Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)

Our new preprint is out: www.biorxiv.org/content/10.6... We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs. A reminder of why bias-aware evaluation matters!

After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!

We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7

Do you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17

I’m thrilled to share that our project, FATERNA, has been awarded an ERC Consolidator Grant! We’ll explore the mechanisms of pre-mRNA fate control. Huge thanks go to our awesome research team, colleagues, and the fantastic support from @impvienna.bsky.social & @viennabiocenter.bsky.social CP.

Excited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback. journals.biologists.com/dev/article/...

A close-up piece on the legacy of Sir John Gurdon - so happy to see this out at @natcomms.nature.com. Excellent editorial and community work by @ebardot.bsky.social & thank you, @evahoermanseder.bsky.social et al.! www.nature.com/articles/s41...

We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists. The piece is available open access in Nature Communications: www.nature.com/articles/s41...

We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon. Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications

Yearly Lab Luncheon at John’s place. 2017

The Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story. www.nytimes.com/2025/04/11/s...

#EpigeneticsPodcast with #HelmholtzMunich expert Dr. Eva Hörmanseder, @epihmgu.bsky.social! 🎧 Listen and learn about epigenetic memories & more: 👉 t1p.de/30q54 👉Check out her latest findings on this topic: t1p.de/43yrw @epigeneticspod.bsky.social #Epigenetics #Podcast #Reprogramming #CellFate

In the most recent episode we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de‬ about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics Listen here: activemotif.com/podcasts-eva...

This is very disturbing. Harvard PhD student Kseniia Petrova (Russian citizen) was arrested by ICE for transporting xenopus embryos into Boston from Paris. She has been detained in Louisiana since Feb. 16. www.theguardian.com/us-news/2025...

If I could do it all over again, I’d apply here for my postdoc- look at these fantastic opportunities! ⬇️

Reprogramming efficiency varies across cell types in vivo and is modulated by somatic cell identity memory. Eliminating somatic cell transcriptional memory improves reprogramming success #nucleartransfer ow.ly/g1Au50VimTM @www.helmholtz-munich.de @isscr.org

We’d like to thank our Editors and peer reviewers who made the #fastandfairpeerreview trial possible. Would you like to join our reviewer pool? Visit bit.ly/41N31tO for more details.

Harvard scientist opposed to Ukraine war faces deportation back to Russia: Friends. This sounds like Trump trying to please Putin rather than anything to do with US immigration. www.independent.co.uk/news/world/a...

Our key collaborator, genius scientist and wonderful person Kseniia is in a horrendous situation right now, see article below. Why? Trump. Please share, please do not ignore, if you can, help. www.independent.co.uk/news/world/a...

Thank you very much for this possibility to contribute to this podcast! …but, as it said in my recommendation letter, “she has a tendency to talk fast” :) Thanks to everyone who contributed to these discoveries discussed here 🙏 Especially to those I forgot to mention cause I was so nervous…

🚨NEW PAPER ALERT! 3 of our teams at IES collaborated to understand why some cells reprogram effectively while others fail @hamperllab.bsky.social @antonio-scialdone.bsky.social @evahoermanseder.bsky.social Congrats to all the authors of this exceptional paper published @stemcellreports.bsky.social

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...

Very happy to share the preprint of my main PhD project in the @bonevlab.bsky.social! Huge thanks to @boyanbonev.bsky.social, all co-authors and members of the @bonevlab.bsky.social! This work wouldn’t have been possible without your contributions!

The last chapter of my PhD is finally out! Huge thanks to my supervisor @genikhovich.bsky.social for supporting “at first glance, stupid ideas” — which turned into a nice paper! That was so much fun!

Thank you Antonio for this great collaboration!

Cell Fate Changes – Transcriptional Memory in Reprogramming Dr. Eva Hörmanseder, #HelmholtzMunich & team uncovered why some cells resist reprogramming – a key hurdle for regenerative medicine. 👉 t1p.de/43yrw @epihmgu.bsky.social #CellReprogramming #Epigenetics #StemCells #RegenerativeMedicine

Do you work with reprogrammed cells? Then look at our new paper! We asked: How well do reprogrammed cells differentiate into complete&functional tissues? We found that - some cell types form perfectly but others fail - reducing levels of one specific TF of the previous lineage can fix problems⬇️

A preprint from the lab- Corrections in single cell migration path in vivo are controlled by pulses in polar Rac1 activation. www.biorxiv.org/content/10.1...

We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫 Come join me and my lab in beautiful Copenhagen. 🇩🇰 PhD - lnkd.in/dtKz_gnA PostDoc - lnkd.in/dBgn6AcK

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

🚀 PREPRINT ALERT! 🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development. 👏 Congratulations @meghana-oak.bsky.social & rest of authors. 📑 👀 shorturl.at/6MIRn 🔎 #OpenPeerReview

🎆Next #FragileNucleosome meeting is less than a week away! We are delighted to host @manucazottes.bsky.social, @robertadolling1.bsky.social & @leandrosboukas.bsky.social ! We will discuss evolution of XIST regulatory network, cancer epigenetics, and MDEMs! 🗓️ us06web.zoom.us/webinar/regi...

Congratulations Marcel, Manuel and everyone involved! Wonderful work on transcription replication conflicts, check out highlights below ⬇️

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇

Single Cell Precision Nanocarrier Identification tracks & quantifies targeted drug-delivery by nanocarriers at single-cell resolution 📹: @erturklab.bsky.social lab @www.helmholtz-munich.de in @naturebiotech.bsky.social ➡️: bpod.org.uk/archive/2025...

🚀Excited to share preprint as my last work in the Tachibana lab! Our study shows how the pioneer factor NR5A2 ensures robust gene activation through feed-forward regulatory loops with lineage-determining factors. A quick summary follows (1/n) www.biorxiv.org/content/10.1...

Excited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇

My colleague Meghana @meghana-oak.bsky.social will present her work this Thursday at THE virtual Maternal Zygotic Transition symposium! We are very excited about this opportunity! You can follow her talk by registering here: www.giraldezlab.org/symposium/

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

In 2025, we continue to advocate for policy based on scientific evidence. This 2020 Editorial, “We need leaders that believe in scientific evidence”, resonates today as loudly as ever: plos.io/34lyl59. PLOS Biology also continues to push for DEI and a diverse scientific community: plos.io/3rzxczU 🧪

New Editorial from @natcomputsci.bsky.social out today. Bringing the data to show why diversity matters for everyone's success. www.nature.com/articles/s43...

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that: 1) active histone mods occur independently of transcription 2) transcription coordinates histone deacetylation at active promoters www.science.org/doi/10.1126/...

Interested in exploring epigenetic cell memory? Join us!! 6 PhD and postdoc positions available in our new center, EpiC.

Wow, this seems like an incredible opportunity!

Wonderful work spearheaded by Marco @marcostock.bsky.social !! Interesting for everyone planning to do gene network analyses!!

How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking! www.embopress.org/doi/full/10....

Calling all students. The registration for the European Summer School on Stem Cell Biology and Regenerative Medicine is now open.

Congratulations to all girls and women in science, but also to those who left or had to leave science. Unfortunately not everyone can stay in science, still, today. I would love to see pictures of women working now outside of academia, science, stem- what are you up to now? #STEM #womeninscience

Being a young parent in academia can be rough. In the latest column of the Tilburg Young Academy in Univers, Myrthe Faber describes these challenges spot on. universonline.nl/nieuws/2025/... @universmagazine.bsky.social #academicsky