Seven years. Over 400 pages. About 750 references. Over 40 figures. Finally I get to hold the finished book. It’s a big day. #EpigeneticsBook @cshlpress.bsky.social

Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀 Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com 📄 www.nature.com/articles/s41... 🧵1/n

Major advance for refractory lupus by engineering the T cells in the patient's body (in vivo) and achieving success in 5 patients @nejm.org (uses mRNA/nanoparticle package) www.nejm.org/doi/full/10....

Interested in cellular plasticity? Come to my live virtual talk at the Night Science Seminar Series! Free register here: cassyni.com/events/ApfsK...

I feel deeply honored to receive the 2025 Dr. Josef Steiner Cancer Research Award for our work on decoding and rewiring the immune-evasive TME. It truly is a recognition of the entire team past and present as well as our collaborators and mentors.🙌 Thank you for your trust!

2. www.nature.com/articles/s41...

Paper from me, Michelle Curtis, @soumya-boston.bsky.social and co out now in @natmethods.nature.com! We now call it starCAT instead of *CAT but the strategy is the same: Build a catalog of ~50 interpretable T cell gene expression programs + use them to interpret new data nature.com/articles/s41...

Microbiomes are interactive, multispecies communities, but bulk analysis obscures functional diversification from environmental and genetic heterogeneity. In our new review we describe how single-bacterium transcriptomics dissects microbiomes at cellular resolution. www.science.org/doi/10.1126/...

Postscript by Seamus Heaney who died twelve years ago today

Looks interesting! www.nature.com/articles/s41...

🧨Exciting new pre-print 🧨 Introducing ppmSeq - cost effective, scalable dual-strand 🧬🧬 sequencing. Scalability & ultra-low error in one! A game changer for somatic genome discovery science and cfDNA clinical apps. Check out thread for deets!

Donald Judd

Sapporo cancer meeting

Amichai

Robert Creeley

Wonderful discussion with @landau.bsky.social visiting us at @institut-leucemie.bsky.social @hopitalsaintlouis.bsky.social in sunny Paris to give an inspiring talk on cutting-edge single-cell technologies. Thank you so much Dan for stopping by and see you soon! @lobrylab.bsky.social

Excited to share our exploration @naturemethods.bsky.social into new horizons opening up in the era of low cost sequencing! 🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD 🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA Check out thread 👇

To celebrate National Poetry Month at @georgiatech Poetry@Tech put up our Pause for Poetry yard signs all over campus @gt_lmc thanks to @expeditionpress for helping to curate our lines @ivanallencollege.bsky.social

If Trump can disappear green card holders for protesting war, he can disappear you. If he can disappear visa holders for criticizing him, he can disappear you. If he can disappear asylum seekers for tattoos, he can disappear you. We must speak out now — before there is no one left to speak out.

Say what you want about the camera person. This is remarkable to watch

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

and so it begins...

Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW! woodstock.img.cas.cz

Rest in power to an absolute queen. What a wonderfully talented person. Her solo work is incredible, and her duets with Donny Hathaway are immortal. Thank you for everything, Ms. Flack. variety.com/2025/music/n...

Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon

Wishing everyone a Jo & Ab 2025!

His friends will never believe him. They also may never see him again.

Happy winter solstice 🌌

Rainbow | DH Lawrence. It takes you in for generations, to marvel at how we continuously search for our deeper selves & for others. Each interiority is a garden of delight, provided that it is seen with loving (and curious) eyes. "And the waters shall no more become a flood to destroy all flesh."

Winged wings

In the shape of a human body I am visiting the earth; The trees visit In shapes of trees. --Malena Morling

Advice for anyone using terms in science

Hayden Carruth, written to his daughter at the end of The Bloomingdale Papers

We have a fantastic lineup of invited speakers: Mike Stratton, @nlbigas.bsky.social @kelleyharris.bsky.social @mollyprz.bsky.social @bloodgenes.bsky.social @landau.bsky.social @atjcagan.bsky.social @elinork.bsky.social @petrovadmitri.bsky.social Melissa Davis, Bob Handsaker and Jimmy Bennett

I feed it Roberta Iannamico, tr. Alexis Almeida

if you're looking for books to read (or to offer) before the end of the year, 2 related recommendations: The Maniac by Benjamin Labatut (en.wikipedia.org/wiki/The_MAN...) Playground by Richard Powers (www.richardpowers.net/playground/)

Shane MacGowan who died a year ago today A hungry sound came across the breeze So I gave the walls a talking And I heard the sounds of long ago From the old canal And the birds were whistling in the trees Where the wind was gently laughing "A Pair of Brown Eyes"

Michel Foucault and his cat, Insanity

Incredible read by the brilliant Megan Nolan. So many layers. And the deeper strata of teshuvah as the power to reach back into time and change the meaning of past actions.

'I much prefer the British spelling of “diarrhea” which is “diarrhoea” because it looks like you’ve lost control of your vowels.' -- Sal Robins

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...