Every conference should have easy access to a major body of water and spritz @jclandoni.bsky.social

Asymmetric mitochondrial trafficking balances perinuclear biogenesis to maintain network morphology. New study from Julius Winter (@julius-w.bsky.social), Juan C. Landoni (@jclandoni.bsky.social), Suliana Manley (@sulianamanley.bsky.social) et al. (EPFL): rupress.org/jcb/article/... #Mitochondria

Still buzzing from #EUROMIT2026. What a reminder of how exciting and inspiring the #mito -community is, and an honour to present my work (and my new lab!) to this amazing crowd. What a week, thank you all! #Euromit2026 #Mitochondria

Check out this amazing video by @julius-w.bsky.social (lead author) summarising our paper out this week! doi.org/10.1083/jcb....

@julius-w.bsky.social @jclandoni.bsky.social @sulianamanley.bsky.social et al reveal that perinuclear #mitochondria form a source population, w/ biased anterograde transport spreading material to maintain network connectivity & balanced mitochondrial mass across the cell rupress.org/jcb/article/...

We had such a fun ERC Synergy @erc.europa.eu kickoff workshop for our 6-year MitoContact collaborative project with our partners Kai Johnsson and Wanda Kukulski! Wonderful to share science, ideas, and play games together 💚 fantastic organization by @zimmerli.bsky.social @jclandoni.bsky.social

My first corresponding author 🔬🎸🦾 rupress.org/jcb/article/... Ever wonder what the ultrastructure of dopaminergic neuron presynaptic sites looks like? Using cryo-CLEM/ET we observed the wild changes that happen at these sites when the neurons fire or are more quiet. In the latest @jcb.org

We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social

Juan is awesome! If you like mitochondria and imaging you should work with him

We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below! @fbm-unil.bsky.social @unil.bsky.social

Trainees jump on this! Juan is an awesome human and he’s gonna do some amazing science ✨ Can’t wait to see what he gets up to!

Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/ www.pnas.org/doi/10.1073/...

The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI

My favorite paper in 2026 so far!! Absolutely stunning 🤩

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Mitochondria use a shape-shifting process called "pearling" to evenly distribute their DNA, supporting cellular health and offering new insight into mitochondrial genome organization.

Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

Wonderful and honoured to write a perspective with @prudentlab.bsky.social @mrc-mbu.bsky.social on such an intriguing and cool observation of beautiful mitochondrial biology! Amazing work on how pearling allows mitochondrial genome organisation by @jclandoni.bsky.social @sulianamanley.bsky.social!

Check out the fantastic perspective by @jellevda.bsky.social & @prudentlab.bsky.social on our #pearling work, out in the same @science.org issue! www.science.org/doi/10.1126/...

Easter edition of #Mitochondria in #Health and #Disease! 🐰🐣 biomed.news/bims-mitdis/... @gavinmcstay.bsky.social @mitoscientist.bsky.social @biomednews.bsky.social @mitoscientists.bsky.social Perling drives mtDNA nucleoid distribution www.science.org/doi/10.1126/...

See how PKMito dyes promote mitochondrial research😀 @spirochrome.com

Could this organelle get any cooler? 🤩 Check out this incredible paper by the Juan and only @jclandoni.bsky.social

The longstanding mystery for how mitochondria segregate and position their DNA has been solved! Read all about it: www.science.org/doi/10.1126/... @jclandoni.bsky.social Here is Juan and I at the 4th of July parade at MBL physiology

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

“Why Did This Evolve? It Didn’t. It Was Already There” - @jclandoni.bsky.social 👉 www.iflscience.com/why-did-this...

A #PhD student's documentation of a senior #postdoc in his natural habitat.

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪 www.annualreviews.org/content/jour... #Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

Remote work in 🇨🇭 can look beautifully strange 🚂🏔️

Rare diseases are not so rare. Make a difference: www.rarediseaseday.org #RareDiseaseDay

Our story on #FBXW7 and #biotin in #glutamine_addiction is now peer-reviewed and published in Molecular Cell! Heroic work led by the very first postdoc of the lab @miriamlisci.bsky.social. Have a look! www.cell.com/molecular-ce...

🥜🦀 A research group @jourdainlab.bsky.social @dib-unil.bsky.social @fbm-unil.bsky.social @unil.bsky.social has identified a new mechanism that exposes the vulnerability of #tumor #cells when they are deprived of #vitamin B7, also known as #biotin. Press release here 👉 www.unil.ch/news/en/1770...

Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social : www.biorxiv.org/content/10.6...

The "PIs of Tomorrow" competition at #LS2AM26 was such a fantastic experience, huge thanks to the org team and jury who shared their invaluable advice with us! And thanks to the audience for voting me the popular vote winner! 🎉 If you have the chance to participate of #PIOT you definitely should!

The "PIs of Tomorrow" competition was such a fantastic experience, huge thanks to the great jury who shared their invaluable advice with us, and all the @lifesciswitzerland.bsky.social AM organisers!

Thanks for highlighting our work on combining AI-based organelle dynamics detection in phase contrast with fluorescence! www.nature.com/ncomms/edito... @natcomms.nature.com and Nelio Rodriguez. Spearheaded by @wl-stepp.bsky.social with collaborators @jclandoni.bsky.social @maweigert.bsky.social

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

🎸Why this is exciting!!🦖 Quantitative super-resolution often requires genetically encoded tags to get labeling sufficient for quantitative imaging. Here with qExM we use commercial antibodies for endogenous targets. This opens HUGE opportunities to count in tissues, organisms, or clinical samples!

We then used qExM to measure the abundance of mitochondrial respiratory chain complexes in situ! We measured the abundances for Complex I, III, and IV. How they differ in absolute abundances in metabolically distinct subpopulations And even how T-cell activation changes supercomplex density

How does qExM work? We use cryo-fixation + GMA anchoring to boost antibody labeling efficiency, then apply capture-recapture statistics to dual-labeled samples. The expansion makes epitopes more accessible while reducing label size relative to targets - perfect for quantitative imaging!

We validated qExM first on nuclear pore complexes, attempting to quantify the 8 fold symmetry without using this prior knowledge. We achieved a mean error of just 9.4% 😍🔬🎸 With these tools in place we moved to tackle protein complex abundances that were unknown....

🔬🚨New preprint alert! 🚨🔬 We developed quantitative expansion microscopy (qExM) - a method to accurately count proteins in situ by combining expansion microscopy's improved labeling with statistical estimators borrowed from ecology www.biorxiv.org/content/10.6... #SuperResolution #CellBiology

#Mitochondria or Alien script? 🧪🔬👽

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site #microscopy #ImageJ #FluorescenceFriday #microscopyMonday imagej.net/plugins/imag...

Accidentally festive #Celegans gonad while trying out some awesome LUTs by @kwolbachia.bsky.social for #FluorescenceFriday 🧪🔬

The PIs of Tomorrow session is part of the LS² Annual Meeting 2026. We have now chosen our 4 finalists: Theodora Constantin Juan Cruz Landoni Olimpia Bompadre Alaz Özcan More info: annual-meeting.ls2.ch/2026/special... Join our AM to see their talks: annual-meeting.ls2.ch/2026/registr...

#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added! #Mito #Mitochondriac go.bsky.app/J6Bu5fL

Co-led with @jclandoni.bsky.social and fantastic support from Keaton Holt, Elena Koslover, @tatjanakleele.bsky.social , @sulianamanley.bsky.social , Sheda Ben Nejma, and Berna Durmus, you can find the preprint here: www.biorxiv.org/content/10.6... It's wonderful to see this project out in the wild

Using photoconversion, volumetric imaging, mitochondrial segmentation, and network simulations, we identified a distinct, proliferative mitochondrial subpopulation positioned around the nucleus. From there, single mitochondria scatter new material across the cell, maintaining network in balance

🔬🥟 What do empanadas and #mitochondria have in common? More than you'd think. Our "empanada-shaped" cells just helped uncover hidden subpopulations of mitochondria in your everyday, unpolarized cell lines. Curious how mitochondrial trafficking shapes network health?

Preprint alert 🚨 Ever wondered what role fast #mitochondria trafficking plays in the simple cells we mostly use? In @julius-w.bsky.social et al. we use mitodynamics + simulations to identify the importance of outwards transport to distribute new material and keep network balance! Link below!