Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025

Interested in #hematopoiesis 🩸? Please join us at the @keystonesymposia.bsky.social Hematopoiesis meeting with an amazing lineup (only some of whom are shown) this February! Poster Abstracts due by February 3rd. #KSHemato26 keysym.us/KSHemato26

Dysregulated activation responses is a defining feature of HSPC aging and establish proliferative stress–based xenotransplantation is a powerful platform for investigating age-related hematopoietic dysfunctions @jem.org @dimiccolab.bsky.social rupress.org/jem/article-...

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

Rest in peace. We need to develop better treatments for so many individuals impacted by 🩸 and other cancers!

Enjoyed writing this commentary with @g-agarwal.bsky.social for @bloodjournal.bsky.social: ashpublications.org/blood/articl... Covers an exciting paper from Tapper and co: ashpublications.org/blood/articl... #mpnsm

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Excited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇

Really enjoying "Mia the Marvelous Lab Explorer: The Case of Leo’s Missing Energy" by @kmirza.bsky.social and Lotte Mulder, while mom is out treating children like Leo with leukemia!

What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music @science.org science.org/doi/10.1126/...

Terrific to have our paper, led by @tjflemin.bsky.social, featured as a plenary article in @bloodjournal.bsky.social today: ashpublications.org/blood/articl...

Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model? This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io www.biorxiv.org/content/10.6...

A major advance in cancer using multimodal AI to do virtual proteomics of H&E slides, unraveling the tumor microenvironment, key proteins, biomarkers, and informing prognosis @cellcellpress.bsky.social @hoifungpoon.bsky.social @msftresearch.bsky.social cell.com/cell/fulltex...

A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients www.nejm.org/doi/full/10....

Inspiring presentations by Radek Skoda & Ruben Mesa for the Beutler prizes and lectures!!! So incredibly well deserved! #ASH25

Amazing talk from Nancy Speck, who is the 2025 recipient of the E. Donnall Thomas Lecture and Award from @ash.hematology.org!!! Congratulations, Nancy! #ASH25

Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award! @ash.hematology.org President Dr. Avalos was honored to present these at #ASH25

Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25

Really enjoyed the fantastic session we had yesterday on applications of AI in hematology at #ASH25 with @wondermixtape.bsky.social, Sanam Loghavi, and @kdpsingh.bsky.social!

Please encourage undergraduates with an interest in biomedical research to apply! Deadline is December 22. $15,000 stipend for the 9 week @hhmi-science.bsky.social Cech Fellows Program.

Practice changing plenary #ASH25‼️ Iron is hypothesized to feed infxn & IV iron often avoided in that setting. >85k people hospitalized w/5 most common bacterial infxns, compared those who recvd IV iron to those who did not. 🩸greater hemoglobin increase 🩸lower mortality at 14 & 90 days

The NIH grant cuts in 2025 www.nytimes.com/interactive/...

Gift link for NY Times article on cuts at NIH and NSF: www.nytimes.com/interactive/...

New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...

How did the devastation of the atomic bombings 80 years ago ultimately help give rise to bone marrow transplantation and modern #stemcell biology? Our historical commentary with Jonas Gudera in @natcellbio.nature.com explores these unappreciated connections: www.nature.com/articles/s41...

In this Nature Medicine paper, we draw from our experiences in evaluating and implementing #genomics in Australia, Canada, England, Hong Kong and the US www.nature.com/articles/s41...

Massive single-cell study by Kanai et al (www.medrxiv.org/content/10.1...): - Once statistical power is high, constrained genes have more (though weaker) eQTLs. - Chromatin-QTLs near constrained genes have "normal" effect sizes, colocalize more with disease, but exhibit attenuated peak-gene effects.

Grateful to Isabella Alves & @cterminiphd.bsky.social for writing this fantastic N&V in @natcellbio.nature.com: www.nature.com/articles/s41... Nicely covers our 📰 led by della Volpe & co: www.nature.com/articles/s41...

🩸 Dr. Lucrezia della Volpe and a team in Dr. Vijay Sankaran's lab (@bloodgenes.bsky.social) discovered that ferroptosis is a key barrier to HSC survival during ex vivo culture. Read their @natcellbio.nature.com paper: https://go.nature.com/4ib4Ln6 Listen to the discussion: https://bit.ly/48dmghX

The US government support of cancer research via NCI has been severely cut. And of June 2025, "There were 181 individual terminated NCI funded grants, with a total award amount of $640,867, 956." jamanetwork.com/journals/jam...

Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank! A thread... 🧵 www.medrxiv.org/content/10.1...

If you have not read this moving and courageous essay from Tatiana Schlossberg in the @newyorker.com, please check it out. You may be wondering why inv(3) leukemia is so deadly? Here is a brief 🧵 (1/n)

I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵

Your bloodstream is a battlefield and a delivery service, all at once! 🩸🧪 Quinten Geldhof, also known as Microhobbyist, takes you into a drop of blood to explain how red blood cells lack a nucleus so they can carry more oxygen throughout your body. Watch the video here:

New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment science.org/doi/10.1126/... science.org/doi/10.1126/... @science.org

Ferroptosis and 🩸 stem cell biology have a lot to say to each other... Hoping this work inspires #ferroptosis researchers to explore HSCs and #hematopoiesis researchers to lean into ferroptosis 🤝

Excited to share our new study, led by @dellaVolpe_L, now out in @natcellbio.nature.com! Blocking #ferroptosis enhances human 🩸 stem cell expansion, with implications for transplantation and gene therapy. www.nature.com/articles/s41...

Honored to be recognized by @usnews.com as a 2025 #BestLeader alongside so many incredible colleagues and individuals I admire! www.usnews.com/news/best-le...

Really excited for this session at #ASH25 💻🧠🩸!! Please come and join us on Saturday, December 6th, at 4 pm!

Therapeutic benefit of intratumoral inhibition of FSP1 & ferroptosis in pre-clinical lung cancer and versus melanoma growth in lymph nodes @nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

Great to see these fantastic studies defining thymic stromal cells that could enable regeneration of T cells from @ScaddenLab (mesenchymal) and from @dudakov-lab.bsky.social, @DrMvandenBrink, and colleagues (epithelial): www.nature.com/articles/s41... www.nature.com/articles/s41...

Really fortunate to have had the privilege to work with Parmesh Thakoordial! Congratulations, Parmesh!!! www.albany.edu/news-center/...

What happens to our immune system with aging, reducing vaccine response? Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production @alleninstitute.org @nature.com www.nature.com/articles/s41...

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

New findings from Xiaohui Zhang, Bo Huang et al. not only elucidate the molecular mechanism of JAK2V617F essential #thrombocythemia but also provide a potential strategy for its treatment. rupress.org/jem/article/... #Hematopoiesis

Terrific work from @kyleferchen.bsky.social, @nathansalomonis.bsky.social, @leegrimeslab.bsky.social, and colleagues that advances our understanding of hematopoiesis by integrating multiple single-cell data types in @natimmunol.nature.com: rdcu.be/eL8oO

If you are stuck in an airport, it is made so much better by having friendly hematologists around!🩸

1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from? Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria. www.biorxiv.org/content/10.1...