Now online in Cancer Discovery @aacrjournals.bsky.social: A Covalent Allosteric Molecular Glue Suppresses NRF2-dependent Cancer Growth - Nilotpal Roy, Matthew Patricelli and colleagues doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Serotonin Modulates Lineage Plasticity in Neuroendocrine Prostate Cancer via Epigenetic Reprogramming - by Yiyi Ji, Cheng-Wei Ju, Lei Chen, Yinjie Zhu, Jiangbo Wei, Qi Wang, Wei Xue, and colleagues doi.org/10.1158/2159...

Look back at the AACR Journals 2025! Molecular Cancer Therapeutics welcomed Daniel K. Nomura, PhD, as Editor-in-Chief. ⏯️ Watch our interview with Dr. Nomura to learn about his vision for Molecular Cancer Therapeutics and why authors should publish with the journal: buff.ly/IehgJMq

I-Mei Siu, PhD, Senior Editor for Cancer Discovery is attending @theaacr.bsky.social Conference on The Rise in Early-Onset Cancers. If you have a question about the journal or are interested in discussing your research, reach out to her at [email protected]. @i-mei.bsky.social #AACRearlyonset25

Now online in Cancer Discovery @aacrjournals.bsky.social: Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain #Dormancy - by @amulyasreekumar.bsky.social, Lewis Chodosh, and colleagues doi.org/10.1158/2159...#Dormancy@pennmedicine.bsky.social @penncancer.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: Trends in Childhood and Adolescent Cancer Incidence Rates in the United States between 2001 and 2022 - by Meredith Shiels and colleagues doi.org/10.1158/2159...

Our recent manuscript in @aacrjournals.bsky.social Cancer Discovery! Can a high fiber diet delay progression to myeloma? doi.org/10.1158/2159... #ASH25 #mmsm

Now online in Cancer Discovery @aacrjournals.bsky.social concurrent with the #ASH25 presentation by Elvin Wagenblast: Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia - by Ke Wang, Elvin Wagenblast, et al. doi.org/10.1158/2159...

Now in Cancer Discovery @aacrjournals.bsky.social: A High-Fiber Plant-Based Diet in Myeloma Precursor Disorders – Results from the NUTRIVENTION Clinical Trial & Preclinical Vk*MYC Model doi.org/10.1158/2159...

Glad to see our article on how cancer drugs and bacterial (S. aureus) infections can affect co-existing malignant subclones very differently in cutaneous T-cell lymphoma. Thank you Cancer Discovery (@aacrjournals.bsky.social) for the beautiful title-page graphics!

The December issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features work by Yuan, Ji, Dwyer, Gray, Corsello, et al. defining the mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex. aacrjournals.org/cancerdiscov...

Are you an early career researcher who has published in Cancer Discovery or do you know someone who is? Nominations for the Cancer Discovery Early Career Award are open until Friday, January 9, 2026. View award eligibility and submit a nomination today! buff.ly/jUwZsdd

Now online in Cancer Discovery @aacrjournals.bsky.social: Now online in @CD_AACR: Molecular & Immune Correlates of Response to First-Line De-Escalated Chemotherapy + Penpulimab & Anlotinib in Advanced Cervical Cancer - by Dan Hu, Huaiwu Lu, Yang Sun, Shengtao Zhou, et al. doi.org/10.1158/2159...

"Editors and staff are fantastic to interact with. It is always easy to reach out, get feedback and suggestions." -Sandra Misale, Cancer Discovery Author See more of what our authors are saying about publishing with the Journals. buff.ly/7x8ra8e

Now online in Cancer Discovery @aacrjournals.bsky.social: DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated with Increased LSC Frequency - by Thomas Köhnke, Daiki Karigane, Ravi Majeti, et al. doi.org/10.1158/2159... @stanfordmedicine.bsky.social

You can read more about sevabertinib in the recent Cancer Discovery @aacrjournals.bsky.social article by Franziska Siegel, Matthew Meyerson, Heidi Greulich, and colleagues: doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Spatial Multiomic Analyses Reveal Carcinogenic Pathways in End-Stage Renal Disease - by Jun Takahashi, Yosuke Tanaka, Hiroyuki Mano, and colleagues doi.org/10.1158/2159...

The Cancer Discovery Early Career Award recognizes outstanding early career investigators who have authored peer-reviewed, original articles published in the journal that have made a significant impact in one or more of the fields represented by the journal. Nominations are open! buff.ly/jUwZsdd

Now online in Cancer Discovery @aacrjournals.bsky.social: PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis - by Shuang Tang, Qian Zhou, Jean, Zhao, and colleagues doi.org/10.1158/2159... #FUSCC @danafarber.bsky.social

AACR Shares Key Updates from AACR on Campus Malaysia @theaacr.bsky.social oncodaily.com/voices/aacr-... #OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews

The abstract deadline for the AACR Annual Meeting 2026 is 11:59 PM ET on Tuesday, November 18. Submit an abstract and join the cancer research community in San Diego, April 17-22. Learn more: buff.ly/dzZnhJr #AACR26

New office Lego flower 🌺

Now online in Cancer Discovery @aacrjournals.bsky.social: Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding - by Wanyi Chen, @joshdragomd.bsky.social, @saratchandarlapaty.bsky.social, and colleagues doi.org/10.1158/2159... @mskcancercenter.bsky.social

In this manuscript, online today in Cancer Discovery, we investigate target-mediated resistance to ADCs, and propose ways to overcome it. aacrjournals.org/cancerdiscov...

Tagging @joshdragomd.bsky.social!

Robert Kruger, PhD, Senior Executive Editor of Cancer Discovery, joined Zhongshan Hospital Assistant President Qiang Gao, PhD, to chair the opening session of the 2025 CACA Cancer Discovery Symposium at CCHIO 2025. We thank all of the speakers for their contributions to an outstanding program.

One week left - please reach out with your ideas, we want to hear from YOU!

Who knew? Sucralose can suppress CPI response by regulating the gut microbiome 🤯. Congrats @overacrelab.bsky.social team for this fascinating study!

The November issue of Cancer Discovery @aacrjournals.bsky.social is online! The cover features work by Diwakar Davar, @overacrelab.bsky.social, et al. showing sucralose consumption ablates cancer immunotherapy response via microbiome disruption - read that & more: aacrjournals.org/cancerdiscov...

Nominations for the 2026 Early Career Awards are open for Cancer Discovery, Cancer Research, and Clinical Cancer Research! View criteria and be the first to submit a nomination: buff.ly/Vhxuyt5

Now online in Cancer Discovery @aacrjournals.bsky.social: A Prognostic Signature for Lung Adenocarcinoma in Patients Who Have Never Smoked - by Wei Zhao, Maria Teresa Landi, and colleagues doi.org/10.1158/2159...

How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle. aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression & Progression that Can Be Reversed by Senolytic Therapy - by Lin Zhou, @marcus-ruscetti.bsky.social, and colleagues doi.org/10.1158/2159... @umasschan.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program by Mengxiong Wang, @AttardiLaura, and colleagues doi.org/10.1158/2159... @stanfordmedicine.bsky.social

One of the best parts about my recent trip to China was meeting so many previous Cancer Discovery @aacrjournals.bsky.social authors, including those who have now started their own labs! a 🧵👇

One of the best parts about my recent trip to China was meeting so many previous Cancer Discovery @aacrjournals.bsky.social authors, including those who have now started their own labs! a 🧵👇

Now online in Cancer Discovery @aacrjournals.bsky.social: Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma - by Cheng Huang, Yan Gao, Jianfeng Chen, Choon Kiat Ong, Huiqiang Huang, and Jing Tan doi.org/10.1158/2159...

Cancer Discovery Senior Executive Editor Robert Kruger, PhD, will be at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. If you have a question about the journal or want to discuss your research, please reach out to him at [email protected]. #Targets25

Now in Cancer Discovery @aacrjournals.bsky.social: A Plastic EMP1⁺ to LGR5⁺ Cell State Conversion as a Bypass to KRASG12D Inhibition in mCRC - by Alessia Centonze, Adrià-Jaume Rour, Meritxell Novillo-Font, Carme Cortina, Marc Marti-Renom, @batllelab.bsky.social, et al. doi.org/10.1158/2159...

A study published in #CancerDiscovery reveals why some colorectal cancers withstand pharmacological inhibition of #KRAS oncogene activity. Read more here ➡️ https://bit.ly/3L0Cl2G #CancerResearch #ColorectalCancer @batllelab.bsky.social#ColorectalCancer @batllelab.bsky.social  🧪

Curious about opportunities to publish in AACR Journals? Visit AACR booth #101 at #Targets25 on October 24 at 1PM to chat with in-house editors Emily Frieben, PhD, and Danielle Large, PhD, about your research and publishing opportunities.

Just got back from an amazing trip to China! (a 🧵) I started off with the warmest of welcomes to Beijing and went straight to the Great Wall!

ICYMI at #ESMO25, published concurrently in Cancer Discovery @aacrjournals.bsky.social: Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer Franziska Siegel,Matthew Meyerson, Heidi Greulich, and colleagues doi.org/10.1158/2159...#ESMO25,@danafarber.bsky.social @broadinstitute.org

A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.

Now online in Cancer Discovery @aacrjournals.bsky.social: Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGF β Axis - by Charles Earnshaw, @santiagozelenay.bsky.social, and colleagues doi.org/10.1158/2159... @cruk-mi.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression - by Daniel Azorín, Dirk Hoffmann, @winklerlab.bsky.social, and colleagues doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer - by Nofar Gumpert, Shira Sagie, @yardenasamuels.bsky.social, and colleagues doi.org/10.1158/2159...

Now online in Cancer Discovery @aacrjournals.bsky.social: HIF-2-dependent Regulation of PTHrP and Paraneoplastic Hypercalcemia in Aggressive Clear Cell Renal Cell Carcinoma - by Arijit Mal, Bingqing Xie, James Brugarolas, and colleagues doi.org/10.1158/2159...

📢Exciting news! Cancer Discovery @aacrjournals.bsky.social is issuing another call for commentaries ahead of #AACR26! The meeting's theme is "Precision, Partnership, Purpose: Advancing Cancer Science to Save Lives Globally" - we want to hear YOUR ideas on how to achieve this goal. (1/2)