@landau.bsky.social @rdrapkin8-penn.bsky.social Paul Mischel, and Adam Widman are searching for pre-cancerous signals of ovarian cancer in the blood, laying the foundation for non-invasive screening test. 🩸@tinaswish.bsky.social @weillcornell.bsky.social @mskcancercenter.bsky.social

TDP43 dysfunction in ALS leads to transposon mayhem in the transcriptome. Nice work from @nygenome.org ‘s ALS consortium, lead by Hemali Phatnani, and @nyulangone.bsky.social ‘s @karthiknatarajan.bsky.social & @mollygale.bsky.social. Nice work guys! www.biorxiv.org/content/10.6...

📣Excited to announce a new pre-print from the lab 📣 Led by my student @storiesofisobel.bsky.social in collab with Hemali Phatnani @nygenome.org We discovered a novel class of TDP-43 dependent cryptic gene-TE spliced transcripts: crypTEs #TEsky #RNAsky #ALS doi.org/10.64898/2026.01.09.698641

Now online in Cancer Discovery @aacrjournals.bsky.social: Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations & mRNA Transcripts by @dennisjyuan.bsky.social, @landau.bsky.social, et al. doi.org/10.1158/2159... @nygenome.org @weillcornell.bsky.social

A comprehensive spatial splicing analysis in the brain under normal and neoplastic conditions @natbiotech.nature.com @raulrabadan.bsky.social @columbiauniversity.bsky.social @davidaknowles.bsky.social @nygenome.org www.nature.com/articles/s41...

Congratulations to NYGC Core Faculty Members, @nevillesanjana.bsky.social and Rahul Satija for their feature on the @clarivate.com #highlycited2025 list! Learn more here: www.nygenome.org/news-events/...

Don't forget to watch our new Faces of IICD Video Series featuring Beatrice Grauman, a PhD student in the Vicković Lab @nygenome.org. ⤵️

The November newsletter is out now. Don’t miss our alumni spotlight, cutting-edge research on colon aging, a new K-12 partnership, and other exciting updates: cancerdynamics.columbia.edu/news/iicd-ne... cc: @nygenome.org @brentstockwell.bsky.social

Tissue and cellular spatiotemporal dynamics in colon aging - @nygenome.org @flatironinstitute.org @broadinstitute.org @cancerdynamics.bsky.social go.nature.com/47I1RBF

Congrats to our lab's recent MD-PhD grad Rachel Yan ( @rachelyan.bsky.social) on the beautiful cover art accompanying her MultiPerturb-seq study!

From patient to scientist: Sergei German beat cancer thanks to clinical trials, inspiring him to leave his career in finance and drive research @nygenome.org A NY statewide biomedical institute will make more incredible stories like his possible. Help make this happen, sign up at www.nycures.org/

Meet Beatrice Grauman, PhD student in the Vicković Lab at @nygenome.org 🌟. Her research explores tumor–microenvironment interactions and cancer evolution. 🎥Find out what inspires her outside the lab in our latest Faces of IICD feature 🔗 bit.ly/3K0Xidr #FacesOfIICD #PhDLife #WomenInSTEM

Massive team effort. A huge thank you to the Ultima Genomics team, our clinical collaborators and sequencing team @nygenome.org Look at the author list, it's huge! Takes a village. Super proud of trainees Aaron, Sam and Sri

Our intern spotlight continues with Joel Joseph, a CS + Data Science senior @arizonastate.bsky.social. Mentored by Dr. Sanja Vicković @nygenome.org, his research focuses on using computational tools to study tumor interactions in colorectal cancer. bit.ly/SRPQA2025 @columbiauniversity.bsky.social

Meet Daniel Alshansky, a rising junior studying Biology & Computer Science @hofstrau.bsky.social. At the @nygenome.org Vicković Lab, he’s developing new transcriptomic engineering tools to push the boundaries of genomic research. Read more: bit.ly/SRPQA2025

The SRP and Alliance interns had a great time touring the New York Genome Center this week! 🧬 Thanks to @nygenome.org for the warm welcome and an inside look at innovative research in action. #Genomics #SRP2025

NYGC Core Faculty Member @nevillesanjana.bsky.social presented at GEN bio’s “The State of CRISPR and Genome Editing” virtual summit. He spoke about CRISPR, the noncoding genome, & its potential to transform precision therapies. For more on Dr. Sanjana’s work: bit.ly/43YshNC

Just under a week until the #MLCB2025 paper/abstract deadline on June 1st! In-person registration is full but you can join the wait list forms.gle/gnj6AAV7oWj6... or watch online at youtube.com/@mlcbconf. Sept 10-11 at @nygenome.org. Full deets at mlcb.org! Please RP.

Free in-person registration is open for #MLCB2025! Sept 10-11 at @nygenome.org and online at youtube.com/@mlcbconf. Paper/abstract deadline is June 1, more deets including our fantastic invited speaker lineup at mlcb.org! Please RP.

Our next NYC Postdoc Night Science event will be June 2nd! We'll start off at @nygenome.org, then head to a bar to continue the conversation. Register here to join us! docs.google.com/forms/d/1s9W...

Our new contribution to the quest to find causal GWAS genes! Sam Ghatan from my lab at @nygenome.org led a systematic comparison of eQTLs and CRISPRi+scRNA-seq screens. TL;DR: they provide highly complementary insights, with ortogonal pros and cons. 🧵👇 www.biorxiv.org/content/10.1...

Single Cell Genomics Day 2025 has begun! Join the live stream here: satijalab.org/scgd25

Join the Satija Lab for the seventh annual Single Cell Genomics Day on 4/25 — a free, one-day workshop featuring recent advances & practical insights in single cell genomics, designed for researchers at all levels. All talks will be live-streamed via: satijalab.org/scgd25. Hope to see you there!

Adam Widman & collaborators at @nygenome.org led a study to evaluate a low-cost, error-corrected whole-genome sequencing method to detect cancer DNA & assess disease burden in individuals with melanoma and urothelial cancer. @mskcancercenter.bsky.social www.nature.com/articles/s41...

The New York Genome Center will receive $125 million from Simons Foundation International and the Carson Family Charitable Trust to continue its operations through 2029. phlnthrp.com/4jfRPfs #grantsroundup

Super excited to share the first 3D genome paper from my lab @narjournal.bsky.social , led by my smart and hardworking student Carlos (joint with @LuLaboratory) with assists from a brilliant summer intern Narjis. (1/n) academic.oup.com/nar/article/...

What happens when sequencing costs go ⏬ ? Imagination and new opportunities go ⏫ @landau.bsky.social Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇 Lets goooo!! rdcu.be/ehkUb

Our vision for Precision Omics Initiative Sweden (PROMISE) is now published in Nature Medicine! By boosting data-driven precision omics in Sweden, we can not only empower research but also integrate it with healthcare in a new way, with an impact in 🇸🇪 and 🌎. 🧵: rdcu.be/egmXY

New publication from my @nygenome.org group, in close collaboration with @wcmenglanderipm.bsky.social colleagues Jones Nauseef, Juan-Miguel Mosquera! A complex phylogeny of lineage plasticity in metastatic castration resistant prostate cancer www.nature.com/articles/s41...

We are proud to announce Bing Ren, PhD, as the new Scientific Director & CEO of the New York Genome Center Dr. Ren brings his expertise in the fields of genomics & epigenetics to the NYGC & Columbia University, where he will hold a joint appointment. For more on Dr. Ren: bit.ly/3DJXtah

For decades, government funding “has positioned the United States as a global leader” in science, says scientist Tom Maniatis of @zuckermanbrain.bsky.social and the New York Genome Center. He highlights how a new #NIH policy cutting money for research “jeopardizes” this, in Cell tinyurl.com/ubw6uphe

Former NIH director Dr. Harold Varmus joins us to discuss what cuts to the institutes’ staff and research funding could mean for science.

Super happy to announce the latest work from my lab together with Hemali Phatnani @nygenome.org & NYGC ALS Consortium! We've combined ALS patient profiling (100s!), ML classifiers and matched bulk/single-cell data to dive into ALS Molecular Subtypes #NIHfundedResearch www.cell.com/cell-reports...

We proudly recognize the 54 Nobel Laureates who have signed the NYGC’s petition urging NIH to reverse its recent policy change capping indirect funds. Thank you for your support and commitment to advancing scientific research at institutions nationwide Learn more: bit.ly/3XupqJM

Following the NIH decision to cap funding for indirect cost reimbursements at 15%, @nygenome.org Scientific Director Tom Maniatis calls for swift, united action. cell.com/cell/fulltex... Read his Commentary now in @cp-cell.bsky.social

Safeguarding the future of biomedical science in the United States, by @nygenome.org Tom Maniatis www.cell.com/cell/fulltex...

The world is on fire but we must continue doing science! With immense pride, I share the latest from my lab: privateQTL - a method for federated and secure eQTL mapping, led by my brilliant student Annie from @ColumbiaDBMI www.cell.com/cell-genomic... (1/n)

NIH's new policy (NOT-OD-25-068) capping indirect cost reimbursement at 15% threatens the future of research, training, & scientific infrastructure at research institutions nationwide. The NYGC has drafted a petition urging reversal. Please sign & share within your networks: bit.ly/40KK21a

We hope you can join us tonight at the NYGC! Register here: bit.ly/4avopX9

#MLCB2025 will be Sept 10-11 at @nygenome.org in NYC! Paper deadline June 1st & in-person registration will open in May. Please sign up for our mailing list groups.google.com/g/mlcb/ for future announcements. More details at mlcb.github.io. Please RP!

“We’re trying to maximize the research advantages available in the U.S. and Sweden respectively. And @scilifelab.se offers a unique combination of technologies that I haven’t seen anywhere else in the world” says @tuuliel.bsky.social about running labs at @nygenome.org and SciLifeLab/KTH🧪🧬

We’ve got a great lineup for the upcoming IN-PERSON New York Cancer Genomics Research Network Meeting! For more information, and to register, click here: bit.ly/4avopX9

Doctors and researchers from @mskcancercenter.bsky.social, including the NYGC's Dr. Marcin Imieliński, were featured in a @newsweek.com article on how genetic sequencing offers hope for precise and effective cancer treatments. Read more: bit.ly/4gUn8eI

We are excited to announce that Lea Davis, PhD, has joined the NYGC as an Associate Faculty Member! Learn more about Dr. Davis here: bit.ly/4jdMAxd

A touching tribute to Dr. Thomas Lehner and his distinguished career published [email protected]. www.nature.com/articles/s41...

It's an honor to be part of this lecture series to honor Casey's legacy.

🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄 In this work, superstar postdoc @xinhexue.bsky.social combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.

🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We're excited to bring PhD students together with an all-star list of leaders in human genetics. 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at www.lpshg.com

@nygenome.org polyethnic-1000 in action! #ASH24

The NYGC is proud to collaborate with the Department of Ob/Gyn at Columbia University Irving Medical Center and NewYork-Presbyterian Hospital on the Women’s Genetic Center. An initiative that aims to make whole-genome sequencing a routine part of women's healthcare. bit.ly/4hck3a8