Abstracts & scholarship apps for #KSHemato26 are due Oct 29—but @beaudinlab.bsky.social explains why you should submit early! 🎥 youtu.be/FcO6D87EC_Q Join us Feb 23–26, 2026 in Keystone, CO 👉 keysym.us/KSHemato26 @bloodgenes.bsky.social #hematopoiesis #bonemarrow #hematopoieticstemcells

Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀 Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com 📄 www.nature.com/articles/s41... 🧵1/n

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

Such an important article on the challenges facing our ability to develop 🧬 gene therapies for genetic 🩸 disorders: www.nytimes.com/2025/09/22/h...

Today is World Marrow Donor Day! We hope you will join us today in thanking the selfless individuals who register and donate stem cells to save the lives of patients in need. #WMDD25 #PedsHemeOnc #PHODocs #hematology

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Congratulations to this amazing group who received the @laskerfdn.bsky.social awards!!! www.nytimes.com/2025/09/11/h...

Check out MitoScribe in our new preprint led by Linhan Wang: www.biorxiv.org/content/10.1... It's an analog molecular recorder that uses neutral base edits to the mitochondrial genome to store information about historical signaling in a cell. Single cell resolution at scale (see next post)!

RIP David. So fortunate to have had the opportunity to interact with David and to have worked with many of his trainees, including his last graduate student. www.nytimes.com/2025/09/07/s...

Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

Your DNA sequence reveals a rare mutation. Will you get the disease, i.e. penetrance? A new study using machine learning predicts this across 10 common diseases, 1,600 genomic variants New @science.org science.org/doi/10.1126/...

Grateful for this terrific commentary by @tomonroe.bsky.social in @jclinical-invest.bsky.social on our paper that is out in final print format today: www.jci.org/articles/vie... Please check it out: www.jci.org/articles/vie...

Delighted to share that our @natimmunol.nature.com paper has now a fantastic News & Views 🔗 www.nature.com/articles/s41... Thank you, @esegura-lab.bsky.social, for a clear and thoughtful summary 🙏 And thanks to our 3 amazing reviewers: your feedback made this work stronger. Peer review at its best!

Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in @natrevcancer.nature.com 🧬 Great to work with @sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...

Online now! Tumor dynamics & spatial proteomics-informed personalized predictions of growth & response Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer www.biorxiv.org/content/10.1...

Amazing choice for this incredible program! Meeting Alice 22 years ago had a lasting impact on my career trajectory!

Excited to share our new preprint, led by Kirandeep Deol! 🤩 Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to ferroptosis. www.biorxiv.org/content/10.1...

🚨Preprint alert 🚨 We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants. www.biorxiv.org/content/10.1.... pls check @olzmannlab.bsky.social www.biorxiv.org/content/10.1... #ferroptosis #FSP1 #antioxidants

New online! Towards improved fine-mapping of candidate causal variants

Very excited that our most significant work, a collaboration w/ Dr. Can Cenik at UT Austin on translational gene regulation, was finally published in Nature Biotechnology in a dual set of studies: Paper 1 -- an AI model trained to predict translation rates from mRNA sequences: rdcu.be/exN1l

Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in @nature.com by @glennislogsdon.bsky.social & colleagues. 👇🧬🧪

Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

Full text is now up 🩸🧬: www.biorxiv.org/content/10.1...

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

Delighted to have our preprint led by @lvchosen1.bsky.social up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells biorxiv.org/content/10.1... 🧵 below ...

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

Wow!!! Big advance for women with pathogenic mitochondrial DNA variants in @nejm.org! www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

New paper by Luke O'Connor @lukeoconnor.bsky.social and Guy Sella @gs2747.bsky.social

Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social

Really valuable resource in @natcellbio.nature.com from @ninacabezas.bsky.social and team - Metabolomic and lipidomic profiling of human hematopoietic stem and progenitor cells: www.nature.com/articles/s41...

How much of the TCR repertoire can we make sense of? Can your TCR and GEX data be put in the context of other conditions/tissues? How many varieties of T cells are in the repertoire zoo? All these questions (& more) addressed in our latest preprint: MetaCoNGA www.biorxiv.org/content/10.1... . a 🧵

Wow!!! Such a wonderful choice! Congratulations, @neilshubin.bsky.social!!!

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

Amazing to see the broadening reach of HSC transplant-based therapies!!! 🩸 -> 🧠 www.science.org/doi/10.1126/...

Child walks again after receiving experimental treatment for rare genetic condition www.statnews.com/2025/07/09/n... via @statnews.com

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

[email protected]‬, @romberglab.bsky.social‬ and @bloodgenes.bsky.social‬ review how genetic variation impacts early B cell development, & discuss inherited rare variants & more common polymorphisms that predispose to B cell-related immune disorders & malignancies rupress.org/jhi/article/...

Wow!!! 👏👏👏 Amazing to see this develop over the years! www.nytimes.com/2025/06/20/h...

Atul Butte died yesterday. The world lost a giant. A big bear of a man. With a huge smile. With love for everyone. With energy that could power a room. I loved everything about Atul. I loved how he was always happy. I loved how excited he was about science and helping people.

UPDATE ON NON-COMPETITIVE RENEWALS Since I always want to get the facts right, I checked NIH Reporter this morning. Part of the issue was unusually slow uploading of data to NIH Reporter (more NIH dysfunction, just different). Better, but still fewer than half of the awards due in May were made.

Who funds biomedical research? @nature.com www.nature.com/articles/d41...

The proposed deep cuts to the NIH budget will hit biotechs-in fact, the upheaval already is affecting some. In addition to hobbling academia, where innovation starts, it'll shrink the gov seed $ that tiny firms, esp those outside biotech hubs, rely on. My latest @opinion.bloomberg.com (🎁 link):

👇 An insidious situation emerging at NIH!

Check out this fantastic plenary paper from @katanlab.bsky.social and colleagues in @bloodjournal.bsky.social: tinyurl.com/mr9nzj3k Michael Poeschla and I had the privilege to write a commentary, "Getting to the root of high-risk leukemias" tinyurl.com/htf3e8d2

Fascinating!!! Always more to learn about the globin loci! 🩸🧬 genomebiology.biomedcentral.com/articles/10....

Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...