingly I am coming around to the perspective that nothing in genetics makes sense except in the light of cell biology.

Imagine if our skin was so absorbent that our immersion in liquid caused molecules to enter our bodies. Clearly it isn’t. Histologically we see stratified squamous epithelium covered in supple shell of keratin. And that is why Epsom Salts do absolutely nothing: pmc.ncbi.nlm.nih.gov/articles/PMC...

The US health system. So in need of innovation, so refractory to innovation. But we should keep trying to fix this broken system. Fascinating proposal for New York State, may now pass the tipping point of feasibility in an era of savage Medicaid cuts.

I'm going to do a thread of all the references and context behind Bad Bunny's performance and what it means for Puerto Ricans to see this on the biggest stage. The opening title screen is a street mural in Puerto Rico that comes to life with footballs as coconuts. Follow along!

Is the @nytimes.com trolling Gina Kolata? Relentlessly negative about the medical profession, her headline asks what we physicians are really good for? The answer is in the second headline — we are really good at medicine. No apologies, not buying into this ridiculous framing.

The NYTs comment section for our feature yesterday got so heated, they shut it down immediately. However, people want to donate to #IDSov. Here’s ours: www.bonfire.com/store/native... donorbox.org/help-to-empo... www.bonfire.com/store/native... Here’s the movement’s indigenousdata.org nativegov.org

A conservative economist writing about capitalism today. Fascinating perspective. www.nytimes.com/2026/02/06/o...

Maith thú Joe @joseph-yracheta.bsky.social www.nytimes.com/2026/02/05/s...

Please share this with your network: Postdoctoral position available in my group. www.linkedin.com/jobs/view/43...

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine. faculty-einstein.icims.com/jobs/17847/a...

Please spread the word — a 2-year postdoctoral fellowship is available in my group funded by the Simons Foundation Autism Research Initiative (SFARI) to perform a study testing the contribution of functional non-coding variants in glutamatergic neurons to autism. 1/3

We're testing AlphaGenome. It's a very valuable step forward towards the goal of identifying functional non-coding variants (FNCVs) causing human diseases. Congrats to @avsecz.bsky.social and the team for this landmark publication. www.nature.com/articles/s41...

RIP Sly Dunbar, hopefully back to jamming with Robbie Shakespeare somewhere beyond the clouds youtu.be/o_PNL3djy54

Interested in the genetic history of the island of Ireland? From Edmund Gilbert. Includes relationships with Britain, Vikings, Iceland, and Newfoundland. youtu.be/m5AwYzzCAF4

Geneticist John Greally fears above all that the tests could exacerbate existing inequalities. “I work in the Bronx, where 26 percent of the population lives in poverty and 40 percent receive food assistance,” says Greally,... www.zeit.de/2026/04/kuen...

📺 OMG—who made this?! Noah Wyle has a message for all you—vaccine skeptics… Share with a friend who needs to hear it.

I appreciate these authors publishing a well-powered, entirely negative epigenome-wide association study (EWAS). www.medrxiv.org/content/10.1...

Rare Disease Day 2026 at the New York Center for Rare Diseases (NYCRD) @newyorkcrd.bsky.social This year we are focused on rare disease therapeutics, where there is unprecedented hope for our patients. www.linkedin.com/posts/john-g... @einsteinmededu.bsky.social

Nice interview with Karman Saini up on LinkedIn www.linkedin.com/posts/john-g...

Read our full statement by AAP President Dr. Andrew Racine on today’s HHS announcement about the childhood immunization schedule: www.aap.org/en/news-room...

There is always so much more to learn about Albert Einstein as a person. Such a good guy. Hopefully this link will allow sharing of this fondly-written piece about his life in Princeton. www.theatlantic.com/culture/2026...

I finally got around to putting together a quick overview of what my book is all about. youtu.be/xPt1xy4_i-o?... #epigenetics #epigeneticsbook #epigenome

Ending 2025 w/ our new paper @natcomms.nature.com which shows that the immediate early gene Egr1 induces sex-dependent changes in ventral hippocampal (vHIP) structure and in anxiety- & depression-related behavior, via direct regulation of chromatin structure 🧵👇 1/ www.nature.com/articles/s41...

In Galway this week. Shop Street and Quay Street looking festive. Being home is good for the soul.

I couldn't resist using the very festive-looking cover art from my book as a holiday card (image attribution to follow).

Incredible piece on Oliver Sacks. If you were ever awed at his supposedly true stories (I remember being stunned by the account of the autistic twins who rattled off large prime numbers), read this. He told wonderful stories, but they were in large part fiction. www.newyorker.com/magazine/202...

Make it stop

Take a bad idea. Add DNA methylation. Price it for the wealthy. Sell it to the gullible. partners.lifedna.com/methylation-... We can't offer basic health care in the US and yet this kind of nonsense is permitted for direct-to-consumer sales? Something is rotten.

📢 SIGN & SHARE THE PETITION! 📢 New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW