Jelle van den Ameele
@jellevda.bsky.social
📤 250
📥 68
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reposted by
Jelle van den Ameele
Eva Hörmanseder
2 months ago
We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗
nature.com/articles/s41467-025-67692-7
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https://nature.com/articles/s41467-025-67692-7
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
3 months ago
Closes 12/01/2026. A great team and a great centre to be a part of!
@camneurodept.bsky.social
@taylorlabncl.bsky.social
@jellevda.bsky.social
@ritahorvath.bsky.social
@robpitceathly.bsky.social
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reposted by
Jelle van den Ameele
Rita Horvath
3 months ago
www.gimjournal.org/article/S109...
I am very proud of this new paper! Congratulations to Thiloka and the team of young researchers! 👍
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Charting the phenotypic landscape of mitochondrial diseases through a systematic evaluation of pathogenic mitochondrial DNA and nuclear gene variants
Primary mitochondrial diseases (PMD) arise from variants in the mitochondrial or nuclear genomes. Phenotype-based recognition of specific PMD genotypes remains difficult, prolonging the diagnostic ody...
https://www.gimjournal.org/article/S1098-3600(25)00267-9/fulltext
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reposted by
Jelle van den Ameele
James Nathan
5 months ago
Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab
@jellevda.bsky.social
, we developed DamMapper
damid-seq.readthedocs.io/en/latest/
, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy.
rdcu.be/eK2TS
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Mapping SET1B chromatin interactions with DamID using DamMapper, a comprehensive Snakemake workflow
https://rdcu.be/eK2TS
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Jelle van den Ameele
Emma Rawlins
5 months ago
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including
@jamesnathanlab.bsky.social
@jellevda.bsky.social
authors.elsevier.com/sd/article/S...
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Jelle van den Ameele
Michele Frison
5 months ago
Bluesky, I am pleased to present to you the main product of postdoc work, published in
@science.org
☝️ As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
7 months ago
This is amazing news!!
@camneurodept.bsky.social
@mrc-mbu.bsky.social
@jellevda.bsky.social
@ritahorvath.bsky.social
@mito-news.bsky.social
add a skeleton here at some point
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
7 months ago
📢 We are hiring a Senior Research Associate in Bioinformatics & Statistical genetics
@cam.ac.uk
@mrc-mbu.bsky.social
@camneurodept.bsky.social
@jellevda.bsky.social
It's a great time to join this dynamic and world leading team working on
#mitochondria
Closes 28/8/25
www.cam.ac.uk/jobs/senior-...
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Senior Research Associate (Fixed Term)
Nuclear-mitochondrial genetic interactions in health and neurodegenerative diseases Fixed-term: The funds for this post are available until 30 September 2028 in the first instance. The University of
https://www.cam.ac.uk/jobs/senior-research-associate-fixed-term-ze46819
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reposted by
Jelle van den Ameele
Cambridge Fly Club
9 months ago
Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
10 months ago
Thanks to
@lilyfoundation.bsky.social
for taking these snaps of the centre leads and team members! Together we hope to do great things over the next 5 years of the LifeArc Centre!
#mito
@ucl-qs-cnmd.bsky.social
@taylorlabncl.bsky.social
@ritahorvath.bsky.social
@jellevda.bsky.social
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
10 months ago
We spent a great afternoon at the House of Lords for the launch of the
@lifearc.bsky.social
Centre for
#Rare
#Mitochondrial
Diseases, supported by
@mdukcharity.bsky.social
The event centre hosted staff, dignitaries, patients, MPs & those involved in rare disease policy & research. We even unveiled…
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
11 months ago
It was a great day and a fantastic
#PPIE
workshop!!
@lifearc.bsky.social
@ritahorvath.bsky.social
@jellevda.bsky.social
@robpitceathly.bsky.social
@taylorlabncl.bsky.social
@dwong47.bsky.social
@mitogene.bsky.social
@mrc-mbu.bsky.social
@mitonewcastle.bsky.social
@uclqsion.bsky.social
add a skeleton here at some point
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reposted by
Jelle van den Ameele
Michal Minczuk
11 months ago
🚨 Join us for the
@faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out:
events.faseb.org/event/mitoch...
Please re-post!
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
11 months ago
2x CRA posts extended until end of April. So you have another chance to work with
#mito
disease patients as part of the
@lifearc.bsky.social
centre for
#rare
#mito
diseases! See links below to apply!
@eastgenomics.bsky.social
@camneuro.bsky.social
@cuhnhs.bsky.social
add a skeleton here at some point
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reposted by
Jelle van den Ameele
Hannah Dickmänken
11 months ago
Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2!
www.biorxiv.org/content/10.1...
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
11 months ago
We are hiring
#bioinformaticians
. One post to work on the new
@lifearc.bsky.social
centre for rare
#mitochondrial
diseases, and one is a joint project
@mrc-mbu.bsky.social
with Prof Patrick Chinnery &
@mitogene.bsky.social
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/
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Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) - Job Opportunities - University of Cambridge
Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) in the Division of Neurology at the University of Cambridge.
https://www.jobs.cam.ac.uk/job/50861/
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reposted by
Jelle van den Ameele
Seth Cheetham
12 months ago
Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc
@laura-leighton.bsky.social
found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics.
www.biorxiv.org/content/10.1...
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
All the jobs, all in one place!!
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
📢 We have not 1 but 3 clinical/patient-facing jobs working with
#mitoCAMB
on the
#LifeArc
#raredisease
centre for
#mito
diseases. 1x pre/post-doctoral CRA; 1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator Join us! Links below.
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reposted by
Jelle van den Ameele
Robert Krautz
about 1 year ago
We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫 Come join me and my lab in beautiful Copenhagen. 🇩🇰 PhD -
lnkd.in/dtKz_gnA
PostDoc -
lnkd.in/dBgn6AcK
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LinkedIn
This link will take you to a page that’s not on LinkedIn
https://lnkd.in/dtKz_gnA
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
BBC news article about one of our patients with
#neuroferritinopathy
on the DefINe clinical trial, funded by
#LifeArc
. Spread the word about this disease, and also this trial - more participants needed!
www.bbc.com/news/article...
@ritahorvath.bsky.social
@jellevda.bsky.social
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Brain drug cure needed for future 'trapped in' generations
Scientists hope to find a cure for a genetic condition linked back to a single Cumbrian family line.
https://www.bbc.com/news/articles/c7vdq8zzj79o
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
Very excited to share this
#LifeArc
video about the 4 new
#rare
disease centres across the UK, with our centre for
#mitochondrial
diseases being one of them!
@jellevda.bsky.social
@ritahorvath.bsky.social
@frisophagy.bsky.social
@mrc-mbu.bsky.social
www.linkedin.com/posts/lifear...
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LifeArc on LinkedIn: Rare disease research faces unique challenges including lack of…
Rare disease research faces unique challenges including lack of investment, small patient populations, fragmented research and challenging routes to…
https://www.linkedin.com/posts/lifearc_rare-disease-research-faces-unique-challenges-activity-7290292607086133248-MsUQ?utm_source=share&utm_medium=member_desktop
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Congratulations Meghana, Marco and Eva! Great to have played a small part in this beautiful work!
add a skeleton here at some point
about 1 year ago
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reposted by
Jelle van den Ameele
Meghana Oak
about 1 year ago
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025...
👇 Highlights below
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H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
https://doi.org/10.1101/2025.01.20.633863
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
Final week to apply for this research coordinator position, working on all things
#mito
& the LifeArc centre for rare diseases. Join us!
www.jobs.cam.ac.uk/job/48491/
@ritahorvath.bsky.social
@jellevda.bsky.social
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Research Coordinator (Fixed Term) - Job Opportunities - University of Cambridge
Research Coordinator (Fixed Term) in the Division of Neurology at the University of Cambridge.
https://www.jobs.cam.ac.uk/job/48491/
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
For any patients (or researchers) interested in
#mito
research, the Lily Foundation has launched its new 'research zone':
www.thelilyfoundation.org.uk/affected-by-...
@ritahorvath.bsky.social
@jellevda.bsky.social
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Research Zone - The Lily Foundation
Your hub for the latest news, views and breakthroughs in mitochondrial disease research. categories: Research on the road,Researcher spotlight,PPIE round-up,Science unwrapped,Journal club,Trials hub
https://www.thelilyfoundation.org.uk/affected-by-mito/our-research/research-zone/
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
New year, new bluesky account, and new website:
mitocamb.medschl.cam.ac.uk
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MitoCAMB - Cambridge Clinical Mitochondrial Research Group
Studying the genetic basis and mechanisms of mitochondrial diseases. Our aim is to provide a precise diagnosis and to discover new treatments.
https://mitocamb.medschl.cam.ac.uk
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