Interesting, from @garvaninstitute.bsky.social. "We identify putative common regulatory variants for 83% of all 21,404 genes tested and cumulative rare variant signals for 47% of genes...about half of the effects are observed only in one or a few cell types" www.medrxiv.org/content/10.1...

Irish culture. No apologies.

When I read the history of Waddington, I realized that, in using the epigenetic landscape model, this geology dropout student may have been trolling the field of biology! www.amazon.com/Epigenetics-...

Relatable

On the event of James Watson's death, I highly recommend this 2023 commentary from @matthewcobb.bsky.social and Nathaniel Comfort with crucial new insights into the discovery of the double helix. (And also check out Cobb's brand new biography of Francis Crick) www.nature.com/articles/d41...

He made a massive impact. Respect.

Hot take — could this be a possible clue as to why @zohrankmamdani.bsky.social did so well in the #NYC election yesterday?

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

People cheering in the streets in the East Village #NYC right now.

📣 I am hiring a postdoc! aial.ie/hiring/postd... applications from suitable candidates that are passionate about investigating the use of genAI in public service operations with the aim of keeping governments transparent and accountable are welcome pls share with your networks

‘Exododus’ is an exodus of dodos. Not going to happen for many reasons. Happy Election Day, New Yorkers

Pumpkin carvers in #NYC don’t mess around

Really concerned for Jamaica, this looks like a really horrible situation, only a year after the Southwest of the island took the brunt of another damaging hurricane www.nytimes.com/live/2025/10...

The figures from this book are all freely available through @figshare.com, hopefully helpful for presentations and teaching: figshare.com/projects/Epi... Please let me know if you find any inaccuracies and I'll fix them. I've already updated one of the figures. #EpigeneticsBook

Amazing job opportunity at the @institutimagine.bsky.social, Head of the Genomics Platform. I am adding an English translation of the opportunity, but fluency in French is a (reasonable) requirement for the position. Application link below. www.welcometothejungle.com/fr/companies...

It's publication day, and Cold Spring Harbor Laboratory Press is running a promotion bundling the hard cover and e-book, and other offers: cshlpress.com/default.tpl?... #EpigeneticsBook

Watching @wiringthebrain.bsky.social and @aylwyn-scally.bsky.social go at it in this thread, staying polite and respectful but challenging each other, gives me the old #ScienceYwitter vibes. Good on you lads.

DNA methylation does not mediate ageing. #epigenetics

Here's the link to the system, try it! qedscience.com @qedscience.bsky.social

Apparently Maynard has never done this with a book before, according to his owner. I feel honoured. #EpigeneticsBook @cshlpress.bsky.social

Looks like @leandrosboukas.bsky.social has been busy doing useful stuff. DNV detection in duos, very valuable in communities in which families are less stable. www.medrxiv.org/content/10.1...

My book on Epigenetics: History, Molecules and Diseases www.amazon.com/Epigenetics-... #EpigeneticsBook #Epigenetics

1/3 Start by getting highlighted in the @theguardian.com www.theguardian.com/society/2025...

What an amazing assay. DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform: www.biorxiv.org/content/10.1... This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.

Decades of research have proven that acetaminophen is safe for children when taken correctly and under the guidance of a child’s pediatrician. Learn more. www.aap.org/en/news-room...

Seven years. Over 400 pages. About 750 references. Over 40 figures. Finally I get to hold the finished book. It’s a big day. #EpigeneticsBook @cshlpress.bsky.social

Public service announcement 1: jamanetwork.com/journals/jam...?

Unhelpful framing. Scientists know we always need to be improving what we do, but science is not “broken”. To suggest this justifies the misplaced destruction of US scientific institutions. @nytimes.com

1/ One of the questions I get asked about my book is what new they'll discover about #epigenetics. I hope there will be a lot to learn, but maybe one of the most intriguing stories will be about the contribution of John Pugh. www.amazon.com/Epigenetics-...

Superb piece of reporting. We should pay attention to the remedies in particular. You Might Have Already Fallen for MAHA’s Conspiracy Theories www.nytimes.com/2025/09/09/o...

My multitalented colleague Mark Lawler performing at the best bar in #NYC, The Dead Rabbit, on the subject of James Joyce. What more could you ask for? Tickets for this September 22 show at the link below. www.eventbrite.com/e/doctoring-...

Free sample downloads now available from Epigenetics: History, Molecules, and Diseases The Introduction and Index (probably a lot of familiar names) can now be browsed. www.cshlpress.com/default.tpl?...

I’m in Dublin Friday afternoon this week, who’s around for a chat?

NEW: In March, the Trump administration announced a massive purge of workers at the nation's health agencies. We asked them how many workers were laid off, pushed out or left. They refused to give us numbers. So we conducted our own analysis... 🧵 projects.propublica.org/federal-heal...

A postdoc position in genomics available at our infrastructure in Uppsala, Sweden! An interesting R&D role a bit outside the traditional academic environment, great colleagues, work at the forefront of (long-read) sequencing. www.uu.se/en/about-uu/...

Looks like my book is available for pre-order: a.co/d/cTKIwBN #EpigeneticsBook

We discussed the physiological relevance #epigenetics

Plant #epigenetics colleagues, is this the consensus opinion? "...these methylation marks and epiallelic variations found in natural populations are mainly attributed to genetic variations in epigenetic machinery and transposable element (TE) insertions" pmc.ncbi.nlm.nih.gov/articles/PMC...

I’m very excited to announce that I’ve just signed a contract with @princetonupress.bsky.social for a new book, tentatively titled “The Genomic Code” 📖 😊

My book Epigenetics: History, Molecules and Diseases will be published in exactly one month (September 2). Finalizing cover (looks great), probably going to printer this week. Nervous anticipation is the mood right now.

Very pleased to say we have an Assistant Professor job opening (tenure track) in the Department of Genetics at Trinity College Dublin! 😀 www.jobs.ac.uk/job/DOA399/a... - deadline is August 19th! Please repost!

Fried fish on City Island in the Bronx, at the legendary Johnny’s Reef. I feel lucky to have such great people working here in my lab and with Sri Raj, and in the @newyorkcrd.bsky.social @einsteinmededu.bsky.social

📣 We are recruiting! Please share!! Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺 We have two roles available 👇 🧵 1/4

More of these studies coming out, showing that post-translational modifications of transcription factors adds another layer of complexity to transcriptional regulation. www.nature.com/articles/s41... Yes, our challenge just got bigger, but so did our potential insights.

Reminder! Tenure track position in Genetics at Trinity College Dublin! Come join us, we're nice... 😊 Please repost! 🙏

For what I consider the best inter-generational study to date @jamiehackett.bsky.social used over 2,000 mice. www.nature.com/articles/s41... While that's a lot of mice, it is better animal welfare to perform a definitive study than to perform hundreds of uninterpretable studies.

Research Ireland, on behalf of @deptoffhed.bsky.social, have today launched Global Talent Ireland - a new initiative to attract exceptional mid-career and established researchers from across the globe to Ireland. For more information visit: www.researchireland.ie/funding/glob...

We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity! www.nature.com/naturecareer...

I fail to understand the value of using epigenetic aging clocks in any situation. They are being correlated with...stuff. Name the exposure/condition, someone will find a perturbation in one of today's many epigenetic aging clocks. More expensive and less meaningful than a fortune telling machine.

Big news for science in NYC www.jax.org/news-and-ins...