Michael Kharas
@kharaslab.bsky.social
📤 211
📥 28
📝 3
Professor scientist lab head
reposted by
Michael Kharas
Vijay G. Sankaran
about 1 month ago
And nice coverage by
@angusrohan.bsky.social
from
@statnews.com
(3/n):
www.statnews.com/2026/01/01/b...
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Genetic variant appears to protect some people against certain blood cancers
Researchers found a genetic variant that appears to protect against the development of CHIP, a phenomenon that can lead to certain blood cancers
https://www.statnews.com/2026/01/01/blood-cancer-protective-genetic-variant-found-in-study/
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reposted by
Michael Kharas
Vijay G. Sankaran
about 1 month ago
Please check out this terrific preview from Caido & Manz (2/n):
www.science.org/doi/10.1126/...
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Genetic resistance to leukemia
A genome-wide association study identifies a genetic variant that reduces the risk of leukemia
https://www.science.org/doi/10.1126/science.aed5244
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reposted by
Michael Kharas
Vijay G. Sankaran
about 1 month ago
Delighted to have our work on 🧬 resilience to 🩸cancer led by
@g-agarwal.bsky.social
& amazing collaborators, including
@kharaslab.bsky.social
, published in
@science.org
:
www.science.org/doi/10.1126/...
🧵
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reposted by
Michael Kharas
Eric Topol
about 1 month ago
New
@science.org
today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
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Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
http://science.org/doi/10.1126/science.adx4174
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HAPPY 4th and excited to be part of this. Congrats to the talented Dr. Harold Elias for getting this epic Nature Comm story
rdcu.be/euQb7
on how kitlow HSCs have superior thymic reconstitution. Big congrats to Marcel Van Den Brink and all of our collaborators!! .
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Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution
Nature Communications - Hematopoietic stem cells (HSCs) differentiate into multiple lineages, with such capacity impacted by aging. Here the authors identify Kitlo HSCs as a functionally distinct...
https://rdcu.be/euQb7
7 months ago
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reposted by
Michael Kharas
Vijay G. Sankaran
11 months ago
So proud of this incredible work from
@g-agarwal.bsky.social
from our group with help from many fantastic folks in our lab and inspiring collaborators, including
@kharaslab.bsky.social
, Alex Bick,
@yashpershad.bsky.social
, and many others! Please check out Gaurav's awesome 🧵👇👇
add a skeleton here at some point
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