Boyan Bonev
@boyanbonev.bsky.social
📤 366
📥 195
📝 24
Group Leader at Helmholtz Center Munich * Brain Epigenomics
pinned post!
Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14
www.biorxiv.org/content/10.1...
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Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis
The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...
https://www.biorxiv.org/content/10.1101/2025.04.03.647013v1
6 months ago
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reposted by
Boyan Bonev
Hamperl Lab
about 2 months ago
Our latest research is online in the
@biorxivpreprint.bsky.social
! 🧬🎉 🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
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Replisome progression regulates R-loop mediated transcriptional repression
Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...
https://www.biorxiv.org/cgi/content/short/2025.07.29.667376v1
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reposted by
Boyan Bonev
ME Torres-Padilla
3 months ago
🎤 Apply to speak @our TALENT FORUM by July 31! Showcase YOUR research in Epigenetics & NucleicAcids
@www.helmholtz-munich.de
& connect with leading scientists 🧳Travel+accommodation covered if selected! 📝 Info+how to apply:
lnkd.in/drkRvz7N
#postdoc
#career
#groupleader
#HelmholtzMunich
#research
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reposted by
Boyan Bonev
Christian Mayer
3 months ago
Now out in
@natneuro.nature.com
: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors
@annrosebright.bsky.social
, Yana Kotlyarenko,
@flo-neuhaus.bsky.social
, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
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Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
https://www.nature.com/articles/s41593-025-01999-y
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reposted by
Boyan Bonev
ME Torres-Padilla
4 months ago
Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!! Please distribute :) 🙂
add a skeleton here at some point
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reposted by
Boyan Bonev
Lars Velten
5 months ago
Out in Cell
@cp-cell.bsky.social
: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
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Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...
https://www.cell.com/cell/fulltext/S0092-8674(25)00449-0
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reposted by
Boyan Bonev
Arnau Sebé-Pedrós
5 months ago
Check out our latest work on the evolution of animal genome regulation out today in
@nature.com
. Nicely summarized below by
@ianakim.bsky.social
.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap
@erc.europa.eu
at
@crg.eu
add a skeleton here at some point
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reposted by
Boyan Bonev
Epigenetics Podcast
6 months ago
In the most recent episode we talked with
@boyanbonev.bsky.social
from
@bonevlab.bsky.social
at
@epihmgu.bsky.social
about his work on neuroepigenetics, focusing on gene regulation, chromatin architecture, and primate epigenome evolution.
#epigenetics
Listen here:
activemotif.com/podcasts-boy...
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Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14
www.biorxiv.org/content/10.1...
loading . . .
Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis
The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...
https://www.biorxiv.org/content/10.1101/2025.04.03.647013v1
6 months ago
1
42
14
reposted by
Boyan Bonev
Ludovico Rizzuti
6 months ago
I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with
@alessandrovitriolo.bsky.social
, Mariana, and the people of the Testa and Poot Labs. Full paper here:
www.biorxiv.org/content/10.1...
Thread below 🧵
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https://www.biorxiv.org/content/10.1101/2025.03.06.641037v1
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reposted by
Boyan Bonev
Kaessmann Lab
7 months ago
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development!
rb.gy/dbcxjz
Led by
@ioansarr.bsky.social
,
@marisepp.bsky.social
and
@tyamadat.bsky.social
, in collaboration with
@steinaerts.bsky.social
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reposted by
Boyan Bonev
7 months ago
💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze!
www.biorxiv.org/content/10.1...
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🚨New preprint from
@bonevlab.bsky.social
🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇
www.biorxiv.org/content/10.1...
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3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...
https://www.biorxiv.org/content/10.1101/2025.03.11.642620v1
7 months ago
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