Jelle van den Ameele
@jellevda.bsky.social
📤 246
📥 66
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reposted by
Jelle van den Ameele
Eva Hörmanseder
20 days ago
We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗
nature.com/articles/s41467-025-67692-7
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https://nature.com/articles/s41467-025-67692-7
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
30 days ago
Closes 12/01/2026. A great team and a great centre to be a part of!
@camneurodept.bsky.social
@taylorlabncl.bsky.social
@jellevda.bsky.social
@ritahorvath.bsky.social
@robpitceathly.bsky.social
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reposted by
Jelle van den Ameele
Rita Horvath
about 2 months ago
www.gimjournal.org/article/S109...
I am very proud of this new paper! Congratulations to Thiloka and the team of young researchers! 👍
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Charting the phenotypic landscape of mitochondrial diseases through a systematic evaluation of pathogenic mitochondrial DNA and nuclear gene variants
Primary mitochondrial diseases (PMD) arise from variants in the mitochondrial or nuclear genomes. Phenotype-based recognition of specific PMD genotypes remains difficult, prolonging the diagnostic ody...
https://www.gimjournal.org/article/S1098-3600(25)00267-9/fulltext
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reposted by
Jelle van den Ameele
James Nathan
3 months ago
Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab
@jellevda.bsky.social
, we developed DamMapper
damid-seq.readthedocs.io/en/latest/
, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy.
rdcu.be/eK2TS
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Mapping SET1B chromatin interactions with DamID using DamMapper, a comprehensive Snakemake workflow
https://rdcu.be/eK2TS
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reposted by
Jelle van den Ameele
Emma Rawlins
3 months ago
Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including
@jamesnathanlab.bsky.social
@jellevda.bsky.social
authors.elsevier.com/sd/article/S...
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reposted by
Jelle van den Ameele
Michele Frison
3 months ago
Bluesky, I am pleased to present to you the main product of postdoc work, published in
@science.org
☝️ As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
5 months ago
This is amazing news!!
@camneurodept.bsky.social
@mrc-mbu.bsky.social
@jellevda.bsky.social
@ritahorvath.bsky.social
@mito-news.bsky.social
add a skeleton here at some point
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
5 months ago
📢 We are hiring a Senior Research Associate in Bioinformatics & Statistical genetics
@cam.ac.uk
@mrc-mbu.bsky.social
@camneurodept.bsky.social
@jellevda.bsky.social
It's a great time to join this dynamic and world leading team working on
#mitochondria
Closes 28/8/25
www.cam.ac.uk/jobs/senior-...
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Senior Research Associate (Fixed Term)
Nuclear-mitochondrial genetic interactions in health and neurodegenerative diseases Fixed-term: The funds for this post are available until 30 September 2028 in the first instance. The University of
https://www.cam.ac.uk/jobs/senior-research-associate-fixed-term-ze46819
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reposted by
Jelle van den Ameele
Cambridge Fly Club
8 months ago
Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
8 months ago
Thanks to
@lilyfoundation.bsky.social
for taking these snaps of the centre leads and team members! Together we hope to do great things over the next 5 years of the LifeArc Centre!
#mito
@ucl-qs-cnmd.bsky.social
@taylorlabncl.bsky.social
@ritahorvath.bsky.social
@jellevda.bsky.social
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
8 months ago
We spent a great afternoon at the House of Lords for the launch of the
@lifearc.bsky.social
Centre for
#Rare
#Mitochondrial
Diseases, supported by
@mdukcharity.bsky.social
The event centre hosted staff, dignitaries, patients, MPs & those involved in rare disease policy & research. We even unveiled…
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
9 months ago
It was a great day and a fantastic
#PPIE
workshop!!
@lifearc.bsky.social
@ritahorvath.bsky.social
@jellevda.bsky.social
@robpitceathly.bsky.social
@taylorlabncl.bsky.social
@dwong47.bsky.social
@mitogene.bsky.social
@mrc-mbu.bsky.social
@mitonewcastle.bsky.social
@uclqsion.bsky.social
add a skeleton here at some point
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reposted by
Jelle van den Ameele
Michal Minczuk
9 months ago
🚨 Join us for the
@faseborg.bsky.social
Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out:
events.faseb.org/event/mitoch...
Please re-post!
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
9 months ago
2x CRA posts extended until end of April. So you have another chance to work with
#mito
disease patients as part of the
@lifearc.bsky.social
centre for
#rare
#mito
diseases! See links below to apply!
@eastgenomics.bsky.social
@camneuro.bsky.social
@cuhnhs.bsky.social
add a skeleton here at some point
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reposted by
Jelle van den Ameele
Hannah Dickmänken
9 months ago
Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2!
www.biorxiv.org/content/10.1...
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
9 months ago
We are hiring
#bioinformaticians
. One post to work on the new
@lifearc.bsky.social
centre for rare
#mitochondrial
diseases, and one is a joint project
@mrc-mbu.bsky.social
with Prof Patrick Chinnery &
@mitogene.bsky.social
Apply here:
www.jobs.cam.ac.uk/job/50861/
www.jobs.cam.ac.uk/job/50860/
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Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) - Job Opportunities - University of Cambridge
Bioinformatician - disease gene discovery - inherited mitochondrial diseases (Fixed Term) in the Division of Neurology at the University of Cambridge.
https://www.jobs.cam.ac.uk/job/50861/
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reposted by
Jelle van den Ameele
Seth Cheetham
10 months ago
Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc
@laura-leighton.bsky.social
found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics.
www.biorxiv.org/content/10.1...
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
11 months ago
All the jobs, all in one place!!
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
11 months ago
📢 We have not 1 but 3 clinical/patient-facing jobs working with
#mitoCAMB
on the
#LifeArc
#raredisease
centre for
#mito
diseases. 1x pre/post-doctoral CRA; 1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator Join us! Links below.
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reposted by
Jelle van den Ameele
Robert Krautz
11 months ago
We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫 Come join me and my lab in beautiful Copenhagen. 🇩🇰 PhD -
lnkd.in/dtKz_gnA
PostDoc -
lnkd.in/dBgn6AcK
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LinkedIn
This link will take you to a page that’s not on LinkedIn
https://lnkd.in/dtKz_gnA
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
11 months ago
BBC news article about one of our patients with
#neuroferritinopathy
on the DefINe clinical trial, funded by
#LifeArc
. Spread the word about this disease, and also this trial - more participants needed!
www.bbc.com/news/article...
@ritahorvath.bsky.social
@jellevda.bsky.social
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Brain drug cure needed for future 'trapped in' generations
Scientists hope to find a cure for a genetic condition linked back to a single Cumbrian family line.
https://www.bbc.com/news/articles/c7vdq8zzj79o
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
12 months ago
Very excited to share this
#LifeArc
video about the 4 new
#rare
disease centres across the UK, with our centre for
#mitochondrial
diseases being one of them!
@jellevda.bsky.social
@ritahorvath.bsky.social
@frisophagy.bsky.social
@mrc-mbu.bsky.social
www.linkedin.com/posts/lifear...
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LifeArc on LinkedIn: Rare disease research faces unique challenges including lack of…
Rare disease research faces unique challenges including lack of investment, small patient populations, fragmented research and challenging routes to…
https://www.linkedin.com/posts/lifearc_rare-disease-research-faces-unique-challenges-activity-7290292607086133248-MsUQ?utm_source=share&utm_medium=member_desktop
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Congratulations Meghana, Marco and Eva! Great to have played a small part in this beautiful work!
add a skeleton here at some point
12 months ago
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reposted by
Jelle van den Ameele
Meghana Oak
12 months ago
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025...
👇 Highlights below
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H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
https://doi.org/10.1101/2025.01.20.633863
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
12 months ago
Final week to apply for this research coordinator position, working on all things
#mito
& the LifeArc centre for rare diseases. Join us!
www.jobs.cam.ac.uk/job/48491/
@ritahorvath.bsky.social
@jellevda.bsky.social
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Research Coordinator (Fixed Term) - Job Opportunities - University of Cambridge
Research Coordinator (Fixed Term) in the Division of Neurology at the University of Cambridge.
https://www.jobs.cam.ac.uk/job/48491/
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
For any patients (or researchers) interested in
#mito
research, the Lily Foundation has launched its new 'research zone':
www.thelilyfoundation.org.uk/affected-by-...
@ritahorvath.bsky.social
@jellevda.bsky.social
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Research Zone - The Lily Foundation
Your hub for the latest news, views and breakthroughs in mitochondrial disease research. categories: Research on the road,Researcher spotlight,PPIE round-up,Science unwrapped,Journal club,Trials hub
https://www.thelilyfoundation.org.uk/affected-by-mito/our-research/research-zone/
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reposted by
Jelle van den Ameele
Cambridge Clinical Mitochondrial Research Group
about 1 year ago
New year, new bluesky account, and new website:
mitocamb.medschl.cam.ac.uk
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MitoCAMB - Cambridge Clinical Mitochondrial Research Group
Studying the genetic basis and mechanisms of mitochondrial diseases. Our aim is to provide a precise diagnosis and to discover new treatments.
https://mitocamb.medschl.cam.ac.uk
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