New pre-print from our lab (@erturklab.bsky.social) www.biorxiv.org/content/10.1... Skeetorial to follow, but check it out now if you are interested in targeted drug delivery

Your Brilliant Idea Won't Get You a PI Position As scientists, we are passionate about our research and great ideas. But this is a dream that rarely gets you hired. 1/9

We discovered that the skull bone marrow has direct connections to the brain surface & mirrors brain inflammation, making it a new site for diagnosing & monitoring brain pathologies. Kolabas…Ertürk, Cell (2023): www.cell.com/cell/pdf/S00... Our Tech: www.biorxiv.org/content/10.1... bit.ly/3PQuymm

We developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. biorxiv.org/content/10.1...

Don’t Be Afraid to Use AI Tools: Learn How to Utilize Them to Drive Innovation Many people are concerned about using AI tools in science. They say it hallucinates or that using it is cheating. I disagree. I think these fears focus on the wrong thing and discourage many. 1/10

BIG NEWS: As the CEO, I am thrilled to announce the closure of our seed financing round for Deep Piction. 👉🏻https://bit.ly/3TnFpXq Our vision is to bring the fastest and most precise therapeutics to millions using our transparency and AI technology platform.

Failure is Inevitable: How to Build a Resilient Lab Culture In my last posts, I shared my experiences with building a team and focusing. When you look from the outside, you might see a story of quick, impactful papers and major grants. But that’s only half the story. 1/11

The importance of focusing on 1-2 projects as a starting PI. Something that might sound crazy: when I finished my postdoc, I didn't have a job lined up. No position, no safety net. As the academic job market is brutal, taking time off before securing my next position felt like career suicide. 1/10

Post 1: 𝐁𝐮𝐢𝐥𝐝𝐢𝐧𝐠 𝐮𝐩 𝐭𝐡𝐞 𝐭𝐞𝐚𝐦 𝐢𝐬 𝐰𝐡𝐞𝐫𝐞 𝐭𝐡𝐞 𝐦𝐨𝐬𝐭 𝐞𝐟𝐟𝐨𝐫𝐭 𝐬𝐡𝐨𝐮𝐥𝐝 𝐠𝐨. When I posted my first position, not surprisingly, I wasn't known as a young PI. Yet I received over 250 applications for that single position. How? 🧵

Our Nature Biotech paper hit 225K+ accesses in 3 months! 🤩 7 first authors from computer science, biology & chemistry prove that great science is teamwork. We combined AI & imaging to visualize single cells across whole organisms. Team synergy > individual brilliance. www.nature.com/articles/s41...

We build some of the most advanced AI for biomedical research, leveraging unique data and algorithms to drive precision medicine at scale. People ask if AI will replace humans. It isn’t about idea generation—it’s about selecting and implementing the right ideas with minimal effort & maximum impact.

Germany’s Science Minister @cem_oezdemir is spot on—we must welcome top scientific talent, especially as the US’s political attitude toward scientists shifts. Many exciting AI & biotech roles opening soon at our biotech @deeppiction.bsky.social. @danyalbayaz.bsky.social www.n-tv.de/politik/Grue...

Want to know what we do at our startup Deep Piction? Check out our paper with Denali Therapeutics. Using our proprietary clearing & imaging technologies, we mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in whole mouse bodies and monkey brains. go.nature.com/3Xifva2

Excited to share our latest work with Denali Therapeutics as Deep Piction. Using our proprietary clearing & imaging, we’ve mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in both whole mouse bodies and monkey brains. nature.com/articles/s41...

Single Cell Precision Nanocarrier Identification tracks & quantifies targeted drug-delivery by nanocarriers at single-cell resolution 📹: @erturklab.bsky.social lab @www.helmholtz-munich.de in @naturebiotech.bsky.social ➡️: bpod.org.uk/archive/2025...

🌟Check out more about "SCP-Nano: A New Technology to Visualize Nanocarriers in Cells and Tissues" in our news: t1p.de/muluc @erturklab.bsky.social @naturebiotech.bsky.social @bpodaily.bsky.social #HelmholtzMunich

A fantastic new study in @cp-cellhostmicrobe.bsky.social led by @erturklab.bsky.social reveals that SARS-CoV-2 S1 protein can accumulate in the brain for years, potentially contributing to #LongCOVID symptoms. Happy to see our 🦙 #sdAb ( #nanobody) as a key reagent here: doi.org/10.1016/j.ch...

See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...

Ali Ertürk’s Journey in Transformative Biomedical Imaging Prof. Ali Ertürk’s pioneering research is opening up new possibilities for #medicine & transforming how we understand & treat #diseases. t1p.de/56w3i @erturklab.bsky.social

🚀 Excited to share my journey in transformative tissue clearing for biomedical imaging! Our research at @HelmholtzMunich is making the invisible visible, unlocking new possibilities for medicine and AI-driven discoveries.

Imagine being able to visualize life-saving drugs or genetic therapies being delivered to the target cells without causing harmful side effects? Another amazing study from @erturklab.bsky.social at @naturebiotech.bsky.social 🤩

As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳 Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn.... 🧵

Congratulations to the @erturklab.bsky.social lab for another big paper on nanoparticles, with some nice manual ground-truth segmentation created in syGlass. Some pretty nice movies in supplemental materials, too! (Video speed set to 2X to accommodate Bluesky's 1 min limit)

Very excited that this study led by @erturklab.bsky.social is finally out. Among deep insight into in vivo distribution of LNP and AAV (together with some unexpected effects), it shows how DNA origami nanoparticles distribute in organisms and can be targeted to cells. www.nature.com/articles/s41...

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning - @erturklab.bsky.social @hendrikdietz.bsky.social go.nature.com/4gNLjeC

Twitter: LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...

New paper from our lab (@erturklab.bsky.social) We show how tissue clearing, light sheet microscopy, and AI-based image analysis can be combined to determine the biodistribution and drug delivery efficiency of nanocarriers throughout entire mouse bodies with single-cell resolution.

The denialists can keep trying, but the science will keep coming. I know it is scary, but we won't stop talking about it. As @erturklab.bsky.social said, this is not just an individual health issue – it is a societal challenge. www.cell.com/cell-host-mi... #NeuroCovid #LongCovid

Spike-Proteine verbleiben jahrelang im Gehirn "Dies ist nicht nur ein individuelles Gesundheitsproblem - es ist eine gesellschaftliche Herausforderung", sagt Prof. Ertürk @erturklab.bsky.social "Unsere Studie zeigt, dass mRNA-Impfstoffe das Risiko langfristiger … bsky.app/profile/ralf...

Reflecting on 2024 📚🎧: Read 50 books, including Island Beneath the Sea, Ego is the Enemy, How Not to Age, The Anxious Generation, & Nexus. Balanced learning with podcasts like Matt Wolfe, The AI Advantage, Lex Fridman, & Huberman Lab. Books for depth, podcasts for speed—perfect mix! Your favorites?

Spatial proteomics is crowned Method of the Year! 🎉 Explore our groundbreaking work on bringing proteomics into 3D (yes, spatial! 😉): www.cell.com/cell/pdf/S00.... And don’t miss my latest review on 3D spatial omics using tissue-clearing and AI: www.nature.com/articles/s41.... 🚀

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵 biorxiv.org/content/10.1...

How does obesity reshape peripheral nerves and immune cells at the whole-body level? 🌟 Our preprint explores this using an AI-driven pipeline to precisely identify, map, and quantify these changes. Thrilled to share it with you here on BlueSky! 🦋😀 www.biorxiv.org/content/10.1...

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf

New paper from our lab @erturklab.bsky.social www.cell.com/cell-host-mi...

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇 @cellpress.bsky.social cell.com/cell-host-mi...

Also contributing to #FluorescenceFriday (also follow our lab account @erturklab.bsky.social for more stuff like this)

Hey Bluesky! As Erturklab, we are also moving to alternative social media 😉. Stay in touch to follow our work on AI and tissue clearing driven cell-level imaging of intact mouse bodies and human organs, and how we use these methods to study diseases and develop therapeutics at the cellular level.

Hey Bluesky! As Erturklab, we are also moving to alternative social media 😉. Stay in touch to follow our work on AI and tissue clearing driven cell-level imaging of intact mouse bodies and human organs, and how we use these methods to study diseases and develop therapeutics at the cellular level.

And our lab is here, too, now. @erturklab.bsky.social Stay tuned ...