Boyan Bonev
@boyanbonev.bsky.social
๐ค 408
๐ฅ 198
๐ 25
Group Leader at Helmholtz Center Munich * Brain Epigenomics
pinned post!
Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14
www.biorxiv.org/content/10.1...
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Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis
The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...
https://www.biorxiv.org/content/10.1101/2025.04.03.647013v1
about 1 year ago
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Boyan Bonev
Helmholtz Munich
about 1 month ago
#M1
Launches First Funding Period & Advances Translation in Munich๐ Seven projects receive โฌ7.45โฏmillion through the M1 โ Munich Medicine Alliance.
#HelmholtzMunich
is involved in four funded projects. ๐
t1p.de/disle
@tum.de
@lmu.de
@boyanbonev.bsky.social
@erturklab.bsky.social
#MunichMedicine
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Boyan Bonev
Enard/Hellmann Lab
7 months ago
Out now: weโre happy to share our new preprint on CroCoNet (Cross-species Comparison of Networks), a framework for robust comparative network analyses. ๐
doi.org/10.1101/2025...
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Boyan Bonev
Alex Pollen
8 months ago
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package:
www.nature.com/articles/s41...
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Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
https://www.nature.com/articles/s41586-025-09592-w
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๐ ๐ฃ๐ผ๐๐๐ฑ๐ผ๐ฐ ๐ข๐ฝ๐ฒ๐ป๐ถ๐ป๐ด Weโre recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens. ๐ Apply by Nov 30 |
www.bonevlab.com/join
8 months ago
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Boyan Bonev
The Hassan Brain Development Team
8 months ago
A wonderful collaboration with
@alexbaffet.bsky.social
@boyanbonev.bsky.social
and
@neurogenesis-i3s.bsky.social
labs
add a skeleton here at some point
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Boyan Bonev
Hamperl Lab
11 months ago
Our latest research is online in the
@biorxivpreprint.bsky.social
! ๐งฌ๐ ๐ We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
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Replisome progression regulates R-loop mediated transcriptional repression
Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...
https://www.biorxiv.org/cgi/content/short/2025.07.29.667376v1
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Boyan Bonev
ME Torres-Padilla
12 months ago
๐ค Apply to speak @our TALENT FORUM by July 31! Showcase YOUR research in Epigenetics & NucleicAcids
@www.helmholtz-munich.de
& connect with leading scientists ๐งณTravel+accommodation covered if selected! ๐ Info+how to apply:
lnkd.in/drkRvz7N
#postdoc
#career
#groupleader
#HelmholtzMunich
#research
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Boyan Bonev
Christian Mayer
12 months ago
Now out in
@natneuro.nature.com
: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors
@annrosebright.bsky.social
, Yana Kotlyarenko,
@flo-neuhaus.bsky.social
, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
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Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
https://www.nature.com/articles/s41593-025-01999-y
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Boyan Bonev
ME Torres-Padilla
about 1 year ago
Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this ๐๐ is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...
Peer-networking / Career orientation and more !!! Please distribute :) ๐
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Boyan Bonev
Lars Velten
about 1 year ago
Out in Cell
@cp-cell.bsky.social
: Design principles of cell-state-specific enhancers in hematopoiesis ๐งฌ๐ฉธ screen of fully synthetic enhancers in blood progenitors ๐ค AI that creates new cell state specific enhancers ๐ negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
๐งต
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Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...
https://www.cell.com/cell/fulltext/S0092-8674(25)00449-0
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Boyan Bonev
Arnau Sebรฉ-Pedrรณs
about 1 year ago
Check out our latest work on the evolution of animal genome regulation out today in
@nature.com
. Nicely summarized below by
@ianakim.bsky.social
.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap
@erc.europa.eu
at
@crg.eu
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Boyan Bonev
Epigenetics Podcast
about 1 year ago
In the most recent episode we talked with
@boyanbonev.bsky.social
from
@bonevlab.bsky.social
at
@epihmgu.bsky.social
about his work on neuroepigenetics, focusing on gene regulation, chromatin architecture, and primate epigenome evolution.
#epigenetics
Listen here:
activemotif.com/podcasts-boy...
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Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14
www.biorxiv.org/content/10.1...
loading . . .
Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis
The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...
https://www.biorxiv.org/content/10.1101/2025.04.03.647013v1
about 1 year ago
1
42
14
reposted by
Boyan Bonev
Ludovico Rizzuti
about 1 year ago
I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with
@alessandrovitriolo.bsky.social
, Mariana, and the people of the Testa and Poot Labs. Full paper here:
www.biorxiv.org/content/10.1...
Thread below ๐งต
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https://www.biorxiv.org/content/10.1101/2025.03.06.641037v1
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Boyan Bonev
Kaessmann Lab
over 1 year ago
How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development!
rb.gy/dbcxjz
Led by
@ioansarr.bsky.social
,
@marisepp.bsky.social
and
@tyamadat.bsky.social
, in collaboration with
@steinaerts.bsky.social
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Boyan Bonev
over 1 year ago
๐ซ New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schรผtze!
www.biorxiv.org/content/10.1...
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๐จNew preprint from
@bonevlab.bsky.social
๐จ: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Hereโs what we discovered ๐
www.biorxiv.org/content/10.1...
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3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development
The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...
https://www.biorxiv.org/content/10.1101/2025.03.11.642620v1
over 1 year ago
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