Cancer Discovery @i-mei.bsky.social, PhD, will be attending @theaacr.bsky.social Special Conference on the Science of Cancer Health Disparities. If you have a question about the journal or are interested in discussing your research, please reach out to her at [email protected]. #AACRdisp25

AACR CEO Margaret Foti, PhD, MD (hc), welcomes attendees to today's release of the 15th edition of the AACR Cancer Progress Report. Read the Report: cancerprogressreport.aacr.org/progress/ #CancerResearchSavesLives® #CancerProgressReport

AACR President Lillian Siu, MD, FAACR, explains how the AACR #CancerProgressReport highlights the breakthroughs in precision medicine over the last 15 years, how they have transformed clinical care for patients, and why continued federal investment is critical to sustaining progress.

Today, we released the results of a national survey measuring voters’ attitudes about federal funding for medical research, which found 89% of voters support using federal funds for medical research, and 83% want increased funding for cancer research. Learn more: buff.ly/bBaDDVJ

The work of the 2025 AACR Journal Award recipients showcased insights with the potential to inform approaches to cancer prevention and care worldwide. Learn more on the #AACRBlog: buff.ly/ORGUU7x

Watch our interview with Minah Kim, PhD, recipient of the 2025 Cancer Research Early Career Award, to learn more about her research: buff.ly/cxZqOIR

In the September issue of Blood Cancer Discovery: “Refined Disease Classification in Myeloid Neoplasms.” Watch the interview with Dr. Sanam Loghavi. buff.ly/Nd05b1T Read the article: buff.ly/vniHKPM

Read article collections featuring impactful, cutting-edge research on Developmental Therapeutics, Early Detection, and more: buff.ly/Oi8by86

An AACR study presented at the 10th International Congress on Peer Review & Scientific Publication found authors & reviewers for the AACR journals are increasingly using generative AI, but only a small proportion are disclosing this usage as required by the journals. @peerreviewcongress.bsky.social

Cancer Research Communications’ @adscheid3.bsky.social, PhD, will be attending @theaacr.bsky.social Conference on the Science of Cancer Health Disparities. If you have a question about the journal or are interested in discussing your research, reach out to him at [email protected]. #AACRdisp25

Just like there are good and bad macrophages..., there are good and bad NK cells!! This has profound therapeutic implications, far beyond oncology! Thanks to CD for highlighting both papers and the superb and efficient editorial work! Thanks to our collaborators (especially Zihai Li) and funders!

Finally, we are OPEN! meetings.embo.org/event/26-can.... You dont' want to miss this one. Capped at 180 partecipants, so register super early to avoid disappointment. Amazing speakers, incredible location and the best vibe. Come to learn, share, discuss and enjoy some of the most exciting ideas.

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀 Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities. Sign up. Stay informed. Join the movement: www.nycures.org/

Congratulations to the team on all their hard work on developing this first of its kind model! @andreaventura.bsky.social @psalmotoxin.bsky.social @wtklab.bsky.social @kytsailab.bsky.social @moffittnews.bsky.social

📰Rogue DNA rings could provide early clues to brain cancer’s growth, according to new results co-led by Dr @benjaminwerner.bsky.social, as part of international @cancergrand.bsky.social collaboration @qmul.bsky.social | @crick.ac.uk | @stanford.edu | @aacrjournals.bsky.social | #medsky #oncosky 🧪

Research from the Cancer Grand Challenges eDNyamiC team found that rogue rings of DNA appear early in glioblastoma, a very aggressive form of brain cancer. Co-first author Imran Noorani explains how this work makes the case for early detection of these tumours. www.crick.ac.uk/news/2025-09...

⭐️The first genetically engineered endogenous cancer model in naked mole-rats 👇

Now online in Cancer Discovery @aacrjournals.bsky.social: An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole-Rat - by Alyssa Shepard, Daniel Lester, @kissillab.bsky.social, and colleagues doi.org/10.1158/2159... @moffittnews.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: ecDNA–Driven Oncogene Spatial Heterogeneity & Evolution in Glioblastoma - by Imran Noorani, @magnushaughey.bsky.social, Paul Mischel, @charlesswanton.bsky.social, @benjaminwerner.bsky.social, and colleagues doi.org/10.1158/2159...

I am very excited that Imrans and @magnushaughey.bsky.social article in @aacrjournals.bsky.social is now online. This was a great collaboration with @charlesswanton.bsky.social and Paul Mischel amongst many others. A small thread will follow below. aacrjournals.org/cancerdiscov...

Published today in @aacrjournals.bsky.social Imran Noorani & @magnushaughey.bsky.social share the first evidence that ecDNA can build up in the healthy brain before tumours form in #glioblastoma — pointing to new early intervention strategies. 👉 www.cancergrandchallenges.org/news/ecdna-u...

The September issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features work by Yuxuan Wang, Nickolas Papadopoulos, Elizabeth Platz, Bert Vogelstein, et al. showing ctDNA is detectable ≥3 years before cancer diagnosis - read that & more: aacrjournals.org/cancerdiscov...

Not only do AACR Members receive a 10% discount on publishing fees, but some AACR scientific working groups offer additional discounts on top of this. Learn more: buff.ly/12PgSmX

Watch our interview with Sandra Misale, PhD, recipient of the 2025 Cancer Discovery Early Career Award, to learn more about her research: buff.ly/viWlUSl

Now online in Cancer Discovery @aacrjournals.bsky.social: Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T Cell Polarization - by Brian Griffith, Timothy Frankel, and colleagues doi.org/10.1158/2159... @umich.edu

Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18

Now online in Cancer Discovery @aacrjournals.bsky.social: Defining the Antitumor Mechanism of Action of a Clinical-Stage Compound as a Selective Degrader of the Nuclear Pore Complex - by Linjie Yuan, Wenzhi Ji, Brendan Dwyer, Nathanael Gray, Steven Corsello, et al. doi.org/10.1158/2159...

Now in Cancer Discovery @aacrjournals.bsky.social: Detection of Brain Cancers Using Genomic & Immune Cell Characterization of Cerebrospinal Fluid via CSF-BAM - by Alexander Pearlman, Yuxuan Wang, Christopher Douville, Chetan Bettegowda, et al. doi.org/10.1158/2159... @hopkinsmedicine.bsky.social

Did you catch this #AACRBlog on artificial intelligence and cancer research? buff.ly/hfbLsYm Learn about more AI applications across the cancer research spectrum in the new series, Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI buff.ly/bHspBiz

Cancer Discovery News: Highlighting Must-Read Industry News. buff.ly/hNe0xKN

Phuong Ho participates in an NIH-funded study to identify causes of lung cancer in female Asian non-smokers—but proposed cuts could delay or cancel studies that advance cancer prevention, detection, and treatment. Please ask Congress to restore NIH investments in cancer research: buff.ly/txajooL

The 2025 AACR Journal Awards honors cancer researchers whose studies have had a significant impact in their respective fields. Visit the #AACRBlog to learn more:

A friendly reminder that the NIH Public Access Policy IS NOT “you must publish open access” but rather “you must ensure your copy of your paper is deposited into PubMed Central.” Yes, it is very confusing. Yes, you should be able to do that deposit yourself without paying anything to a journal.

You can read the @aacrjournals.bsky.social journal policy here - "The Author Accepted Manuscript is permitted to be deposited in PMC and made available to the public on or after the first online publication date of the Version of Record." aacrjournals.org/pages/open-a...

Congratulations to Veronika Lutz, PhD, Christian Bauer, MD, and colleagues, recipients of the 2025 Cancer Immunology Research Award for Outstanding Journal Article. Learn more: buff.ly/E623akQ

Learn how AACR’s #openaccess, peer-reviewed journal—Cancer Research Communications—supports authors from presubmission through publication: buff.ly/NTCCGgR

Congratulations, Tingting Zhai, PhD, recipient of the 2025 Cancer Prevention Research Award for Outstanding Journal Article. Learn more: buff.ly/MD6MAnZ

Read article collections featuring impactful, cutting-edge research on Clinical Trials, Immuno-oncology and more: buff.ly/Oi8by86

In the United States, cases of early-onset cancer are on the rise. Featured in a recent #AACRBlog on early-onset cancer, this Cancer Discovery article explores how changes in risk factor prevalence and/or improvements in detection could affect risk across an age range. Read more: buff.ly/NLssp4H

The @fda.gov granted accelerated approval to the protease activator dordaviprone for patients 1 year old and older with H3 K27M-mutant diffuse midline glioma whose disease progressed following prior therapy. This Cancer Discovery article was part of the basis for this new approval: buff.ly/HDZuqK0

Now online in Cancer Discovery @aacrjournals.bsky.social: Integrative Proteogenomics & Forward Genetics Reveals a Novel Mitotic Vulnerability in TNBC - by Nicholas Neill, Shankha Satpathy, Trey Westbrook and colleagues doi.org/10.1158/2159... @bcmfromthelabs.bsky.social @broadinstitute.org

Read the Tumor Evolution Collection: buff.ly/VvSxo7I Through state-of-the-art clonal lineage tracing, single-cell multiomics, and evolutionary analyses, these studies represent important advances that inform the future development of optimal strategies to prevent, diagnose, and treat human cancer.

Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...

Schlafende Krebszellen im Visier Neuroblastome, an denen vor allem Kinder erkranken, sind oft schwer zu behandeln. Forschende um Jan Dörr und Anton Henssen vom ECRC haben entdeckt, woran das liegen könnte. In „Cancer Discovery“ schlagen si... weiterlesen

Excited to announce a new paper in ‪@aacrjournals.bsky.social‬ with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies: aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Evaluation of GAPs & GEFs Identifies a Targetable Dependency for Hematopoietic Malignancies - by Pu Zhang, Zhendong Cao, Anthony Daniyan, Omar Abdel-Wahab, Junwei Shi, et al. doi.org/10.1158/2159...

ICYMI last year in Cancer Discovery @aacrjournals.bsky.social: Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-driven Cancers – by Birgit Wilding, Ralph Neumüller, et al. doi.org/10.1158/2159...

I am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social. @anton-henssen.bsky.social @cancergrand.bsky.social aacrjournals.org/cancerdiscov...

“However, participation remained below cancer incidence rates for Hispanic/Latino and non-Hispanic Black patients, and was negligible among American Indian and Alaska Native populations.”