Saddened to learn of the death of Greg Hannon, a former CSHL colleague and giant of modern molecular biology www.cruk.cam.ac.uk/news/in-memo...

I wrote about why every lab should have AI use guidelines, and how to do it. open.substack.com/pub/blekhman...

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz.bsky.social, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: www.biorxiv.org/content/10.6...

Amazing group!!! Congratulations!!! 👏👏👏

Amazing documentary on cystic fibrosis 🫁 and Michael Welsh’s extraordinary contributions to therapies that have transformed so many lives: www.youtube.com/watch?v=PIXC...

Our thymus gland, neglected and assumed to be non-functional in adults, is taking center stage for healthy aging. Two new landmark studies erictopol.substack.com/p/your-thymu...

🚨🧬🩸 Delighted to have this @naturerevgenet.bsky.social review w/ Michael Poeschla published today - Genetic Influences on #hematopoiesis: rdcu.be/e9vlD

Incredibly fortunate to work with this amazing team and to learn from them every day!! @hhmi-science.bsky.social @bostonchildrens.bsky.social @danafarber.bsky.social @broadinstitute.org

erictopol.substack.com/p/the-missin... A biomarker you might want to know about

Great to see a complementary screen from the @fda.gov identify #ferroptosis inhibition as critical for expanding human 🩸 #stemcells in @moltherapy.bsky.social: www.cell.com/molecular-th... Nicely supports our prior findings: www.nature.com/articles/s41...

1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis. www.nature.com/articles/s41...

Happy to share the final version of the study where we describe a central role for vitaminB2 in regulating membrane redox state - some new cool experiments were added since the preprint was posted - pls check this out thttps://www.nature.com/articles/s41556-025-01856-x

🙏 🙏 @samhegde.bsky.social!! Fantastic talk at #KSHemato26 from @gaoteng.bsky.social on our recent advances in mitochondrial 🧬 lineage tracing! Please check out the preprint: www.biorxiv.org/content/10.6...

Join us in congratulating the award winners from the National Heart, Lung, and Blood Institute, @niaidnews.bsky.social, and the Keystone Symposia Future of Science Fund at #KSHemato26 in Keystone! 👏 #FutureofScience #hematopoiesis #bonemarrow @bloodgenes.bsky.social @beaudinlab.bsky.social

Check out this fascinating MPRA in human hematopoietic cells from Satish Nandakumar, @tewhey.bsky.social, and team!! www.biorxiv.org/content/10.6...

Antibodies harvested from the blood of paediatricians are up to 25 times better at protecting against the common respiratory infection RSV than existing antibody therapies, and are now being developed as preventative treatments

The $100 whole human genome sequence finally reached! www.sandiegouniontribune.com/2026/02/19/s...

Fascinating article by the insightful @jasonmast.bsky.social!! Maybe 🩸 stem cell expansion could help?: www.nature.com/articles/s41...

Exciting clinical study in @nejm.org from Cherqui Lab @ucsdhealth.bsky.social showing how 🩸 stem cell 🧬 therapy can treat cystinosis, a lysosomal metabolic disorder! Expanding the scope of 🩸🧬 tx! www.nejm.org/doi/full/10....

Fascinating paper in @nature.com today about how 🧬 variant impacting cyclin D3 alters malaria infectivity of red cells! www.nature.com/articles/s41..., www.nature.com/articles/d41... ... Follows up on some of our original studies from over 14 years ago: genesdev.cshlp.org/content/26/1...

Check out this important advance in mitochondrial 🧬 lineage tracing by @gaoteng.bsky.social and @wengchen.bsky.social from our group, in collaboration with @jswlab.bsky.social 👇👇

@biorxivpreprint.bsky.social Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans www.biorxiv.org/content/10.6... @bloodgenes.bsky.social @jswlab.bsky.social @bostonchildrens.bsky.social @hhmi-science.bsky.social @broadinstitute.org

🙏 🙏

Really grateful to all the wonderful folks at @yalecancer.bsky.social for hosting me, particularly @halenelab.bsky.social!! 🙏 🙏

Another major triumph for a refractory autoimmune disease—hemolytic anemia—through engineered T cells @nejm.org nejm.org/doi/full/10....

Thank you to @aacrjournals.bsky.social and Elie Dolgin for this wonderful piece covering our work! Features great insights from Danielle Hammond & Lachelle Weeks: aacrjournals.org/cdnews/news/...

Enjoyed writing this Preview with Jonas Gudera on GoT-Multi 🪄 A powerful #singlecell approach from the teams of Anna Nam and @lgmartelotto.bsky.social Preview: www.cell.com/cell-genomic... Paper: www.cell.com/cell-genomic...

Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025

Interested in #hematopoiesis 🩸? Please join us at the @keystonesymposia.bsky.social Hematopoiesis meeting with an amazing lineup (only some of whom are shown) this February! Poster Abstracts due by February 3rd. #KSHemato26 keysym.us/KSHemato26

Dysregulated activation responses is a defining feature of HSPC aging and establish proliferative stress–based xenotransplantation is a powerful platform for investigating age-related hematopoietic dysfunctions @jem.org @dimiccolab.bsky.social rupress.org/jem/article-...

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

Rest in peace. We need to develop better treatments for so many individuals impacted by 🩸 and other cancers!

Enjoyed writing this commentary with @g-agarwal.bsky.social for @bloodjournal.bsky.social: ashpublications.org/blood/articl... Covers an exciting paper from Tapper and co: ashpublications.org/blood/articl... #mpnsm

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Excited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇

Really enjoying "Mia the Marvelous Lab Explorer: The Case of Leo’s Missing Energy" by @kmirza.bsky.social and Lotte Mulder, while mom is out treating children like Leo with leukemia!

What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music @science.org science.org/doi/10.1126/...

Terrific to have our paper, led by @tjflemin.bsky.social, featured as a plenary article in @bloodjournal.bsky.social today: ashpublications.org/blood/articl...

Our latest preprint revisits the classic model of mutation-selection balance. Do human recessive genes fit Haldane's 100-year old model? This work is by the wonderful @jonj-udd.bsky.social, and co-mentored by @jeffspence.github.io www.biorxiv.org/content/10.6...

A major advance in cancer using multimodal AI to do virtual proteomics of H&E slides, unraveling the tumor microenvironment, key proteins, biomarkers, and informing prognosis @cellcellpress.bsky.social @hoifungpoon.bsky.social @msftresearch.bsky.social cell.com/cell/fulltex...

A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients www.nejm.org/doi/full/10....

Inspiring presentations by Radek Skoda & Ruben Mesa for the Beutler prizes and lectures!!! So incredibly well deserved! #ASH25

Amazing talk from Nancy Speck, who is the 2025 recipient of the E. Donnall Thomas Lecture and Award from @ash.hematology.org!!! Congratulations, Nancy! #ASH25

Congratulations to Dr. Jorge Di Paola for winning the 2025 ASH Mentor Award and Dr. Diane Krause for winning the ASH Advancing Inclusive Excellence Award! @ash.hematology.org President Dr. Avalos was honored to present these at #ASH25

Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25

Really enjoyed the fantastic session we had yesterday on applications of AI in hematology at #ASH25 with @wondermixtape.bsky.social, Sanam Loghavi, and @kdpsingh.bsky.social!